• PharmaTutor
    30 January 2013

    SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS

    About Author:
    ABHISHAK SINGH PARMAR,
    M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
    B.R.NAHATA COLLEGE OF PHARMACY,
    MANDSAUR (M.P).
    *abhishakparmar@gmail.com

    1. INTRODUCTION
    1.1 Medicinal and Pharmaceutical chemistry
    It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.1

  • 30 January 2013
    INSIGNIFICANT EFFECT OF SUPERPOROUS HYDROGEL PARTICLES AS A SUPERDISINTEGRANTS IN FAST DISPERSIBLE TABLETS OF ACECLOFENAC

    About Authors:
    Dr. HV Chavda1*, Ms. SK Patel1,     Dr. CN Patel1,
    1Shri Sarvajanik Pharmacy College,
    Nr. Arvind Baug, Mehsana, Gujarat-384001, India.
    *hvchavda@sspcmsn.org

    ABSTRACT
    Background:     In present investigation an attempt has been made to formulate a fast dispersible formulation of aceclofenac using three different superdisintegrants. The role of superporous hydrogel particle as a superdisintegrant was checked for its further future applications. Materials and Methods: The selection of superdisintegrants viz. poly (Acrylamide-co-Acrylic acid) superporous hydrogel particles, cross carmellose sodium and starch 1500 were done using the simplex lattice design. Tablet formulations were prepared using direct compression technique and evaluated for hardness, weight variation, friability, drug content, dispersion time, wetting time, water absorption ratio and in vitro drug release studies. Results and Discussion: The dispersion time of all formulation showed less than 21 second. Superporous hydrogel particles did not showed significant improvement in dispersion time compared cross carmellose sodium and starch 1500. The in vitro drug release from batch F7, tablets containing equal proportions of superdisintegrants showed fast dispersion and fast release compared to other batches. Batch F7 was stable for the period of six months at 40 oC / 75 %RH. Conclusions: Combination of three superdisintegrants was more suitable in fast dispersible tablet formulation of aceclofenac. The superporous hydrogel particles showed equivalent effect as a superdisintegrant, however process complexity of its preparation suspects its role or an option as a superdisintegrant in fast dispersible or immediate release formulations.

  • 29 January 2013
    BETA-LACTAM CLASS OF DRUGS : A REVIEW

    About Authors:
    Mayure.Vijay Kumar*, V. Sravanthi Yadav, C.P.Meher,
    Department of pharmaceutical chemistry
    Maheshwara College of Pharmacy, Chitkul (V)
    Isnapur “X” Road, Patancheru, Hyderabad.
    mayurevijaykumar@gmail.com

    ABSTRACT:-
    β- lactam antibiotics are  the most commonly prescribed drugs. The β- lactam group of antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contain a β- lactam nucleus in their molecular structures. This includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems. Most of the β- lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organisms and are the most widely used group of antibiotics. Bacteria often develop resistance to β- lactam antibiotics by synthesizing that attacks the β- lactam ring. To overcome this resistance, β- lactam antibiotics are often given with β- lactamase inhibitors such as clavulanic acid. Presnted article deals about the structure of various marketed as well as drugs under investigation containing β-lactam nucleus and  their pharmacological activities. The presented article is related wth the various β- lactam derivative with their various pharmacological activities.

  • 29 January 2013
    HEALING ANXIETY WITH HERBS

    About Author:
    Bhatt Mehul K,
    Asst.professor, PhD continue
    Department of Pharmacognosy,
    Shivam Pharmaceutical Studies & Research Centre,
    Valasan-388 326, Anand-380 015, Gujarat, India.
    mkb_0999@yahoo.co.in

    Abstract:
    Now-a-days many people of the world are suffering from anxiety, stress and depression. They experience feelings of anxiety before an important event such as exam, business deal or first date. Anxiety disorders however are illness that fills people’s lives with unreal & imaginary fear that are chronic, unremitting and can grow progressively worse. By now, most of us know that anxiety is quite a common complaint and many people have tried some of the various medications used for anxiety. But many don’t know that there are a variety of herbs available used to treat anxiety in natural way. This article includes, “What is Anxiety?” Herbs used to cure Anxiety, depression, and Stress”, and “Natural Self-Healing”.

  • 28 January 2013
    Herbal Cosmetics: A safe and effective approach

    About Author:
    Bhuwanchandra Joshi,
    Division of Pharmaceutical Science
    SHRI GURU RAM RAI INSTITUTE OF TECHNOLOGY AND SCIENCES,
    PATEL NAGAR, DEHRADUN, UTTARAKHAND
    *bhuwan.joshi000@gmail.com

    Abstract:
    The concept of beauty and cosmetics is as ancient as mankind and civilization. Women are obsessed with  looking beautiful. So, they use various beauty products that have herbs to look charming and young. Indian herbs and its significance are popular worldwide. An herbal cosmetic have growing demand in the world market and is an invaluable gift of nature. Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. Herbs and spices have been used in maintaining and enhancing  human beauty.  Indian women have long  used herbs such as Sandalwood and Turmeric for skin care, Henna to color the hair, palms and soles; and natural oils to perfume their bodies. Not too long ago, elaborate herbal beauty treatments were carried out in the royal palaces of India to heighten sensual appeal and maintain general hygiene. The herbal cosmetics manufactured and used commonly for daily purpose include herbal face wash, herbal  conditioner,  herbal  soap,  herbal  shampoo  etc. The industry is now focusing on the growing segment with a vast scope of manifold expansion in coming years. Herbal cosmetics are defined as the beauty products which posses desirable physiological activity such as healing, smoothing appearance, enhancing and conditioning properties because of herbal ingredient. Here we reported the introduction, classification, common herbs used in cosmetics.

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  • 28 January 2013
    PHARMACOLOGICAL EVALUATION OF ETHANOLIC EXTRACT OF EMBELIA RIBES: (VIDANGA) FRUIT IN EXPERIMENTAL ANIMAL MODELS

    About Authors:
    Saritha.A.Surendran*, Asa Samuel
    *St. James College of Pharmaceutical Sciences,
    Chalakudy, Kerala
    *sarithaasurendran@gmail.com

    ABSTRACT
    Analgesics are the drug that selectively relieves pain by acting in the CNS or peripheral pain mechanism without significantly altering consciousness. They are classified into centrally acting analgesics and peripherally acting analgesics. Embelia ribes seeds was collected and extracted by continous hot percolation process using ethanol. Phytochemical analysis of the extract was preformed, screened and compared the analgesic activity of the extract with Pentazocine. Animal treated with ethanolic extract of Embelia ribes was showed an increased reaction time compared to control group. Ethanolic extract was showed significant reduction in algesia when compared with pentazocin.

  • 28 January 2013
    TREATMENT OF MALARIA IN PAEDITRICS: A REVIEW

    About Author:
    Kambham Venkateswarlu
    Final Year Graduate Student
    Sri Lakshmi Narasimha College of Pharmacy,
    Palluru, Chottoor-517132, Andhra Pradesh, India.
    k.v.reddy9441701016@gmail.com

    ABSTRACT:
    Malaria is an infectious disease caused by a parasite (plasmodium) which is transmitted from human by the bite of infected female Anopheles mosquitoes. Four species of the parasite plasmodium are responsible for Malaria in humans: Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Plasmodium falciparum.
    This disease cause a nearly 300 to 400 million clinical episodes of malaria occur worldwide, out of which 1.5 to 2 million die every year. So this is also a most dangerous disease in children. This review reveals the treatment of malaria in paediatrics.

  • 27 January 2013
    SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL THIAZOLO[3,2-a]PYRIMIDINES

    About Authors:
    Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
    Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
    Ahmedabad-382210, India.
    *shaishavi21@rediffmail.com

    Abstract
    Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.

  • 27 January 2013
    DEVELOPMENT OF UV SPECTROPHOTOMETRIC METHOD OF DRONEDARONE HYDROCHLORIDE IN BULK AND PHARMACEUTICAL FORMULATION

    About Authors:
    Gedam V. K., Shrivastav S. R., Raut N.A.
    Department of Pharmaceutical Sciences RTM, Nagpur University, Amravati Road,
    Nagpur- 440033.
    *vkgedam8@hotmail.com

    ABSTRACT
    The present research work discusses the development of a UV spectrophotometric method for Dronedarone hydrochloride. Simple, accurate, cost efficient and reproducible spectrophotometric method has been developed for the estimation of Dronedarone hydrochloride in bulk and pharmaceutical dosage form. UV spectrophotometric method, which is based on measurement at maximum wavelength (λmax) at 290nm using methanol as a solvent. The percentage recovery of Dronedarone hydrochloride ranged from 98.48 to 98.96% in pharmaceutical dosage form. Beers law was obeyed in the concentration range of 2-30μg/ml having line equation y = 0.0397x - 0.0060 with correlation coefficient of 0.9998. Results of the analysis were validated statistically and by recovery study.

  • 25 January 2013
    BUCCAL DRUG DELIVERY SYSTEM

    About Author:
    Prathipati padmaja
    vathsalya college of pharmacy, JNTU
    prathipatipadmaja@gmail.com

    INTRODUCTION
    Buccal drug delivery was introduced by Orabase1 in 1947, when gum tragacanth was mixed with dental adhesive powder to supply penicillin to the oral mucosa (Sudhakar et al., 2006). In recent years, delivery of therapeutic agents through various transmucosal routes has gained significant attention.
    Buccal delivery of drugs provides an attractive alternative to the oral route of drug administration, particularly in overcoming deficiencies associated with the latter mode of dosing.  Buccal mucosa consist of stratified squamous epithelium supported by a connective tissue lamina propia (Squire and Wertz, 1996) was investigated as a site for drug delivery several decades ago and the interest in this area for the trasmucosal drug administration is still growing.

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