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Curcumin Nano drug delivery systems: A Review on its type and therapeutic application
- Posted on: 30 November 2017
- By: admin
PharmaTutor (December - 2017)
ISSN: 2347 - 7881
(Volume 5, Issue 12)
Received On: 02/08/2017; Accepted On: 14/08/2017; Published On: 01/12/2017
S. Dhivya*, A. N. Rajalakshmi
Department of Pharmaceutics,
Mother Theresa Post Graduate and Research Institute of Health Sciences,
Gorimedu, Puducherry, India
Design and development of herbal nanoparticles has become a frontier research in the nanoformulation arena. Curcumin, a hydrophobic polyphenol (diferuloyl methane) is a potent phytomolecule obtained from turmeric (Curcuma longa, Family-Zingiberaceae) has a wide range of biological activities in chronic diseases and has wide therapeutic efficacy. But the clinical application of curcumin was limited due to its poor water solubility, rapid metabolism and rapid elimination which ultimately results in poor bioavailability upon oral administration. Therefore introduction of nanotechnology provides a solution towards increased bioavailability of curcumin. In this review, an overview of curcumin nanoparticles is discussed.
How to cite this article: Dhivya S, Rajalakshmi AN;Curcumin Nano drug delivery systems: A Review on its type and therapeutic application; PharmaTutor; 2017; 5(12); 30-39
1. Masuda T, Isobe J, Jitoe A, and Nakatani N, (1992): Antioxidative curcuminoids from rhizomes of Curcuma xanthorrhiza. Phytochemistry., 31: 3645-7.
2. Sreejayan S, and Roa M.N, (1994): Curcuminoids as potent inhibitor of lipid peroxidation. J. Pharm. Pharmacol, 46: 1013-6.
3. Unnikrishnan, M.K. and Roa, M.N. (1995): Inhibition of nitrite induce oxidation of hemoglobin by curcuminoids. Pharmazie., 50: 490-2.
4. Kiuchi F, Goto Y, Sugimoto N, Akao N, Kondo K, Tsuda Y: Nematocidal activity of turmeric: synergistic action of curcuminoids. Chem Pharm Bull (Tokyo) 1993; 41:1640–3.
5. Sharma K, Agrawal SS, Gupta M. Development and validation of uv spectrophotometric method for the estimation of curcumin in bulk drug and pharmaceutical dosage forms. Int J drug dev res, 2012; 4(2): 375-380.
6. Sabita N, Saldanha and Trygve O, Tollefsbol: The Role of Nutraceuticals Chemoprevention and Chemotherapy and Their Clinical Outcomes. Journal of Oncology., vol. 2012, 23 pages.
7. Lao C.D, Ruffin M.T, Normolle D, Heath D.D, Murray S.I, Bailey J.M, Boggs M.E, Crowell J, Rock C.L, Brenner D.E: Dose escalation of a curcuminoid formulation. BMC Complement. Altern. Med. 2006, 6, 10.
8. Letizia, Da Sacco, Andrea, Masotti: Chitin and Chitosan as Multipurpose Natural Polymers for Groundwater Arsenic Removal and As2O3 Delivery in Tumor Therapy. Mar. Drugs., 2010, 8: 1518-1525.
9. Anwunobi1 A.P, and Emeje M.O: Recent Applications of Natural Polymers in Nanodrug Delivery. J Nanomedic Nanotechnol., 2011., S4: 1-6.
10. Paul, D.R. and Robeson, L.M: Polymer nanotechnology: Nanocomposites. Polymer., 2008, 49: 3187– 3204.
11. Malam Y, Loizidou M, and Seifalian A. M: Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer, Trends in Pharmacological Sciences, 2009, vol. 30, no. 11, pp. 592– 599.
12. Li L, Braiteh FS, and Kurzrock R: Liposome-encapsulated curcumin: in vitro and in vivo effects on proliferation, apoptosis, signaling, and angiogenesis, Cancer, 2005, vol.104, no.6, 1322–1331.
13. Rahman S, Cao S, Steadman KJ, Wei M, Parekh HS: Native and ??-cyclodextrin-enclosed curcumin: entrapment within liposomes and their in vitro cytotoxicity in lung and colon cancer, Drug Delivery, 2012, vol.19, no.7, pp.346–353.
14. Chen Y, Wu Q, Zhang Z, Yuan L, Liu X, Zhou L: Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics., Molecules, 2012; vol.17, no.5, 5972–5987.
15. Li DC, Zhong XK, Zeng ZP: Application of targeted drug delivery system in Chinese medicine., 2009, Journal of Controlled Release, vol. 138, no. 2, pp. 103–112.
16. Anitha A, Maya S, Deepa N: E?cient water soluble O-carboxy methyl chitosan nanocarrier for the delivery of curcumin to cancer cells, Carbohydrate Polymers, 2011, vol.83, no.2, pp. 452–461.
17. Das RK, Kasoju N, and Bora U: Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells., Nanomedicine, 2010, vol. 6, no. 1, pp.153–160.
18. Yallapu MM, Gupta BK, Jaggi M, Chauhan SC: Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic e?ects in metastatic cancer cells., Journal of Colloid and Interface Sci, 2010, vol. 351, no. 1, pp. 19–29.
19. Anand P, Nair HB, Sung B: Design of curcumin loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo, Biochemical Pharmacology, 2010, vol. 79, no. 3, pp. 330–338.
20. Shaikh J, Ankola DD, Beniwal V, Singh D, Kumar MNVR: Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer, European Journal of Pharm Sci, 2009, vol. 37, no. 3-4, pp. 223–230.
21. Song Z, Feng R, Sun M: Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo, J. of Colloid and Interface Sci, 2011, vol. 354, no. 1, pp. 116-123.
22. Pardeike J, Hommoss A and Muller RH: Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products, International Journal of Pharmaceutics, 2009, vol. 366, no. 12, pp. 170–184.
23. Michael D. Triplett, PhD thesis: Enabling Solid Lipid Nanoparticle Drug Delivery Technology By Investigating Improved Production Techniques, 2004.
24. Kakkar V, Singh S, Singla D, Kaur IP: Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin., Molecular Nutrition and Food Research, 2011, vol. 55, no. 3, pp. 495–503.
25. Dadhaniya P, Patel C, Muchhara J: Safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studies, Food and Chemical Toxicology, 2011, vol.49, no.8, pp.1834–1842.
26. Aqil, Munagala R, Jeyabalan J, Vadhanam MV: Bioavailability of phytochemicals and its enhancement by drug delivery systems, Cancer Letters, 2013, vol.334, no.1, pp.133–141 .
27. Jones MC and Leroux JC: Polymeric micelles- a new generation of colloidal drug carriers, European J. Of Pharmaceutics and Biopharmaceutics, 1999, vol. 48, no. 2, pp. 101–111.
28. Liu L, Sun L, Wu Q: Curcumin loaded polymeric micelles inhibit breast tumor growth and spontaneous pulmonary metastasis, International Journal of Pharmaceutics, 2013, vol.443, no. 1-2, pp. 175–182.
29. Raveendran R, Bhuvaneshwar G, and Sharma CP: In vitro cytotoxicity and cellular uptake of curcumin-loaded fluronic/ Polycaprolactone micelles in colorectal adenocarcinoma cells, Journal of Biomaterials Applications, 2013, vol.27, no.7, pp.811– 827.
30. Yang Y, Jiang JS, Du B, Gan ZF, Qian M, Zhang P: Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting., Journal of Materials Science, 2009, vol. 20, no. 1, pp. 301–307.
31. Yallapu MM, Othman SF, Curtis ET, BGupta BK, Jaggi M, Chauhan SC: Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy, Biomaterials, 2011, vol.32, no.7, pp.1890–1905.
32. Tran LD, Hoang NMT, Mai TT: Nanosized magneto?uorescent Fe3O4-curcumin conjugate for multimodal monitoring and drug targeting, Colloids and Surfaces, 2010, vol.371, no. 1–3, pp. 104–112.
33. Goncalves C, Pereira P, Schellenberg P, Coutinho P, Gama F: Self-assembled dextrin nanogel as curcumin delivery System, Journal of Biomaterials and Nanobiotechnology, 2012, vol.3, no. 2, pp. 178–184.
34. Wu W, Shen J, Banerjee P, Zhou S: Water-dispersible multifunctional hybrid nanogels for combined curcumin and photothermal therapy, Biomaterials, 2011 vol.32, no.2, pp.598–609.
35. Omidfar K, Khorsand F, Darziani Azizi M: New analytical applications of gold nanoparticles as label in antibody based sensors, Biosensors and Bioelectronics, 2013, vol.43, pp.336–347.
36. Rajesh J, Rajasekaran M, Rajagopal G, Athappan P: Analytical methods to determine the comparative DNA binding studies of curcumin-Cu(II) complexes, Spectrochimica Acta: Molecular and Biomolecular Spectroscopy, 2012, vol.97, pp.223–230.
37. Singh DK, Jagannathan R, Khandelwal P, Abraham PM, Poddar P: In situ synthesis and surface functionalization of gold nanoparticles with curcumin and their antioxidant properties: An experimental and density functional theory investigation, Nanoscale, 2013, vol.5, no.5, pp.1882–1893.
38. Manju S and Sreenivasan K: Gold nanoparticles generated and stabilized by water soluble curcumin-polymer conjugate: Blood compatibility evaluation and targeted drug delivery onto cancer cells, Journal of Colloid and Interface Science, 2012, vol.368, no.1, pp.144–151.
39. Sweet MJ and Singleton I: Silver nanoparticles: A microbial Perspective, Advances in Applied Microbiology, 2011, vol.77, pp.115–133.
40. Varaprasad K, MuraliMohan Y, Vimala K, Mohana Raju K: Synthesis and characterization of hydrogel-silver nanoparticle-curcumin composites for wound dressing and antibacterial application, Journal of Applied Polymer Science, 2011, vol.121, no.2, pp.784–796.
41. Zhou H, Wu X, Xu W, Yang J, Yang Q: Fluorescence enhancement of the silver nanoparticales-curcumin-cetyl trimethyl ammonium bromide-nucleic acids system and its analytical application, Journal of Fluorescence, 2010, vol.20, no.4, pp.843–850.
42. Somasundaram S, Edmund NA, Moore DT, Small GW, Shi YY, Orlowski RZ: Dietary curcumin inhibits chemotherapy induced apoptosis in models of human breast cancer, Cancer Res, 2002, vol.62, 3868–3875.
43. Lvov, Shutava TG, Akundi SS, Vangala P, Steffan JJ, Bigelow RL, Cardelli JA, O'Neal DP: Layer-by-Layer-Coated Gelatin Nanoparticles as a Vehicle for Delivery of Natural Polyphenols. American Chemical Society (ACS Nano), 2009 ; 3(7); 1877-1885.
44. Lin W, Cooper C, Camarillo I: The effectiveness of electroporation based nanocurcumin and curcumin treatments on human breast cancer cells. In Proceedings of ESA annual meeting on electrostatics., 2014 ,17-19; University of Notre Dame, Notre Dame, Indiana, USA: Electrostatics Society of America; p. 1-7.
45. Yallapu MM, Maher DM, Sundram V, Bell MC, Jaggi M, Chauhan SC: Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res, 2010; 3: 11.
46. Ganta S, Amiji M: Co-administration of Paclitaxel and Curcumin in nanoemulsion formulation to overcome Multidrug resistance in tumour cells., Mol Pharm, 2009; 6(3): 928-939.
47. Bisht S, Mizuma M, Feldmann G, Ottenhof N, Hong SM, Pramanik D, Chenna V, Karikari C, Sharma R, Goggins MG, Rudek MA, Ravi R, Maitra A, Maitra A: Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer. Mol Cancer Ther, 2010; 9(8): 2255-2264.
48. Yallapu MM, Ebeling MC, Khan S, Sundram V, Chauhan N, Gupta BK, Puumala SE, Jaggi M, Chauhan SC: Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment., Mol Cancer Ther, 2013; 12(8): 1471-1480.
49. Amarnath Maitra, Anirban Maitra, Collins Karikari, Dipankar Pramanik, Georg Feldmann, Masamichi Mizuma, Michael G. Goggins, Michelle A.Rudek, Systemic Administration of polymeric nanoparticle-encapsulated curcumin(Nanocurc) blocks tumour growth and metastases in Preclinical Models of Pancreatic Cancer. Molecular Cancer Therapeutics, 2010; 9:2255-2264.
50. Ruddon RW. Cancer biology, 4th ed. Oxford University Press, Oxford, 2007, pp. 223.
51. Yallapu MM, Khan S, Maher DM, Ebeling MC, Sundram V, Chauhan N, Ganju A, Balakrishna S, Gupta BK, Zafar N, Jaggi M, Chauhan SC: Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer., Biomaterials, 2014; 35(30): 8635-8648.
52. Mukerjee A, Vishwanatha JK: Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy., Anticancer Res, 2009; 29(10): 3867-3876.
53. Roy M, Chakraborty S, Siddiqi M, Bhattacharya RK: Induction of apoptosis in tumor cells by natural phenolic compounds, Asian Pac. J. Cancer Prev. 3 (2002) 61–67.
54. Aggarwal B, Bhatt ID, Ichikawa H, Ahn KS, Sethi G, Sandur SK, Sundaram C, Seeram N, Shishodia S: Curcumin – biological and medicinal properties and Turmeric the Genus Curcuma, CRC Press, NY, 2007, pp. 297–368.
55. Chearwae W, Anuchapreeda S, Nandigama K, Ambudkar SV, Limtrakul P, Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III puri?ed from turmeric powder, Biochem. Pharmacol. 68 (2004) 2043–2052.
56. Divya CS, Pillai MR: Antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of NFkB and AP-1 translocation, and modulation of apoptosis, Mol. Carcinog. 45 (2006) 320–332.
57. Bhawana B, Basniwal RK, Buttar HS, Jain VK, Jain N: Curcumin nanoparticles: Preparation, characterization and antimicrobial study, Agricultural and Food Chemistry, 2011, vol. 59, no. 5, pp. 2056–2061.
58. Krausz AE, Adler BL, Cabral V, Navati M, Doerner J, Charafeddine RA, Chandra D, Liang H, Gunther L, Clendaniel A, Harper S, Friedman JM, Nosanchuk JD, Friedman AJ: Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent., Nanomedicine, 2015; 11(1): 195206.
59. Mirnejad R, Jahromi MAM, Al-Musawi S, Pirestani M, Ramandi MF, Ahmadi K, Rajayi H, Hassan ZM, Kamali M: Curcumin-loaded Chitosan Tripolyphosphate Nanoparticles as a safe, natural and effective antibiotic inhibits the infection of S.aureus and S.aeruginosa in vivo: Iran J Biotech, 2014; 12(3): e1012.
60. Golla Kishore, Raju C.Reddy, R.K.Chaitanya and Upendhar Gandapu: Curcumin Loaded Apotransferrin Nanoparticles Provide Efficient Cellular Uptake and Effectively Inhibit HIV-1 Replication in vitro, 2011. DOI: 10.1371/journal.pone.0023388.
61. Dandekar PP, Jain R, Patil S, Dhumal R, Tiwari D, Sharma S, Vanage G, Patravale V: Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation., J Pharm Sci., 2010; 99(12): 4992-5010.
62. Akhtar F, Rizvi MM, Kar SK: Oral delivery of curcumin bound to chitosan nanoparticles cured Plasmodium yoelii infected mice., Biotechnol Adv, 2012; 30(1): 310-320.
63. Rocha BA, Gonçalves OH, Leimann FV, Rebecca ESW, Silva-Buzanello RA, Filho LC, Araújo PHH, Cuman RKN, Bersani-Amado CA: Curcumin encapsulated in poly-L-lactic acid improves its anti-inflammatory efficacy in vivo., Adv Med Plant Res, 2014; 2(4): 62-73.
64. Sun D, Zhuang X, Xiang X, Liu Y, Zhang S: A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes., Mol Ther., 2010, 18: 1606–1614
65. Luan-Feng Pan, Ping Zhou, Teng Jiang , Xiu-Ling Zhi , Yue-Hong Zhang: Inhibitory effect of curcumin on the Al(III)-induced Aß42 aggregation and neurotoxicity in vitro. Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 2012; 1822(8): 1207-1215.
66. Cheng KK, Yeung CF, Ho SW, Chow SF, Chow AH, Baum L: Highly Stabilized Curcumin Nanoparticles Tested in an in Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice., AAPS J, 2013; 15(2): 324-336.
67. Mathew A, Fukuda T, Nagaoka Y, Hasumura T, Morimoto H, Yoshida Y, Maekawa T, Venugopal K, Kumar DS: Curcumin loaded PLGA Nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer’s Disease., PLoS One, 2012; 7(3): e32616.
68. Tiwari SK, Agarwal S, Seth B, Yadav A, Nair S, Bhatnagar P, Karmakar M, Kumari M, Chauhan LK, Patel DK, Srivastava V, Singh D, Gupta SK, Tripathi A, Chaturvedi RK, Gupta KC: Curcumin-Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/ß-Catenin Pathway., ACS Nano, 2014; 8(1): 76-103.
69. Ballerini P, Bau C, D'Alimonte I, Jiang SC, Pettifer KM, Rathbone MP and Werstiuk ES: MPP+ induced cytotoxicity in neuroblastoma cells: Antagonism and reversal by guanosine. Purinerg Signalling, 2007, 3(4): 399-409.
70. Chen J, Chen P.X, Cui Y, Feng J.Q, Sun S.N, Tang X.Q, Tang E.H, Yu H.M, Zhi J.L. Curcumin protects PC12 cells against 1-methyl-4 phenylpyridinium ion-induced apoptosis by Bcl-2-mitochondria-ROSiNOS pathway. Apoptosis: An International Journal on Programmed cell Death, 2006, 11(6): 943-953.
71. Adcock IM and Rahman: Oxidative stress and redox regulation of lung inflammation in COPD. European Respiratory Journal, 2006,28, 219-242.
72. Backs J and Olson EN: Control of cardiac growth by histone acetylation/deacetylation, Circulation Research,2006; 98: 15-24.
73. McKinsey TA and Olson EN: Cardiac histone acetylation-therapeutic opportunities abound, Trends in Genetics, 2004; 20(4): 206-213.
74. Akira Shimatsu, Atsushi Nagasawa, , Hiromichi Wada, Koji Hasegawa, Masashi Komeda, Masatoshi Fujita, Tatsuya Morimoto, , Teruhisa Kawamura, Tomohide Takaya, Toru Kita and Yoichi Sunagawa. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. The Journal of clinical Investigation, 2008, 118(3): 868–878