February 2013

About Authors:
Rathod Garuji*, G. Ganesh Kumar
Srikrupa Institute of Pharmaceutical Sciences,
Velikatta, Kondapak, Siddipet,
Dist: Medak.A.P.
*rathodpharma@gmail.com

ABSTRACT
Transdermal drug delivery is an alternative route for systemic drug delivery which minimizes the absorption and increases the bioavailability. Orally lornoxicam has a short elimination half-life (3-4 hrs.), low oral bioavailability undergoes extensive first pass metabolism and frequent high doses are required to maintain the therapeutic level as a result, dose development toxic effect. The purpose of this research work was to formulation and evaluation of lornoxicam transdermal patches using various polymers such as HPMC, Eudragit RL 100 and Eudragit RS 100 by solvent evaporation technique for improvement of bioavailability of drug and reducing toxic effects. The prepared formulations were evaluated for different physicochemical characteristics like thickness, folding endurance, drug content, percentage moisture absorption, percentage moisture loss and weight uniformity. Drug-excipient interaction studies were carried out using Fourier transform infrared (FTIR) spectroscopy technique.The diffusion studies were performed by using modified Franz diffusion cells. The result of diffusion study shows that formulation, F2 showed maximum release of 94.19 % in 24 h, whereas F5 showed minimum release of 51.59 % in 24 h. Based on the drug release and physicochemical values obtained the formulation F2 is considered as an optimized formulation which shows higher percentage of drug release of 94.19 % in 24 h. The developed transdermal patches increase the therapeutic efficacy and reduced toxic effect of lornoxicam.

About Author:
Ravi Kant
B.Pharm
Maharshi arvind institute of pharmacy, jaipur
rvkantyadav00@gmail.com

1. Introduction:-
Wheat grass consists of carbohydrates, proteins, all essential minerals and vitamins. As wheat grass juice bears a closer resemblance to the " haemogolobin " in our blood, the juice is often called as " green blood" and the therapy using it is called as " green blood therapy" wheat grass juice is complete food. Wheatgrass (baby wheat) juice is an extremely natural food. Since Dr. Anne Wigmore rediscovered the nutritional qualities of wheatgrass juice in 1960, the juice has helped hundreds of thousands of people around the world to overcome serious health problems.

However wheatgrass juice is not a panacea. If you continue to consume processed foods, drugs, alcohol, tobacco, burned foods and other toxic substances that can make you ill, a few milliliters of wheatgrass juice each day won't make much difference. Instead, try consuming a predominately (or entirely) raw food diet with organic wheatgrass juice. You will most likely experience a world of improvement.

Gauhati Universities Post Graduate Correspondence school started in May, 1998 with the objective of helping those who could not enroll as regular students . The PGCS aims at providing an opportunity to these students to obtain a Post Graduate degree of the Gauhati University through the mode of correspondence education. The degree from PGCS shall have the same standard and status as the regular Post Graduate degree as the syllabi for the two courses are the same.