Articles

HEPATOPROTECTIVE ACTIVITY OF GLIMEPIRIDE BY INDUCING CCL4 HEPATOTOXICITY

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ABOUT AUTHORS
C.V.H.Hemavathy*, B. Raj kumar, R. Kiran kumar, G. Hema latha

Department of Pharmacy,
Kottam Institute of Pharmacy,
Erravally X Roads, Mahaboob Nagar
*hemarayudu19@gmail.com

ABSTRACT
Hepatoprotective activity of  by inducing ccl4 hepatotoxicity. To study the hepatoprotective activity of against CCL4 induced hepatotoxcity. To evaluate the mechanism of hepatoprotection in terms of Liver antioxidant mechanism, Histopathological study. The animals were divided into Four groups of  three animals each. Except the normal group all the other groups received ccl4 in at a dose of 0.1 ml/kg by intraperitoneally for 14 days. Normal groups received plain tween 80 orally.  On the 14th day all the rats from all the groups were sacrificed, blood was collected from each animal for serum analysis  and their livers were stored  under freezing conditions for the estimation of endogenous anti oxidants and one sample from each group was stored in 10% formalin for histopathological studies.  In bio-chemical studies- Serum analytical methods (AST), (ALT), (Alk.P), (Bil), (TP), (TC). The present findings observed in this study revealed that,glimepirideis natural antioxidant lignin possess significant antioxidant activity against ccl4 induced hepatotoxicity via antioxidant mechanism. However, further research is required to find out the other possible mechanism of hepatoprotection to conform that  as glimepiridehepatoprotective molecule.


EMERGENCE OF NOVEL PEPTIDE MOLECULAR CLASS AS ANTIBIOTICS

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ABOUT AUTHORS
Akansha Bhandari1, Nitisha Bhandari2*
1
Department of Lifesciences,
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar, Dehradun, India
2 Department of Biotechnology, Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Modern era diseases bring more challenges and hurdles to the rational drug targeting. However chemotherapy is the most affected area as most reports are related to antibiotics resistance. Although some successes are accounted as new molecules and new structures are keep on synthesizing or either isolated. One such example is Teixobactin which is isolated for Eleftheria terrae, which was found to be active against Staphylococcus and Mycobacterium bacteria. The story of Teixobactin isolation could open new horizon and opportunistic ways for future designing of useful drugs against these resistance bacteria. In the similar context we tried to compile the relevant paper that was published in nature in 2015 into a commentary based critical review.


AN ISOCRATIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RABEPRAZOLE AND MOSAPRIDE IN TABLET DOSAGE FORMS BY USING RP-HPLC

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ABOUT AUTHORS
S. Ashutosh Kumar*, Manidipa Debnath, Venugopal Padala,
Department of Pharmaceutical Analysis and Quality Assurance,
A.K.R.G College of Pharmacy, Nallajerla, West Godavari, A.P
*ashu.mpharm2007@gmail.com

ABSTRACT
Objective:
The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines.
Method: The HPLC separation was achieved on an Inertsil-C18 ODS column (250 X 4.6 mm; 5 µ) column in an Isocratic Mode. The mobile phase composed of Methanol [HPLC Grade] (55 %) and Buffer (45 %) [pH 4.0 adjusted with triethylamine]. The flow rate was monitored at 1.0 mL/min. The wavelength was selected for the detection was 276 nm.
Results:The retention times found for rabeprazole and mosapride was 2.946 and 4.186 min respectively. The % recovery was 99.98- 100.03 for rabeprazole and 99.97 - 100.02 for mosapride. The linearity was established in the range of 20-80 µg/mL for both rabeprazole and mosapride. The LOD for rabeprazole and mosapride were 0.01 and 0.035 µg/mL respectively. The LOQ for rabeprazole and mosapride were 0.032and 0.11 µg/mL respectively.
Conclusion:The proposed method was adequate sensitive, reproducible, and specific for the determination of rabeprazole and mosapride in bulk as well as in tablet dosage forms.


A SHORT REVIEW ON ZIKA VIRUS PAST, PRESENT STRATAGIES AND FUTURE PROSPECTIVES

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ABOUT AUTHORS
M .Manasa Rekha1*, A. Bharath Kumar1, T.Mubeena1, C. Gopinath2
1Department of Pharmacy Practice,

Annamacharya college of Pharmacy, Rajampet, Andhra Pradesh, India.
2Department of Phytopharmaceuticals and Pharmacognosy,
Annamacharya college of Pharmacy, Rajampet, Andhra Pradesh, India.
manasarekharoyal@gmail.com

Zika virus(ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus and It is transmitted Aedes mosquitoes like A. aegypti and A. albopictus,which are active at day times[1,2].


REVIEW ON: INDIAN MEDICINAL PLANTS HAVING ANTICANCER PROPERTY

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Nandu Kayande*, Rakesh Patel
Department of Pharmacy,
OPJS University, Churu, Rajasthan, India
* nandu_kayande@rediffmail.com

ABSTRACT
The traditional Indian medicine - Ayurveda, describes various herbs with anticancer as well as antioxidant properties. Various plant products have been used in treatment of cancer over the years. India is a peninsula of herbal hub, in which ayurvedics system of medicine has flourished as an enlightment in the field of Medicine. Currently medicinal plants have become the paramount source of drug discovery in research for treating diverse form of diseases including Cancer. In this review ayurvedas classical literature and evidence based research data were emphasized to explore the ayurvedic medicinal plants with potent anticancer activity.


A REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEMS

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Hemendrasinh J. Rathod*, Dhruti P. Mehta, Jitendra singh Yadav
Department of Pharmaceutics,
Vidyabharti Trust College of Pharmacy,
Umrakh, Gujarat, India.
* hariomh.j.rathod@gmail.com

ABSTRACT
The purpose of writing the review on gastroretentive drug delivery systems (GRDDS) was to accumulate the current literature with a special emphasis on several gastroretentive approaches that have recently become important methodologies in the field of site-specific orally administered sustained/controlled release drug delivery. Technological efforts have been made in research and development of rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS are an approach to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Conventional oral dosage forms pose low bioavailability problems because of their quick gastric transition from the stomach, particularly in case of drugs that are less soluble at an alkaline pH of the intestine. Also, drugs that produce their local action in the stomach get quickly emptied and don’t get sufficient residence time in the stomach. Several efforts have been made to extend the retention time of drug delivery system to reduce the frequency of dose administration. GRDFs not only prolong dosing intervals, but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview on advantages, disadvantages and characterization of gastroretentive drug delivery systems. This review also includes commercially available gastroretentive products and patents.


FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE BUCCAL PATCH

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S. Z. Chemate, Vaishali N. Garje*, Shubhada A. Gayake
Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India
*garjev@gmail.com

ABSTRACT
The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of Metformin hydrochloride, a BCS class II drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The patches were prepared using HPMC K4M as a polymer, polyethylene glycol 400 as a plasticizer, by solvent casting technique. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight and drug content; showed no visible cracks; and showed good folding endurance. The amount of polymer, which significantly influenced characteristics like swelling index, mucoadhesive strength, diffusion study


CHROMATOGRAPHY BASED CHEMOMETRIC FINGERPRINTING, ISOLATION & QUALITY CONTROL OF PHYTOCHEMICALS

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Deepak chowrasia
Institute of Pharmacy, CSJM University,
Kanpur, Uttar Pradesh
chowrasia.deepak@gmail.com

ABSTRACT
The present paper explores key consideration of different chromatographic procedures in phytochemical screening of natural products to investigate novel plant based therapeutically active compounds. Sophistication in instrumentation has sharpened the edges of chromatography making the technique an indispensable specialized laboratory as well as industrial tool for isolation, identification, and quality control of herbal products round the globe.


REGULATORY CANVAS OF INDIAN PHARMACEUTICAL INDUSTRY: CHALLENGES AND FUTURE

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ABOUT AUTHORS
Ayushi Srivastava*, Veena Gupta
QC Department,
Akums Drugs & Pharmaceuticals Ltd, Haridwar, India
*ayushisr@gmail.com

ABSTRACT
This article undertakes a review and assessment of regulatory framework in the Indian pharmaceutical industry. Understanding the regulatory circumstances in this segment is extremely critical. The Pharmaceutical industry is one of the major industries in India and it contributes a large share in the overall macro level growth of the India. It is one of the most dynamic sectors in the country but its compliance structure is more complex. The pharmaceutical industry has always been a buoyant sector in the eyes of Investors. With increasing returns, lower risks and high growth, investors are more interested in this industry than ever before.


IN VITRO EVALUATION OF ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF CHLOROFORM EXTRACT OF GARUGA PINNATA LEAVES

ABOUT AUTHOR
Sonia Zaman
Department of Pharmacy,
Southeast University, Banani, Dhaka, Bangladesh
sonia_6995@yahoo.com

ABSTRACT
Garuga pinnata
(family: Burseraceae) has many traditional medicinal uses including as astringent, bronchodilator, stomachic, expectorant, pulmonary infection, antidiabetic etc. The present study is based on this plant to evaluate the antimicrobial, antioxidant and cytotoxic properties of G. pinnata leaves. Antimicrobial activity of chloroform extract was evaluated against four Gram positive bacteria Bacillus megaterium, Bacillus subtilis, Sarcina lutea, Staphylococcus aureus and five Gram negative bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi, Shigella dysentriae, Vibrio mimicus, and two common fungus Aspergillus niger, Candida albicans by applying disc diffusion method where Kanamycin disc (30 µg/disc) was used as reference standard. The chloroform extract of G. pinnata leaves showed very good antimicrobial activity against both gram positive and gram negative bacteria and fungus A. niger. The most susceptible microorganism was S. paratyphi (19 mm zone of inhibition) followed by B. subtilis (15 mm zone of inhibition). The antioxidant activity of chloroform extract of G. pinnata leaves was evaluated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for radical scavenging and  ascorbic acid was used as standard. The extract exhibited strong DPPH radical scavenging activity with IC50 value of 57.06 µg/ml as compared to the IC50 value of the reference standard, ascorbic acid (37.21 µg/ml). The cytotoxic activity of G. pinnata  was determined by brine shrimp lethality bioassay using vincristine sulfate as standard. The chloroform extract revealed significant cytotoxic activity with LC50 of 6.607 µg/ml whereas LC50 of Vincristine sulphate was 6.026 µg/ml.


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