Articles

DEVELOPMENT AND VALIDATION OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR ANALYSIS OF GATIFLOXACIN & ITS IMPURITY

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ABOUT AUHTOR
Narendra M.Petha, J.G.Patil,Mr J.G.Chandorkar

Indofil Industries Ltd, Gujarat
jchandorkar-icc@modi.com

ABSTRCT 
Gatifloxacin is a antibacterial agent, Rapid, sensitive and selective analytical method is essential for monitoring the different reactions steps involved in process development of Gatifloxacin. A simple isocratic reverse phase High Performance Liquid Chromatographic [HPLC] method was developed for simultaneous separation of different intermediates and other impurities. The method was utilized successfully in analyzing the reaction streams, related substances in final product and for the assay in drug.


ANALYTICAL TECHNIQUES FOR ANALYSIS OF INORGANIC ELEMENTS – A REVIEW

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ABOUT AUHTOR
G.Swapna
Department of pharmaceutical Analysis & Quality Assurance,
Nirmala college of pharmacy, Guntur,
AP, India
swapna.goday.gs@gmail.com

ABSTRACT
To make drugs serve their purpose various chemical and instrumental methods were developed and regular intervals which are involved in the estimation of drugs. A photoelectric flame photometer is a device used in inorganic chemical analysis to determine the concentration of certain metal ions, among them sodium, potassium, lithium, and calcium. Group 1 and Group 2 metals are quite sensitive to Flame Photometry due to their low excitation energies [1].These pharmaceuticals would serve their intent only if they are free from impurities and are administered at appropriate amounts [2] . These pharmaceuticals develop  impurities at various stages of their development, transportation and storage which makes the pharmaceuticals risky to be administered thus they may be detected and quantified. For this analytical instrumentation and methods play important role. This review highlights a variety of analytical techniques for analysis of inorganic elements. Analytical techniques for analysis of inorganic elements. The most commonly used techniques for the determination of inorganic elements is atomic spectroscopy the different branches of atomic absorption spectroscopy are(1) flame photometry or flame atomic emission spectrometry. (2) atomic absorption spectrophotometer, (aas). (3) inductively coupled plasma-atomic emission spectrometry (icp-aes).(4)  uv - visible    spectrophotometer.


BIOTECHNOLOGY FOR A BETTER WORLD

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ABOUT AUHTORS
SRIJITA DUTTA
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY
BENGAL SCHOOL OF TECHNOLOGY
Hooghly,  West Bengal
srijitadutta1991@gmal.com

ABSTRACT: Biotechnology is a manipulation technology of living organisms and organic material to serve Human Needs. To make a better world some basic need (sufficient food, healthy life, eco-friendly/anti-polluted environment and employment) of the people should be fulfill. For that biotechnology can be used to struggle with these issues


IN-VITRO ANTIPROLIFERATIVE ACTIVITY OF M. AZEDARACH

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 ABOUT AUHTORS
Deepak Chowrasia1*, Nisha Sharma1, Mohammad Arshad2
1 University Institute of Pharmacy,
CSJM University, Kanpur, U.P., India
2Molecular Endocrinology Lab, Department of Zoology,
Lucknow University, Lucknow, U.P., India
* chowrasia.deepak@gmail.com

ABSTRACT
Preliminary screening of different crude extract of. M. azedarach was evaluated against human cancer cell lines viz. MCF-7 (breast cancer), SaOS-2 (osteosarcoma), and A431 (epidermoid carcinoma) to search for better herbal based anticancer agent. Solvents used were water, methanol, ethanol, n-butanol, & n-hexane. It has been found that among solvents, methanolic extract of M. azedarach shows comparatively superior activity suggesting presence of phytoconstituents comprising polar functionalities.


A BRIEF REVIEW ON ION EXCHANGE CHROMATOGRAPHY

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ABOUT AUHTORS
Jaha Sultana Mohammed
Pelcat Formulation PVT ltd
sohnivya786@gmail.com

ABSTRACT:
Ion exchange chromatography is probably the most powerful and classic type of liquid chromatography. The popularity of ion exchange chromatography has been increased in recent years because this technique allows analysis of wide range of molecules in pharmaceutical, biotechnology, environmental, agricultural and other industries for water purification to separation of various antibiotics from fermentation broths which will enhance the yields and reduce the production time for industrial process. The main objective of this particular study is to develop some understanding for the process of ion exchange and helps to determine whether or not ion exchange will be useful for a particular application. This topic includes background, theory, instrumentation, application which covers both the production of the ion exchange substance, a resin and its operation depending on the condition of matrix during use.


IMPACT AND MANAGEMENT TOOL FOR IDENTIFICATION AND REDUCTION OF HUMAN ERRORS IN PHARMACEUTICALS INDUSTRY

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ABOUT AUHTORS
Suleman S. khoja 1 , Sohil S. khoja 1,
Farhad S. Khoja 2,Shamim Khoja2,Narmin Pirani2

1)Resource person in pharmaceutical quality assurance and Audit Compliance,VAPI 2) Registered Pharmacist , Gujarat
Suleman salim khoja
Email: premukhoja@gmail.com

Scope 
Human Error is commonly defined as “a failure of a planned action to achieve a desired outcome”. GMPs clearly state in CFR 211.22 that “[the quality control unit has]…the authority to review Production records to assure that no errors have occurred or, if errors have occurred, that they have been fully investigated.” Let’s analyze this statement. If the FDA expects that errors be fully investigated, it is safe to assume that the term error is NOT a root cause. That’s why it needs to be fully investigated, hence determine the root cause of the human error.  In order to successfully achieve this goal, we have to understand how to improve the way we deal with these types of situations. review article accurately how to accurately identify human errors, determine when a deviation or nonconformance requires CAPA, and get started using human performance improvement tools and processes in your organization.


BASICS OF AGING THEORIES AND DISEASE RELATED AGING - AN OVERVIEW

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ABOUT AUHTORS
Abhijit De*, Chandan Ghosh
Department of Pharmaceutical Science,
Bengal School of Technology, Sugandha,
Hooghly, West Bengal, India
* abhi8981@gmail.com

ABSTRACT
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. This deterioration is the primary risk factor for major human pathologies including cancer, diabetes, cardiovascular disorders, and neurodegenerative diseases. In this review, several theories and mechanisms have been put to explain the molecular basis of aging. For example, random damage of the DNA of somatic cell is believed to accumulate with increasing age. Free radicals produced during oxidation of metabolites for energy production also damage DNA and proteins.


SOLID DISPERSION- A REVIEW

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ABOUT AUTHORS
Bhumika Kumar*
Department of pharmaceutics,
Delhi pharmaceutical sciences and research university,

New Delhi, India

ABSTRACT
Solid dispersion is an effective way of improving the dissolution rate of poorly water soluble drugs and hence its bioavailability.  The water soluble carriers used in preparation of solid dispersion enhance the dissolution rate of the poorly water soluble drug. The review article focuses on the methods of preparation, advantages, disadvantages and characterization of the solid dispersions.


VALIDATION-IN PHARMACEUTICAL INDUSTRY : CLEANING VALIDATION - A BRIEF

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ABOUT AUHTORS
Jaha Sultana Mohammed
Pelcat Formulation PVT
sohnivya786@gmail.com

ABSTRACT
The purpose of cleaning validation is to establish the documented evidence with high degree of assurance that the cleaning process followed as per standard operating procedure for cleaning the equipment used for the processing, consistently and concurrently yields the results not exceeding predetermined acceptance limit. The main objective of this particular study is to develop some understanding for the process of validation and its type along with importance of cleaning validation in pharmaceutical industry to prevent cross contamination. This topic includes Types of validation, cleaning validation, Levels of cleaning Validation, Cleaning mechanisms, cleaning agents used and process followed by pharmaceutical industry to achieve cleaning validation. The various methods used for cleaning validation are clearly discussed in this review.


THERAPEUTIC GASES PHARMACOLOGY AND IT’S ADVANCED DELIVERY

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  ABOUT AUHTORS
AKASH S MALI1,2*,AUDRIUS MARUŠKA2
1University of Würzburg Germany.
2Vytautas Magnus University, Lithuania
*Akashmit97@gmail.com

ABSTRACT
Pharmaceutical gases molecules (Therapeutic medical Gases) are plays vital role in various disease conditions. In particular, Carbon monoxide, Oxygen, Nitric oxide, Hydrogen sulfide are generated in the human body and mediate signaling pathways as biological messengers and shown pharmacological effects on cardiovascular disorders, nervous system, respiratory track and gastrointestinal disorder. Appropriate oral delivery of gases is challenging concept in front of novel drug delivery system, recently microbubbles, nanobubbles, liposomes, ultrasound technology provides new oral and parenteral delivery platform for therapeutic gases. This review provides pharmacological effects of therapeutic medical gases and its novel delivery aspects.


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