Articles

15 April 2011

Effect of curcumin (Curcuma longa, Zingiberaceae) against sciatic nerve ligation induced behavioral and biochemical alterations: Possible involvement of nitric oxide mechanism

About Authors: Seema Meena, Anil Kumar and Shikha Chauhan
a) Amity Institute of Pharmacy, Amity University, Noida,-201301, India.
b) Neuropharmacology division, University Institute of Pharmaceutical Sciences, UGC Centre for Advance Studies, Panjab University, chandigarh-160014, India.

Abstract:
Neuropathic pain represents a real clinical challenge because of its severity, chronic nature, and inadequate drug therapy. Recently, nitric oxide pathway has been proposed in the pathogenesis neuropathic pain like conditions. Curcumin is a well known for its antioxidant and medicinal values. The objective of the present study was to explore possible nitric oxide mechanism in the protective effect of curcumin against sciatic nerve ligation induced behavioral and biochemical alterations in rats.Sciatic nerve ligation was performed in Wistar rats. Various behavioral parameters (thermal hyperalgesia, cold allodynia) followed by assessment of biochemical parameters (lipid peroxidation, reduced glutathione, catalase, and nitrite) both on sciatic nerves and brain. Sciatic nerve ligation significantly caused thermal hyeralgesia, cold allodynia and oxidative damage as compared to sham (Sciatic nerve without ligation) and naïve animals. Chronic administration of curcumin (20 mg/kg, po) significantly reversed behavioral alteration and attenuated oxidative damage in both sciatic nerve and brain as compared to control. Further, L-NAME (5 mg/kg) pretreatment with curcumin (10 mg/kg, po) potentiated protective effect of curcumin as compared to their effect per se. However, L-arginine (100 mg/kg) pretreatment with curcumin (10 mg/kg, po) significantly reversed the protective effects of curcumin. Result of present study suggests that nitric oxide mechanism could be involved in the protective effect of curcumin against sciatic nerve ligation induced behavior and biochemical alterations in rats.
15 April 2011

Overview and Information of BENFOTIAMINE

About Author: Sayani Chakrabarti
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

ABSTRACT
Benfotiamine (rINN, or S-benzoylthiamine O-monophoshate) is a synthetic S-acyl derivative of thiamine (vitamin B1). It has potential anti oxidant effect. A three-armed, randomized, multicentre, placebo-controlled double-blind study was used to examine the efficacy of benfotiamine vs a combination containing benfotiamine and vitamins B6 and B12 in out-patients with severe symptoms of alcoholic polyneuropathy (Benfotiamine in treatment of Alcoholic Polyneuropathy. BAP I). The study period was 8 weeks and 84 patients fulfilled all the prerequisite criteria and completed the study as planned. Benfotiamine led to significant improvement of alcoholic polyneuropathy. Vibration perception (measured at the tip of the great toe) significantly improved in the course of the study, as did motor function, and the overall score reflecting the entire range of symptoms of alcoholic polyneuropathy. A tendency toward improvement was evident for pain and co-ordination, no therapy-specific adverse effects were seen.
12 April 2011

RECENT TRENDS IN INSULIN DRUG DELIVERY SYSTEM

About Authors: Ms.Komal R. Nikam (B.Pharmacy), Mr.Mahendra G. Pawar (B.Pharmacy), Mr. Kishor S. Salunkhe (M.Pharm,PhD), Mr.Devidas G.Bachhav(M.Pharm)
Amrutvahini college of pharmacy,Sangamner.(Pune University)

Abstract:
The demand for novel drug delivery technologies is ever increasing. These drug delivery technologies includes oral, transdermal, inhalation and parenteral. The main goal for the delivery of any drug therapy is oral administration with once or twice daily dosing. However, there are large numbers of therapies, particularly protein-based, gene-based vaccine-based that cannot be delivered by this route for example insulin, growth hormones and other similar biologicals.
The pitfalls of needle-based injections are well known. Psychological resistances to self-injection or needle-phobia have been documented across large demographic groups, such as diabetics. The result of this phobia is that many outpatient injectables are dosed sub-optimally. Furthermore, awareness of serious problems has caused physicians and their patients to either delay therapy initiation or seek out less-invasive alternatives, even at some cost to clinical effectiveness.
For some, especially those suffering from chronic diseases requiring injectable products two or three times a day, this process is an ongoing reality of daily life for example diabetics-accepted, but always with the hope that something new will replace the ritual of needle insertion. To overcome the problems related to needle based injections, there is one technology that has received considerable attention during the past few years and that offers all of the sought after benefits is—Needle Free Injection Technology (NFIT).
9 April 2011

Lawsonia inermis - From traditional use to scientific assessment

About Authors: Inder Kumar Makhija
Department of Pharmacognosy,
Manipal College of Pharmaceutical Sciences,
Manipal University, Manipal-576 104,
Karnataka

ABSTRACT
The world is endowed with a rich heritage of medicinal plants. The use of medicinal agents presumably predates the earliest recorded history. Medicinal plants are widely used by traditional practitioners for various ailments. Lawsonia inermis (Lythraceae) commonly known as ‘Henna’is a well-known plant used in the Indian medicine. Various parts of this plant have been used in traditional Indian medicine. The plant has wide range of phytochemicals including lawsone, isoplumbagin lawsoniaside, lalioside, lawsoniaside B, syringinoside, daphneside, daphnorin, agrimonolide 6-O-β-D-glucopyranoside, (+)-syringaresinol O-β-D-glucopyranoside, (+)-pinoresinol di-O-β-D-glucopyranoside, syringaresinol di-O-β-D-glucopyranoside, isoscutellarin3β, hennadiol, (20S)-3β, 30-dihydroxylupane, lawnermis acid, 3-methyl-nonacosan-1-ol, laxanthones I, II, III and lacoumarin etc. The various in-vitro and in-vivo studies of L. inermis reported the plant to have antibacterial, antifungal, antiparasitic, antiviral, anticancer, antidiabetic, tuberculostatic, anti-inflammatory, antifertility and wound healing properties. This review discusses on the botany, traditional use, phytochemistry and pharmacological data of the plant.
9 April 2011

A Brief overview on ImmunoPharmacology and Study of Drugs on Immune System

About Author: Bharat Lal
MSIP,
Delhi

STUDY OF DRUGS ON IMMUNE SYSTEM: IT MAY STIMULATE THE IMMUNE SYSTEM OR SUPPRESS THE IMMUNE SYSTEM. STIMMULATION IS REQUIRE FOR DISEASE LIKE AIDS AND SUPPRESSION IS REQUIRE FOR ORGAN TRANSPLANTATION.
9 April 2011

Stress Induced Method Development and Validation of Olmesartan in Bulk and Pharmaceutical Dosage Form by UV Spectrometric Method

About Authors: ¹Arun Kumar Dash*, ²Amitesh Palo,
1. Royal College of Pharmacy and Health Sciences, Berhampur.
2. College of Pharmaceutical Sciences, Mohuda, Berhampur

ABSTRACT
A simple method for the estimation of Olmesartan in bulk and pharmaceutical dosage forms has been developed. Methanol was chosen as the solvent system. The λmax was found to be 257nm and all absorbance values were carried out at 257nm. The responses were linear in the range of 5-35µg/ml. The regression equation of the calibration graph and correlation coefficient were found to be y = 0.049x + 0.007 and 0.999 respectively. The %RSD values for both intraday and interday precision were less than 1%. The recovery of the drug from the sample was ranged between 99.36 and 100.49%. The proposed method was validated for precision, accuracy, intraday, interday assay, robustness and ruggedness. Commercial tablets containing 20mg and 40mg of Olmesartan were analyzed by the proposed method and the results were well within the claimed limits. Furthermore stability studies of Olmesartan were carried out under acidic, alkaline, hydrolytic and photolytic conditions as per SIAM (Stability Indicating Assay Methods).

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9 April 2011

Synthesis and biological evaluation of newer analogues of 2,5-disubstituted 1,3,4-oxadiazole as antioxidant and anticonvulsant agents

About Authors: Arun Dureja*, Kalpana Divekar and M.S.Sandhyavali
Department of Pharmaceutical Chemistry,
Dayananda Sagar College of Pharmacy,
Kumaraswamy Layout,
Bangalore

Abstract
A series of 3-(4-acetyl-5H-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives were synthesized and evaluated for their anticonvulsant and antioxidant activities. Initially Ethyl-2-oxo-2H-chromene-3-carboxylate was prepared by reacting Salicylaldehyde with Diethyl malonate in presence of piperidine. This compound was treated with hydrazine hydrate to give aromatic hydrazides. Those hydrazides were refluxed with different aldehydes to form arylidines, which were then treated with acetic anhydride to form 3-(4-acetyl-5H-5-phenyl-4,5-dihydro-1,3,4-oxadiazol-2-yl)- 2H-chromen-2-one derivatives. The structures of synthesized compounds were characterized and confirmed by IR and ¹HNMR and then screened for antioxidant activity by DPPH reduction method and anticonvulsant activity by MES method. The investigation revealed that out of eight newly synthesized derivatives five were found to possess significant anticonvulsant activity but none of the derivative was found with antioxidant activity.
9 April 2011

ESTIMATION OF QUETIAPINE FUMARATE IN TABLET DOSAGE FORM BY HPTLC METHOD

About Authors: Deepak Sahu
M.Pharm, Geetanjali Institute of Pharmacy
Dabak,
Udaipur, Rajasthan

ABSTRACT
A simple, accurate, low cost and specific HPTLC method for estimation of quetiapine fumarate in tablet has been developed. It was performed on Silica gel G₆₀ F₂₅₄ aluminium foil using acetonitrile : chloroform in the ratio of 1:9 as mobile phase. The mobile phase having chamber was saturated for 20 minutes at room temperature. The R_f value of quetiapine fumarate was found to be 0.45. The plate was scanned and quantified at 242 nm. The calibration curve response was observed between 5-25 μg. The linear regression data showed good linear relationship of r = 0.999. The percent recovery was found to be 100.0 ± 0.01.The developed method was validated for its accuracy and precision with suitable parameters.
6 April 2011

AN ARTICLE ON LEAN SIGMA

About Author
Sayani Chakrabarati,
M.Pharm in Pharmaceutical Chemistry
SIPS, Jharpokharia
Mayurbhanj-757086
Orissa

Introduction
In pharmaceutical industries, many unprecedented challenges have to be faced regarding cost, time, labour, tough competition by other companies etc. To overcome these problems & curve a significant niche in global market, a new approach has been brought named lean sigma. This concept is used to make work BETTER & FASTER. Many companies have embarked on major improvement programs, including internal re-organization, greater externalization to embrace the biotech culture & capture innovation, & the movement of investments to lower cost countries. The Lean Sigma is a very positive approach in such third-world countries like India. This approach will help to beat the recession after effects very soon with appreciable efficiency.
6 April 2011

AGELESS AGING

About Authors: NEHA BATRA, S K Dubey
M.PHARMACY-PHARMACOGNOSY
JNU-JAIPUR

ABSTRACT:
Ageing or aging is the accumulation of changes in an organism or object over time. Ageing in humans refers to a multidimensional process of physical, psychological, and social changes, the things you do this year can halt and even reverse many of health and cognitive issues faced by those over age 50. You could be in better shape, have fewer aches and pains AND have more energy than you did 10 years ago. Anti aging is possible. The body requires two vital materials- energy and raw material for anti-aging. There are many food and herbal treatment available in market for anti aging.

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