January 2013

NBRI is a premier plant based multidisciplinary, state-of-art national R&D Centre of CSIR undertaking research from classical taxonomy to cutting edge areas of modern biology-including both applied and basic research in the fields of biochemistry, bioinformatics, biotechnology, conservation biology, cytogenetics, environmental sciences, ethnopharmacology, floriculture, microbiology, molecular biology and genetic engineering, pharmacognosy, pharmacy, physiology, phytochemistry, plant biodiversity, plant breeding, tax

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About Authors:
Shaishavi Parikh*, Arun Parikh, Vijayalakshmi Gudaparthy
Department of pharmaceutical chemistry, L. J. Institute of Pharmacy,
Ahmedabad-382210, India.
*shaishavi21@rediffmail.com

Abstract
Thiazolo[3,2-a]pyrimidine were synthesized by the reaction of the indole aldehyde with thiourea and methyl isobuterylacetate to generate thioxo pyrimidine compound which condensed to phenacyl bromide to form thiazolo[3,2-a]pyrimidine. All synthesized compounds are characterized by the IR, Mass and NMR spectroscopy and evaluated for the antibacterial and anti fungal activity by using B. cereus, S. aureus strains of Gram positiveE. coli strain of Gram negative andC.albicans strain of fungus. The compound having nitro and methoxy substituent shows significant activity in thiazolo[3,2-a]pyrimidine derivatives.

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