Articles

  • PharmaTutor
    12 February 2015

    PHARMACY: BOON OR BANE

    { DOWNLOAD AS PDF }

    ABOUT AUTHOR:
    Pranita Pradip Dharmadhikari
    Department of Phrmacology,
    N.D.M.V.P. College of Pharmacy, Nashik
    2009pranitadh@gmail.com

    “Pharmacy is the health profession that links the health science with the chemical science and it is charged with ensuring safe and effective use of pharmaceutical drugs.” That’s how the Wikipedia defines it. For a student it is a career, an ambition and of a course a learning process.

    Pharmacy education in India was initiated by Medical College; Madras in 1860, the purpose was to develop pharmaceutical skills of students of medical degree or diploma course or of that pursuing hospital assistance. From 1860 to 2014 the pharmacy profession shows a tremendous growth in India, it shows that pharmacist is one of the major fraternities of health care system around the world. As a pharmacist, I must say that pharmacy is profession which benefits to the world. But certain area in pharmacy are consistently points the pharmacist as towards negative aspects. Hence it’s a pharmacist’s duty to focus on wrong practices to make a profession as boon for world.[1]

  • 9 February 2015
    PRESCRIBING TREND OF ANTIHYPERTENSIVE DRUGS IN SRI GANGANAGAR DISTRICT: A RETROSPECTIVE STUDY

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Amarjeet Singh*, Sudeep Bhardwaj, Ashutosh Aggarwal
    Department of Pharmacology,
    Seth G. L. Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research,
    Sri Ganganagar, Rajasthan 335001, India
    *amarjeetsingh024@gmail.com

    ABSTRACT
    Objective    : The choice of drug for the treatment of hypertension changes at short intervals. Drug utilization studiesconducted at regular intervals help to guide the physician in prescribing drugs rationally. The present study was done toanalyze the prescribing patterns of antihypertensive drugs in a NorthIndian  hospital.

    Material & method: A retrospective, crosssectional analysis of prescriptions of antihypertensive cases admitted in Medicine in-patient wards of civil hospital of Sri Ganganagar was conducted. All the prescription files with diagnosis ofessential hypertension were analyzed. Prescriptions for hypertension with other co-morbid conditions were also included. Frequency and proportions of utilization of antihypertensive medications were charted and figured.

    Result: During the studyperiod, there were 435 prescriptions for essential hypertension. The most frequently prescribed antihypertensive medications were:  monotherapy (42.06%), (57.94%) of patients were on multiple drugtherapy, the most favored fixed drug combination being diuretics with angiotensin receptor blockers (31.74%).

    Conclusion: The present study revealed that Angiotensin receptor blockers arethe drugs of choice as monotherapy and as combination therapy for hypertensives. This pattern of prescription is also supported by the current JNC VIII guidelines for the treatment of hypertension.

  • 8 February 2015
    MOLECULAR MODELING STUDIED FOR INHIBITION OF CALCIUM CHANNEL RECEPTOR: A STRATEGY FOR THE DEVELOPMENT OF NEW ANTIEPILEPTIC DRUG

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Vinit Raj*, Amit Rai, Deepak Kumar and Vinod Kumar
    Department of Pharmaceutical Sciences,
    Babasaheb Bhimrao Ambedkar University (A Central University),
    VidyaVihar, Raebreli Road, Lucknow, Uttar Pradesh, 226025, India
    *raj.vinit24@gmail.com

    ABSTRACT
    Epilepsy is a common brain disease that is characterized by recurrent and spontaneous seizures that result from abnormal and excessive synchronization of neuronal activity. Whereas, accumulation of Ca++ in presynaptic terminals, leading to improved neurotransmitter release. In additional, depolarization-induced inauguration of the NMDA subtype of the excitatory amino acid receptor, which causes more Ca++ influx and neuronal activation. The main aim of this study to focus on the deactivation of Ca++ influx and prevent the augmentation of neuron activation. However, we performed molecular modeling of  novel 1,3,4-thiadiazole derivatives keeping in view structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, targeted ligand  produced significantly affinity with the calcium channel receptor which is slightly higher than the phenytoin drug. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. All above parameter was calculated which exhibited slightly excellent compared than standard Phenytoin drug. The above observation suggested that these compounds would serve as better lead for anticonvulsant screening for future drug design perspective.

  • 6 February 2015
    EVALUATION OF ADAPTOGENIC ACTIVITY OF VARIOUS EXTRACTS OF BREYNIA VITIS-IDAEA (BURM.F) C. FISHER LEAVES BY USING SWIM ENDURENCE TEST

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Manju Gowda M R*, Gnanasekaran D, Ashik navas T, Antony george
    Department of Pharmacology, Bharathi College of Pharmacy,
    Bharathinagara, Mandya, Karnataka-571422
    manjugowdamr@gmail.com

    ABSTRACT
    The present study was under taken to study the Adaptogenic activity of ethanol, aqueous and ethyl acetate extracts of Breynia vitis-idaea (burm.f) c. fisher. (Euphorbiaceae) leaves. Adaptogenic activity of these extracts were studied using in-vivo Swim Endurance test and compared with the standard Fluoxetin. All the extracts showed significant increase in the swimming time. Adaptogenic nature of the extracts may be attributed to the presence of constituents such as alkaloids, glycosides, flavonoids and saponins in plant extracts. This study proven that the potential adaptogenic nature of the extract of Breynia vitis-idaea leaves.

  • 5 February 2015
    RESOURCES, GUIDANCE, CONTROL AND PREVENTION FOR EBOLA VIRUS DISEASE-AN OVERVIEW

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Jadhav Santosh1*, Mali Audumbar1, Tamboli Ashpak2
    Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India1.
    Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India2.
    jadhavsan88@gmail.com*

    ABSTRACT
    Since the current Ebola Virus Disease (also referred to as Ebola Haemorrhagic Fever) outbreak began in Guinea in December of 2013, the outbreak now involves trans-mission in Guinea, Liberia, Nigeria, and Sierra Leone. Ebola haemorrhagic fever (EHF) is a zoonosis affecting both human and non-human primates (NHP). Ebola virus (formerly officially designated Zaire Ebolavirus, or EBOV) was first seen infecting humans in African continent; especially  Sudan, Democratic Republican of Congo, Zaire and nearby countries. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. The World Health Organization (WHO) reports that this is the largest Ebola Virus Disease (EVD) outbreak ever recorded. EVD outbreaks have a case fatality rate ofup to 90%. The research is on-going on development of making vaccine to curb this virus yet licensed success or specific treatment is not achieved.

    [adsense:336x280:8701650588]

  • 4 February 2015
    PLANT SPECIES USED BY LOCALS AS ETHANO - MEDICINE IN GOHAR TEHSIL, DISTT. MANDI REGION OF NORTH WESTERN HIMALAYA

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Monika Rana*1, Atul Kabra1, Ruchika Kabra1, Meenakshi Rana2, Vinay Dhatwalia3
    1 Department of Pharmacy, Abhilashi university, Chailchowk, Mandi (H.P)
    2 HIPER college of Pharmacy, Nadaun, (H.P)
    3 Abhilashi College of Pharmacy, Mandi (H.P)
    *sairana.rana43@gmail.com

    ABSTRACT
    Objective:     An exhaustive ethno medicinal investigation of plants was carried out in Gohar Tehsil of Distt. Mandi.
    Methods:     The paper encompasses 38 medicinal plants, collected from forest of Chailchowk and its adjoining areas, and authenticated. The information was collected from local people. This study reveals the status of ethno-medicinal plants and their importance preserved by locals of Gohar Tehsil of Distt. Mandi.
    Results:     Total 38 medicinal plants were studied in the forest of Chailchowk Village and its adjoining areas of Gohar Tehsil are very valuable medicinal plants which are already known for their numerous medicinal values.
    Conclusion:     This study will assist the forest, pharmaceutical firm, medicos and wild life manager in their efforts for improving the public health service and medicinal plant wealth of the area.

  • 30 January 2015
    DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF DICLOFENAC SODIUM BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Mali Audumbar Digambar*, Jadhav Santosh, Mane Pandurang, Tamboli Ashpak
    Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
    Sangola- 413307, Solapur, Maharashtra, India
    maliaudu442@gmail.com

    ABSTRACT
    A simple, precise, accurate and economical UV visible spectrophotometric method has  been developed for estimation of Diclofenac sodium drug by AUC method. The standard and  sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 270-282 nm. The linearity was established over the concentration range of 05,10,15,20&25µg/ml for Diclofenac sodium with correlation coefficient value of 0.9981. Precision studies showed that % relative standard  deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.38%.The proposed method has been validated as per ICH guidelines.

  • 29 January 2015
    THE USE OF EXPERIMENTAL DESIGN IN THE DEVELOPMENT AND OPTIMIZATION OF A RP-HPLC METHOD FOR THE DETERMINATION AND QUANTITATION OF NEVIRAPINE

    ABOUT AUTHORS:
    Chiluba Mwila1*, Sandile S. M. M. Khamanga2, Roderick B. Walker2
    1University of Zambia, School of Medicine, Department of Pharmacy, Lusaka, Zambia
    2Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown, 6140, South Africa
    *mwilachiluba@yahoo.co.uk

    ABSTRACT
    A simple, accurate and specific reversed phase high performance liquid chromatography (RP-HPLC) method that was developed and validated for the analysis of NVP is presented. The stationary phase used was Phenomenex® Luna C18 (2), 5 µm, 250 x 4.6 mm I.D. The mobile phase comprised of acetonitrile and water in the ratio 44: 56 (v/v) and detection was accomplished using UV detector set at 284 nm. RSM using CCD was used to facilitate method optimization. Organic phase composition, flow rate and column temperature were identified as critical factors to be studied to establish the retention times of NVP and CBZ (internal standard) and the resolution factor between the two compounds. Twenty experiments including center points were performed and quadratic models were derived for the retention times of the two compounds and the resolution factor using the experimental data. The method was validated for linearity, precision, limits of quantitation and detection, and stability indicating as per ICH guidelines. The method was found to produce sharp and well resolved peaks for NVP and CBZ with retention times of 4.30 and 7.60 minutes respectively. The method was linear in the concentration range 1 – 240 µg/ml, with the calibration curve showing a good linear relationship with a regression correlation coefficient of 0.9996. The linear regression equation was y = 0.0064x – 0.0016. The limit of quantitation (LOQ) and detection (LOD) were found to be 1.0 and 0.3 µg/ml, respectively.

  • 28 January 2015
    RISK ASSESSMENT OF DEVELOPING TYPE 2 DIABETES MELLITUS IN PATIENT ON ANTIHYPERTENSIVE MEDICATION

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS
    Amarjeet Singh*, Sudeep bhardwaj, Ashutosh aggarwal
    Department of Pharmacology,
    Seth G. L. Bihani S. D. College of Technical Education,
    Institute of Pharmaceutical Sciences & Drug Research
    amarjeetsingh024@gmail.com

    ABSTRACT
    Objective:     The purpose of this study was to examine the risk assessment of developing type 2 diabetes mellitus in patient on antihypertensive medication.

    Material & Method: In the present study total 30 patient with essential hypertension of both sex with mean age (48.6±0.8313) were recruited as per the inclusion criteria. Patients were segregated on the behalf of therapy they were using. 22 patients were on Losartan+HCTZ therapy and 8 patients were on Atenolol therapy.

    Result: After six month of antihypertensive therapy Atenolol group showing a significant difference in their blood glucose (0.0014) whereas in Losartan+HCTZ group significant difference was not observed (0.1542). Patients of Atenolol group when compared with patient of Losartan+HCTZ group a significant difference was observed in the serum cholesterol level (0.0290).

    Conclusion: We found that the use of β-blocker was independently associated with increased risk of type 2 diabetes. So increase in blood glucose in the Atenolol group patient revealed a significant association between use of Atenolol therapy and metabolic dysfunction whereas in Losartan+HCTZ group significant increase in blood glucose was not observed and from these we can conclude therapy with Losartan+HCTZ therapy not associated with metabolic dysfunction.

  • 15 January 2015
    WONDERS OF IMMUNE SYSTEM: SPONTANEOUS REGRESSION OF CANCERS

    { DOWNLOAD AS PDF }

    About Author
    Vishwas B. Chavan
    Consultant, Sunflower laboratory and diagnostic Center and Clinical Diagnostic Center
    Mumbai, Maharashtra.
    vishwaschavan2003@yahoo.co.in

    Cancer incidence is increasing worldwide [1]. It can affect any part of the body, showing symptoms often in late stages. Diagnosis of cancer has a huge impact on patient and his/her family. Cancer treatments are costly and toxic, many times giving rise to secondary cancers. Even after successful treatment, risk of recurrence of cancer is significant sometimes.

Subscribe to Articles