Articles

About Authors:
Shaik .Shabbeer*, V.Sruthi, P.Usha, K.Mahesh
Department of Pharmaceutical sciences, Swami Ramananda Tirtha Institute of Pharmaceutical Sciences,
Nalgonda, Andhra Pradesh, India-508001
*shkshabbeer@yahoo.com

About Authors:
Ms.Roseline
MBA, B.Pharm.
Independent Cosmetic Consultant.
Hyderabad.
g.roseline28@gmail.com

ABSTRACT
The Indian cosmetic Industry has witnessed rapid growth over the last couple of decades. In that time the range of cosmetic and beauty products in India has widened tremendously. Beauty products manufacturers in India mostly cater to the great demand for cosmetics and toiletries that fall into the low or medium-price categories as the greatest demand in India has always been for these economically priced products.
However, in recent years in the cosmetics market India competitors have begun to manufacture products to cater to an International need. For instance, herbal cosmetics from India have a great demand in the overseas market and many cosmetic products that are manufactured in India today are supplied to international suppliers of branded cosmetics products like The Body Shop for example. New facts that have been unveiled by a series of cosmetics business market analysis India reveal that many International companies are now outsourcing cosmetics to India and that the industry of cosmetic products India is growing at an average rate of almost twenty percent annually. This increase is attributed to two main factors. The first being the increase for the demand in Indian cost-effective products and the second being the increased purchasing power of the average Indian.

About Authors:
Chandorkar J.G.
Head, Analytical development laboratory
Indofil Industries Limited
Thane.
jchandorkar-icc@modi.com

Abstract-
2 methyl Imidazole is the active raw material in the manufacturing of  Micanazole Nitrate, Ketokenazole type Active pharma ceuticals. Imidazole is the Impurity which get form during manufacturing of 2Methyl Imidazole.
The Proposed Method is to determine the Impurity as well as Content in 2 Methyl Imidazole.

About Authors:
Middha Akanksha*, Kataria Sahil, Kukkar Vipin
Seth G. L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Akankshamddh@gmail.com

Abstract
Good Distribution Practice (GDP) deals with the guidelines for the proper distribution of medicinal products for human use. GDP is a quality warranty system, which includes requirements for purchase, receiving, storage and export of drugs intended for human consumption.

GDP regulates the division and movement of pharmaceutical products from the premises of the manufacturer of medicinal products, or another central point, to the end user thereof, or to an intermediate point by means of various transport methods, via various storage and/or health establishments.

About Authors:
Kapil Sharma*, Priyanka Sharma
Yaresun Pharmaceutical Pvt. Ltd.,
India.
*pharma_kapil@rediffmail.com

ABSTRACT
Herbalism is a traditional medicinal or folk medicine practice based on the use of plants and plant extracts. Many plants synthesize substances that are useful to the maintenance of health in humans and other animals because herbal medicine have harmless advantages. Humans, and even neanderthals, have used plants to treat their ailments for at least tens of thousands of years; most likely even longer than that. The first written accounts of the use of herbs originate in china, although all other civilizations from the ancient world were using plants as natural remedies for their ailments. Western herbal medicine dates back to ancient greece and its famous doctors like hippocrates and galen.The 15^th to 17^th centuries were the most popular time for herbalism in europe. Herbal remedies are still relatively popular today, mainly due to the fact that they are regarded as harmless because they are natural. So this paper describe basic information  involved in preparation of herbal remedies for internal use and for external useand gives a detail account about standardization and evaluation in formulations of herbal drugs.

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About Authors:
Krunal Parikh^1*, Maheshkumar Kataria^2
1 M.Pharm, Quality Assurance,
²Assistant professor, Department of pharmaceutics,
Seth G.L. Bihani S.D. College of Technical Education,
Institute of Pharmaceutical Sciences and Drug Research,
Sri Ganganagar, Rajasthan, INDIA
*Krunal_2922@yahoo.in

ABSTRACT
The Quality System regulation requires that “when computers or automated data processing systems are used as part of production or the quality system, the manufacturer shall validate computer software for its intended use according to an established protocol.” This has been a regulatory requirement for GMP since 1978. In addition to the above validation requirement, computer systems that implement part of a regulated manufacturer’s production processes or quality system (or that are used to create and maintain records required by any other FDA regulation) are subject to the Electronic Records, Electronic Signatures regulation. This regulation establishes additional security, data integrity, and validation requirements when records are created or maintained electronically. These additional Part 11 requirements should be carefully considered and included in system requirements and software requirements for any automated record keeping systems.

About Authors:
Nirav D.Langhneja^1*, Tushar  Vaja¹, Dr. Vijay K. Parmar^2
1M.Pharm, Department of Pharmaceutical Sciences,
²Associate Professor, Department of Pharmaceutical Sciences,
Sardar Patel University,
Vallabh Vidyanagar-388120, Gujarat.
*laghnejanirav@gmail.com

INTRODUCTION
Sildenafil citrate 1-[[3-(6,7-Dihydro -1-methyl- 7-oxo-3-propyl -1H-pyrazolo [4,3-d] pyrimidin-5-yl) -4-ethoxyphenyl]sulphonyl]-4-methyl piperazine citrate and it is a popularly known as Viagra .It is a compound of the pyrazolo-pyrimidinyl-methyl piperazine class, and is used to treat male erectile dysfunction (Boolell.M et.al 1996, Morales. A, et.al 1998). It is a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5  inhibitor. The structural formulae is C22H30N6O4S. It is an ampholyte with pKa value 4 (pirydinium ion) and 8.8 (benzimidazole). Sildenafil citrate is twice as soluble in methanol than in water. Its solubility decreases with pH up to 9 when it starts to increase again. Sildenafil citrate could be determined by several analytical techniques, Densitometry, spectrophotometry, colorimetry, HPLC, GC-MS, MEKC and capillary electrophoresis.

About Authors:
Sanober Parveen*, Maju Vyas Singh
Delhi institute of Pharmaceutical Sciences & research University (DIPSAR), Delhi.
*sanober.parveen@gmail.com

Abstract
The present study was aimed Pharmacognostic and preliminary phytochemical study of the fresh fruits of Alstonia scholaris, belonging to family Apocynaceae.The pharmacognostic investigation were carried out in terms of macroscopic, microscopic and physical parameters. The extract obtained after successive Soxhlet extraction of dried fruit using n-hexane, chloroform, methanol and water were subjected to a preliminary phytochemical screening which revealed the presence of alkaloids, carbohydrate, glycoside, terpenoids and flavanoids.

About Authors:
Birajdar Shivprasad M.*, Mule Madhav¹
*Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga.
¹School of Pharmacy, Swami Ramanand Teerth Marathwada University
Vishnupuri, Nanded-431606, Maharashtra, India,
*birajdar100@gmail.com

Abstract
Preservatives have been used and known to mankind since a very long time. These are used in cosmetics to increase the shelf life of product so that aroma, taste and the cosmetics itself can be stored for a longer period of time. Also cosmetics degradation is prevented by them. Preservatives, whether natural or artificial, work as in three different ways: Antimicrobial, Antioxidants and Act on enzymes. In antimicrobial, the growth of microbes like bacteria and fungi is inhibited. In antioxidants the process of oxidation is either delayed or stopped. And the one that acts on enzymes stops the ripening or aging of cosmetics product. Preservation is important part in many industries, such as the cosmetic and pharmaceutical industries, as the shelf life of many cosmetic and pharmaceutical products is important. The present review is an extensive compilation of various preservatives obtained from plant, synthetic and microbial source.The safety of preservatives is always coming into question. Since these are all biologically active products, they all have potential for being toxic, or irritating, or sensitizing.