SIMULTANEOUS ESTIMATION OF LINEZOLID AND CEFIXIME IN THEIR COMBINED DOSAGE FORM
{ DOWNLOAD AS PDF }
ABOUT AUTHORS:
Joshi HV*1, Patel JK2, Shah UA1, Patel Kinjal1
1Department of QA,
2Department of Pharmaceutics,
Nootan Pharmacy College, Visnagar, Gujarat, India
hirakjoshi@gmail.com
ABSTRACT
Simple, accurate, precise, reproducible, requiring no prior separation and economical procedures for simultaneous estimation of Linezolid (LIN) and Cefixime (CEF) in tablet dosage form have been developed. The method is simultaneous equation method; in this method 257.0 nm and 288.0 nm were selected respectively for LIN and CEF to measure the absorbance of both the drugs at mentioned wavelengths. Both the drugs show linearity at 10-50 μg/mL, the range was selected by studying their ratio present in combined formulation. Recovery studies range from >99.35% for CEF and >99.23% for LIN in mentioned analytical method i.e. simultaneous equation method. The proposed methods are recommended for routine analysis since it is rapid, simple, accurate and also sensitive and specific (no heating and no organic solvent extraction is required).
The Confederation of Indian Industry (CII) works to create and sustain an environment conducive to the development of India, partnering industry, Government, and civil society, through advisory and consultative processes. CII is a non-government, not-for-profit, industry-led and industry-managed organization, playing a proactive role in India's development process. Founded in 1895, India's premier business association has over 7200 members, from the private as well as public sectors, including SMEs and MNCs, and an indirect membership of over 100,000 enterprises from around 242 national and regional sectoral industry bodies.
