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  • Concepts and philosophy of ICH

    About Authors:
    Sahithya Bitragunta, Ponnuru Venkata Suresh, Nadendla RamaRao
    Chalapathi institute of pharmaceutical sciences,
    Lam,Guntur,
    India.

    Abstract:
    In 1960’s, different countries used to have different set of guidelines and laws for the registration and marketing of pharmaceuticals. But tragedies like Thalidomide disaster made harmonization of all technical requirements which are required for the registration of pharmaceuticals for the human use. Thus ICH has been launched in 1990 by drug regulatory authorities and pharmaceutical industrial members of Europe, Japan and US with an objective of providing guidelines to ensure the registration and marketing of safe, effective and high quality medicines.

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  • An Overview on Gastro retentive drug delivery systems

    About Authors:
    Debayan Dey*, G.D Pattnaik, Bijay kumar Sahoo
    Dept.of Pharmaceutics
    College of Pharmaceutical Sciences,
    Puri, Orissa

    INTRODUCTION
    Oral administration is the most convenient and preferred means of any drug delivery to the systematic circulation. Oral controlled release drug delivery have recently been of increasing interest in pharmaceutical field to achieve improved therapeutic advantages, such as ease of dosing administration, patient compliance and flexibility in formulation. Drugs that are easily absorbed from gastrointestinal tract (GIT) and have short half-lives are eliminated quickly from the systemic circulation. Frequent dosing of these drugs is required to achieve suitable therapeutic activity.

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  • Formulation and evaluation of immediate release tablets with different types of paroxetine hydrochloride powders prepared by direct compression

    About Authors:
    Nishant Gupta
    Department of pharmaceutics,
    B.N. College of pharmacy,
    Udaipur-313002,
    Rajasthan

    ABSTRACT:
    Paroxetine (PRX) crystals exhibit poor compressibility, poor flowability and its tablets show a tendency to cap. To improve the mechanical strength of tablets several kinds of “Paroxetine for direct compression” are present on the market. Current research demonstrated the best tablet properties with coated paroxetine (mass of tablets, diameter, height and mechanical strength, friability RSD<2%). Furthermore, coated paroxetine in combination with both investigated superdisintegrants such as Vivasol® and Polyplasdone® XL-10 shows faster disintegration time and dissolution rate in comparison to paroxetine for direct compression. Eventually, the major advantages of the formulation with coated paroxetine for industrial production are decrease of friability and superiority in terms of flowability, compressibility, quick disintegration and dissolution. Regarding the results, coating of PRX particles is beneficial for the manufacturing of tablets with immediate release.

  • DESIGN AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF ROSIGLITAZONE MALEATE BY USING NOVEL COPROCESSED SUPERDISINTEGRANTS

    About Authors:
    S.Pradeep kumar, D.Prathibha, Dr.N.L.Gowrishankar, R.Parthibarajan, L.Matsyagiri
    Department of Pharmaceutics, 
    Swami Vivekananda Institute of Pharmaceutical Sciences,
    Vangapally (V), Yadagirigutta (M), Nalgonda,
    Andhra Pradesh, India.

    ABSTRACT
    The goal of the present investigation was to formulate and evaluate fast dissolving tablets (FDT) of Rosiglitazone maleate. To improve patient compliance, mouth dissolving tablets have emerged as an alternative to conventional dosage forms. Rosiglitazone and Sulfonylurea are given in combination for treatment of type 2Diabetes Mellitus for long term therapy. During this therapy, it is observed that there is uncontrolled increase of blood glucose level, andthe drug undergoes hepatic metabolism. Therefore, mouth dissolving tablets of Rosiglitazone were prepared to overcome this unusual problem and to make use of the inherent advantages of the novel drug delivery system.The tablets were prepared by using direct compression method using Superdisintegrants. Rosiglitazone mouth dissolving tablets containing Cross povidone & Cross carmellose sodium in the ratio 1:1 showed maximum drug release. Formulations were subjected to stability studies. Formulations are stable for 28 days at 40 oC / 75 % RH with insignificant change in the hardness, disintegration time and in vitro drug release pattern.

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  • A Review on -A Rare Disorder of Waldenstrom’s Macroglobulinemia

    About Authors:
    Ms. Shilpa G. Lodha1,  Vanita Nimje2, Ramzan Virani3

    1 Department of Biotechnology,
    Agnihotri College of Science, Ram Nagar,
    Wardha 442001, India.
    2 Department of Biotechnology,
    Jankievi Bajaj college, Arvi Naka,
    Wardha 442001, India.
    3 Department of Biology,
    Shivramji Moghe College of Science,
    Panharkawada- 445 302, India.

    Abstract
    Many types of Cancer and Malingancy are known, in that Waldenstrom’s macroglobulinemia is rare cancer of an uncommon lymphoproliferative disorder characterized primarily by bone marrow infiltration and IgM monoclonal gammopathy. It should be considered a distinct clinicopathological entity rather than a clinical syndrome secondary to IgM secretion. The concentration of monoclonal IgM can vary widely in Waldenstrom’s macroglobulinemia and it is not possible to define a concentration that reliably distinguishes it from monoclonal gammopathy of undetermined significance (MGUS).  Besides having lots of diagnosis method, there is no single accepted treatment for Waldenstrom’s macroglobulinemia.  Commonly used treatment includes the monoclonal antibody rituximab, sometimes in combination with chemotherapeutic drugs such as chlorambucil, cyclophosphamide, or vincristine or with thalidomide. We have to find out the successful and low cost methods to cure Waldenstrom’s macroglobulinemia.

  • TROUBLESHOOTING IN HIGH PERFORMANCE LIQUID CHROMATOGRAPHY

    About Authors:
    Ipshita Chattopadhyaya, Ekta Malhotra
    Department of Pharmacy,
    Jaipur National University,
    Jaipur, India

    ABSTRACT
    (1)The developments in column packing technology and suitable equipment paved the way for what is now called High Performance or High Pressure Liquid Chromatography (HPLC). The new technique provided much higher resolution, more accurate quantitative results, as well as shorter analysis times in comparison to the earlier techniques .During the sixties, new theoretical insights accompanied by important. Since its introduction, HPLC has evolved into an indispensable tool in many analytical laboratories and is applied to diverse analytical problems. Actually, HPLC refers to a number of separation techniques that use a liquid mobile phase, or eluent. Troubleshooting HPLC instrumentation and separations require a fundamental understanding of how the instrument functions and how the separation works. (2)This article provides a practical guide to common HPLC problems, along with more in-depth information to help the reader understand the relationships between the observed symptoms and the underlying causes. The practical approach presented here is meant to serve as both a troubleshooting guide and an HPLC learning tool.

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  • BRAIN TARGETING NOVAL APPROACHES: A COMPREHENSIVE REVIEW

    About Authors:
    Sandhu Premjeet1, 2,Rathore Devashish2, Kataria Sahil1 , Middha Akanksh1
    1Seth G. L. Bihani S.D. College of Technical Education,
    Institute of Pharmaceutical Sciences and Drug Research,
    Sri Ganganagar, Rajasthan, INDIA
    2 School of Pharmaceutical Sciences, RGPV University campus,
    Bhopal, M.P, INDIA

    ABSTRACT
    The blood – brain barrier (BBB) has always presented a challenge to scientists for brain drug targeting . the BBB evolved in such a way that it protects the brain from various foreign substance such as neurotoxins. This mechanism makes the BBB an insurmountable . This mechanism makes BBB an insurmountable barrier for numerous highly essential drugs , including antibiotics, cytostatics and other CNS active drug Drugs may be administered directly into the CNS or administered systematically (e.g. by intravenous injection) for targeted action in the CNS. The major challenge to CNS drug delivery is the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. Various strategies that have been used for manipulating the blood-brain barrier for drug delivery to the brain include osmotic and chemical opening of the blood-brain barrier as well as the use of transport/carrier systems. Other strategies for drug delivery to the brain involve bypassing the BBB. Various pharmacological agents have been used to open the BBB and direct invasive methods can introduce therapeutic agents into the brain substance. It is important to consider not only the net delivery of the agent to the CNS, but also the ability of the agent to access the relevant target site within the CNS. Various routes of administration as well as conjugations of drugs, e.g. with liposomes and nanoparticles are considered. Some routes of direct administration to the brain are non-invasive such as transnasal route whereas others involve entry into the CNS by devices and needles such as in case of intrathecal and intracerebroventricular delivery.

  • MOISTURE CONTENT: A STABILITY PROBLEM IN PHARMACEUTICAL PRODUCTS

    About Authors:
    Anil kumar
    Jubilant chemsys Limited, Noida-201301
    Babu Banarsi Das National Institute of Technology and Management
    Akhilash Das Nagar, Lucknow

    Abstract
    Presence of moisture influences chemical stability, crystal structure, powder flow, compaction lubricity, dissolution rate, and polymer film permeability in solid dosage forms and lead to growth of microorganisms, change in thixotropy in semi-solid dosage forms. Moreover, unit operations obviously depending on the amount and state of water present are also influenced by it. Therefore, moisture influences the properties of individual active ingredients and excipients, and it is essential to characterize the effect of moisture on these individual components. This article lay emphasis on determination of moisture by various methods and illustrates the changes induced by moisture on several product and process attributes

  • Transdermal Drug Delivery System- A Total View

    About Authors:
    Vinay Mishra, Shilpi Bhargava
    Advance Institute of Biotech and Paramedical Sciences,
    Kanpur

    Introduction:
    Delivering medicine to the general circulation through the skin is seen as a desirable alternative to taking it by mouth. Patientsoften forget to take their medicine, and even the most faithfullycompliant get tired of swallowing pills, especially if theymust take several each day. Additionally, bypassing the gastrointestinal(GI) tract would obviate the GI irritation that frequently occursand avoid partial first-pass inactivation by the liver. Further,steady absorption of drug over hours or days is usually preferableto the blood level spikes and troughs produced by oral dosageforms.1

  • Gold nanoparticles for detection of cancerous cell: A Review

    About Auhtors:
    NIDHI KARIA, RAKHI CHANDAK,
    P.WADHWANI COLLEGE OF PHARMACY,
    YAVATMAL

    Abstract:
    In nanotechnology, a particle is defined as a small object that behaves as a whole unit in terms of its transport and properties. It is further classified according to size: In terms of diameter, fine particles cover a range between 100 and 2500 nanometers, while ultrafine particles, on the other hand, are sized between 1 and 100 nanometers. Similarly to ultrafine particles, nanoparticles are sized between 1 and 100 nanometers. Nanoparticles may or may not exhibit size-related properties that differ significantly from those observed in fine particles or bulk materials1. Although the size of most molecules would fit into the above outline, individual molecules are usually not referred to as nanoparticles.

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