Articles

ABOUT AUTHORS:
Jalaram H Thakkar^*, Ashiyana A Mansuri, Chirag Patel, Girish K Jani,
SSR College of Pharmacy,
Silvassa.
^*jay_143143@yahoo.com
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ABSTRACT:
The term Angiogenesis was coined by DR. John Hunter, a British surgeon in 1787. Later professor Judah Folkman gave the idea that growth of tumor depends on their blood supply and a new began research in this new field of therapeutics called ANGIOGENESIS.  Then, the identification of angiogenic growth factors, Vascular Endothelial Growth Factor (VEGF) and Fibroblast Growth Factor (FGF) fueled interest in using these factors in inducing therapeutic angiogenesis.^[1] Initially angiogenesis was implicated only in few diseases like cancer, psoriases and arthritis. But, in recent years, it has been evident through a deep research that even excessive, insufficient and abnormal angiogenesis contribute to the pathogenesis of many disorders. Angiogenesis is regulated by a balance between pro- and anti- angiogenic factors. Research shows that angiogenesis and anti angiogenesis has given promising results in treatment of diseases like AIDS, atherosclerosis, ischemic heart disease and Alzheimer’s. In twenty first century, application of angiogenesis in therapeutics may have an impact on disorders similar to that which the discovery of antibiotics had in twentieth century.

About Author:
Amitava Sinha Ray,
Department of Pharmacy, Bengal School of Technology
West Bengal University of Technology,
West Bengal
^*a.amitava.s@gmail.com

INTRODUCTION:-
Diabetes is a chronic disease, which occurs when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. This leads to an increased concentration of glucose in the blood (hyperglycaemia).
The body is unable to produce or unable to properly use and store glucose (a form of sugar). Glucose backs up in the bloodstream and blood glucose or "sugar" to rise too high.

ABOUT AUTHORS:
Rajani Pathuri^*, M.Muthukumaran, B.Krishnamoorthy, Amreen Nishat
Montessori Siva Sivani Institute of Science & Technology-College of pharmacy
Mylavaram, Vijayawada, Andhrapradesh-521230
*rajani.prakash4@gmail.com

ABSTRACT
Analytical methods development and validation play important roles in the discovery, development and Manufacture of pharmaceuticals. Method development is the process of proving that an analytical method is acceptable for use to measure the concentration of an API in a specific compounded dosage form which allow simplified procedures to be employed to verify that an analysis procedure, accurately and consistently will deliver a reliable measurement of an active ingredient in a compounded preparation. The analytical method validation is essential for analytical method development and tested extensively for specificity, linearity, accuracy, precision, range, detection limit, quantization limit, and robustness. In summary, analytical method development and validation allows to confirm that an accurate and reliable potency measurement of a pharmaceutical preparation can be performed. 

ABOUT AUTHORS:
Lohithasu Duppala*, Santhosh naidu Matsa, Manikumar Kothakota,
GITAM Institute of Pharmacy, GITAM University, visakhapatnam, Andhra Pradesh, India-530045.
lohithasu@gmail.com, +91-9491894432

ABSTRACT:
Generally, almost all communication in higher plants was thought to be mediated by the five classes of classical plant hormones  i.e. auxins, cytokinins,  gibberellins, abscisic acid and ethylene. The plant hormone action thus appeared to be basically different from that in animals. This article discusses the general role for new generation of plant hormones includes Brassinosteriods, Salicylic acid. Peptides,Polyaminesand Jasmonates.

About Author:
Dr. Vishwas B. Chavan
Ph.D. (Biochemistry)
Andheri (East), Mumbai – 400069
vishwaschavan2003@yahoo.co.in

Abstract:
The word “Cancer” is still synonymous with death for common people and the “stage IV cancer”, which is typically known as “last stage cancer”, is loss of hope even for medical community.
Many times patient presents to clinic, when cancer had already crossed II^{nd or} III^rd stage. This is mostly due to the reason that cancer may not have any symptoms at initial stages. Even if there are any symptoms, they can be mild and vague. Further rising cost of healthcare forced many patients, particularly women, to delay approach to physician. Therefore it is not uncommon for cancer patients to hear sentences like, “You are too late”, “You should have come earlier” etc. which is more depressing. This is a humble attempt to give the these patients some ray of hope.
So, in this 21^st Century, is it necessary, that cancer should be equal to death all the times, even when it has reached stage IV? To get answer of this question, we need to first know what stage IV cancer is and what its effects on human body are.
As most people know, cancer or malignancy means uncontrolled growth of any cell of the body. The mechanism which controls the growth of cells is lost in malignant cells. Cancer can occur in any cell of body and hence any organ can be affected by cancer, though cancers of some organs are more prevalent in some populations.