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MARFAN SYNDROME

ABOUT AUTHORS:
Jyotirmoyee Patnaik
Kanak Manjari Institute of pharmaceutical Sciences.
Rourkela, Orissa
patnaik.jyotirmoyee@gmail.com

ABSTRACT:
Marfan syndrome is an inherited disease that affects the body's connective tissue, which provides the strength, support and elasticity to tendons, cartilage, heart valves, blood vessels, and other vital parts of the body. Marfan syndrome is a systemic, heritable connective tissue disorder that affects many different organ systems.


JAN AUSHADHI STORE: A NEW APPROACH IN PROVIDING LOW COST DRUGS TO THE PUBLIC

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About Authors:
Rohit Gujarati, T.M.Pramod Kumar, Parasiya Sachin R.
Pharmaceutical Regulatory Affairs Group, Dept. of Pharmaceutics,
JSS College of Pharmacy, JSS University, S.S Nagar, Mysore-570015, Karnataka, India
rohitgujrati@gmail.com

Abstract
India has one of the best developed pharmaceutical industries, and produces about 20 per cent of the world’s drugs. Currently many top Indian companies are exporting generic drugs worth Rs 45,000 crore every year to many countries including the US and Europe. But ironically, drugs are beyond the reach of people in India itself, especially the poor, because their prices are very high. It is not that the cost of R&D and manufacturing is high, but that the profit margins are exorbitant and in many cases exploitative, which can be explained by reasons like, lack of proper regulation on price control (except for few DPCO drugs), prescription made by the doctors, lack of awareness in public about the generic drugs.

Government of India is taking certain steps in providing cost effective drugs to the public without compromising with the quality of the medicines. Recently Union government and regulatory bodies appear to be serious in ending the pharma-doctor nexus and curb unethical marketing practices. In its latest effort, the Medical Council of India (MCI) has directed doctors, hospitals and medical colleges to prescribe generic medicines as far as possible. This has not benefited much to the public. This Paper give a brief scenario about the various measures taken by the Govt. of India to scale down the rates of high cost medicines, among which, the concept of “jan aushadhi”, which talks about various measures taken by the Govt. of India on increasing the availability of the generic drugs throughout the country, has been highlighted.


FORMULATION AND CHARACTERIZATION OF MICROEMULSION BASED GEL OF ANTIFUNGAL DRUG

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About Authors:
Patel Rahul R.*, Dr Kanu R Patel, Dr Mukesh R Patel
Department of Pharmaceutics,
Shri B.M.Shah College of Pharmaceutical Education and Research
Dhansura Road College campus Modasa,
Dist:- Arvali. Pin code:- 383315 Gujarat, (india)
rahulrpatel21089@yahoo.com

Abstract
Micro emulsion based Gel formulation provides better application property and stability & makes it dual control release system in comparison to cream and ointment. Topical Microemulsion based gel drug administration is a localized drug delivery system anywhere in the body through ophthalmic, rectal, vaginal and skin as topical routes. Many advantages of gels a major limitation is in the delivery of hydrophobic drugs. So to overcome this limitation an Microemulsion based approach is being used so that even a hydrophobic therapeutic moiety can enjoy the unique properties of gels. Whenever, it is used for fungal disease for topical delivery system soit is good for compare to oral delivery. When gels and Micro emulsions are used in combined form the dosage form are referred as Microemulsion based gel. Skin is one of the most extensive and readily accessible organs on human body for topical administration and is main route of topical drug delivery system. It is prepared by mixing an oil-in-water type or water-in-oil type emulsion with a gelling agent.The use of Micro emulsion based gels can be extended in analgesics and antifungal drugs.


A REVIEW ON CHRONIC OBSTRUCTIVE PULMONARY DISEASE

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ABOUT AUTHORS:
1Rashmi Verma, 2Rakesh Tiwle
1Rungta College of Pharmaceutical Sciences & Research, Bhilai, 491024, C.G
2Shri Laxmanrao Maker Institute of Pharmacy, Amgaon, Gondia, Maharashtra, India- 441902.
rashmi.verma501@gmail.com

ABSTRACT
In the ancient age COPD has a variable natural history and not all individuals follow the same course about 15-20% of smokers develop clinically significant COPD. It is characterized by the airflow obstruction that is not fully reversible. It is predominantly caused by smoking, particularly occupational exposures, may also contribute to the development of COPD. Chronic obstructive pulmonary disease is diagnosed using a medical device called a spirometer, which measures air volume and flow, the main components of common clinical breathing tests (pulmonary function tests). Long-term exposure to lung irritants that damage the lungs and the airways usually is the cause of COPD. In this article we are focus about and detail review on the COPD.


NANOCOCHLEATE: NOVEL BYPASS OF CONVENTIONAL DRUG DELIVERY SYSTEM

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ABOUT AUTHORS:
Harsh Vyas1*, Tulsi Upadhyay1, Nirali Thakkar1, Kruti Patel1, Umesh Upadhyay2,
1Students, 2Faculty of pharmacy
Sigma Institute of Pharmacy,
Bakrol, Vadodara, Gujarat, India
*vyas123harsh@gmail.com, tulsiupadhyay90@gmail.com

ABSTRACT:
Nanocochleate is a novel lipid based drug delivery system offering systemic and oral delivery of various charged drug molecules. It is formed by negatively charged lipid bilayer. Nanocochleate can encapsulate drugs which are hydrophobic, positively charged, negatively charged and poor orally bioavailable. It is also very much beneficial for oral absorption for peptide drugs that possess a net positive charge. Nanocochleate is beneficial for molecules having binding sites inside the cell. The property that nanocochleates can facilitate cross membrane diffusion for charged and impermeable molecules finds wide application in drug delivery. Nanocochleate have been proven better than liposomes and more compatible with body environment. They differ from liposomes by its structure and compatibility to the body. Liposomes are lipid bilayer with aqueous inner environment and unlike liposomes nanocochleates are having charged lipid bilayer without aqueous environment and are multilayer lipid matrix i.e. Cochleate.

Various methods of its formulation, structure, merits demerits and wide range of application are described in this article.


A PARADIGM SHIFT IN DRUG REGULATIONS IN TAIWAN

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About Authors:
*Parasiya Sachin kumar R., Balamuralidhara V., Pramod Kumar T.M., Rohit Gujarati, Abhisek Shukla, Vandana Kshatri
Pharmaceutical Regulatory Affairs Group, Dept. of Pharmaceutics,
JSS College of Pharmacy, JSS University, S.S Nagar, Mysore-570015, Karnataka, India
*sachin_patel2007@yahoo.com

Abstract
Across Asia, a convergence of economic trends, government policies and greater awareness among the general public of healthcare issues has created an environment that is poised for dramatic growth and change. Taiwan, for instance, can be taken as an example. Taiwan has one of Asia's most highly-praised healthcare systems with excellent provision of healthcare and key health outcomes. Nevertheless, the government is facing new pressures for public healthcare reforms as result of a rapidly ageing population and rising healthcare costs. This paper provides an introductory overview of Taiwan’s sudden changes in its drug regulations due to TFDA (The Taiwan Food and Drug Administration) establishment in 2010, TFDA of the Department of Health (DOH) made an advance announcement about the “amendment draft of the Provisions Governing the Registration and Market Approval of Drugs”, which amends a total of 40 Articles. Without impeding the quality, safety and therapeutic effect of drugs, most of the amended Articles are about simplification of application procedures and loosening of regulations for drug registration and market approval. Regulations loosened are imposed on new drugs, radioactive drugs, allergenic drugs and drugs for export that is intended to accelerate the process to sell new drugs on the market and promote the export of domestically manufactured drugs. As a result of these changes in regulations many pharmaceutical MNCs and local manufacturers explored their business in Taiwan due to quick approval of their NDAs and gained more flexibility in the local market. To support Taiwan's generic drug industry, DOH has also decided to take measures to simplify and reduce the ANDA application time.


NOVEL ANTI-DIABETES MECHANISM – NEXT GENERATION OF IMPROVED THERAPIES

ABOUT AUTHORS:
Kambham Venkateswarlu1*, N.Devanna2, R.Venu Priya3, P.Bharath Rathna Kumar4
1M.Pharm Scholar, Department Of Pharmaceutics,
2Faculty Of Pharmacy, Department Of Pharmaceutical Chemistry,
3Faculty Of Pharmacy, Department Of Pharmaceutical Analysis,
4Director Of JNTUA-Otri
JNTUA-Oil Technological Research Institute,
Beside Collector Office, Anantapur,
Anantapur District, Andhra Pradesh, India. Pin Code: 515001
k.v.reddy9441701016@gmail.com

ABSTRACT:
Scientists have uncovered a novel mechanism that dramatically increases insulin sensitivity and reduces the risk of developing type-2 DM and cardio vascular disease. According to American diabetes association, type-2 DM is closely associated to obesity. The new studies on DM focus on controlling a fat-regulating protein known as PPARg. In fact, excess body fat is the most problematic risk factor among all the factors of metabolic syndrome.  The formation of fat cells in the body is regulated by a protein called PPARg finding of drugs that can promote increased insulin sensitization but not activate the classical fat cell generating pathway of PPARg is the thrust area for research.  Hence targeting the fat regulating ability of this protein in order to treat DM important.


PRELIMINARY ASSESSMENT OF THE ANTIPROLIFERATIVE POTENTIAL OF THE HERBAL FORMULA "EKPO AGANWO"

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About Authors:
Enegide Chinedu*, David Arome, Solomon Fidelis Ameh
Department of Science Laboratory Technology (Physiology & Pharmacology Technology),
University of Jos, Jos Nigeria
chinex.snow@gmail.com

Abstract
Background:
Cancer is a major global public health problem and has metamorphosed to a leading cause of death globally. Latest predictions by the Word Health Organization suggest that cancer death rate may escalate to about 15 million deaths by 2030. Though various anticancer agents have been discovered and are in use currently, they have not been able to tame the disease effectively. This has left the scientific community with the task of discovering/developing better agents with high efficacy and minimal adverse effect. There have been increased interests by both developed countries and the scientific community towards the importance of herbs as a fountainhead in the development of newer drugs, as many classes of drugs now in use contain models from natual product. Ekpo aganwo (EA) is an herbal formulation prepared from the stem bark of Khaya senegalensis and is its main constituent.
Aim:
This study was design as a preliminary assessment of the antiproliferative potential of EA.
Materials and Method:
The modified Ayinde et al., bench top assay method was employed for the study.
Result:
Methotrexate compared with control, caused a significant (P<0.05) decrease in radicle lenght throughout the study. The percentage inhibition was however highest after 72 hours, with a rate of 86.67%. EA 10 mg/ml did not produce any significant decrease in radicle growth after 48 hours, but however showed a significant (P<0.05) decrease in radicle growth after 72 hours of experiment. The percentage inhibition after 72 hours was 24.56%. EA doses of 20 - 100 mg/ml produced significant (P<0.05) decrease in radicle growth throughout the experiment. The percentage inhbition of EA doses of 20 - 100 mg/ml was 28.07 - 59.65 % after 72 hours.
Conclusion: The results obtained have favoured the postulation of EA having an anticancer potential, and this have been supported by the significant antiproliferative activity it produced during the experiment.


DRUG INDUCED MITOCHONDRIAL TOXICITY: MECHANISTIC DIVERSITY AND DELETERIOUS CONSEQUENCES FOR THE LIVER

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About Authors:
Keyur S. Patel*, Mital Mehta
Department of Pharmacology,
Anand Pharmacy College, Anand.
Gujarat, India.
keyurpatel200189@gmail.com

Abstract
Drug-induced liver injury (DILI) has become a leading cause of severe liver disease and withdrawal of an approved drug from the market. DILI accounts for acute liver failure, liver transplantation or death in the United States today. A recent retrospective study indicates that the risk of DILI is enhanced when the administered daily dosage is higher than 50 mg or when the drug undergoes significant liver metabolism. Hence airs a major clinical and regulatory challenge.
This review Sum up Direct mitochondrial impairment and Specific drug induced mitochondrial dysfunction, current mechanistic concepts of DILI in a 2-step model that limits its principle mechanisms to this main ways of initial injury. Umpteen Studies that evaluate the risk of hepatotoxicity from Statins in Hyperlipidemic Patients.  In this article, It will review the pathogenesis of drug induced mitochondrial liver toxicity and deleterious consequences of Atorvastatin.


TILLING: VERSATILE REVERSE GENETIC TOOL

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About Authors:
Navgeet1, Balraj Singh Gill2, Arvind Negi3*, Shashi Shekhar Anand2
1Institute of Himalayan Bioresource and Technology (CSIR-IHBT), Palampur (HP)
2Centre for Biosciences Central University of Punjab, Bathinda (Punjab)
3Centre for Chemical and Pharmaceutical Sciences, Central University of Punjab, Bathinda (Punjab)
*arvindnegi2301@gmail.com, arvindnegicup@gmail.com

Abstract:
Recent years have been witnessedfor exhaustive genome sequencing, nourishing a cause to track the mutation and its consequences at the phenotypic level. Butreliabilityof these genomic studiesis the critical issuewhich is still unaddressed and not properly understood. Moreover via TILLING techniques (reverse genetic tool), can be valuable in evaluation of these studies to much extent. Usually TILLING account on a specific gene mutation in order to observe the extent of the functionality of that particular gene at morphological level. This review compiles the literature pertaining to the art of tilling in the evaluation of genomic studies and majorly in concern of functionalgenomics. Moreover this review also covers the example of the most common species so as to buildbetter understanding of the concept behind this technique of reversegeneticsand can be fruitfully applied in extractingthe ethano-botanical and therapeuticeffect of various medicinal plants.