February 2012

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3 February 2012

ANTI-INFLAMMATORY AND ANALGESIC ACTIVITIES OF THE AQUEOUS LEAF EXTRACT OF ALLOPHYLUS SERRATUS IN EXPERIMENTAL ANIMAL MODELS

About Authors:
A. Srilakshmi, SK. Afsar, B. Priyanka, G. Jyothi Reddy, R.E.Amrutha, B.Jagadeesh babu, C. Raja ram
1. Department of Pharmacology,
P. Rami Reddy Memorial College of Pharmacy,
Kadapa, Andhra Pradesh, India.

ABSTRACT
ALLOPHYLUS SERRATUS is a medicinal plant used for the treatment of various risk factors like analgesia, inflammation, ulcers, and wounds. The aqueous extract of the leaf was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 100, 200 and 400mg/kg body weight reduced significantly the formation of oedema induced by formalin. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 0.05ml of 10% formalin. These results were also comparable to those of ibuprofen, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations.

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