TREATMENT OF MALARIA IN PAEDITRICS: A REVIEW

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VIII.TREATMENT:

Management of Uncomplicated Chloroquine Sensitive P.Falciparum Malaria In Children:

Start with Chlorquine

Follow up with ( to check spread)

Chloroquine Suspension

Primaquine Tablet

1 st Option:

( Pharmacokinetically superior option)

Day 1:10 mg (base) / kg followed by 5 mg (base) kg 6-8 hrs later.

Day 2 & 3: 5 mg (base) / kg in a single dose on each day. Total dose : 25 mg (base) / kg

Children < 1 year : Not Recommended


Children over 1 year :
Primaquine
0.5mg – 0.75 mg / kg in single dose

2 nd Option: Practical Alternative

Weight

Age

Dosage Schedule



Day 1

Day 2

Day 3

5-10 kg

Up to 11 months

5-10 ml

5-10 ml

5 ml

11-14 kg

1-2 yrs

15 ml

15 ml

5 ml



15-18 kg

3-4 yrs

20 ml

20 ml

5 ml

19-24 kg

5-7 yrs

25 ml

25 ml

10 ml

Note: Chloroquine doses in terms of bases.

Reference: The Use of Antimalarial Drugs: Report of WHO Informal Consultation 13th-17th Nov, 2000.

Management of Uncomplicated Chloroquine Resistance P.falciparum Malaria in Children:

Start with Quinine & follow up with Primaquine Tablet (to check spread) (1st line)

(Or)    Recommended β  Arteether Inj

1 st Line Theory

2 nd Line Theory

Quinine

Primaquine

β Arteether

Suspension (150 mg / 5ml) 10mg / kg every 8 hours for 7-10 days

Children < 1 year: not recommended children over 1 year: Primaquine Tab 0.5-0.75 mg / kg in a single dose

3 mg / kg body weight/ day by I.M.Injection over a period of 3 days i.e. β Arteether Inj.

Note: Quinine doses are in terms of salt

Reference: The Use of Antimalarial Drugs: Report of WHO Informal Consultation 13th-17th Nov, 2000.

Management of Uncomplicated P.vivax Malaria in Children:

Start with Chloroquine

Follow up with ( to check spread)

Chloroquine Suspension

Primaquine Tablet

1 st Option:

( Pharmacokinetically superior option)

Day 1:10 mg (base) / kg followed by 5 mg (base) kg 6-8 hrs later.

Day 2 & 3: 5 mg (base) / kg in a single dose on each day. Total dose : 25 mg (base) / kg

Children < 1 year :

Not Recommended.

Children over 1 year :
Primaquine
25 mg / kg OD for 14 days.

2 nd Option: Practical Alternative


Weight

Age

Dosage Schedule



Day 1

Day 2

Day 3

5-10 kg

Up to 11 months

5-10 ml

5-10 ml

5 ml

11-14 kg

1-2 yrs

15 ml

15 ml

5 ml




15-18 kg

3-4 yrs

20 ml

20 ml

5 ml

19-24 kg

5-7 yrs

25 ml

25 ml

10 ml

Note: Chloroquine doses in terms of bases.

Reference: The Use of Antimalarial Drugs: Report of WHO Informal Consultation 13th-17th Nov, 2000.

Management of Uncomplicated Mixed Malaria in Children:


Start with Chlorquine + Sulphadoxine + Pyrimethamine



Follow up with Primaquine  ( to prevent Relapse & to check spread)

Chloroquine Suspension

Sulphadoxine + Pyrimethamine

Primaquine Tablet

1 st Option:

( Pharmacokinetically superior option)

Day 1:10 mg (base) / kg followed by 5 mg (base) kg 6-8 hrs later.

Day 2 & 3: 5 mg (base) / kg in a single dose on each day. Total dose : 25 mg (base) / kg





Children < 1 year : Not Recommended



Children over 1 year :

Primaquine 0.5mg – 0.75 mg / kg in single dose

2 nd Option: Practical Alternative

Weight

Age

Dosage Schedule

Weight

Age

Dosage Schedule



Day 1

Day 2

Day 3




5-10 kg

Up to 11 months

5-10 ml

5-10 ml

5 ml

5-10 kg

2-11 months

5 ml

11-14 kg

1-2 yrs

15 ml

15 ml

5 ml

11-14 kg

1-2 yrs

7.5 ml


15-18 kg

3-4 yrs

20 ml

20 ml

5 ml

15-18 kg

3-4 yrs

10 ml

19-24 kg

5-7 yrs

25 ml

25 ml

10 ml

19-24 kg

5-7 yrs

15 ml

Note: Chloroquine doses in terms of bases.

Reference: The Use of Antimalarial Drugs: Report of WHO Informal Consultation 13th-17th Nov, 2000.

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