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  • REVIEW ON ONCOLYTIC VIRUS

    ABOUT AUTHORS
    Ashwini Dhusiya, Ritu Mahajan,
    Mahakal Inatitute of Pharmaceutical Studies, ujjain
    Madhya Pradesh
    .
    *ashwinidhusiya@gmail.com

    ABSTRACT
    Oncolytic virus is a wonderful discovery of 21st century. The basic concept of Oncolytic virus was developed since 1946 but it was not produce its effect properly. Now latest technology and modern biotechnology introduce a very efficient Oncolytic virus. This is a genetically modified virus that can treat various type of cancer with fewer side effects than other treatment of cancer. It follows different mechanism of killing tumor by specifically replication; induction of tissue necrosis factor; activation of immunity and treat incurable cancer even in metastatic stage of cancer so it is also effective in leukemia. Oncolytic virus therapy is undergoing in clinical trial and shows better results.
    This article covers brief knowledge of cancer, Virus and Oncolytic virus. It is helpful to understand history, mechanism, benefits and clinical data of Oncolytic virus. And a summary of marketed product ready to launch in near future.

  • ASPECT OF NEUROSCIENCE AND NEUROCHEMISTRY

    ABOUT AUTHORS
    Chaitanya Prasad Meher*2 , M.V.Kumar1, V.Sravanthi1 , K.Ramya1, K.Satyanarayana1
    1Maheshwara College  of Pharmacy, Chitkul, Isnapur,
    Patancheru, Hyderabad-502307  (A.P)
    2Assistant professor, Department of pharmaceutical chemistry,
    Maheshwara College of Pharmacy, Hyderabad-502307  (Andhra Pradesh)

    *chaitanyameher84@gmail.com

    ABSTRACT
    Neuroscience is a broad, multidisciplinary field concerned with the nervous system, its components, and functional activities, including behavior and consciousness. It relates to nerve cells function and development,  how do they communicate, how do brains work, and how have they evolved,  Nature of consciousness, and the neural basis for behaviors and for human brain dysfunction. These are among the many questions being answered by contemporary neuroscience. The present review article is concern on the aspect that usually reated to the neurochemistry.

  • PRESENT SCENARIO OF PROSTAGLANDINS

    ABOUT AUTHOR:
    Mayure Vijay Kumar*, G.J.Finny, C.P.Meher
    Department of pharmacology,
    Maheshwara College Of Pharmacy, Chitkul(v), Isnapur “X” Road,, Patancheru, Hyderabad-A.P-502307
    *mayurevijaykumar@gmail.com

  • EVALUATION OF ANTI HYPERLIPIDEMIC ACTIVITY OF GMELINA ARBOREA ON CHOLESTEROL INDUCED HYPELIPIDEMIC RAT MODEL

    About Auhtor:
    Avula Parthasarthi Yadav*,
    Krishna Theja Pharmacy College,
    Jawaharlal Nehru University, Anantapur.
    *parthu298@gmail.com

    1. Introduction
    Currently natural products are gaining popularity to combat various physiological threats including oxidative stress, cardiovascular complexities, cancer insurgence, and immune dysfunction. The use of traditional remedies may be encountered more frequently due to an array of scientific evidence in their favor1.  It has been well established that nutrition plays an important role in the etiology of hyperlipidimia, atherosclerosis and other coronary heart disease (CHD) complications like myocardial infarction1.
    The etiology and pathogencity of coronary heart diseases lie in the casual relationship between the development of atherosclerosis, elevated plasma lipid percentage cholesterol levels in blood and plasma, genetic makeup, endicrinological aberration, immunologic and autonomic factors, blood flow and coagulation2.

  • A DETAIL REVIEW ON DIABETES MELLITUS (DM)

    About Author:
    Amitava Sinha Ray,
    Department of Pharmacy, Bengal School of Technology
    West Bengal University of Technology,
    West Bengal
    *a.amitava.s@gmail.com

    INTRODUCTION:-
    Diabetes is a chronic disease, which occurs when the pancreas does not produce enough insulin, or when the body cannot effectively use the insulin it produces. This leads to an increased concentration of glucose in the blood (hyperglycaemia).
    The body is unable to produce or unable to properly use and store glucose (a form of sugar). Glucose backs up in the bloodstream and blood glucose or "sugar" to rise too high.

  • STAGE IV CANCER: BATTLE NOT LOST YET !

    About Author:
    Dr. Vishwas B. Chavan
    Ph.D. (Biochemistry)
    Andheri (East), Mumbai – 400069
    vishwaschavan2003@yahoo.co.in

    Abstract:
    The word “Cancer” is still synonymous with death for common people and the “stage IV cancer”, which is typically known as “last stage cancer”, is loss of hope even for medical community.
    Many times patient presents to clinic, when cancer had already crossed IInd or IIIrd stage. This is mostly due to the reason that cancer may not have any symptoms at initial stages. Even if there are any symptoms, they can be mild and vague. Further rising cost of healthcare forced many patients, particularly women, to delay approach to physician. Therefore it is not uncommon for cancer patients to hear sentences like, “You are too late”, “You should have come earlier” etc. which is more depressing. This is a humble attempt to give the these patients some ray of hope.
    So, in this 21st Century, is it necessary, that cancer should be equal to death all the times, even when it has reached stage IV? To get answer of this question, we need to first know what stage IV cancer is and what its effects on human body are.
    As most people know, cancer or malignancy means uncontrolled growth of any cell of the body. The mechanism which controls the growth of cells is lost in malignant cells. Cancer can occur in any cell of body and hence any organ can be affected by cancer, though cancers of some organs are more prevalent in some populations.

  • DISCUSSION ON THE ROLE OF Rb PROTEIN AND P53 IN CELL CYCLE REGULATION

    About Authors:
    Lohithasu Duppala* , Manikumar Kothakota
    GITAM Institute of Pharmacy,
    GITAM University, visakhapatnam, Andhra Pradesh, India-530045.

    * lohithasu@gmail.com, +919491894432

    INTRODUCTION:
    Cell Theory:

    · All organisms consist of one  or more cells.
    · Cell is the smallest unit of life.
    · All cells come from pre-existing cells.

    Cell cycle:
    The dividing and non –dividing stages in the life of a cell are described by a series of events called the cell-cycle. The cell cycle  is the sequence of events by which a cell duplicates its genome and divides into daughter cells.Some cells, like skin cells ,divide continuously throught the life of the organism.Cardiac muscle cells are arrested in G2 phase.

  • A REVIEW ON CHAGAS DISEASE

    About Author:
    B. Krishna
    Vasavi Institute of Pharmaceutical Sciences,
    Kadapa, JNTUA
    krishna5432.b@gmail.com

  • PHARMACOLOGICALLY IMPORTANT MARINE SPECIES

    About Authors:
    1Uma Nath, 2Nitha p. mohan, 3Revathy sivan
    1Assistant professor, department of pharmaceutical chemistry,
    2Assistant professor, department of pharmacognosy,
    3Department of pharmacology,
    1,2,3daleview college of pharmacy and research centre punalal trivandrum kerala.

  • PHARMACOVIGILANCE: THE PRESENT STATUS AND FUTURE PROSPECTS IN INDIA

    About Authors:
    Roohi Kesharwani1*, Devendra Singh2, Vishal Jacob1
    1-Institute Of Foreign Trade And Management Lodhipur Rajput,
    Delhi Road, Moradabad, India
    2-Raj Kumar Goel Institute Of Technology, Delhi-Meerut Road, Ghaziabad, India
    *roohi4mail@gmail.com, devendrasingh.pisces@gmail.com

    ABSTRACT:
    Pharmacovigilance is now accepted to be a continuous process of evaluation accompanied by steps to improve safe use of medicines which involves pharmaceutical companies, regulatory authorities, health professionals and patients. The methodologies have broadened to encompass many different types of study, with spontaneous reporting remaining the cornerstone. The concern for ADRs in highly vulnerable populations is of even greater concern.Pharmacovigilance is especially important since most of the adverse effects are reversible by modifying the dosage or omitting the offending medicine. All medicines (pharmaceuticals and vaccines) haveside effects.In a vast country like India with a population of over 1.2 Billion with vast ethnic variability, different disease prevalence patterns, practice of different systems of medicines, different socioeconomic status, it is important to have a standardized and robust pharmacovigilance and drug safety monitoring programme for the nation.  Collecting this information in a systematic manner and analyzing the data to reach a meaningful conclusion on the continued use of these medicines is the rationale to institute this program for India. In this review article various hospitals survey are done and the  survey questionnaire was analyzed question wise and their percentage value was calculated. Our study strongly suggests that there is greater need to create awareness and to promote the reporting of ADR among healthcare professionals of the country. Only such approach can greatly influence in bringing reporting culture among healthcare professionals and may improve the reporting rates of ADR in our country. Pharmacists, as doctors opined that their involvement may increase the reporting rate, have a greater role to play in the area of pharmacovigilance.

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