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Umakant Sahu1,2, Nrusingha Charan Panda2, B.V.V Ravikumar2, Anjan Kumar2
1Drugs testing laboratory avam anusandhan Kendra, First Floor, Govt. Ayurvedic College Hospital Building, Ayurvedic College Campus, G.E. Road Raipur, Chhattisgarh- 492010
2Department of Pharmaceutical Chemistry, Roland Institute of Pharmaceutical Sciences, Berhampur, Orissa-760010, India
Chalcones considered as the precursor of flavonoids and isoflavonoids abundantly found in plants, and have also been shown to display a diverse array of pharmacological activities. This review is complementary to earlier reviews and covers more recent report of antimicrobial activity of chalcones as well as its important role as an intermediate for the synthesis of different synthetic molecules. The enone linkage presents in basic structure play crucial role for the activity of chalcone and chalcone derivatives. The members of the chalcone and flavonoid family have attracted a great deal of interest due to it has showed diffent activity as antibacterial, antifungal, anti-inflammatory, antihyperglycemic anti HIV and anticancer pharmacological activity. Recently a molecule of chalcone has been reported as a novel class of HIV-1 integrase inhibitors. The purpose of this review is to focus on some important pharmacological activity of the chalcone and its derivatives.
*1Mr. Ronak Patel, 2Mr. Ripal Mistry
1M.Pharm, Bhupal Nobels’ College Of Pharmacy, Udaipur 313001
2M.pharm, Indubhai Patel College Of Phaarmacy And Research Center, Dharmaj
Ocular administration of the drug is primarily associated with the need to treat ophthalmic diseases and is not regarded as a means for gaining systemic drug action. Major classes of drugs used are miotics, mydriatics/cyclopegics, anti-inflammatory, anti- infectives surgical adjutants and diagnostics, which are all meant for local therapy. Systemic action by using eye as a portal is generally avoided in order to prevent the risk of eye damage from high blood concentrations of drug not intended for eye. The unique anatomy, physiology and biochemistry of eye renders this organ exquisitely impervious to for gain substances thus presenting a constant challenge to the formulator to circumvent the protective barriers of the eye without causing any permanent tissue damage. Currently, the knowledge in this field is rapidly expanding, and many concept and drug delivery strategies are emerging out.
Clinical Research Coordinator(CRC)
Tech Observer India Pvt Ltd
The Global CRO, N.Delhi
The Clinical trial design is the formulation of trials and experiments in Medical and epidemiological research. Clinical trials are research studies that involve patient or healthy people. They are designed to test new treatments such as drugs, vaccines, new approaches to preventing disease, surgery, radiotherapy, physical and psychological therapies and methods of diagnosing disease. The choice of trial design is always a critical decision in designing a clinical trial: That choice affects the inferences that can be drawn from the trial, the ethical acceptability of the trial, the degree to which bias in conducting and analyzing the study can be minimized, the type of subjects that can be recruited and the pace of recruitment, the kind of endpoint that can be studied, the acceptability of the results by the regulatory authorities, and many other features of the study, it conduct and its interpretation.
Tapan Behl*, Monika Sharma, Dr. Heena Goel
Assistant Professor, Department of Pharmacology,
Doaba Group of Colleges, Kharar, Mohali
Neurofibromatosis is genetic disease characterized by lesions mainly in brain region with a broad array of complications associated with it. The prime role of treatment is to obtain a relief from the symptoms associated this disease.
Prof. (Dr.) N.V.Satheesh madhav, Rohit Singh Negi, *Vikash kumar
DIT-Faculty of Pharmacy,
Dehradun Institute of Technology,
Mussoorie Diversion Road,
Makkawala, P.O. Bhagwantpur,
The aim of research work was to isolate novel biopolymer from the seeds of Tagetes erecta and to characterize its physicochemical properties along with the acute toxicity. The isolated polymer was subjected for screening its retard ability by using as a bio nano carrier for formulating Doxycycline (model drug) loaded floating films. Tagetes is a genus of 56 species of annual and perennial mostly herbaceous plants in the sunflower family. The genus is native to North and South America, but some species have become naturalized around the world. Tagetes species vary in size from 0.01 to 2.2m tall. They have pinnate green leaves blooms are naturally in golden, orange, yellow and white colors, often with maroon highlights. Tagetes grow well in almost any sort of soil. It contains essentials oils, fatty acids, carotenoids and lutein. Tagetes erecta has long been known for its medicinal use, especially for strengthening the heart, and for treating ailments like headaches, swellings and tooth aches. Tagetes erecta seeds were soaked in water and then washed with chloroform and ethyl acetate. Obtained 100 gm of fine powder was soaked in 100ml boiled water for 24 hours. The mixture was filtered and methanol was added in double. The solution was refrigerated for 24 hours and then centrifuged. Precipitate was collected as biopolymer and was dried. The separated biopolymer was subjected for various physicochemical parameters like color, texture, particle size, solubility, colour changing point. Spectral analysis such as IRspectroscopy was done to check the polymeric nature of biopolymers. Drug–polymer interaction and skin irritancy studies are also done to check the polymer safety.
Vishwanadham Yerragunta*, Prathima Patil, V.Anusha, T.Kumara Swamy, D.Suman, T.Samhitha.
Department of Pharmaceutical Chemistry,
Malla Reddy College of Pharmacy,
Maisammaguda, secunderabad-14. A.P.
Pyrimidine is a heterocyclic aromatic organic compound containing two nitrogen atoms at positions 1 and 3 of the six- member ring shows wide range of biological activities. Pyrimidine posses wide spectrum of biological activities like including anti-tubercular, anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, Anti-malarial activity, anti-cancer and anti-neoplastic activity, anti-hiv activity. The present reviews attempted to gather the various biological activities of pyrimidine derivatives and is marketed drugs.
A CRITICAL REVIEW ON PHARMACEUTICAL ANALYSIS OF NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY (HETCOR SPECTROSCOPY)
Reshma. K*, M.Muthukumaran*, B.krishnamoorthy, Amreen Nishat
Montessori Siva sivani Institute of Science&Technology- College Of
Vijayawada, Andhrapradesh-521 230
Nuclear magnetic resonance (NMR) has progressed rapidly over the last decade as a result of improved experimental technology and development of novel approaches. NMR spectroscopy has evolved into an important technique in support of structure-based drug design. It was most useful as a technique to provide structural information regarding protein drug targets and target–ligand interactions. More recently, it has been shown that NMR may be used as an alternative method for identification of small molecule ligands that bind to protein drug targets. High throughput implementation of these experiments to screen small molecule libraries may lead to identification of potent and novel lead compounds. NMR as a probe of microscopic dynamic behaviour through relaxation and direct diffusion measurements over a wide temperature range is examined.
Dr. D. Nagendrakumar, Reddy VM, Keshavshetti G G, Shardor A G*
Department of Pharmaceutics, SVET’s College of Pharmacy,
Humnabad- 585 330 (Karnataka).
Sustained release matrix system are favored because of their simplicity, patient compliance etc, than traditional drug delivery which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. For the purpose of enhancement the bioavailability of furosemide, a dosage form with sustained release of furosemide was designed in this study.
Sustained release tablets of furosemide were fabricated using xanthan gum(13.33 % to 66.67 %). Thepreparedtablets were evaluated for pre compression and post compression studies likeangle of repose, bulk density, tapped density, hardness, weight variation, fraibilty, drug content, in-vitro releaseof drugetc. among the five formulations A better controlled drug release (85 %) was obtained with the matrix tablet SX5 containingxanthan gum66.67%. Short-term stability studies of all formulations indicates that there were no significant changes in drug content and dissolution parameter values after 3 month storage at 40° ± 2°C/75 ± 5% RH.
Kanak Manjari Institute of pharmaceutical Sciences.
Morgellons disease is a mysterious skin disorder that was first described more than 300 years ago. The disease is characterized by fiber-like strands extruding from the skin in conjunction with various dermatologic and neuropsychiatric symptoms Morgellons is a disease of skin lesions, where patients’ complain of itching with skin patches, discomfort and a feeling of something rolling under their skin, and finding fibers, whether single or in bunch on the surface of the skin, mostly on exposed areas such as the face, neck, chest, arms and other parts of the body. The signs and symptoms vary in different individuals.
Kanak Manjari Institute of pharmaceutical Sciences.
Wilson disease (WD) is an autosomal recessive disorder characterized by toxic accumulation of copper in the liver and subsequently in the brain and other organs. On the basis of sequence homology to known genes, the WD gene (ATP7B) appears to be a copper-transporting P-type ATPase.