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Brijesh Dasvani*, Avani Khristi
Department of Quality Assurance
Parul Institute of Pharmacy, Waghodiya,Limda, Vadodara, Gujarat

Oral dosage forms are the best medicine administration way of taking medication, despite having some disadvantages compared with other methods like risk of slow absorption of the medicament, which can be overcome by administering the drug in liquid form, therefore, possibly allowing the use of a lower dosage. However, instability of many drugs in liquid dosage form limits its use. Effervescent technique can be used as alternate to develop a dosage form which can accelerate drug disintegration and dissolution, is usually applied in quick release preparations. Along with the development of new pharmaceutical technique, effervescent tablet are more and more extensively to adjust the behaviour of drug release, such as in sustained and controlled release preparations, pulsatile drug delivery systems, and so on.

Reference Id: PHARMATUTOR-ART-2683

Oral drug delivery has been known for decades as the most widely utilized route of administered among all the routes that have been employed for the systemic delivery of drug via various pharmaceutical products of different dosage forms. The reasons that the oral route achieved such popularity may be in part attributed to its ease of administration. (AS, 2012) (Abolfazl A, 2013) Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). Rapid GI transit can prevent complete drug release in the absorption zone and reduce the efficacy of the administered dose. (Aboud HM, 2012) (Agyilirah GA, 1991)

Effervescent tablets are becoming increasingly popular in a variety of sectors including supplements and pharmaceutical use due to the ease in which they can be consumed. Effervescent tablets are designed to break in contact with liquid such as water or juice, often causing the tablet to dissolve into a solution. (Ahmed I, 2007)

These delivery systems utilize matrices prepared with swellable polymers such as Methocel or poly saccharides, e.g., chitosan, and effervescent components, e.g., sodium bicarbonate and citric or tartaric acid[6] or matrices containing chambers of liquid that gasify at body temperature (Ashish P, 2016) (Biswas D and Halquist M, 2016) Flotation of a drug delivery system in the stomach can be achieved by incorporating a floating. (Biswas D and Halquist M, 2016) (SK., 2015) (Deepali DW, 20111) (Dhakar RC, 2010) (Dhakar RC M. S., 2010) (Dixit N, 2013) (ED, 2014) (Gharti KP, 2009) (Harald S, 2003) (Hassali MA, 2016) (Howard CA, 2000)

 Benefits of effervescent tablets over simple tablets:  (Indian Pharmacopoeia, 1996) (RR, 2014) (Lachman L, 1986) (Larry LA and Stephan WH, 1993) (Maurya SD, 2013) (Maurya SD T. V., 2011) (Mohrle, 2005) (Obara T, 2015) (JS, 2000) (JS, 2015) (A, 2015)

Easy Alternative to Regular Tablets:
They can be a great alternative for those who may have trouble swallowing either due to illness or age. Older individuals may have difficulty swallowing but need to take medication or supplements on a regular basis and in this respect, effervescent tablets can be a lot easier than having to swallow a tablet. In addition to this, they can be a great way of ingesting medicine for individuals with sore throats or medical issues that make swallowing difficult and so are a viable alternative to regular tablets.

Increased Liquid Intake:
Effervescent tablets provide the nutritional benefits intended, but in addition to this they also increase liquid intake. This can be especially beneficial if you are dehydrated or ill and not ingesting as much fluid as usual. Effervescent tablets can be a fantastic way of rehydrating as well as reaping the benefits you are taking the tablets for whether this is a dietary supplement, herbally or medicinally.

Distributed More Evenly:
Conventional tablets dissolve gradually in the stomach once ingested and can sometimes only partially dissolve which can lead to irritation in some cases. The benefit of effervescent tablets is that they dissolve completely and evenly meaning that localised concentrations of the ingredients cannot occur. This means not only a better taste but also less chance of irritation and a more efficient means of ingesting the ingredients.

Chemical responsible for  effervescents (Ashish P, 2016), (Swarbrick J, 2002), (Lachman L, 1986), (Yanze FM D. C., 2000), (Thoke SB, 2013)
Potassium bicarbonate, Tartaric acid, Malic acid, Sodium bicarbonate, Sodium carbonate, Potassium carbonate, Citric acid, Fumaric acid.

Advantages of effervescent tablets
No need to swallow tablet, Good stomach and intestinal tolerance, More portability, Improved Therapeutic Effect, Fast onset of action, Improved palatability, Superior stability, More consistent response, Incorporation of large amounts of active ingredients, Accurate Dosing. (Lachman L, 1986), (RR, 2014), (Indian Pharmacopoeia, 1996)

Disadvantages of effervescent tablets
Clear solution is preferred for administration, although a fine dispersion is now universally acceptable, Unpleasant taste of some active ingredients, Relatively expensive to produce due to large amount of more or less expensive excipients and special production facilities. (Indian Pharmacopoeia, 1996), (Lachman L, 1986)

Quality control test of effervescent tablet  (Yanze FM D. C., 2000), (Vergeire DG, 2016), (Formulary, 2008), (Thoke SB, 2013), (Swarbrick J, 2002), (Skalkz BN, 2016), (Singh LP, 2011), (Singh BN, 2000), (Shimodaira S, 2016), (Sastry SV, 2000), (Sandhyarani G, 2017),  (Indian Pharmacopoeia, 1996)

Weight variation: Weight variation was determined to know whether different batches of tablets have uniformity. Weighed 20 tablets individually, calculated the average weight and compared the individual tablet weights to the average. The tablets meet the test if not more than two tablets are outside the % limit and none of the tablet differ by more than two times the % limit. Weight variation specification as per I.P.

Table: 1 : Weight variation specification

Tablet Thickness and Diameter:
Thickness and diameter of tablets were important for uniformity of tablet size. Thickness and diameter were measured using Vernier Calipers.

Tablet Hardness:
The resistance of tablets to shipping or breakage under conditions of storage, transportation and handling before usage depends on its hardness. The hardness of tablet of each formulation was measured by Monsanto Hardness Tester. The hardness was measured in items of kg/cm2. Hardness or tablet crushing strength is the force required to break a tablet in a diametric compression. The force is measured in kg and the hardness of about 3-5 kg/cm2 is considered to be satisfactory for uncoated tablets.

Friability (F):
Friability of the tablet determined using Roche friabilator. This device subjects the tablet to the combined effect of abrasion and shock in a plastic chamber revolving at 25 rpm and dropping a tablet at a height of 6 inches in each revolution. Pre weighted sample of tablets was placed in the friabilator and were subjected to the 100 revolutions. Tablets were dusted using a soft muslin cloth and reweighed. USP limit is 0.5 to 1%. The friability (F) is given by the formula.


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