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THALIDOMIDE AND ITS ANALOGUES IN ANTICANCER THERAPY

ABOUT AUTHORS:
Shikha Attri, Arti Choudhary, Devendra Gupta
M.Pharm in Pharmaceutical Chemistry, Lachoo
Memorial College of Science and Technology,
Jodhpur University, Rajasthan University Of Health Sciences, Jaipur
*shikhu921@gmail.com

ABSTRACT
Thalidomide, removed from clinical use because of severe teratogenicity, is back. In a comeback that has proceeded with remarkable speed, the drug that adversely affected more than 10,000 infants just over four decades ago now seems to be a lifesaver for patients with advanced plasma cell malignancies. Thalidomide and its immunomodulatory (IMiDs) analogs (lenalidomide, CC-4047, ACTIMID) are a novel class of compounds with numerous effects on the body’s immune system, some of which are thought to mediate the anticancer and anti- inflammatory results observed in humans. Thalidomide is currently being used experimentally to treat various cancers and inflammatory diseases. Immunomodulatory activities along with anti-angiogenic, anti-proliferative,and pro-apoptotic properties are thought to mediate the IMiDs’antitumor responses observed in relapsed and refractory multiple myeloma and some solid tumor cancers. This has led to their use in various oncology clinical trials.
A review is presented of the history of thalidomide and its analogues properties with an emphasis on applications in malignant disease.



FEMALE INFERTILITY- UNDERSTANDING CAUSES, TESTS AND TREATMENT

ABOUT AUTHOR:
Balram Soni*
M.Pharm., Ph.D. Scholar
Psychiatric Centre, S.M.S. Medical College, Jaipur, Rajasthan
*brpharma@rediffmail.com

ABSTRACT:
Studies indicate that slightly over half of all cases of infertility are a result of female conditions, while the rest are caused by either sperm disorders or unidentified factors. Infertility in female is very often observed. It is inability to conceive and produce the child. ART (Assisted Reproductive Technology) has been carried out such as IVF, ICSI but common people cannot afford the cost of such procedures. Various allopathic, Ayurvedic and other alternatives medicines and physiotherapy with acupuncture are been effective to enhance the pregnancy and these drugs and exercises will even prevent the recurrent abortions. In this regard the present review is aimed to provide all the necessary information regarding the effective method for treatment of female infertility.


Opening for Marketing Executives in Pukhraj Herbals | 10 Posts

Pukhraj Herbals Pvt Ltd is well known name in the field of Herbal API, recently Company extended with Immuno Health Care Research Center with large number of Finished herbal products.

Post: Marketing Executives - 10 posts



Walk in interview for Faculties at DR. K.N. MODI INSTITUTE OF PHARMACEUTICAL EDUCATION & RESEARCH

The Foundation has been established with a mission to be a nucleus of excellence in varied fields of education with positive attitude, high values, commitment and dedication.
With the blessing of his respected mother & father Dr. D.K. Modi, Chairman cum President, under whose able guidance the Foundation offers a series of Technical and Professional Programmes. Each of the Foundation Institute is dedicated to offer an unrivaled learning, self- development and career building environment and facilities. At present, the Foundation is nurturing the future of more than 35,000 students,enrolled with the Colleges.


AN OVERVIEW: AQUEOUS FILM COATING TECHNOLOGY ON TABLETS

About Authors:
Parmar Krutin D.1*, Pandya Kirtan B.2, Gajjar Alpesh M.3, Zala Shivraj D.3, Kela Amit N.1, Nathani Hitesh S.
1
1*
C. U. Shah College of Pharmacy and Research, Wadhwan city, Surendranagar, Gujarat, India.
2
Shree Balaji pharmacy college, Jaipur, Rajasthan, India.
3
Shree V.B. Manvar college of pharmacy, Upleta, Gujarat, India.
*krutinkp@gmail.com

Abstract:
Tablet coating is perhaps one of the oldest pharmaceutical processes still in existence. Earlier, Sugar coating was adopted for pharmaceutical as from confectionary industry. But as it was tedious process and required skilled manipulation, film coating was started to be preferred over sugar coating.  Development of film coating was mainly based on solutions of different polymers in various organic solvents. All these solvents are toxic in nature. Nobody ever was concerned about the problems like material cost, toxic effects due to coating or pollution etc. In today's competitive business environment, any cost saved will improve the market viability and success of any product. Therefore, left with no other choice but to eliminate the use of organic solvents and to start using water as the solvent system for tablet coating.
The main focus of this review is, to study various aspects of aqueous based film coating.



AN UPDATED PHARMACEUTICAL CRUDE DRUG PROFILE

Pharmacognostical Crude drug Profile:


INDUSTRIAL TRAINING IN PHARMACOLOGY / ANALYTICAL INSTRUMENTATION / STRUCTURAL ELUCIDATION for Pharmacy Graduates & Postgraduates @ RASA LSI

RASA Life Science Informatics, a Bio-Chemoinformatics company based in Pune, provides unmatchable training facilities to students and professionals in Life Science Informatics. We are now launching a 100% Job oriented Training program, Academic & Industrial Projects to enable anyone and everyone to get trained and get placed.


A REVIEW ON MÖSSBAUER SPECTROSCOPY

About Authors
Deepak Kumar Shukla*, Nazia Shahid, Vikas Kumar Alaria
Rajasthan Pharmacy College, Bhankrota, Jaipur (Raj.)
*deepakshukla.pharma@gmail.com

Abstract
Over the past several years spectroscopy has become the preeminent technique for determining the structure of organic compounds. The study of recoilless nuclear resonant absorption or fluorescence is more commonly known as Mossbauer spectroscopy. From its first origins in 1957, it has grown rapidly to become one of the most important research methods in solid-state physics and chemistry. Mossbauer spectroscopy uses the nuclear properties to get information regarding the environment surrounding the nucleus. This technique is now valid application in diverse fields, such as solid state physics, metallurgy, chemistry and biochemistry. For example, it is possible to use this method for estimating the iron or tin content in ores, alloys and wasters in a non-destructive manner to concentration down to 0.03 percent in a short time of  the order of 10 minutes. The technique can also detect the relative percentage of  different charged states of the same atom, for example fe2+ and Fe3+ present in the material. This is somewhat difficult to get from any other technique.


Opening as Regional Manager – Institutional Sales,Business Manager in Unichem Labs

Unichem Laboratories has grown to become one of India’s most respected pharmaceutical companies. It is committed to delivering better health through superior products. By combining strategic research and in-depth industry knowledge, Unichem aims to transform itself into a global pharmaceutical drug company with an increasing focus on cutting-edge research and developed markets.

 

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