Articles

DIFFERENCE SPECTROPHOTOMETRIC ESTIMATION OF CAPECITABINE FROM TABLET DOSAGE FORM

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ABOUT AUTHORS:
Rohit A. Patil, Rajendra C. Doijad, Pravin D.Lade, Pournima S. Sankpal
Department of Pharmaceutical Chemistry,
Shree Santkrupa College of Pharmacy,
Ghogaon, Karad (M.S.) India
rohitpharma3250@gmail.com

ABSTRACT:
Simple, sensitive and specific spectrophotometric method were developed and validated for quantification of CAPECITABINE (CAP) by difference spectroscopy. CAP exhibits a substantial difference in absorbance in the two solvents that is in 0.01 N HCL and 0.01 N NAOH at 295 nm. Beer’s law was obeyed in the concentration range of 1 to 20 µg ml-1for CAP. Results of tablet analysis showed standard deviation in the range of 98.42 to 101.95 % for CAP which indicate repeatability of the method. The results indicated excellent recoveries ranging from 98.45 to 101.70 % for CAP with a mean of 99.12 %. Recoveries obtained do not differ significantly from 100% showed that there was no interference from the common excipients used in the tablet formulation indicating accuracy and reliability of the method.


AN OVERVIEW ON NIOSOMES A NOVEL VESICULAR APPROACH FOR OPHTHALMIC DRUG DELIVERY

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ABOUT AUTHORS:
Anupriya Kapoor
University Institute Of Pharmacy,
Chhatrapati Shahu Ji Maharaj University, Kanpur
anupriya321@gmail.com

ABSTRACT
Non-ionic surfactant vesicles (Niosomes or NSVS) are widely studied as an alternative to hydrated surfactant monomers. Non-ionic surfactants of wide structural types have been found to be useful alternatives to phospholipids in fabrication of vesicular system. They are the microlamellar structures formed by the mixing of Non-ionic surfactant of alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. This review article deals with the detailed use of Niosome as novel drug delivery system for ophthalmic use, since this route is most frequently used for the treatment of eye infection.


TOMATO CUISINES: A DELECTABLE REJOINDER TO THREAT OF CHRONIC AILMENTS?

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ABOUT AUTHORS:
Vikram S. Chauhan1*, Bina Rani2, Priyanka Bishnoi3, Raaz K. Maheshwari3

1
Department of Botany, SBRM Govt PG College, Nagaur, Rajasthan, India
2Department of Engineering chemistry & Environmental Engineering, Poornima College of Engineering, Jaipur, India
3Department of Chemistry, SBRM Government PG College, Nagaur, Rajasthan, India
*vikkysingh2000@yahoo.com; rkmgreenchem.jaipur@gmail.com

ABSTRACT
With the advent of modern times, stress and pollution have led to major effect on rise of death toll due to chronic diseases. Such diseases are major cause of concern for the medical society. Lycopene, a carotenoid pigment found in tomatoes and its products has antioxidant properties due to the presence of numerous double bonds. Increased consumption of lycopene containing diet has been proposed to offer a protection against many types of cancers and cardio-vascular diseases. Its potential role as nutraceutical has been suggested in many studies. The present review deals with fundamental biochemistry, bio-availability and benefits of lycopene rich diet and its relation with some chronic diseases like various forms of cancers and cardiovascular diseases.


STUDY ON AGARWOOD (AQUILARIA MALACCENSIS) TO EVALUATE ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF N – HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS

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ABOUT AUTHOR:
Yesmin Begum
Department of Pharmacy,
Southeast University, Banani, Dhaka
yesumyta@gmail.com

ABSTRACT
The present research aims to investigate the antibacterial and antioxidant activities of different leaf extracts of Aquillaria malaccensis. Antibacterial tests were done by Disc diffusion method using Kanamycin as standard. The chloroform extract showed good antibacterial activity against Shigella boydii and Escherichia coli with 19 mm and 17 mm zone of inhibition respectively. All other extracts showed mild to moderate antibacterial activity against other bacteria with 7 – 16mm zone of inhibition. The antioxidant activity of the extracts was determined by using DPPH spectrophotometrically and ascorbic acid was used as standard. All three extracts showed significant antioxidant activities having IC50 value of 38.96 µg/ml, 39.63 µg/ml and 64.75 µg/ml for ethyl acetate, n –hexane and chloroform extracts respectively.


THERAPEUTIC POTENTIAL OF TRITICUM AESTIVUM LINN. (WHEAT GRASS OR GREEN BLOOD THERAPY) IN THE TREATMENT AND PREVENTION OF CHRONIC AND ACUTE DISEASES: AN OVERVIEW

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ABOUT AUTHORS:
Keshari Roshan*, K.S. Rathore, M. Bharkatiya, P.K. Goel, P.S Naruka, S.S Saurabh
Bhupal Nobel’s Institute of Pharmaceutical Sciences,
Udaipur, Rajasthan, India.
roshankeshari220@gmail.com

ABSTRACT
It is the shoot of Triticum aestivum Linn. And in Hindi it is called as gehun kanak, and in Sanskrit it is known as gohuma and in English it is known as wheat grass. It is unique therapy. It has got all the nutritional value that is required for the person to keep healthy. As it consist of fat, carbohydrate, sugar, protein, vitamin such that thiamine, riboflavin, niacin, pantothenic acid, folate, choline, Vitamin E, Vitamin K, amino acid, enzymes, minerals  such that calcium, potassium, zinc, sodium, magnesium, choline, chlorophyll which is most important of the therapeutic activity of wheat grass, and some trace element. Wheat grass juice is close resemblance to haemoglobin in our blood so it is called green blood and known as green blood therapy. As it is recommended for the patient suffering from cancer, ulcer, disease related to joint such as gout, osteoarthritis, thalasemia, skin disease such as eczema, ache, disease related to digestive system, blood and circulatory system, reproductive system, respiratory system, tooth and gum, migraine. As it is easily absorbed in the bloodstream and gives energy. In empty stomach it is easily assimilated in blood in approximately 20 min. And their activity remains throughout the day. This review is concluded that wheat grass have highly curative value by easily available substance.


EFFECT OF PULSATILLA ON POLYCYSTIC OVARIAN SYNDROME AND ITS ASSOCIATED CANCER

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ABOUT AUTHORS:
Debpratim Chakraborty
Persuing M.Pharm (Pharmacognosy),
Jadavpur University, West bengal.
debpratim008@gmail.com

ABSTRACT
Polycystic Ovarian Syndrome is one of the most common female endocrine. Many papers reported the correlation between infertility that most eminently predisposes towards cancer in PCOS women from many years. From both clinical and experimental research one can conclude that correlation between PCOS and endometrial cancer is the strongest. Most studies on correlation between PCOS and ovarian cancer as well as breast cancer failed to show a link though Pulsatilla have a strong effect on it. Various synthetic drugs which mainly used in the treatment of PCOS and endometrial cancer but here the problem is those drugs has lots of side effect/Adverse effect so we should go with the natural product Pulsatilla Sp. Which is used on PCOSand various cancer. Pulsatilla is a well establish drug for PCOS with unknown mechanism of action. Deoxypodophyllotoxin, which was isolated from the roots of P. koreana, was found to inhibit the tube-like formation of HUVECs (human umbilical venous endothelial cells) and have a potent antitumor effect. The chemical constituent saponin D present in Pulsatilla root is responsible for the anti tumor activity. The results, which are expressed as Pulsatilla saponin D has such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). 23-Hydroxybetulinic acid synthesized from Pulsatilla chinensis also shows anti tumoral activity. Though the potency of pulsatilla sp. Are less than synthetic marketed drugs but by structural modification we may get potent anti canceral agent with least toxicity by Pulsatilla.


BIODEGRADABILITY AND WASTE MANAGEMENT OF JAIPUR FOOT

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ABOUT AUTHORS:
Anil Kumar Jain1*, Mona Kejariwal2
1 Dr. P.K. Sethi Rehabilitation Centre, Santokba Durlabhji Hospital, Jaipur, Rajasthan, India
2Department of Botany, R.D. National and W.A. Science College,  Bandra (west), Mumbai, India.
*anil.rehab64@gmail.com

ABSTRACT
Designed in and named after Jaipur, India, the prosthetic foot was designed to be inexpensive, water-resistant, and quick to fit and manufacture. Several field trials case studies were made and this artificial aid was found to be very comfortable and acceptable to the amputee population following floor sitting culture.  The quality assertion and standards related to these prostheses at affordable cost assume great significance especially for India and other developing countries. Environmental issues such as biodegradability of various components like microcellular rubber, tread rubber, nylon cord, cushion compound and skin colour rubber and other. It is necessary that biodegradation issues should be widely held at various platforms beside its bioengineering and designing issues for proper handling and storage concerns. Approval standards and quality control should be a part of the development effort prior to regular production and use of these low cost prostheses.


REGULATORY REQUIREMENTS AND REGISTRATION PROCESS OF GENERIC DRUGS IN CHINA

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ABOUT AUTHORS:
Jitendra Kumar Badjatya
Deputy Manager-DRA,
Montajat Pharmaceutical Company Limited, Dammam, KSA
jeetbadjatya@gmail.com

ABSTRACT
A Generic Product must meet the standards established by China Food and Drug Administration (CFDA) to be approved for marketing in China respectively. This study covers the introduction to generic drugs, in China regulatory authorities. It also includes the requirements and registration of Generic Drugs.
Many large pharmaceutical companies have increased their presence in emerging markets in recent years like China markets is predicted to be the second largest market after US in Pharmaceuticals. China is moving past its phase as a supply market for ingredients and generic finished drugs. So, is more important to know about Regulatory considerations and Registration process of Generic Drugs. This article focuses in particular on pharmaceuticals companies, the Registration process of Generic Drugs, and their activities in the China.


FORMULATION AND EVALUATION OF GASTRORETENTIVE HYDROCHLOROTHIAZIDE FLOATING MICROSPHERES: STATISTICAL ANALYSIS

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ABOUT AUTHORS:
Y. Veda Pravallika* , K.Rajyalakshmi
Bapatla college of pharmacy,
Bapatla, Andhra Pradesh
yadlapallivedapravallika@gmail.com

ABSTRACT:
The main objective of this work is to formulate gastroretentive floating microspheres of hydrochlorothiazide and to study the effect of formulation variables like drug to polymer ratio and concentration of polymer dispersion. The hydrochlorothiazide floating microspheres were formulated by using orifice-ionic gelation technique. These microspheres were formulated by using sodium alginate as sustained release polymer, sodium bicarbonate as gas generating agent and calcium chloride as a cross linking agent. The rheological properties of the polymer dispersion were studied. The microspheres were formulated by different drug to polymer ratio’s at various concentrations of sodium alginate dispersion. Thus formulated microspheres were evaluated for floating behaviour, drug entrapment efficiency, drug content, micromeritic properties, particle size, swelling index, invitro drug release studies and release kinetics. The better formulation was subjected for stability studies and SEM analysis. The effect of formulation variables on the entrapment efficiency and release rate constant was studied by statistical analysis. The hydrochlorothiazide microspheres formulated with 1:3 drug to polymer ratio and 3.5% sodium alginate dispersion concentration was selected as optimized formulation based on the results.


ANTIBACTERIAL, CYTOTOXIC AND ANTIOXIDANT ACTIVITIES OF N-HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS OF TRICHOSANTHES CUCUMERINA LEAVES

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ABOUT AUTHORS
Israt Jahan Bulbul*, Khadiza-tul-Kubra, Mohita Chowdhury Shimu
Department of Pharmacy,
Southeast University Banani, Dhaka, Bangladesh
*israt_jahanb872@yahoo.com

ABSTRACT
The main aim of this study was to find out the antibacterial, cytotoxic and antioxidant activities of n-hexane, chloroform and ethyl acetate extracts of T. cucumerina (Cucurbitaceae). Disc diffusion technique was used for in vitro anbacterial screening against gram positive, gram negative human pathogenic bacteria. Here kanamycin disc (30 mg/disc) was used as standard. The chloroform and the n-hexane extract of T. cucumerina showed moderate antibacterial activity with the average zone of inhibition 7-13 mm and 7-9 mm respectively. The brine shrimp lethality bioassay method was used to determine the cytotoxic activity and vincristine sulphate was used as positive control. Among the extractives the chloroform soluble fraction demonstrated the highest cytotoxic activity with LC50 17.09 µg/ml which indicates the compounds present in the chloroform extract are promisingly cytotoxic. Antioxidant activity test of the crude extracts were assessed by means of DPPH free radical scavenging method where ascorbic acid was used as standard. The ethyl acetate fraction of T. cucumerinashowed strongest antioxidant activity with IC50 value of 52.18 µg/ml.Incase of phenolic content, the n-hexane, chloroform and ethyl acetate extracts of T. cucumerina revealed 18.79, 31.33 and 29.04 mg of GAE / gm of extractives, respectively.


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