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BIOCHEMISTRY OF PROSTAGLANDINS AND CYCLOOXYGENASE IN CANCER

ABOUT AUTHORS:
Rajwinder Rattan*, Tapan Behl, Puneet Sudan, Rashi Wanchoo Misri, Dharmender Jaglan
Department of Applied Sciences,
Doaba Group of Colleges, Kharar, Punjab, India.
rajwinder.rattan1990@gmail.com

ABSTRACT:
Colorectal is the third most prevalent form of cancer in the world. Several studies report that prostaglandins are mediators of carcinogenesis cyclooxygenase known as prostaglandin endoperoxidase H synthase. Levels of COX-2 isoenzyme and prostaglandins like PGE2, PGF2 alpha and PGE1 are found to be higher in certain cancers like colorectal carcinoma, squamous cell carcinoma of head and neck, also in certain types of breast cancer. Prostaglandins may contribute to the cancer processes through one or more of several mechanism including increased proliferation, apoptosis, inhanced carcinogen metabolism of immune system. Decreasing the high level of COX-2 and prostaglandins already mentioned has shown to decrease carcinogenesis. The understanding of the regulation of substrate availability and of a regulation (Dysregulation in many neoplasis) of the synthesis enzymes has opened avenues leading to design of isoenzyme specific inhibitors and better cancer strategies.


A REVIEW ON CANDIDIASIS: TYPES AND MEDICATIONS

ABOUT AUTHORS:
V. Sravanthi*1, Mayure vijay kumar1, Donthineni Kalyan2, C.P.Meher1, G.J.Finny1
1Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
2Department of Pharmaceutical Analysis, Saraswathi College of Pharmaceutical Sciences.
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com

ABSTRACT:
Candida albicans are the most effective organism that makes quite an yeast infection to form a inflammation in the different parts of the body like oral, vaginal, hepatic, renal etc…, During the infection of Candidiasis there are less chances of human death can occur, but in patient with damaged immune systems there is a chance of death, but to the Candidiasis flow to the blood streams and kills. In this review the full outline of the Candidiasis and the types and medication are put forth to be aware on the diseases caused by Candidiasis. According to FDA approval, the Ketoconazole is the first-line drug used for the treatment of the different types of Candidiasis.


PHYTOCHEMICAL, IN VITRO AND IN SILICO EVALUATION ON CLITORIA TERNATEA FOR ALZHEIMER’S DISEASE

ABOUT AUTHORS:
Nadia Shahnas*, Akhila.S
Department of pharmaceutical chemistry,
University College of Pharmacy (RIMSR),
Puthupally, Kottayam
nadiya.ameer@gmail.com

ABSTRACT
Alzheimer’s disease (AD) is a complex, multifactorial, progressive, neurodegenerative disease primarily affecting the elder population and is estimated to account for 50–60% of dementia cases in persons over 65 years of age. Natural products, including plants, animals and minerals have been the basis of treatment of human diseases. Secondary metabolites have been the most successful source of potential drug leads and continue to provide unique structural diversity in comparison to standard combinatorial chemistry, traditional medicinal practices have formed the basis of early medicines followed by subsequent clinical, pharmacological and chemical studies which provides opportunities for discovery for many novel low molecular weights lead compounds. In silico approach has been of great importance as a versatile tool to develop fast and accurate target identification and prediction method for the discovery. Traditionally docking was used as computational tool for screening databases of natural products to mine a set of a few candidate drug-like compounds. Reverse docking was a comparatively new application of docking in which a database of proteins (drug targets) was docked against a set of natural products to predict binding affinities. Therefore, plant extracts may in future provide more effective medicines than the single purified natural products of modern medicine, in some cases. Studies on identification of compounds from traditionally used medicinal plants to cure neurodegenerative diseases and brain injuries is increasing scientific interest in recent years as this a major concern in public. In Ayurveda the roots, seeds and leaves of Clitoria ternatea have been widely used as brain tonic and believed to promote memory and intelligence. Hence the present study was designed to assess the Alzheimer’s activity of Clitoria ternatea and to identify and isolate the major bioactive constituent attributing the activity.


CERVICAL CANCER AND ITS VARIOUS EMERGING IMPACT

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ABOUT AUTHOR:
Shambhavi Singh
Department of Pharmacology, Singhania University,
Jhunjhunu, Rajasthan
shambhavisingh6777@gmail.com

ABSTRACT
Cervical cancer, malignant neoplasm, appears in tissues of the cervix, a likely preventable disease that originates as the second most widespread malignancy in women. In spite of being considering as a treatable disease, 95% preventive and conditions that can be easily examined through Pap smear. This disease accounts for a miserable condition, probable 24 percent of India’s cancer cases among women and in addition to that 80,000 Indian women die annually from the disease, which results from the unusual growth of cells in the cervix. No proper vaccination program from Indian government and miserable earning can be said responsible for this condition. Though the disease is both preventable and curable but still mortality rate in India is aggravating subsequently.


ATHEROSCLEROSIS: RESEARCH REVIEW

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ABOUT AUTHOR:
Shambhavi Singh
Department of Pharmacology, Singhania University,
Jhunjhunu, Rajasthan
shambhavisingh6777@gmail.com

ABSTRACT
Atherosclerosis a disease of the larger arteries is the major cause of heart disease and stroke.  Nowadays, serve as leading reason of death not only in senility peoples but in youth also worldwide. Researches in the atherosclerosis disease have led to many persuasive hypotheses about the pathophysiology of atherosclerotic lesion development and of tricky situation such as myocardial infarction and stroke. It is now unambiguous that atherosclerosis is not simply an unavoidable degenerative consequence of ageing, but somewhat a chronic inflammatory situation that can be transformed into an acute clinical occasion by plaque rupture and thrombosis. Evidently, crystallization of information concerning atherosclerosis will approach only by the appropriate free interplay and satisfactory fusion of the three foremost looms to the trouble, epidemiologic, clinical and investigational.


MEDICATIONS OF QUINAZOLINES AND QUINOXALINES (Qs & Qs): AN OVERVIEW

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ABOUT AUTHORS:
Mayure Vijay kumar*1, V. Sravanthi1, Donthineni Kalyan2, Sathyanarayana1, C.P.Meher1
1Department of Pharmaceutical Chemistry, Maheshwara College of Pharmacy,
2Department of Pharmaceutical Analysis, Saraswathi College of Pharmaceutical Sciences.
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad.
*mayurevijaykumar@gmail.com

ABSTRACT:
The heterocyclic compounds are also called as Hetero-cycle, as majority of the chemical compounds are characterized as hetero-compound due to the joining of atoms with the other compounds. The cyclic part (from Greek kyklos, meaning “circle”), while the prefix hetero- (from Greek heteros, meaning “other” or “different”). Although, Quinazolines and Quinoxalines derivatives are known to possess wide range of activities, the major activity of the compound depend on the position of the appropriate hetero-compound, explained to show the pharmacological activities, the theme of these review is to explain the derivatives of the Q&Q compounds with their medications.


A SHORT REVIEW ON POTENTIAL ACTIVITIES OF BENZIMIDAZOLE DERIVATIVES

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ABOUT AUTHOR:
Balram Soni*
Psychiatric Centre, S.M.S. Medical College,
Jaipur, Rajasthan, India
brpharma@rediffmail.com

ABSTRACT
Benzimidazole derivatives have shown hopeful activity in the treatment of several diseases, for this reason, the synthesis of novel benzimidazole remains a main focus for researchers. This review article summarizes the chemistry of different derivatives of benzimidazole along with their biological activities. The review article also covers the most active benzimidazole derivatives that have shown considerable pharmacological actions.


A REVIEW ON IMMEDIATE RELEASE DRUG DELIVERY SYSTEMS

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ABOUT AUTHORS:
Mohalkar Rahul1*, Poul Bhagwat2, Patil S.S1, Shetkar M.A1, Dilip Chavan1
1 Department of Quality Assurance, Maharashtra College of Pharmacy, Nilanga
2 Principal of Maharashtra College of Pharmacy, Nilanga,
Latur, Maharashtra, India.
*rahulmohalkar@gmail.com

ABSTRACT:
The oral drug delivery system which includes the solid dosages form such as conventional dosages form and immediate release dosages form. Form last several decades conventional dosage forms like capsule, solid, pills, powder, solution, emulsion, suspension aerosols are used in the various treatments of acute or chronic disease. Today this formulation can be considered as primary pharmaceutical product are mostly seen in overalls market. Tablet is most popular among the all dosages forms today and recently found mostly accepted tablet dosages forms. Because of its convenience easy to administration, convenience of self administration, compactness and easy for the manufacturing. In number of cases immediate onset of action is required than conventional therapy. The basic approach used in development immediate release solid dosages form by using superdisintegrant like sodium starch glycolate (Primogel, Explotab), Polyvinylpyrrolidone (PVP) etc. which provides in instantaneous disintegration of tablet after administration. By using various techniques in can be formulate like wet granulation, direct compression etc. Hence its having A new dosage form allows a manufacturer to extend market exclusivity, while offering its patient population a more convenient dosage form or dosing regimen.


REVIEW ON STABILITY INDICATING ASSAY METHODS (SIAMS)

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ABOUT AUTHORS:
Salma S. Quadri*, Lalit V. Sonwane, Bhagwat N. Poul, Sharada N. Kamshette
Department of Quality Assurance,
MSS’s Maharashtra College of Pharmacy, Nilanga,
Latur, Maharashtra, India.
Salmaq13@gmail.com

ABSTRACT
The main contemporary goal of stability indicating methods is to provide information about condition for stress testing so as to establish the stability of drug substances and product. This paper reviews the regulatory aspects for development of stability indicating methods. SIMs are used to differentiate the API from its potential decomposition product. Regulatory guidance in ICH Q1A (R2) ICH Q3B (R2) Q6A and FDA 21 CFR section 211 requires validated stability indicating methods. Force degradation is required to demonstrate the specificity when developing SIMs and for this reason, it should be perform prior to implementing the stability studies. Force degradation of drug standard and excipients is carried out under different conditions to determine whether the analytical method is stability indicating. The approaches for the development of stability indicating method is discussed.


COMPARATIVE EVALUATION OF PURIFICATION METHODS FOR PRODUCTION OF POLYPEPTIDE ANTIBIOTICS – “POLYMYXIN B” AND “CEREXIN A” FROM BACILLUS SPECIES

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ABOUT AUTHORS:
Pratyush Kumar Das1, Shilpa Das1, Debasish Sahoo2, Jikasmita Dalei2, V.Madhav Rao2, Sunakar Nayak2, Swadhin Palo3
1Centre of Biotechnology, Siksha O Anusandhan University, Bhubaneswar, Odisha, India.
2Nitza Biologicals (P.) Ltd.Chandra Towers, Near Fortune Honda Showroom, Neredmet 'X' Road, Secundrabad, Andhra Pradesh, India.
3Roland Institute of Pharmaceutical Sciences, Berhampur, Odisha, India.
onlypratyush11@gmail.com

ABSTRACT:
Polymyxin B and Cerexin A are two polypeptide antibiotics, the first one discovered and incorporated quite earlier and the later one has still not been used in clinical trials for its high cytotoxic nature. Although Polymyxin was discovered very earlier but in the mid-way for some time it had lost its importance and was not used frequently due to its narrow spectra of action that only acts on gram negative microbes and because of its toxicity level. But with several new resistant gram negative microbes coming into the limelight responsible for causing many infections, Polymyxin B (the least toxic of all Polymyxins) has again been started to be used in pharmaceutical formulations and drugs. In this project, both Bacillus polymyxa and Bacillus cereus responsible for production of Polymyxin B and Cerexin A respectively were isolated from the rhizosphere of grass and cultured in the lab. They were confirmed by biochemical tests and then used to produce the corresponding antibiotics by submerged fermentation. The crude antibiotic thus obtained were purified by various methods like adsorption through activated charcoal, acetone precipitation, dialysis, Ion Exchange and Sephadex column chromatography and the results were compared to find the best possible way to purify the antibiotics keeping in mind that they show the maximum activity as possible on a lab scale. Further work on Cerexin A was not possible due to the unavailability of its standard solution. Work was carried out for quantitative estimation of purified and crude Polymyxin B by performing spectrophotometric assay against standard polymyxin.