PYRIMIDINE AND ITS BIOLOGICAL ACTIVITY: A REVIEW
Cytosine arabinoside (IX) is established drug for the treatment of acute leukemia's of childhood and adult granulocytic. It has also incidental antiviral activity against herpes and herpes zaster types.
El-Gaby, Adel-Hamide and Gharab prepared some new pyrimidine-2-thiones (X). Some of these compounds were tested for in vitro anticancer activity against Ehrlich Ascites Carcinoma Cells.
Molina et al synthesized a number of pyrido[1,2-C] pyrimidines (XI-XIII) and tested for effects on leukocyte function in vitro and anti-inflammatory activity.
Bahekar et al reported the synthesis of some [2-amino-6-(4-substituted aryl)-4-(4-substituted phenyl)-1,6-dihydropyrimidin-5-yl]acetic acid derivatives (XIV) and evaluated for anti-inflammatory activity. Only few of them showed remarkable anti-inflammatory activity.
Bruno et al reported the synthesis of some new 2,5-cycloamino-5H - benzopyrano[4,3-d]pyrimidines (XV) and screened them for anti-inflammatory, analgesic and antipyretic activities and in vitro antiplatelet activity. All the compounds failed to exhibit anti-inflammatory, analgesic and antipyretic activities but they showed an interesting antiplatelet activity
Orotic acid, a simple pyrimidine derivative and its mineral forms are used in metabolic therapy, especially for cardiovascular patients to prevent heart failure in car- diomyopathy. Oroate is needed as a key intermediate in biosynthesis of pyrimidine nucleotides, which are building blocks for DNA and RNA required for the final protein synthesis.
Yuga O et al synthesized a series of pyrrolo[3,2-d] pyrimidine derivatives and evaluated their application as type-II inhibitors of vascular endothelial growth factor receptor 2 (VEGFR2) kinase. Incorporation of diphenylurea moiety at C 4-position of pyrrolo [3, 2-d] pyrimidine core via an oxygen linker (Fig. 23) resulted in potent inhibitors.
Marketed Drugs Containing Pyrimidine Nucleus:-
Anti-inflammatory & Analgesic agents:
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