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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF SILYMARIN

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ABOUT AUTHORS:
Brij Mohan*, Seema Saini, NS Gill
Department of Pharmaceutics,
Rayat Institute of Pharmacy, SBS Nagar, Punjab
rana.brijmohan@gmail.com

ABSTRACT:
In this investigation mouth dissolving tablets of Silymarin were prepared using different superdisintegrants by dry granulation method. Fast dissolving tablets were evaluated for physicochemical properties and in vitro dissolution. The preformulation studies and tablet evaluation test were performed and result were within the limit. The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The powder blend show satisfactory flow properties. The silymarin tablet evaluated for tablet general appearance, hardness test, weight variation and drug content estimation. Oral route is the most preferred route for administration of various drugs because it is regarded as safest most convenient and economical route. Recently researcher develop the new dosage form fast dissolving tablet (FDT) with improve patient compliance and convenience. Fast dissolving tablets which dissolve rapidly in saliva without additional water and chewing. Fast dissolving tablets overcome the disadvantages of conventional dosage form especially dysphagia in pediatric and geriatric patients.
All the formulations shows uniform weight, hardness and friability data indicates good mechanical resistance of the tablet. All the tablets were disintegrated between min. The optimized (F6) formulation showed good disintegration time and release profile with maximum drug being released.


MEDICATION ERROR - MAJOR PROBLEM IN HEALTHCARE PRACTICE

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ABOUT AUTHOR:
Dinesh Kumar Meena
Department of Pharmacy,
Annamalai University, Annamalai nagar, Tamil Nadu.
*dinesh8989pharmd@gmail.com

ABSTRACT
A medication error is the failure of treatment process that may be harmful for the patient. A medication error can occur in deciding which medicine and dosage regimen to use, prescription writing, manufacturing the formulation, administrating the medicine, monitoring therapy. Avoiding medication error is important for the safety of patient as well as better therapeutic outcomes. Medication error may not be clinically significant on many occasions but they have serious economic consequences like extended hospital stays, additional treatment and malpractice litigation. Medication error are well known problem in hospitals. Medication error and adverse drug reactions are one of the main causes for adverse events in hospital leading to disability and death. Pharmacist is responsible for the safe and appropriate use of medication in all pharmacy practice settings. As the part of the multidisciplinary health care team, the pharmacist role is to cooperate to establish patient-specific drug therapy regimens designed to achieve predefined therapeutic outcomes without subjecting the patient to undue them. As pharmacist becomes more involved in patient – specific care, technician is asked to perform tasks that have previously been restricted to pharmacists. As their responsibilities expand, technician need to be aware of the significance and cause of medication errors and to recognize their role in preventing those errors.


A REVIEW ON GOOD MANUFACTURING PRACTICE (GMP) FOR MEDICINAL PRODUCTS

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ABOUT AUTHORS:
Vikash Kumar Chaudhari1*, Vijay Yadav2, Praveen Kumar Verma1, Amit Kumar Singh2
1Department of Pharmaceutical Chemistry,
2Department of Pharmacognosy,
Kunwar Haribansh Singh College of Pharmacy, Jaunpur, U.P.
*vikashk464@gmail.com

ABSTRACT
Good manufacturing practices (GMP) is a part of quality assurance which ensures that products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the marketing authorization. GMP guidelines provide minimum requirements for pharmaceutical or a food product manufacturer must meet to assure that the products are of high quality and do not pose any risk to the consumer or public.


A REVIEW PAPER ON PSYCHIATRY DISORDERS & ITS TREATMENT BY AYURVEDIC APPROACH

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ABOUT AUTHORS:
Kuntal Pal1, Sampat Kumar Kundu2, Shatabisha Bhattacharjee2, Shounak Roy3
1Institute of Medical Sciences, Rajiv Gandhi South Campus, Banaras Hindu University, Barkaccha, Mirzapur.
2Gurunanak Institute of Pharmaceutical Sciences & Technology, Sodepur, West Bengal.
3Birla Institute of Technology, Mesra, Ranchi, Jharkhand
sampatkundu001@gmail.com

ABSTRACT
Psychiatric disorders are astonishingly common. In any given year, over 25 percent of adults have one or more diagnosable mental disorders, according to the National Institute of Mental Health. For the most part, psychiatric disorders are highly responsive to treatment. There have many ayurvedic plants/medicine which are effectively use for the psychiatric disorders. Ayurveda, being a stream of treatment, can no way ignore the importance of psychic condition of a patient to effectively diagnosis and treat disorders. Medical science admits that the root cause of multiple disorders lies in psychic tensions. Ayurveda too has a well developed branch of psychiatry, which has clinically proven practices of treating mental ailments and also physical problems associated with psychological imbalances. On a psychological level we naturally try to harmonies these problems but if we are not able to it can lead to a mental disorders. The causes are many but often stem from our own way of looking at things and the inability or unwillingness of our mind to process what is happening. Sometimes we just don’t want to let go of a belief or viewpoint. At other times we might be attached to a result and when something comes to challenge this, as life tends to do, we find our mind under stress in trying to work through the issue. On an unconscious level the mind may know what to do but at a conscious level the mind wants to do something else creating a conflict between the inner and outer, or the personality and the soul. The result often manifests as a Mental Disorder or sickness.


TOXICOLOGICAL SCREENING OF ‘GOWRI CHINTHAMANI CHENDOORAM'- A SIDDHA METALLIC PREPARATION

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ABOUT AUTHORS:
Shanmugapriya.P1, Thamodharan.S1, M.Ramamurthy2, V.C. Jiji Mol3, M. Nijavizhi3
1 Department of Nanjunool, National instistute of siddha, Chennai, Tamil Nadu, India
2Assistant medical officer, Salavakkam
3PG scholars, National institute of siddha, Chennai, Tamil Nadu, India
drjijivijay@gmail.com

ABSTRACT
'Gowri chinthamani chendooram', a siddha drug was evaluated for its acute and chronic toxicity studies in wistar albino rats with reference to haematological, bio-chemical and histopathological studies. Acute study revealed a maximum tolerated does of 640 mg/100 gm b.w chronic toxicity study revealed a minimum toxic effect at adoes level of 40 mg/100 gm b.w. Where in, the changes observed were non-specific. The toxicity findings were dose specific, which had tissue damage in higher dosages.


PREVALENCE OF MALNUTRITION AMONG SCHOOL CHILDREN IN RURAL NORTH KARNATAKA

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ABOUT AUTHORS:
Srividya V.L, Ashok Kumar Malpani, A.Manjunath
Department of Pharmacy Practice, NET Pharmacy College,
Navodaya Medical Hospital & Research Centre, Raichur, Karnataka
drsrividyapharmacy@gmail.com

ABSTRACT
The objective of the present study is to evaluate the level of malnutrition and the impact of households on the nutritional status of school children in a rural area of north karnataka region. Factors included:  the number of children of 5 to 14 years of age in the family, occupation of the parents, family income, maternal education, type of residence (kacha  or pucca) and children gender. The study was a cross-sectional descriptive survey using a structured questionnaire which includes Anthropometric measurements height (H/A) and weight (W/A). Two hundred and seventy school children representing a rural area of Raichur district, North karnataka were participated in the study. Reference standards used were those of WHO growth charts. The results showed the level of stunting and underweight in school children as per percentile standards from the WHO. Most of the boys and girls of the study fall under < 3rd percentile. Hence, malnutrition was significantly higher among the school children. The higher the level of the mother’s education, the lower the level of child’s underweight was observed. In the present study, growing children by and large are deprived of good nutrition on account of their poor socio-economic status, ignorance and lack of health promotional facilities. The study findings imply that efforts for redressing child under nutrition issues in rural areas should focus on factors associated with development outcomes such as family income, maternal education and the creation of employment.


A VALIDATED STABILITY- INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC METHOD FOR DARUNAVIR ETHANOLATE IN TABLET DOSAGE FORM

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ABOUT AUTHORS:
Palak G. Chaudhary1*, Bhavini N. Patel1, Chhagan N. Patel2
1Department of Quality Assurance,
2Department of Pharmaceutical Chemistry
Shri Sarvajanik Pharmacy College, Mehsana, Gujarat, India.
*palakc24@gmail.com

ABSTRACT
High performance liquid chromatographic method was developed and validated for the determination of Darunavir Ethanolate in tablet dosage form. The method was carried out on a Phenomenex luna C18 Column (150 × 4.6 mm id, 5µ) maintained at 30oC. The mobile phase consisted of water-acetonitrile (60 + 40, v/v) pumped at a flow rate 1.0 mL/min. Photo diode array detection was at 265 nm. The chromatographic separation was obtained with a retention time of 11.8 min, and the method was linear in the range of 1-30 µg/mL (r2 = 0.9997). The specificity and stability indicating capability of the method was proven through forced degradation studies, which also showed that there was no interference of the excipients. The method was validated for linearity, precision, accuracy, robustness, specificity, limit of detection and limit of quantitation. The developed method, after being validated was successively applied to the analysis of tablet formulations. The drug could be effectively separated from different degradation products and hence the method can be used for stability analysis.


ISOLATION OF PHYTOCONSTITUENTS FROM THE STEM BARK OF BAUHINIA VARIEGATA LINN.

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ABOUT AUTHORS:
Vijay Kumar MMJ1*, Eswarappa B2, Yadav D. Bodke3, Jayadevaiah KV1, Basavaraja HS1
1PG Dept. of Pharm.Chemistry, SJM College of Pharmacy, SJMIT Campus, Chitradurga, Karnataka, INDIA.
2Dept. of PG Studies and Research in Industrial Chemistry, Sir MV Govt. Science College, Bommanakatte, Bhadravathi, Karnataka, INDIA.
3Dept. of PG Studies and Research in Industrial Chemistry, Kuvempu University, Shankaraghatta, Karnataka, INDIA
*vijaykumarmmj@yahoo.in

ABSTRACT
Fractionation of crude petroleum ether extract of the stem bark of Bauhinia variegata Linn (Caesalpiniaceae) led to the isolation of heptatricontan-12, 13-diol, friedelin, n-docosanoic acid, stigmasterol, β-sitosteryl, n-hexadecanoic acid, lupeol. Eriodictyol & Quercetin were isolated from methanolic extract. Their structures were elucidated by spectroscopic methods such as UV, IR, 1H NMR and MASS. Eriodictyol was isolated for the first time from this plant.


GOOD CLINICAL PRACTICE (GCP): A REVIEW

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ABOUT AUTHOR:
Bushra Shamim
Department of Pharmaceutics, Faculty of Pharmacy,
Hamdard University, New Delhi.
bushrashamim21@gmail.com

ABSTRACT
Good Clinical Practice (GCP) is an international ethical and scientific quality standard designed to conduct, performance, monitor, audit, record, analyse and report clinical trials. It protects the rights, integrity and confidentiality of trial subjects. Clinical research trails are increasingly playing a role in various medical disciplines.  GCP guidelines are used in clinical trials through out the globe with the main aim of protecting and preserving human rights. In this review article the historical background and the events that led up to the formation of these guidelines, key trial activities and principles of GCP are discussed.


PHARMACOLOGICAL PROPERTIES OF AEGLE MARMELOS: A MINI REVIEW

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ABOUT AUTHORS:
Sampat Kumar Kundu1, Shatabisha Bhattacharjee1, *Kuntal Pal2
1 Gurunanak Institute of Pharmaceutical Science & Technology, Sodepur, West Bengal, India
2 Faculty of Ayurveda, Institute of Medical Sciences, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur
kuntalpal20@gmail.com

ABSTRACT
Ayurvedic plants have shown their effects on various kind of diseases. Those properties of the plants are sublimed in some molecules in the plants, which can be extracted out by performing various kind of processes (eg. Soxhlation, Percolation). Many plants which are used by the human being in daily life, also have some effects in curing some disease conditions. Likewise in our current review Aegle marmelos (Beal) have Antidiarrhoeal, Antidiabetic activities etc. Many Pharmacological Activities have been revealed & organized in this review article, but there have a wide scope of research to perform on this plant.