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  • Antimicrobial Activity of Plants Belong to Solanaceae Family

    About Authors: Ajay Kumar Pathak,
    Analytical Science Division,
    Shriram Institute for Industrial Research,
    19 University Road, Delhi, 110007

    The plant kingdom comprises many species of plants containing substances of medicinal value, which are yet to be explored. A large number of plants are constantly being screened for their possible medicinal value.[12] The use of plant extracts in traditional medicine has been going on from ancient time.[13] Herbalism and folk medicine, both ancient and modern, have been the source of much useful therapy.[14-16] In the recent years, the development of resistance of pathogens against antibiotics has become a difficult issue caused by the indiscriminate use of modern antibiotics.[17-23] Therefore, the demand for new and effective antimicrobial agents with broad spectrum activities from natural sources are increasing day by day. Infectious diseases account for approximately one-half of all deaths in tropical countries. The use of and search for drugs and dietary supplements derived from plants have accelerated in recent years. Ethnopharmacologists, botanists, microbiologists, and natural-products chemists are combing the Earth for phytochemicals and "leads" which could be developed for treatment of infectious diseases. While 25 to 50% of current pharmaceuticals are derived from plants, none are used as antimicrobials.

  • A Review on Complex Enhancer

    About Authors: Shahin Shahida, Seema Kathait

    Reference ID: PHARMATUTOR-ART-1082

    In this report, we explored the mechanisms underlying keratinocyte-specific and differentiation-specific gene expression in the skin. We have identified five keratinocyte-specific, open chromatin regions that exist within the 6 kb of 5' upstream regulatory sequence known to faithfully recapitulate the strong endogenous keratin 5 (K5) promoter and/or enhancer activity. One of these, DNase I-hypersensitive site (HSs) 4, was unique in that it acted independently to drive abundant and keratinocyte-specific reporter gene activity in culture and in transgenic mice, despite the fact that it was not essential for K5 enhancer activity. We have identified evolutionarily conserved regulatory elements and a number of their associated proteins that bind to this compact and complex enhancer element. The 125-bp 3' half of this element (referred to as 4.2) is by far the smallest known strong enhancer element possessing keratinocyte-specific activity in vivo. Interestingly, its activity is restricted to a subset of progeny of K5-expressing cells located within the sebaceous gland. The other half of HSs 4 (termed 4.1) possesses activity to suppress sebocyte-specific expression and induce expression in the channel (inner root sheath) cells surrounding the hair shaft. Our findings lead us to a view of keratinocyte gene expression which is determined by multiple regulatory modules, many of which contain AP-2 and/or Sp1/Sp3 binding sites for enhancing expression in skin epithelium, but which also harbor one or more unique sites for the binding of factors which determine specificity. Through mixing and matching of these modules, additional levels of specificity are obtained, indicating that both transcriptional repressors and activators govern the specificity.


    About Authors: Mayank Panchal1*, Biren Shah1, Krishna Murti1, Megha Shah1
    1*Department of Pharmacognosy,
    Vidyabharti Trust College of Pharmacy,
    Umrakh, (Gujarat) INDIA

    Reference ID: PHARMATUTOR-ART-1081

    Moringa oliefera Lam. is one of the best known and most widely distributed and naturalized species of a monogenetic family Moringaceae. The roots of plant were extracted with ethanol by soxhlet technique and aqueous extract of roots are prepared by maceration technique. Both the extracts are subjected to phytochemical screening. Require quantity of alcoholic and aqueous extracts were obtained from the plant which is used as test drug in Streptozotocin induced diabetic model. The present investigation is undertaken to study the effect of the potential hypoglycemic effect of Moringa oliefera Lam. in Streptozotocin (STZ) induced Diabetes Mellitus.

  • Herbal Drug Development and Pharmacological Potential of Some Herbs

    About Authors: Amit Tamiya (M.Pharm), Dr. Gopal Rai,
    Department of Pharmacology Shri Ram Institute of Technology,
    Jabalpur (M.P.), India

    Reference ID: PHARMATUTOR-ART-1078

    In the recent time the science is proved the new aspects of herbal medicine, as therapy to treat disease, known as phytotherapy, is to be developed. It include the nutritional sciences, in it the phytochemicals that are ingested in the form of complex mixtures that are incompletely characterized in the past whose scientific study is being performed. The new methodologies developed in the area of nutritional sciences can inform phytotherapy research, opportunities for observational studies. Randomized clinical trials of single - herb interventions are relatively easy to justify its pharmacological effect. However, phytotherapy is the natural therapy, using lifestyle advice, nutrition and individually use of the combination of herbs, for the restoring the homeostasis. Now the clinical trial evaluated, this approach is useful in a wide range of conditions, Central nervous system, Hepatoprotective, mental disorder including chronic disease, associated with the human being.

  • A Complete Overview of C. Hirsutus

    About Authors: Parag Ghosh
    Bharat Technolgy & West Bengal Universuty of Technology,

    Reference ID: PHARMATUTOR-ART-1067

    Antioxidant activity of ethanolic extract of C .hirsutus Diels leaves was studied for it free radical scavenging property in different in vitro models as 1, 1- Dipheheny1 – 2 picry1 hydrazy1, nitric oxide, superoxide and hydroxy1 radical model. The extract shows significant dose dependent free content suggesting the plant to exhibit antioxidant activity.

  • Scope of Ayurvedic Pharmaceutical Sciences

    About Author:Shahin Sahida,
    Sagar group of institution, department of pharmacy,

    Ayurvedic Pharmaceutical Sciences has been recently reinforced in Indian pharmacy institute due to global acceptance of Ayurveda. Some pharmacy institute have continued curriculum related to Ayurvedic Pharmaceutical Sciences as integral part of pharmacognosy or medicinal chemistry. Some pharmacy schools pioneered courses related exclusively to Ayurvedic Pharmaceutical Sciences. The courses available range from diploma to master’s level however there is little information has accumulated for doctorate and postdoctrate level studies in Ayurvedic Pharmaceutical Sciences.


    1. Assistant professor, Department of pharmaceutics, R. K. College of Pharmacy, Kasturbadham,Rajkot.
    2. Principal, Department of pharmacology, R. K. College of Pharmacy, Kasturbadham,Rajkot.
    3. Research Scholar, R. K. College of Pharmacy, Kasturbadham, Rajkot

    Reference ID: PHARMATUTOR-ART-1061

    This article provides a basic view of what defines biological medicinal Products, often called biologicals, and how they differ from chemical products. In entering into this thought process, let us remember that proteins range in size from small amino acid chains up to macromolecules of hundreds of kilodaltons in size. In addition, in order to appreciate the science behind the regulations, an understanding of organic chemistry is necessary, and preferably knowledge of molecular cell biology and how proteins are created in cells via the DNA expression mechanisms. Although the details are inevitably complex and specialist as a result, we will look at some basic concepts pertinent to biologicals so that a regulatory generalist can be effective in dealing with such products.


    About Author: Mr.Mahendra G. Pawar* (B.Pharmacy) Ms.Komal  R. Nikam (B.Pharmacy), Mr.Rakesh D.Amrutkar (M.Pharmacy)

    Reference ID: PHARMATUTOR-ART-1059

    Biotechnologists in recent years have come up with a new concept.This new concept is about edible vaccine. The difference here lies, that crops like “golden rice” provided extra nutrition that naturally didn’t occur in it. But edible vaccines are GM crops that would provide extra added “immunity” from certain diseases.
    Edible vaccines are composed of antigenic proteins and do not contain pathogenic genes (because obviously they use attenuated strains). Thus, they have no way of establishing infection and safety is assured.Oral administration is possible , production is highly efficient and can be easily scaled up.For example, hepatitis-B antigen required to vaccinate whole of China annually, could be grown on a 40-acre plot and all babies in the world each year on just 200 acres of land,Cheaper (single dose of hepatitis-B vaccine would cost approximately 23 paise), grown locally using standard methods and do not require immense capital investment of pharmaceutical manufacturing facilities, exhibit good genetic stability. Do not require special storage condition. Since syringes and needles are not used chances of infection are also less. Fear of contamination with animal viruses - like the mad cow disease, which is a threat in vaccines manufactured from cultured mammalian cells - is eliminated, because plant viruses do not infect humans.

  • Invitro Anticancer Activity of Alium Sativum and Emblica Officinalis : A New Regimen for Cancer Research

    About Author: Vikas Mahajan* (M.Pharm 1st  year), Naiyer Shahzad, Sachin Mager
    Singhania University,
    Pacheri Bari, Rajasthan - 333515

    Reference ID: PHARMATUTOR-ART-1054

    In this study Cytotoxic potential of two Indian medicinal plant extracts were investigated. The invitro cytotoxic potentiality investigated as the ability of these two extracts to inhibit tumour cell line growth with help of MTT & Trypan blue assay. With this investigation we had also focused on angiogenesis. The cell lines studied are MCF7, A549 and DU145 with the methanolic extract of Alium sativum (MEAS) (garlic) and Emblica officinalis (MEEO) (amla). Both drugs are extracted by maceration method. The extract were concentrated & dissolved in DMSO Solvent & stock solution is prepared of conc. 1mg/10 ml. from which different conc. are prepared as 100, 10, 1, 0.1,0 .001 µg/ml. Both plant extracts preapared concentration are exposed in MCF7, A549 & DU145 in 96 well plate in which MTT dye was added later & allow it for 96 hr. after incubation period absorbance was taken in spectrophotometer at 517nm. With same trypan blue also performed & Counting of cell was done on inverted microscope.  Results indicates that the above plant extracts hsowing anticancer and antiangiogenesis activity of Same plant extract were studied on tube formation cell based models also. From this study we can conclude that both drugs possess anticancer activity for MCF7, A549 & DU145 for different concentrations.


    About Author: Naresh Sharma,
    M.pharma (Pharmacognosy)
    Department of Pharmacognosy, Lachoo Memorial College of Science and Technology,
    Jodhpur, India.

    Due to Lack of knowledge regarding the toxic effects of synthetic compound in mosquito repellents,synthetic mosquito repellents are widely used. The prolong use of synthetic mosquito repellents shows many side effects like neurotoxic hazards, immunotoxic hazards, skin allergy, seizures, eye irritation, insomnia, impaired congnitive function, cough, sneezing, headache, asthma, bronchial irritation, itching,ear, nose and throat pain, dermatitis, reproductive dysfunction, development impairment and cancer, death. Synthetic mosquito repellents contains very toxic compounds such as DEET, picaridin, permethrin, P?Menthane?3, 8?diol (PMD) etc. These draw backs created a pathway for herbal mosquito repellents coil. Large numbers of herbal drugs are used in these mosquito repellents like Neem, Vekhand, Tulsi, Ajowan, Raal, etc along with other natural ingredients. The efforts are made to study the traditional beliefs from scientific approach. The main aim of this product development is to provide employment to the rural youth and to promote the use of herbal mosquito repellent coil as complete safe alternate of chemical repellents.

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