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SIMULTANEOUS SPECTROPHOTOMETRIC ESTIMATION OF DICLOFENAC SODIUM AND EPERISONE HYDROCHLORIDE USING ABSORBANCE RATIO METHOD IN CAPSULE DOSAGE FORM
Lalit F. Raiyani*1, Dharanant V. Borakhatariya2, Bhargav D. Patel3, Kuldip R. Marwada4, Dr.Priti D. Trivedi5, Mr.Rajendra K. Patel6
1Parul institute of Pharmacy, Vadodara
2B. K. Modi Government Pharmacy College, Rajkot
3Ramanbhai Patel College of Pharmacy, Changa
4R. K. College of Pharmacy, Rajkot
5Professor at K. B. Institute of Pharmaceutical Education and Research, Gandhinagar
6Lecturer at K. B. Institute of Pharmaceutical Education and Research, Gandhinagar
A simple, rapid, sensitive, precise and accurate UV-spectrophotometric method (absorbance ratio) was developed and validated for simultaneous estimation of Diclofenac sodium and Eperisone hydrochloride in pharmaceutical capsule dosage form. In absorbance ratio method absorbance measurement of sample at 239.2 nm (isoabsorbtive point, λ1) and 256 nm, λ2.The absorbance ratio method was developed using methanol as solvent. Developed method is linear between 4-12µg/ml and 5-15µg/ml for diclofenac sodium and eperisone hydrochloride respectively. The mean % recovery was found to be 99.68% & 99.14% for diclofenac sodium and eperisone hydrochloride respectively.
Simultaneous Spectrophotometric Determination of Cefixime and Moxifloxacin in Bulk Drug and Drug Formulation by Absorption Ratio Method
Shah Chirag K.*, Umalkar Deepak, Dr. Rajesh KS.
Parul Institute of Pharmacy, Gujarat University,
Waghodia-391760, Dist. Vadodara,
The present manuscript described the simple, rapid, accurate, sensitive, precise and economical Q- absorption ratio method for simultaneous determination of Cefixime and Moxifloxacin in combined tablet dosage form. Absorption ratio method uses the ratio of absorbances at selected wavelengths, one which is isoabsorptive point and other being the λmax of the one of the components. Cefixime and Moxifloxacin shows isoabsorptive point at 275nm in 0.1N HCl. The second wavelength used is 295nm, which is λmax of Moxifloxacin. The concentrations of the drugs were determined by using ratio of absorances at isoabsorptive point and at λmax of Moxifloxacin. The method successfully applied to the Pharmaceutical formulation because no interference from the tablet formulation excipients was found. The results of analysis have been validated statistically and by recovery studies.