Skip to main content

Pharmaceutical Analysis Articles

academics

 

Clinical research courses

  • MOLECULAR DOCKING STUDIES OF N-(2-BENZOYLPHENYL)-L-TYROSINE DERIVATIVES WITH ANTI-DIABETIC ACTIVITY OF TYPE 2 DIABETES

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Anuradha Sharma1*, Vaibhav Walia2, Monika Gahlawat3
    1Division of Pharma. Chemistry,2 Division of Pharmacology,3 Division of Pharmaceutics,
    G.V.M. College of Pharmacy,
    Sonepat, Haryana, India
    *anusarswat@gmail.com

    ABSTRACT
    Type 2 diabetes is one of the major life threatening diseases worldwide. These cases are progressing at an incremental rate every year and number of research works is going on to control the disease by targeting its enzymes or proteins. In modern drug designing, molecular docking is routinely used for understanding drug receptor interaction. In the present study molecular docking were performed on a diverse set of N-(2-benzoylphenyl)-L-tyrosine derivatives that demonstrate antidiabetic activity by stimulating peroxisome proliferator activated receptor- γ. The docking program in Glide dock justifies the correlation between the experimental values and the values derived computationally. Therefore, the dock analysis performed in Glide dock suggests the importance of evaluating the prediction accuracy of scoring functions adopted in various docking program.

    (adsbygoogle = window.adsbygoogle || []).push({});
  • RP-HPLC METHOD FOR THE ESTIMATION OF NITAOXANIDE IN PHARMACEUTICAL FORMULATION

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    R.Meera1*, N.Swathylakshmi2, M.Sundarapandian2, P.Raja Soundara Pandian1, Madhavanmallayasamy1
    1Researcher, Radianz Health Care Pvt Ltd, Madurai, Tamilnadu, India
    2Department of pharmaceutical Chemistry, K.M.College of pharmacy, Uthangudi, Madurai, India
    meeraharsa23@gmail.com

    ABSTRACT
    Objective
    : A simple and precise RP-HPLC method was developed and validated for the determination of Nitaoxanide in pharmaceutical dosage forms.
    Materials and Methods
    : Chromatography was carried out using waters RP –C18 150×4.6 mm, 3.5 µ, pH 6.8, buffer: acetonitrile (50:50) as the mobile phase at a flow rate 1.2 ml/min. The analyze was monitored using PDA detector at 254 nm. The proposed method was found to have linearity in the concentration range of 25-150µg/ml with correlation co efficient of r2 =0.9999.
    Results:
    The developed method has been statistically validated and found simple and accurate. The mean recoveries obtained for Nitaoxanide were in the range 100.06-101.9%.
    Conclusion:
    Due to its simplicity, rapidness, high precision and accuracy of the proposed method it may be used for determining Nitaoxanide in bulk and dosage forms.

  • SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF NITAOXANIDE IN BULK DRUG AND ITS PHARMACEUTICAL FORMULATION

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    R.Meera1*, N.Swathylakshmi2, M.Sundarapandian2, P.Raja Soundara Pandian1, Madhavanmallayasamy1
    1Researcher, Radianz Health Care Pvt Ltd, Madurai, Tamilnadu, India
    2Department of pharmaceutical chemistry, K.M.College of pharmacy, Uthangudi, Madurai, India
    meeraharsa23@gmail.com

    ABSTRACT
    Objectives
    :
    A simple spectrophotometric method was developed and validated for the determination of Nitaoxanide in pharmaceutical dosage forms. Two visible spectrophotometric methods have been described for the assay of Nitaoxanide bulk form or dosage forms.
    Methods:
    Method A is based on the formation of Schiff’s base and it was condensed with 4 hydroxybenzaldehyde. Method B is based on diazotization and coupling method with phluroglucinol. The methods are done in UV Visible spectrophotometric method having maximum absorbance at 460 nm.
    Results:
    Regression analysis of Beers law plots showed good concentration range of 10-50µg/ml for method A and B and gives reproducible results.
    Conclusion
    : Due to its simplicity of the method it may be used for determining Nitaoxanide in bulk and dosage forms.

  • A REVIEW ON ANALYTICAL METHODS FOR DETERMINATION OF LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORMS AND BIOLOGICAL SAMPLE

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Monika A. Rana*, Hasumati A. Raj
    Department of Quality Assurance
    Shree Dhanvantary College of Pharmacy,
    Kim, Gujarat, India
    monika92rana@gmail.com

    ABSTRACT
    Levosulpiride is an atypical antipsychotic agent. Levosulpiride is the levo enantiomer of sulpiride. It is a substitute benzamide which is meant to be used for several indications: depression, psychosis, somatoform disorders, emesis anddyspepsia. It blocks the presynaptic dopaminergic D2 receptor. Chemically it is N-[[(2S)-1-Ethylpyrrolidin-2-yl] methyl]-2-methoxy-5 sulfamoylbenzamide. several method such as HPLC in human plasma, area under curve, stability by RP-HPLC is done. The parent drug is given in a dose of 400-1800 mg orally. According to literature survey study of impurity profiling of LIVOSULPIRIDE in presence of intermediate has not been reported.

  • A REVIEW OF ANALYTICAL METHODS FOR DETERMINATION BROMHEXINE HYDROCHLORIDE IN PHARMACEUTICAL AND BIOLOGICAL SAMPLES

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Meera V. Lad1*, Vineet Jain2, Hasumati Raj1
    1Department of Quality Assurance,
    2Department of Pharmacognosy,
    Shree Dhanvantary Pharmacy College, Kim, Gujarat
    meeralad235@gmail.com

    ABSTRACT:
    Bromhexine HCl (BRH)is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus, chemically named 2-amino-3,5-dibromo-N-cyclohexyl-N-methyl benzenemethanamine hydrochloride. According to IUPAC it is 2,4-dibromo-6-[[cyclohexyl(methyl)amino]methyl] aniline hydrochloride. Because of its physiological importance, the drug has been quantified by exploiting its chemical  and physical properties. Bromhexine is a weak base and its precipitate out at pH value above 6. Bromhexine is a synthetic benzyl amine derivative ofvasicine. The different analytical methods used to quantify the drug as a single active pharmaceutical ingredient include flow injection analysis with ionselectiveelectrodes, inductively coupled plasma mass spectrometry, electrokinetic chromatography, electrochemical oxidation at the glassy carbon electrode, liquid chromatography, liquid gas chromatography, GC with mass detection, and voltammetry. The drug has also been quantified in its combined formulations using HPLC, direct and derivative UV spectrophotometry.

  • A REVIEW: ANALYTICAL METHODS FOR DETERMINATION OF CILNIDIPINE IN BIOLOGICAL FLUID AND PHARMACEUTICAL DOSAGE FORMS

    { DOWNLOAD AS PDF }

    ABOUT AUTHORS:
    Farhana V. Buchiya*, Vineet Jain, Hasumati Raj
    Shree Dhanvantary Pharmacy College,
    Kim, Surat, Gujarat
    buchiyafarhana22@gmail.com

    ABSTRACT:
    Cilnidipine is act as a  dual blocker by blocking L- type of calcium channel  present in vascular smooth muscles and  N- type of calcium channel  present in sympathetic nerve  terminal that supply  blood  vessels. Cilnidipine used in treatment of mostly in hypertension and various cardiovascular diseases except in Angina. Cilnidipine used alone or in combination. This review covers most recent analytical methods such as various spectroscopic methods, chromatographic methods and other methods for determination of cilnidipine in various pharmaceutical dosage forms and biological matrix were reported.

    (adsbygoogle = window.adsbygoogle || []).push({});
  • DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS DETERMINATION OF SILDENAFIL CITRATE AND DAPOXETINE HYDROCHLORIDE IN THEIR COMBINED DOSAGE FORMULATION
  • EDARAVONE: A REVIEW ON ANALYTICAL METHOD AND ITS DETERMINATION IN BIOLOGICAL MATRIX AND SYNTHETIC MIXTURE
  • DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR ESTIMATION OF TAPENTADOL HYDROCHLORIDE
  • FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF SILYMARIN
Subscribe to Pharmaceutical Analysis Articles