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  • MENSTRUAL BLOOD-EMBRACING SCENARIO OF FUTURISTIC REGENERATIVE MEDICINE

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    About Authors:
    Languluri Reddenna1*, Sree Nagavalli K2, Kummara Naga Pujitha3
    1Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India-516003
    2Department of Pharmacy Practice, S.J.M College of Pharmacy, Chitradurga, Karnataka, India-577502
    3Department of Medicine, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India-516003
    reddennapharmd@gmail.com

    Abstract
    Women produce natural life; but now they will add medically to save lives through the Endometrial Regenerative Cells (ERC) or stem cells reaped from unwanted menstrual fluid, recognized to be the most revolting stage of woman's life. Menstrual blood, as researchers said that, is found to be the most potent source of stem cells so far. Discovering curative power of stem cells has been a revolutionary break through in the field of surgery and medicine till date, which has actually given many the precious gift of life. The uterine endometrial lining, aannoying source of stem cells, is shed in menstrual process every month. In the rebuilding process that ranges over seven days, billions of cells develop creating almost 5 millimeter-thick lining. These self-renewing cells, also called Endometrial Regenerative Cells, can be developed into other tissues under controlled laboratory conditions and have multipotent markers analogous to stem cells from other sources. The requirement for regenerative therapies incorporating cells that have the ability to engraft and differentiate is vast. Mesenchymal stem cells resulting from bone marrow are presently in clinical trialsafter demonstrating safety and efficacy in animal modelsfor allogeneic use due to their immunosuppressive proper-ties. Due to their simplicity of collection and isolation, MenSCs would be a great impending basis of multipotent cells if they also showed these properties.

  • MEDICATION SAFETY IN CHILDREN
  • A REVIEW ON ETHNOPHARMACOLOGICAL POTENTIAL OF RICINUS COMMUNIS LINN.

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    About Authors:
    KM. Preeti*, Ansu Bala Verma
    Department of Pharmacology, Rameshwaram institute of technology and management,
    Lucknow- 227202,  India
    preeti30sept@gmail.com

    ABSTRACT
    In recent years, Ricinus communis Linn. has become a subject of interest because of its beneficial effects on human health. The present ethnopharmacological review was conducted to evaluate the therapeutic properties of  Ricinus communis by scientific evidences. It belongs to the family Euphobiaceae, which is commonly known as castor. Ricinus communis is found thoughout the hotter parts of India. This plant is extensively used in Ayurveda, Unani, Siddha, Homeopathic and Allopathic system of medicine as cathartic. Traditionally  this plant is used as laxative, purgative, fertilizer and fungicides etc. whereas the plant possess beneficial effects as antioxidant, antifertility, anti-inflammatory, antimicrobial, CNS stimulant, antidiabetic, insecticidal, larvicidal, antinociceptive, antiasthmatic, antiulcer, immunomodulatory, hepatoprotective, lipolytic, wound healing and central analgesic and many other medicinal properties. The extracts or the isolated compounds of this plant have been found to have potent activity against various ailments. The aim of present article is to explore the pharmacological or medicinal importance of the plant Ricinus communis linn.

  • VON HIPPEL-LINDAU (VHL) SYNDROME: A CRITICAL INSIGHT

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    About Authors:
    Tapan Behl*, Ishneet Kaur, Puneet Sudan, Monika Sharma, Dr. Heena Goel
    Assistant Professor, Department of Pharmacology,
    Doaba Group of Colleges, Kharar, Mohali
    tapanbehl31@gmail.com

    Abstract:
    Von Hippel-Lindau (VHL) syndrome is a rare genetic neoplastic disorder, arising from germline mutations in the VHL gene, characterized by the development of visceral cysts, specific benign and malignant tumors in multiple organ systems that have subsequent potential for spiteful change. It is caused by point mutations or deletions in a tumor suppressor gene. A tumor suppressor gene is the one which keeps cells from growing and dividing too rapidly in an uncontrolled way. Mutations in this gene prevent production of the VHL protein or lead to the production of an abnormal version of the protein. An altered or missing VHL protein cannot effectively regulate cell survival and division. As a result, cells grow and divide uncontrollably to form tumors and cysts that are characteristic of Von Hippel-Lindau syndrome. Although there is great variation in the clinical presentation, those who have a mutated gene are at greatly increased risk of developing spinal hemangioblastoma, renal cell carcinoma (RCC), retinal hemangioblastoma, cerebellar  hemangioblastoma, pheochromocytoma, pancreatic and renal cysts, endolymphatic  sac tumors, hemangiomas of the adrenals, liver and lungs, and papillary cystadenoma of the epididymis or broad ligament. The age at which the tumors present ranges from early childhood to the seventh decade of life. Early diagnosis, screening of family members and lifelong surveillance of VHL patients is recommended.

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  • DRUG THERAPY PROBLEMS: A REVIEW OF LITERATURE

    About Authors:
    Languluri Reddenna1*, Sree Nagavalli K2
    1Department of Pharmacy Practice, Rajiv Gandhi Institute of Medical Sciences, Kadapa, Andhra Pradesh, India-516003
    2Department of Pharmacy Practice, S.J.M College of Pharmacy, Chitradurga, Karnataka, India-577502
    *reddennapharmd@gmail.com

  • SYNTHESIS AND ANTICANCER ACTIVITY OF FLAVONE DERIVATIVES AGAINST ESTROGEN DEPENDENT CANCERS BY RATIONAL APPROCH

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    About Authors:
    Vanraj Thakor1*, Jalpa Kher2, Fenil Bhayani1, Bhavini Atodaria1, Malleshappa Noolvi1
    1Shree Dhanvantary college of pharmacy, Kim, Surat, Gujarat, India.
    2Ashok & Rita Patel institute of Biotechnology, New Vallabh Vidyanagar, Gujarat, India
    vanraj7777@gmail.com, jkher3333@gmail.com

    Abstract
    Aromatase and 17-ßHSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Chalcones, Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of breast tumors. So in this topic, Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles synthesised by using simple laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy Benzaldehyde to convert chalcone leads to formation of Flavones by cyclazation using Microwave and followed by attachment of different hetrocycles to form Flavone derivatives and charactrarized by IR, 1H NMR, 13C NMR spectroscopy and elemental analysis. These Flavone derivatives found to exhibit moderate to high inhibitory activity against Estrogen dependent cancers.

  • PLUERAL EFFUSION-DISEASE OF LUNGS

    ABOUT AUTHOR
    Akshay Rajgaria
    Kanak Manjari Institute of pharmaceutical Sciences.
    Rourkela, Orissa
    akshaykrish2007@gmail.com

  • MARFAN SYNDROME

    ABOUT AUTHORS:
    Jyotirmoyee Patnaik
    Kanak Manjari Institute of pharmaceutical Sciences.
    Rourkela, Orissa
    patnaik.jyotirmoyee@gmail.com

    ABSTRACT:
    Marfan syndrome is an inherited disease that affects the body's connective tissue, which provides the strength, support and elasticity to tendons, cartilage, heart valves, blood vessels, and other vital parts of the body. Marfan syndrome is a systemic, heritable connective tissue disorder that affects many different organ systems.

  • A REVIEW ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE

    ABOUT AUTHORS:
    1Rashmi Verma, 2Rakesh Tiwle
    1Rungta College of Pharmaceutical Sciences & Research, Bhilai, 491024, C.G
    2Shri Laxmanrao Maker Institute of Pharmacy, Amgaon, Gondia, Maharashtra, India- 441902.
    rashmi.verma501@gmail.com

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    ABSTRACT
    In the ancient age COPD has a variable natural history and not all individuals follow the same course about 15-20% of smokers develop clinically significant COPD. It is characterized by the airflow obstruction that is not fully reversible. It is predominantly caused by smoking, particularly occupational exposures, may also contribute to the development of COPD. Chronic obstructive pulmonary disease is diagnosed using a medical device called a spirometer, which measures air volume and flow, the main components of common clinical breathing tests (pulmonary function tests). Long-term exposure to lung irritants that damage the lungs and the airways usually is the cause of COPD. In this article we are focus about and detail review on the COPD.

  • NOVEL ANTI-DIABETES MECHANISM – NEXT GENERATION OF IMPROVED THERAPIES

    ABOUT AUTHORS:
    Kambham Venkateswarlu1*, N.Devanna2, R.Venu Priya3, P.Bharath Rathna Kumar4
    1M.Pharm Scholar, Department Of Pharmaceutics,
    2Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry,
    3Faculty Of Pharmacy, Department Of Pharmaceutical Analysis,
    4Director Of JNTUA-Otri
    JNTUA-Oil Technological Research Institute,

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