August 2012

About Authors:
Gupta S^*, Singal A
Apex Institute Of Pharmaceutical Sciences,
Jaipur, Raj., India
*somesh.gupta88@gmail.com

Abstract
The aim of the present study was to correlate the occurrence of hypertension in the diabetics’ patient by the survey report on hypertension associated with diabetics’ patient. The effect of this study is symbolize that 70% patient have diabetes with hypertension and 30% patient with hypertension only so we can say that in this survey as the BGL increased leads to increased in B.P. And it was also found to be that aged patients have more risk of diabetes. Over 60- 70 year age group patient have 40% risk to get diabetes.

Clinical Development Services Agency (CDSA) is an extramural unit of THSTI and has been established as a not-for-profit society to provide cost effective, high quality preclinical and clinical product development support services to meet the country’s growing healthcare needs. It will tend enterprises; particularly SMEs involved in new technology innovation and facilitate translation of scientific know-how into viable products.

Marion Biotech strongly believes in an integrated approach to healthcare. It is also engaged in extensive Research & Development of unique Herbal products. At Marion Biotech, we set Stringent Standards of Quality, Safety and Efficacy for all the Products that we manufacture.

Leading pharma company located in Mumbai; Manufacturing of Sustained & modified release, Pellets, DC granules, Taste mask Granules, Tablets & Capsules.

About author:
Ashish Vishwakarma
Department of Pharmaceutics,
Chandigarh College of Pharmacy,
Mohali-140307
ashish1931@gmail.com

ABSTRACT-
Acceptability of any drug dosage form mainly depends upon its taste i.e. mouth feel. In the formulation of   oro-dispersible tablet of bitter drug, the main challenge is to mask the bitter taste of drug, because the drug is dispersed and released in mouth. This is more essential in the formulation for pediatric and geriatric, bed ribbon and non-cooperative patients. There are many methods of taste masking but the main objective of this article is to explore method, technology and evaluation to mask taste of bitter drug by ion-exchange resins. Here we will study the formulation and evaluation of various oro-dispersible tablets of bitter drug. This is more economical, easiest and efficient method for taste masking.

About Authors:
Abdulrhman A. Akasha
Department of Pharmaceutics, Faculty of Pharmacy,
Tripoli University, Libya-13645
akashaabdu@yahoo.co.uk

Abstract
Bioerodible microspheres may provide a vehicle for achieving good aerosolisation characteristics, whilst offering a slow release depot from the pulmonary deposited fraction.  Polysebasic anhydride (PSA) was synthesised by a melt-polycondensation process using nitrogen gas under high vacuum. The products were characterised by ¹H-NMR (2 & 20 KDa) and DSC (melting point: 68 & 83 ^°C), and with a yield (81 & 89 %) of prepolymer and polymer respectively. The polyanhydride was converted into microspheres using an oil in oil emulsification procedure.  The polymer was dissolved in dichloromethane and using 1 to 5% Span 85 or oleic acid as stabilizer, dispersed into silicone oil. The dichloromethane was removed by evaporation, the microspheres recovered and washed with petroleum ether. Laser diffraction analysis of the microspheres indicated a mean microspheres size <5 mm.  The presence of rough non-porous spheres was demonstrated by SEM.  Initial in vitro experiments were undertaken to examine the degradation rate in 0.1 M phosphate buffer at 37 ^°C, pH 7.4.  The process was followed for 24 hr, by which time 73% of the microsphere mass had eroded. However release of salbutamol base occurred more rapidly with 95% lost within 6-10 hr. The fact that 74% was released in the first 10 min suggest a high fraction of surface adsorbed drug. Microcarrier systems for slow release may provide a vehicle for achieving good aerosolisation characteristics, whilst offering a slow release depot from the pulmonary deposited fraction. The produced rough and non-porous microspheres containing salbutamol base were subjected for Deposition process using Andersen Mark II Cascade Impactor. The Deposition was assessed from both a Spinhaler and Rotahaler after 5s activation at a flow rate of 28.3L/min.  This resulted in an average of 33.5% (Rotahaler and 17.5% (Spinhaler) of the dose found between stages 2 and the filter corresponding to microspheres in the size range 4.7 to 0.4 mm.

Applications are invited for the various research positions (Purely Temporary) for the DST, New Delhi sponsored National Facility on Drug Development for Academic Institutions, Pharmaceutical and Allied Industries in Regional Office, Anna University, Chennai, BIT Campus, Tiruchirappalli – 620 024.

Post: RESEARCH ASSOCIATE, JRF, PROJECT ASSISTANT