Articles

MULTI ORGAN DYSFUNCTION FOLLOWING CONSUMPTION OF TUBERS OF GLORIOSA SUPERBA : A RARE CASE REPORT

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ABOUT AUHTORS
*K. Vinod1, B, Dr. N. Surendra Reddy1,Dr. K. Chandra Sekhar2, Dr. D. Ranganayakulu1

1Department of Pharmacy Practice,
Sri Padmavathi School of Pharmacy,
Tiruchanoor, Tirupati, India.
2 Department of General Medicine,
Sri Venkateswara Medical College,
Tirupati, Andhra Pradesh, India .

*drvinodkatiboina@gmail.com

ABSTRACT:
A 25 years married man was admitted on to emergency acute medical care unit. He had fallen ill after an afternoon meal from 4 days ago which consisted of rice and 3 tubers identified as gloriosa superb. About 3hrs after the ingestion, he developed abdominal pain, vomiting (15-20 episodes), and watery diarrhoea 15-20 episodes. He developed bleeding gums, yellowish discoloration, hematemesis 30-50 ml, 24episodes, haematuria, decreased urine output along with continued diarrhoea and vomiting. He was treated with iv fluids crystalloids and colloids titrated, 1 fresh frozen plasma (FFP), 1fresh platelet transfusion, inj. vit K, supportive treatment with close monitoring of vitals. Therapy as planned for ventilator support, however had ever had bleeding per rectum and hematemesis with aspiration, even with best available resuscitative efforts he succumbed to his illness and declared clinically dead after 36hrs of admission, his cause of death was given as multiorgan dysfunction see to gloriosa superb. Though poisoning with gloriosasuperba is rare it is mostly fatal and requires aggressive and prompt treatment is mandatory from saving the patient from death.


SIGNIFICANCE OF PHARMACEUTICAL REGULATORY BODIES - A REVIEW

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ABOUT AUHTORS
G. TARUN KUMAR REDDY *1, G. NAVEEN KUMAR REDDY 2
1 Department of Pharmaceutics and Drug regulatory affairs,
Annamacharya college of Pharmacy,
Rajampet, Kadapa, Andhra Pradesh, India.
2 Department of Pharmaceutical analysis,
Sri Padmavathi school of Pharmacy,
Chittoor, Andhra Pradesh, India.

*gtarunkreddy@gmail.com

ABSTRACT: 
The regulatory bodies are being established in various pharmaceutical industries across the globe which plays a vital role to meet the requirements of legal procedures related to drug development process in a country. The pharmaceutical industry is considered as the most highly regulated industries worldwide. The regulatory body ensures compliances in various legal and regulatory aspects of a drug. Countries possess their own regulatory authority, which is responsible for enforcing the rules and regulations and issue the guidelines to regulate drug development process, licensing, registration, manufacturing, marketing, labeling and the product life cycle of pharmaceutical products. In an ever-changing regulatory environment, the role of regulatory affairs personnel is essential to ensure compliance with legislation in all regions in which a company wishes to distribute its drug. This article describes about the development of the drugs as it is a cumbersome process which includes several months of time, volunteers, and a huge finical investment majorly through the funding process, so it is strictly regulated as per the norms and regulations as given by those individual countries to carry out the drug development which were generally governed by the Drug Regulatory Affairs Personals.


MICROMERITIC STUDY OF AZADIRACHTA INDICA HERBAL TABLET WITH ITS EVALUATION

ABOUT AUHTORS
*Ladi Alik kumar , Dash Priyadarshini , Nayak Chandan , Barri Prasanta kumar   Gayatri Institute of Science and Technology,
Gunupur, Rayagada,765022, Odisha
*alikkumar3@gmail.com

ABSTRACT
Neem is a large, dense evergreen tree in India growing 10-105m tall leaves divided into numerous leaflets. It has great healing power, acts as purifier, helps in treatment of eczema, leprosy and epiphoram.

The aim of the present work is to improvise the flow ability of herbal powders and minimized processing problems of herbal drug tablet. Macroscopic character of neem tree bark is thick, rough, brown in colour. leaf is alternate estipulate and are closely clustered towards the ends of the branches.
Micromeritic study is done using bulk density and tapped density, porosity, compressibility index, Carr’s index and Hausner’s ratio.
Preparation of extract of neem tablet is done by weight granulation method. It can be evaluated by weight variation, hardness test, friability test and disintegration test.
After all the evaluation is done, the prepared neem leaf passes all the Q.C test.


PREPARATION AND CHARACTERIZATION OF ETHYL CELLULOSE BASED SALBUTAMOL SULPHATE AND THEOPHYLLINE COMBINATION MICROSPHERE

ABOUT AUHTORS
*Nayak Chandan1, PadhiPriyanka1
Gayatri Institute of Science and Technology,
Gunupur Odisha, India
*nayakchandan279@gmail.com

ABSTRACT: 
The study is concerned with the development of Ethyl Cellulose microspheres by the o/w emulsification and solvent evaporation method in the presence of tween 80 as an emulsifying agent. The influence of process parameters such as solvent mixture, composition, concentration of the emulsifying agent and speed of stirring has been examined. The microspheres have been analysed for their size, drug loading capacity and drug release study. Spherical and smooth surfaced microspheres with desired encapsulation efficiencies were obtained. Slow drug release from microspheres observed up to6- 8 h. An optimization procedure was employed to investigate and identify the key parameters affecting the properties of the microspheres.


SUSTAINED RELEASE EFFERVESCENT FLOATING BILAYER TABLETS A REVIEW OF NOVEL APPROACH

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ABOUT AUHTORS
*P.Dhaneshwar1, P.Stephen2, A.N.RAJALAKSHMI1
1* Department of Pharmaceutics,
College of pharmacy,
Mother Theresa Post Graduate & Research Institute Of Health Sciences, Puducherry, India
2 Sai mirra innopharm pvt ltd,
Ambattur, Chennai, India
*dhanesh7pharma@gmail.com

Drug absorption in the gastrointestinal tract is a highly variable process and prolonging gastric retention of the dosage form extends the time for drug absorption. Novel drug delivery system overcomes the physiological problems of short gastric retention through various approaches including floating drug delivery systems (FDDS), these systems float due to bulk density less than gastric fluids and so, remain buoyant in the stomach for a prolonged period of time, releases the drug slowly at the desired rate from the system and increase the bioavailability of narrow absorption window drugs. This review entitles the applications of sustained release effervescent floating bilayer tablets, suitable for sustained release of those drugs incompatible with floating constituents over an extended period of time for better patient compliance and acceptability. The purpose of this paper is to review the principle of sustained release effervescent floating drug delivery system, current technology used in the development of same as well as summarizes the applications, advantages, methodology, evaluation methods and future potential for sustained release effervescent floating bilayer tablets


ANASARCA: A GENERALIZED SWELLING

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ABOUT AUHTORS
L Reddenna1*, Dr. P. Venkatesh1, K Siva Kumar2, A Sai keshava Reddy2
1* Department of Pharmacy Practice,
Jagan’s College of Pharmacy,
Nellore, Andhra Pradesh, India
2 Department of Pharmacy Practice,
Nirmala College of Pharmacy, Kadapa, Andhra Pradesh, India
*reddennapharmd@gmail.com

ABSTRACT
Anasarca is the medical term referred to an individual who experiences generalized oedema. Anasarca is diverse from slight swelling or oedema that occurs mainly in the feet. Anasarca is very familiar in patients with heart failure and kidney failure. Anasarca happens because there is an underlying problem. A selection of diagnostic methods can be used in a challenge to make a diagnosis of anasarca. Formerly anasarca and the underlying problem is diagnosed, suitable measures will be made to treat the problem. In this section, we can communicate the information regarding anasarca.


GOODS AND SERVICES TAX (GST) in Indian Pharmaceutical and Its Impact on Industry

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ABOUT AUHTOR
Neha Bala, Naresh Mali
*
Institute of Health Management Research, Jaipur
Rajasthan,  India
malinaresh888@gmail.com

“GST will be the best example of co-operative federalism. Together we will take India to new heights of progress. We continue to work with all parties and states to introduce a system that benefits all Indians and promotes a vibrant and unified national market. This reform will promote ‘Make in India,’ help exports and thus boost employment while providing enhanced revenue.” — Prime Minister of India, Mr. Narendra Modi, 3rd August 2016


IMPACT OF RADIOPHARMACEUTICALS IN HEALTHCARE SYSTEM

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ABOUT AUHTORS
*1Bhuyan Nadugopal, 1Swain Sabhya Sampada, 1Ojha Sudip Kumar, 2Meher Chaitanya Prasad
1Gayatri Institute of Science and Technology, Gunupur, Rayagada,765022, Odisha
2 The Pharmaceutical College,Tingipali,Barapali,Dist-Bargarh,Odisha
*nadugopal.1997@gmail.com

ABSTRACT:- The radioactive agents used in the nuclear medical field are called radiopharmaceuticals. A radiopharmaceutical is a drug, that contains a radionuclide in the form of a simple salt or a complex.  It may exist as a solid, liquid, gas or a pseudo gas. It is used in nuclear medicine for the diagnosis and therapy of many diseases. The chemical and physical identity and a form of a radiopharmaceutical are very important because in each case, once administered the radiopharmaceutical is intended to target certain tissues, binding sites, biochemical pathways. As the use of image has been increased, so has the use of prescription medications. These trends increase the risk of interactions between medications and radiopharmaceuticals. Many of the radiopharmaceuticals used for the diagnostic purpose, like C14 for pancreatic study and breath test, Cr51used for red cell volume and GFR measurement, Co57 used for gastrointestinal absorption. In radiopharmaceuticals, technetium has a versatile activity due to its large usage.  This review article describes the production of radiopharmaceutical, types of radiation source used in healthcare, diagnostic imaging technique, therapeutic application as well as advantage and disadvantage of radiopharmaceuticals or radiation therapy. The main aim of this review article is to describe how radiation source or radiopharmaceuticals affect the healthcare system.


GENERALIZE CHEMOMETRIC PROTOCOL FOR AQUAMETRY BY KARL FISCHER TITRATION

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ABOUT AUHTORS
Deepak Chowrasia* Dr. Nisha Sharma
University Institute of Pharmacy, CSJM University,
Kanpur, U.P.-208024, India
*chowrasia.deepak@gmail.com

ABSTRACT
Moisture content affects not only the physiochemical property of an organic or inorganic compound but also markedly deviate its stability if present beyond a specific concentration. Numerous methods were available and has been hand-to-hand adopted to determine the water content among which Karl Fischer titration hold a distinct position owing to its simplicity, accuracy, and cost effective measurement. The following paper presented here precisely defines some of the aspects of same.


A NOVEL TRANSDERMAL PATCH OF LAMIVUDINE: IN VITRO- IN VIVO CHARACTERIZATION

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About Authors:
*R. Natarajan., Abirami. M, , Pavan kumar J, G. Murugananthan
Department of Pharmaceutics & research
Swamy Vivekanandha College of pharmacy
Tamil Nadu,  India

*svcpnatarajan@gmail.com

ABSTRACT
The work was carried out to formulate and evaluate the matrix transdermal patches of Lamivudine for the controlled delivery of drug in the body. The transdermal patches were prepared by the solvent casting method using Span-80 as a permeation enhancer and were prepared in different drug: polymer (Lamivudine: HPMC and Lamivudine: EC) ratios of 1:2.5, 1:5, without permeation enhancers and with permeation enhancers. The prepared transdermal patch were found to be good physicochemical properties, shows no skin irritation on the rat skin and  subjected to in vitro drug permeation study by using rat skin in phosphate buffer pH 7.4 for 24 hours. The comparative statistical analytical data (ANOVA) showed ‘p’ value < 0.0001 which suggest that the prepared formulation are extremely significant for transdermal delivery. The formulation (FPE2) ratio 1:5 of (Lamivudine: HPMC) patch with permeation enhancer showed best result among all the formulation. This formulation (FPE2) was subjected to in-vivo studies by using rat. The in-vivo studies of the patches were administrated transdermally to rat skin and while a standard solution of 10μg/ml was used as a control, and collected the plasma drug sample at different time interval and analyzed by HPLC. The in-vitro in-vivo correlation studies shows the regression value (R) 0.863 and correlated and to be linear.


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