ETODOLAC: A PHARMACOECONOMIC AND CLINICALLY EFFECTIVE NSAID FOR ARTHRITIS

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Figure


Fig.1: Spectra of Etodolac in methanol


Fig 2: FTIR spectra of Etodolac

Table-1: Range of Bond lengths and bond angles for Etodolac11

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Parameers PM3                                                  Bond Lengths


 (C-C)                                                                   1.441-1.554

(C=C)                                                                    1.379

(C-O)                                                                     1.353

(C=O)                                                                    1.219

(C-H)                                                                     1.094-1.108

(O-H)                                                                      0.952

(C-N)                                                                     1.421-1.422

(N-H)                                                                     0.990

Bond Angles

(C-C-C)                                                                  112.12-115.29

(C=C-C)                                                                 121.59

(C-C-H)                                                                  107.98-111.07

(C-O-C)                                                                  117.57

(C-O-H)                                                                  109.89

(C-C=O)                                                                 128.55

(O=C-O)                                                                 115.61

(H-C-H)                                                                  106.27-107.90

(C-C-N)                                                                  126.71

(C-N-C)                                                                  107.12

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References:
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2)USP31/NF 26 THE OFFICIAL COMPENDIA OF STANDARDS, ASIAN, 2008, VOL.2,2129
3)Japanese pharmacopoeia, the ministry of health and welfare, etodolac monograph 14th edition,653
4)Indian pharmacopoeia 2010 , The ministry of health and family welfare, volume 2 ,
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10)National Institute for Health and Clinical Excellence, Rheumatoid arthritis The management of rheumatoid arthritis in adults Issue date: February 2009,
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18)The National Institute for Clinical Excellence, THE CLINICAL EFFECTIVENESS AND COST EFFECTIVENESS OF CELECOXIB, ROFECOXIB, MELOXICAM AND ETODOLAC (COX-II INHIBITORS) FOR RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS. 1 November 2000
19)SAVITA VYAS*1, PIYUSH TRIVEDI 2 and SUBHASH CHANDRA CHATURVEDI3DEXTRAN-ETODOLAC CONJUGATES: SYNTHESIS, IN VITRO AND IN VIVO EVALUATIONActa Poloniae Pharmaceutica n Drug Research, Vol. 66 page .no. 201- 206, 2009
20)Magdy M. rahim,1 Mohamed EL-Nabarawi,1 Doaa Ahmed El-Setouhy,1,3 and Montasir Fadlalla2AAPIbPolymeric Surfactant Based Etodolac Chewable Tablets: Formulation and In Vivo EvaluationS PharmSciTech, Vol. 11, No. 4, December 2010
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22)Yasemin Ç?rpanl?*, Cecile Robineau**, Y?lmaz Çapan*, Sema Çal??*Etodolac Loaded Poly (Lactide-Co-Glycolide) Nanoparticles: Formulation, and In Vitro Characterization Hacettepe University Journal of the Faculty of Pharmacy Volume 29 / Number 2 / July 2009 / pp. 105-114
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25)Dirk B. Strickmanna, Bezhan Chankvetadzea, 1, Gottfried Blaschkea ,*, Claudia Desideriob,Salvatore Fanali, Separation and identification of etodolac and its urinary phase I metabolites using capillary electrochromatography and on-line capillary electrochromatography–electrospray ionisation mass spectrometry coupling, Journal of Chromatography A, 887 (2000) 393–407
26)Pareek A 1*, Chandurkar N 1, Tenpe C R 2., Yeole P G 2 , Payghan R 1 , Evaluation of anti-inflammatory activity of etodolac and colchicine combination in experimental animals, INTERNATIONAL JOURNAL OF PHARMACOLOGY AND THERAPEUTICS, Issue 1 : 2011,page no.13-18
27)Patidar R. et al., SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF PARACETAMOL AND ETODOLAC IN TABLET DOSAGE FORMS Journal of Global Pharma Technology. 2009; 1(1): 62-66
28) Swetha, et al. FORMULATION AND IN-VITRO EVALUATION OF ETODOLAC ENTRAPPED IN MICROSPONGE BASED DRUG DELIVERY SYSTEM, Int J Pharma 2011; 1(2): 73-80
29)P.Dwarakanadha Reddy et al. Formulation and Evaluation of Extended Release EtodolacTablets /JITPS 2010, Vol.1 (7), 294-297.

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