PYRIMIDINE AND ITS BIOLOGICAL ACTIVITY: A REVIEW

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Cytosine arabinoside (IX) is established drug for the treatment of acute leukemia's of childhood and adult granulocytic. It has also incidental antiviral activity against herpes and herpes zaster types[22].


El-Gaby, Adel-Hamide and Gharab[23] prepared some new pyrimidine-2-thiones (X). Some of these compounds were tested for in vitro anticancer activity against Ehrlich Ascites Carcinoma Cells.

Molina et al[24] synthesized a number of pyrido[1,2-C] pyrimidines (XI-XIII) and tested for effects on leukocyte function in vitro and anti-inflammatory activity.


Bahekar et al[25] reported the synthesis of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidin-5-yl]acetic acid derivatives (XIV) and evaluated for anti-inflammatory activity. Only few of them showed remarkable anti-inflammatory activity.


Bruno et al[26] reported the synthesis of some new 2,5-cycloamino-5H - benzopyrano[4,3-d]pyrimidines (XV) and screened them for anti-inflammatory, analgesic and antipyretic activities and in vitro antiplatelet activity. All the compounds failed to exhibit anti-inflammatory, analgesic and antipyretic activities but they showed an interesting antiplatelet activity


Orotic acid[27], a simple pyrimidine derivative and its mineral forms are used in metabolic therapy, especially for cardiovascular patients to prevent heart failure in car- diomyopathy. Oroate is needed as a key intermediate in biosynthesis of pyrimidine nucleotides, which are building blocks for DNA and RNA required for the final protein synthesis.


Yuga O et al[28] synthesized a series of pyrrolo[3,2-d] pyrimidine derivatives and evaluated their application as type-II inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) kinase. Incorporation of diphenylurea moiety at C 4-position of pyrrolo [3, 2-d] pyrimidine core via an oxygen linker (Fig. 23) resulted in potent inhibitors.


Marketed Drugs Containing Pyrimidine Nucleus:-

Anti-inflammatory & Analgesic agents:


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