May 2011

Franco-Indian Pharmaceuticals Pvt. Ltd., a name that stands for quality and innovation, is one of the major players in the Pharmaceutical Industry in India.
Our innovative, value added products improve the quality of life of people and ease their sufferings and help them to enjoy, longer, healthier and more productive lives.

Parenteral Drugs (India) Limited is one of the leading and fastest growing healthcare company, that has constantly followed a path created by its own will, hard work and determination. PDPL is involved in research, production and manufacturing of pharmaceutical products viz. intravenous infusion, tablets, capsules, liquids syrups, injections etc. Established in the year 1983, PDPL has dedicated itself to the manufacturing of the best quality vital life saving drugs at the lowest possible cost.

About Author: Vikas Mahajan* (M.Pharm 1^st  year), Naiyer Shahzad, Sachin Mager
Singhania University,
Pacheri Bari, Rajasthan - 333515

Reference ID: PHARMATUTOR-ART-1054

Abstract
In this study Cytotoxic potential of two Indian medicinal plant extracts were investigated. The invitro cytotoxic potentiality investigated as the ability of these two extracts to inhibit tumour cell line growth with help of MTT & Trypan blue assay. With this investigation we had also focused on angiogenesis. The cell lines studied are MCF7, A549 and DU145 with the methanolic extract of Alium sativum (MEAS) (garlic) and Emblica officinalis (MEEO) (amla). Both drugs are extracted by maceration method. The extract were concentrated & dissolved in DMSO Solvent & stock solution is prepared of conc. 1mg/10 ml. from which different conc. are prepared as 100, 10, 1, 0.1,0 .001 µg/ml. Both plant extracts preapared concentration are exposed in MCF7, A549 & DU145 in 96 well plate in which MTT dye was added later & allow it for 96 hr. after incubation period absorbance was taken in spectrophotometer at 517nm. With same trypan blue also performed & Counting of cell was done on inverted microscope.  Results indicates that the above plant extracts hsowing anticancer and antiangiogenesis activity of Same plant extract were studied on tube formation cell based models also. From this study we can conclude that both drugs possess anticancer activity for MCF7, A549 & DU145 for different concentrations.

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About Author: R. C. PATEL, C. K. BHUVA, MR. R. P. SINGH, MR. ABHISHEK DADHICH, MR. ANIL SHARMA.
Department of Quality Assurance, Gyan Vihar School of pharmacy,
Suresh Gyan Vihar University,
Jaipur, Rajasthan, India-302025

Reference ID: PHARMATUTOR-ART-1053

Abstract
Validation has become one of the pharmaceutical industry’s most recognized and discussed subjects. It is a critical success factor in product approval and ongoing commercialization. This article provide brief introduction about the pharmaceutical process validation and its importance according to regulatory provision, also provide the answer of question like why to do, when to do and how to do it. This work is to present an introduction and general overview on process validation of pharmaceutical manufacturing process. Quality is always an imperative prerequisite when we consider any product. Therefore, drugs must be manufactured to the highest quality levels. End-product testing by itself does not guarantee the quality of the product. Quality assurance techniques must be used to build the quality into the product at every step and not just tested for at the end. In pharmaceutical industry, Process Validation performs this task to build the quality into the product because according to ISO 9000:2000, it had proven to be an important tool for quality management of pharmaceuticals.