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PHARMACOSOMES: A NOVEL VESICULAR SYSTEM

ABOUT AUTHORS:
Mayur Pansuriya*, DR. Amit Gupta, Vihar Gadhvi, Kathiriya Hashesh, Patel Chirag
Department of Quality assurance,
Mahatma Gandhi College of Pharmaceutical Sciences,
ISI-15 (A) RIICO Institutional Area,
Sitapura, Tonk Road, Jaipur-302022 (Rajasthan).
*mayurpansuriya45@gmail.com

ABSTRACT
Lipid-based drug delivery systems have been investigated in various studies and shown their potential in controlled and targeted drug delivery. Pharmacosomes are amphiphilic phospholipid complexes of drugs bearing active hydrogen that bind to phospholipids. Pharmacosomes impart better biopharmaceutical properties to the drug, resulting in improved bioavailability. As the system is formed by combining drug (pharmakon) to carrier(soma), they are termed as pharmacosomes. Depending upon the chemical structure of the drug lipid complex they may exist in ultrafine vesicular, micellar and hexagonal aggregate. Any drug having an active hydrogen group(-COOH,-OH etc) can be esterified to lipids, resulting in amphiphillic compound. In general two methods have been employed to prepare pharmacosomes. These are hand shaking method and ether injection method. Developing the pharmacosomes of the drug has been found to improve the absorption and minimize the gastro-intestinal toxicity. Pharmacosomes have been prepared for various non-steroidal anti-inflammatory drugs, proteins, cardiovascular and antineoplastic drug. The drug is released from pharmacosome by hydrolysis (including enzymatic). This article reviews the potential of pharmacosomes as a controlled and targeted drug delivery system and highlights the methods of preparation and characterization.

Work as Zonal Sales Manager, Regional Sales Manager in Systopic

We are an established Pharmaceutical Company having a committed team of 825 professionals across the country. Having created a position for ourselves among Top 35 Pharmaceutical Companies prescription wise, we are further strengthening our presence in potential specialty areas -Cardiovascular and Anti-Diabetic Segments. For our expansion programme we require:

Post: Zonal Sales Manager, Regional Sales Manager

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A REVIEW ON VALIDATION OF PHARMACEUTICAL WATER PURIFYING SYSTEM

ABOUT AUTHORS:
Dr. Amit Gupta, Chirag Sudani*, Hashesh katheriya, Shifalee magazine, Mayur Pansuriya
Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur.
*patel_chirag75@yahoo.com

ABSTRACT:
Water purification systems must be validated to insure that the specified quality of water is consistently produced for use of all purpose as well as formulation, production, analysis, drinking cleaning and to solve the problems arising in the purification system.In present scenario the quality of pharmaceutical water is maintained by setting a good pharmaceutical water system and this system encompasses qualification, attention of the regulatory requirements which are updated time to time. Validation of water treatment systems is necessary to obtain water with all desired quality attributes. This also provides a framework to establish a total control over the process which monitors safety, efficacy and ultimately, the process outcomes.

THALIDOMIDE AND ITS ANALOGUES IN ANTICANCER THERAPY

ABOUT AUTHORS:
Shikha Attri, Arti Choudhary, Devendra Gupta
M.Pharm in Pharmaceutical Chemistry, Lachoo
Memorial College of Science and Technology,
Jodhpur University, Rajasthan University Of Health Sciences, Jaipur
*shikhu921@gmail.com

ABSTRACT
Thalidomide, removed from clinical use because of severe teratogenicity, is back. In a comeback that has proceeded with remarkable speed, the drug that adversely affected more than 10,000 infants just over four decades ago now seems to be a lifesaver for patients with advanced plasma cell malignancies. Thalidomide and its immunomodulatory (IMiDs) analogs (lenalidomide, CC-4047, ACTIMID) are a novel class of compounds with numerous effects on the body’s immune system, some of which are thought to mediate the anticancer and anti- inflammatory results observed in humans. Thalidomide is currently being used experimentally to treat various cancers and inflammatory diseases. Immunomodulatory activities along with anti-angiogenic, anti-proliferative,and pro-apoptotic properties are thought to mediate the IMiDs’antitumor responses observed in relapsed and refractory multiple myeloma and some solid tumor cancers. This has led to their use in various oncology clinical trials.
A review is presented of the history of thalidomide and its analogues properties with an emphasis on applications in malignant disease.

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FEMALE INFERTILITY- UNDERSTANDING CAUSES, TESTS AND TREATMENT

ABOUT AUTHOR:
Balram Soni*
M.Pharm., Ph.D. Scholar
Psychiatric Centre, S.M.S. Medical College, Jaipur, Rajasthan
*brpharma@rediffmail.com

ABSTRACT:
Studies indicate that slightly over half of all cases of infertility are a result of female conditions, while the rest are caused by either sperm disorders or unidentified factors. Infertility in female is very often observed. It is inability to conceive and produce the child. ART (Assisted Reproductive Technology) has been carried out such as IVF, ICSI but common people cannot afford the cost of such procedures. Various allopathic, Ayurvedic and other alternatives medicines and physiotherapy with acupuncture are been effective to enhance the pregnancy and these drugs and exercises will even prevent the recurrent abortions. In this regard the present review is aimed to provide all the necessary information regarding the effective method for treatment of female infertility.

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Walk in interview for Faculties at DR. K.N. MODI INSTITUTE OF PHARMACEUTICAL EDUCATION & RESEARCH

The Foundation has been established with a mission to be a nucleus of excellence in varied fields of education with positive attitude, high values, commitment and dedication.
With the blessing of his respected mother & father Dr. D.K. Modi, Chairman cum President, under whose able guidance the Foundation offers a series of Technical and Professional Programmes. Each of the Foundation Institute is dedicated to offer an unrivaled learning, self- development and career building environment and facilities. At present, the Foundation is nurturing the future of more than 35,000 students,enrolled with the Colleges.

AN OVERVIEW: AQUEOUS FILM COATING TECHNOLOGY ON TABLETS

About Authors:
Parmar Krutin D.1*, Pandya Kirtan B.2, Gajjar Alpesh M.3, Zala Shivraj D.3, Kela Amit N.1, Nathani Hitesh S.
1
1*
C. U. Shah College of Pharmacy and Research, Wadhwan city, Surendranagar, Gujarat, India.
2
Shree Balaji pharmacy college, Jaipur, Rajasthan, India.
3
Shree V.B. Manvar college of pharmacy, Upleta, Gujarat, India.
*krutinkp@gmail.com

Abstract:
Tablet coating is perhaps one of the oldest pharmaceutical processes still in existence. Earlier, Sugar coating was adopted for pharmaceutical as from confectionary industry. But as it was tedious process and required skilled manipulation, film coating was started to be preferred over sugar coating.  Development of film coating was mainly based on solutions of different polymers in various organic solvents. All these solvents are toxic in nature. Nobody ever was concerned about the problems like material cost, toxic effects due to coating or pollution etc. In today's competitive business environment, any cost saved will improve the market viability and success of any product. Therefore, left with no other choice but to eliminate the use of organic solvents and to start using water as the solvent system for tablet coating.
The main focus of this review is, to study various aspects of aqueous based film coating.

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AN UPDATED PHARMACEUTICAL CRUDE DRUG PROFILE

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