ANTIMICROBIAL ACTIVITY OF SCHIFF BASE OF 2-AMINO 5-NITROTHIAZOLE AND ITS COPPER COMPLEX

 

Table -1: Antibacterial Activity of the Schiff’s base Ligand and its complex

 

Zone of Inhibition (diameter in mm)

S.No

Compound

code

E.coli

S. Aureus

Pseudomonas putida

B. Subtilis

1

ATDI-S

-

-

-

-

2

ATDI-C

-

15

-

26.5

3

Positive Control

40

24

34

46

Table-2: Antifungal activity of schiff base ligand and its copper complex

 

Zone of Inhibition (diameter in mm)

S.NO

Compound

Code

Candida albicans

Aspergillus niger

1

ATDI-S

11

-

2

ATDI-C

20

19

3

Positive Control

24

25

Fig-1 Antibacterial activity of schiff base and its copper complex

Fig-2 Antifungal activity of schiff base ligand and copper complex

CONCLUSION
In present study we reported a nonconventional microwave assisted synthesis of schiff base ligand 2,4-diiodo-6-{(E)-[(5-nitro-1,3-thiazol-2-yl) imino] methyl} and their copper complex. In vitro antimicrobial activity of copper complex and ligand were studied and it has been observed that copper complex of schiff base were found to display higher antibacterial activity than free schiff base ligand under identical experimental condition. Some structural modification in free schiff base ligand (2,4-diiodo-6-{(E)-[(5-nitro-1,3-thiazol-2-yl) imino] methyl}) can tune the antimicrobial activity and may serve as a model compound for the development of some efficient antimicrobial activity.

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