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MEDICATIONS OF QUINAZOLINES AND QUINOXALINES (Qs & Qs): AN OVERVIEW

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ABOUT AUTHORS:
Mayure Vijay kumar*1, V. Sravanthi1, Donthineni Kalyan2, Sathyanarayana1, C.P.Meher1
1Department of Pharmaceutical Chemistry, Maheshwara College of Pharmacy,
2Department of Pharmaceutical Analysis, Saraswathi College of Pharmaceutical Sciences.
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad.
*mayurevijaykumar@gmail.com

ABSTRACT:
The heterocyclic compounds are also called as Hetero-cycle, as majority of the chemical compounds are characterized as hetero-compound due to the joining of atoms with the other compounds. The cyclic part (from Greek kyklos, meaning “circle”), while the prefix hetero- (from Greek heteros, meaning “other” or “different”). Although, Quinazolines and Quinoxalines derivatives are known to possess wide range of activities, the major activity of the compound depend on the position of the appropriate hetero-compound, explained to show the pharmacological activities, the theme of these review is to explain the derivatives of the Q&Q compounds with their medications.


A SHORT REVIEW ON POTENTIAL ACTIVITIES OF BENZIMIDAZOLE DERIVATIVES

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ABOUT AUTHOR:
Balram Soni*
Psychiatric Centre, S.M.S. Medical College,
Jaipur, Rajasthan, India
brpharma@rediffmail.com

ABSTRACT
Benzimidazole derivatives have shown hopeful activity in the treatment of several diseases, for this reason, the synthesis of novel benzimidazole remains a main focus for researchers. This review article summarizes the chemistry of different derivatives of benzimidazole along with their biological activities. The review article also covers the most active benzimidazole derivatives that have shown considerable pharmacological actions.


A REVIEW ON IMMEDIATE RELEASE DRUG DELIVERY SYSTEMS

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ABOUT AUTHORS:
Mohalkar Rahul1*, Poul Bhagwat2, Patil S.S1, Shetkar M.A1, Dilip Chavan1
1 Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga
2 Principal of Maharashtra College of Pharmacy, Nilanga,
Latur, Maharashtra, India.
*rahulmohalkar@gmail.com

ABSTRACT:
The oral drug delivery system which includes the solid dosages form such as conventional dosages form and immediate release dosages form. Form last several decades conventional dosage forms like capsule, solid, pills, powder, solution, emulsion, suspension aerosols are used in the various treatments of acute or chronic disease. Today this formulation can be considered as primary pharmaceutical product are mostly seen in overalls market. Tablet is most popular among the all dosages forms today and recently found mostly accepted tablet dosages forms. Because of its convenience easy to administration, convenience of self administration, compactness and easy for the manufacturing. In number of cases immediate onset of action is required than conventional therapy. The basic approach used in development immediate release solid dosages form by using superdisintegrant like sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (PVP) etc. which provides in instantaneous disintegration of tablet after administration. By using various techniques in can be formulate like wet granulation, direct compression etc. Hence its having A new dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen.


REVIEW ON STABILITY INDICATING ASSAY METHODS (SIAMS)

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ABOUT AUTHORS:
Salma S. Quadri*, Lalit V. Sonwane, Bhagwat N. Poul, Sharada N. Kamshette
Department of Quality Assurance,
MSS’s Maharashtra College of Pharmacy, Nilanga,
Latur, Maharashtra, India.
Salmaq13@gmail.com

ABSTRACT
The main contemporary goal of stability indicating methods is to provide information about condition for stress testing so as to establish the stability of drug substances and product. This paper reviews the regulatory aspects for development of stability indicating methods. SIMs are used to differentiate the API from its potential decomposition product. Regulatory guidance in ICH Q1A (R2) ICH Q3B (R2) Q6A and FDA 21 CFR section 211 requires validated stability indicating methods. Force degradation is required to demonstrate the specificity when developing SIMs and for this reason, it should be perform prior to implementing the stability studies. Force degradation of drug standard and excipients is carried out under different conditions to determine whether the analytical method is stability indicating. The approaches for the development of stability indicating method is discussed.


COMPARATIVE EVALUATION OF PURIFICATION METHODS FOR PRODUCTION OF POLYPEPTIDE ANTIBIOTICS – “POLYMYXIN B” AND “CEREXIN A” FROM BACILLUS SPECIES

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ABOUT AUTHORS:
Pratyush Kumar Das1, Shilpa Das1, Debasish Sahoo2, Jikasmita Dalei2, V.Madhav Rao2, Sunakar Nayak2, Swadhin Palo3
1Centre of Biotechnology, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
2Nitza Biologicals (P.) Ltd.Chandra Towers, Near Fortune Honda Showroom, Neredmet 'X' Road, Secundrabad, Andhra Pradesh, India.
3Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India.
onlypratyush11@gmail.com

ABSTRACT:
Polymyxin B and Cerexin A are two polypeptide antibiotics, the first one discovered and incorporated quite earlier and the later one has still not been used in clinical trials for its high cytotoxic nature. Although Polymyxin was discovered very earlier but in the mid-way for some time it had lost its importance and was not used frequently due to its narrow spectra of action that only acts on gram negative microbes and because of its toxicity level. But with several new resistant gram negative microbes coming into the limelight responsible for causing many infections, Polymyxin B (the least toxic of all Polymyxins) has again been started to be used in pharmaceutical formulations and drugs. In this project, both Bacillus polymyxa and Bacillus cereus responsible for production of Polymyxin B and Cerexin A respectively were isolated from the rhizosphere of grass and cultured in the lab. They were confirmed by biochemical tests and then used to produce the corresponding antibiotics by submerged fermentation. The crude antibiotic thus obtained were purified by various methods like adsorption through activated charcoal, acetone precipitation, dialysis, Ion Exchange and Sephadex column chromatography and the results were compared to find the best possible way to purify the antibiotics keeping in mind that they show the maximum activity as possible on a lab scale. Further work on Cerexin A was not possible due to the unavailability of its standard solution. Work was carried out for quantitative estimation of purified and crude Polymyxin B by performing spectrophotometric assay against standard polymyxin.


EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF TRITICUM AESTIVUM

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ABOUT AUTHORS:
K.Charan
A.U.College of Pharmaceutical Sciences,
Waltair, Visakhapatnam, Andhra Pradesh, India.
charan.karumuri@gmail.com

ABSTRACT
The present study was designed to screen anti-depressant activity of Hydro alcoholic extract of Triticum Aestivum using Chronic models (14 day study) of Tail suspension test (TST) and Forced Swim Test (FST) in Swiss Albino rats. Wheat grass were collected and authenticated. Extraction of dried wheat grass was carried out using a Soxhlet apparatus to obtain its Hydro alcoholic extract. The extract of Triticum Aestivum showed the significant anti-depressant activity comparable to the standard drug. The oral administration of Triticum Aestivum extract at doses 200 mg/kg & 400 mg/kg respectively as compared to the control treated group showed an anti-depressant activity comparable to that of standard drug.
The anti-depressant effects of Triticum Aestivum extract seem to be mainly associated with the activation of dopaminergic system and possess potential anti-depressant activity.


ANTI-CANCER (NOVEL AGENTS): A REVIEW

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ABOUT AUTHORS:
V. Sravanthi*, Mayure vijay kumar, G.J.Finny, C.P.Meher
Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com

ABSTRACT:
Cancer is a class of diseases characterized by out-of-control cell growth. Cancer cells damage the body by multiplying their cells uncontrollably to form masses of tissue named as tumor. Tumors cells can grow and interfere with the digestive, nervous, and circulatory systems, and they can release hormones that alter body function. Tumors that are severe to body are called cancerous tumors, and temporary cells that are affected to body are not harmful and called as benign tumors. Nearly 100’s of cancers are known to be effecting the humans. According to this concern the presented review outlines the novel anticancer agents how they are useful, their mechanism, and chemistry has briefly discussed in this article, the main aim of these review is to evaluate the complete novel anticancer drugs under single review paper.


RAPID AND SELECTIVE UV SPECTROPHOTOMETRIC AND RP-HPLC METHODS FOR DISSOLUTION STUDIES OF IVABRADINE CONTROLLED-RELEASE FORMULATIONS

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ABOUT AUTHORS:
Sagarika Panda1*, Srikanta Patra2
1 Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Andhra Pradesh, India;
2 National Institute of Pharmaceutical Education & Research (NIPER), Ahmedabad, Gujarat, India
*niperhsagarika@gmail.com

ABSTRACT
A highly sensitive, selective, reproducible, rapid and stability indicating RP-HPLC and spectrophotometric method has been developed and validated successfully for quantitative evaluation of ivabradine hydrochloride formulations. Chromatography was carried out at 25ºC on a 250 mm x 4.6 mm, 5µm, C18,  100Aº Kromasil column with phosphate buffer pH 7.4: methanol:: 35:65 and U.V. detector at λmax 286 nm. In HPLC method the retention time was about 7.4 minutes. Complete validation study for both the methods was carried out according to ICH guideline. Both methods were found to be selective, linear, accurate and precise in the specified ranges. Linearity of both the methods was achieved in the range 5 to 60 μg/ml with a correlation coefficient (r2) ≥ 0.999. The LOD and LOQ of HPLC method were 0.05 and 0.2 µg/ml, respectively. Intra-day and inter-day variability for both methods were <2% RSD. These methods were successfully used for quantification of ivabradine in drug-release studies from immediate-release tablets and controlled-release (CR) formulations.


IN VITRO EVALUATION OF ANTACID POTENTIAL OF CURCUMA LONGA LINN

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ABOUT AUTHORS:
DK Vir1*, Nandu Kayande1, Pankaj Kushwah2
1Department of Pharmacology
2Department of Pharmacognosy
Nimar Institute of Pharmacy, Dhamnod,
Dhar, Madhya Pradesh, India
*dkvir007@gmail.com

ABSTRACT
The study was aimed to evaluate the antacid properties of Curcuma Longa Linn rhizomes aqueous extract under simulated conditions. Fresh rhizomeof Curcuma Longa Linn was homogenized and dried under shade and thus mass obtained was powdered, weighed and subjected for the evaluation of antacid profile of the drug antacid properties of Curcuma Longa Linn was evaluated using carbondioxide evolution method & Rossette Rice test. The Curcuma Longa Linn rhizome extract showed significant results for antacid effect (P < 0.05) at different doses and the results obtained were comparable to that of standard NaHCO3. The results of the present study suggest that extract of  curcuma longa linn significantly neutralized acid and showed resistance against change in pH and also illustrate good antacid property The extract of curcuma longa linn, has shown to possess significant carminative and antacid property.


REVIEW ON DEVELOPMENT OF ORPHAN DRUG FOR RARE DISEASE

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ABOUT AUTHORS:
Kamshette Sharada*, Poul Bhagwat, Ghodke Amol
Department of Quality Assurance,
Maharashtra College of Pharmacy,
Nilanga, Maharashtra, India.
*sharadakamshette@gmail.com

ABSTRACT
Simply receiving a diagnosis of a rare disease often becomes a frustrating quest, since many doctors may have never before heard of or seen the disease. This is, however, a time of great progress and hope. Biopharmaceutical research is entering an exciting new era with a growing understanding of the human genome. Scientific advances have given researchers new tools to explore rare diseases, which are often more complex than common diseases.
“Who else has this rare disease? How many of us are there? What can I expect now? What is known or not known about this disease?” These are among the questions that patients and family members ask as they become, out of necessity, advocates for themselves or others.