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IN VITRO MEMBRANE STABILIZING AND INSECTICIDAL ACTIVITIES OF METHANOLIC EXTRACT OF STREBLUS ASPER LOUR

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ABOUT AUTHORS:
Fatema Nasrin1*, Nabila Mahrin2, Nisrat Jahan1, Yesmin Begum1, Senjuti Majumder1
1Department of Pharmacy, Southeast University, Banani, Dhaka
2Pharmacology labortory, Department of Pharmacy, Southeast University, Banani, Dhaka
nasrin_0209@yahoo.com

ABSTRACT
We aimed at assessing the effect of methanolic extract of Streblus asper in human red blood cell (HRBC) membrane stabilization and insecticidal (on the stored grain pest, Trogoderma  granarium Everts) as studies. The membrane stabilizing activity was assessed by using erythrocyte in hypotonic solution and heat induced was compared with acetyl salicylic acid. The extract at the doses of  200, 400 and 800 μg/ml significantly inhibited heat induced lysis of the human red blood cell membrane with values of 46.53%, 56.52% and 65.14%, respectively. The results of hypotonic solution induced lysis showed that S. asper has significant reduction (P≤0.01) in inflammation i.e. 40.8 % (400 µg/ml) and 50.8 % (800 µg/ml) as compared to the standard drug, acetyl salicylic acid, which was 62.96 % in insecticidal assay the extract showed dose dependent paralyzing effect and mortality of T.  granarium Everts. All the doses of crude extracts exhibited concentration and time dependent insecticidal activity.


BIOEQUIVALENCE AND PHARMACOKINETIC STUDY OF RANAZOLINE IN HEALTHY MALE VOLUNTEERS: AN OPEN LABEL, RANDOMIZED, SINGLE-DOSE, TWO-WAY CROSSOVER STUDY

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ABOUT AUTHORS:
Suresh VV Babu1, Talasila EGK Murthy2*, Chimakurthy Jithendra3
1Dept. of Pharmaceutics, Natco Pharma Limited, Hyderabad, Telangana, India.
2Dept. of Pharmaceutics, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
3Dept. of Pharmacology, Bapatla College of Pharmacy, Bapatla, Andhra Pradesh, India.
*drgkm@bcop.net

ABSTRACT
The present study was to assess the relative bioavailability and pharmacokinetic properties of extended release formulations of Ranolazine 1000 mg in healthy male volunteers usinga randomized, open-label, balanced, two-treatment, two-period, two sequence, single dose, crossover, bioequivalence study under fasting conditions. Bioavailability of the test product of Ranolazine extended release tablets 1000 mg was compared with that of the reference product of Ranexa® (Ranolazine extended release tablets 1000mg) of CV Therapeutics Inc., California. The plasma samples were collected at 0.50, 1.00, 1.50, 2.00, 2.50, 3.00, 3.50, 4.00, 4.50, 5.00, 5.50, 6.00, 6.50, 7.00, 8.00, 10.00, 12.00, 16.00, 24.00 and 48.00 hours post dose after single administration of Ranolazine 1000mg. The plasma Ranolazine concentrations were estimated by using a validated bioanalytical method by LC-MS/MS. A ten day washout period is followed between two treatments. The formulations were considered to be bioequivalent if the 90% CIs for the log-transformed values were within the predetermined equivalence range 80%–125% for AUC and Cmax. For Ranolazine, at 90% confidence intervals Cmax, AUC0-tand AUC 0-∞ were 83.43-113.29, 82.10-102.87 and 80.94-101.85 for log-transformed data respectively.The present results show that the formulation of Ranolazine was bioequivalent to the reference in fasting, healthy, male volunteers.


FORMULATION AND IN-VITRO EVALUATION OF ANTIEMETIC ORODISPERSIBLE COMBINATION TABLETS OF DOMPERIDONE AND CINNERIZINE BY USING VARIOUS SUPERDISINTEGRANTS

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ABOUT AUTHORS:
Rajmahamad H. Shaikh1*, Mohsin J. Jamadar1, Amol D. Patil1, Audumbar D. Mali2, Sanauaha M.Tamboli1
1Department of Pharmaceutics, Appasaheb Birnale college of Pharmacy, Sangali, Maharashtra, India.
2Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India
rajshaikh71@gmail.com

ABSTRACT:
The purpose of this investigation was to enhancement of solubility of cinnarizine by using solid dispersion technique solvent evaporation method using polymer PEG 6000 & develop combination ODT of cinnarizine with domperidone by using direct compression technique using crospovidone, croscarmellose sodium and sodium starch glycolateas a superdisintegrants. The preformulation study includes the compatability of drugs with the polymers by using FTIR,UV,TLC. The batches were evaluated for weight variation, hardness, friability, drug content, wetting time, IN In-vitro dispersion, in-vitro dissolution. The formulation F2 which contain 8% crospovidone and 10 % sodium starch glycolate showed best results and rapid in-vitro dissolution. The results revealed that the tablets containing superdisintegrants combination had a good dissolution profile. The drug content of all the batches was within the acceptable limits of the United States Pharmacopoeia with maximum drug being released at all timeintervals. The present study demonstrated potentials for rapidabsorption, improved bioavailability, effective therapy and patientcompliance. The results conclusively demonstrate successful enhancement of solubility, disintegration and dissolution of the formulated tablets.


ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF SIMVASTATIN BY TERNARY SOLID DISPERSION TECHNIQUE

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ABOUT AUTHORS:
Shete Reshma S.1*, Gadhave Manoj V.2, Gaikwad D. D.3
1Department of Quality Assurance Techniques,
2Department of Pharmaceutics,
3Department of Pharmaceutics,
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
*reshma.s.shete@gmail.com

ABSTRCT
Simvastatin is a poorly soluble drug exhibiting poor dissolution pattern. Simvastatin, PEG 6000 & Poloxamer 407 solid dispersions were prepared with a view to study the influence of polymer on solubility and dissolution of this poorly soluble drug Simvastatin. Solid dispersions of Simvastatin were prepared using different ratios of PEG 6000 & Poloxamer 407 as carrier by, solvent evaporation method. They were evaluated for percentage yield, drug content, FTIR spectral studies, DSC, XRD, solubility, and in-vitro dissolution. The solubility profile indicated that there is increase in solubility of Simvastatin when polymer concentration is increased. The solid dispersion complex of drug (1:5:5 ratios) was giving better dissolution profile as compared to pure drug and other solid dispersions. This in turn can improve the bioavailability. FT-IR, DSC shows the compatibility of drug and carrier.


AN OVERVIEW ON BENZOTHIAZINONE ANALOGS AS ANTITUBERCULAR DRUGS

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ABOUT AUTHOR:
Mohammad Asif
Department of Pharmacy, GRD(PG) Institute of Management & Technology,
Dehradun, (Uttarakhand), 248009, India
aasif321@gmail.com

ABSTRACT:
The reappearance of tuberculosis and the rush of multidrug-resistant clinical isolates of Mycobacterium tuberculosis have reaffirmed tuberculosis as a key public health concern. Describe findings on the pharmacological status of Benzothiazinones as new agents that are being developed as antitubercular drugs. Benzothiazinones act by targeting the enzymes responsible for the formation of arabinans that are essential parts of the cell wall. In view of their novel mechanism of action, these drugs appear promising as anti-TB drugs and considered to be promising candidates for future development.


DISSOLUTION METHOD DEVOLOPMENT OF FLUCONAZOLE IN FLUCONAZOLE TABLETS DOSSAGE FORM

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ABOUT AUTHORS:
Auti Snehal D.*1, Jadhav S. L2, Gadhave Manoj V3
1Department of Quality Assurance Techniques
2,3Department of Pharmaceutics
VJSM’S Vishal institute of pharmaceutical education and research, Ale, Pune, Maharashtra, 412411
snehal.d.auti@gmail.com

ABSTRACT:
The present research work discusses the development of a dissolution method for Fluconazole using UV spectrophotometer. Simple, accurate and cost efficient dissolution method has been developed for the estimation of Fluconazole in bulk and tablet dosage form. The optimum conditions for the dissolution of the drug were established. The dissolution media was found to be 0.1N HCl (pH 1.2). The apparatus was found to be USP II, Paddle and the speed was found to be 50 rpm for 30 minutes time interval.


FORMULATION AND EVALUATION OF DRY SYRUP CONTAINING LINEZOLID

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ABOUT AUTHORS:
Akash M Patel*, Viren N Sisodiya
* Faculty of Pharmacy,
Dharmsinh Desai University, Nadiad-387001, Gujarat
aku.pharmacy@gmail.com

ABSTRACT
Taste is an important factor in the development of dosage form. The problem of bitter and obnoxious taste of drug in pediatric patient can create a bad psychological effect on mind. The purpose of this research was to mask the intensely bitter taste of Linezolid using ion exchange resin and to formulate the dry syrup of the taste masked drug. When suspension is swallowed the bitter taste of the drug may not be felt as ion exchange resin does not release the drug at salivary pH. When it comes in contact with acidic environment of stomach, the complex will be broken down releasing the drug which may then absorbed. Batch method was used for formation of drug resin complex. Various ion exchange resin like different grade of kyron and indion 214 were used for masking the bitter taste. Optimization of drug loading was carried out. Indion 214 was selected as a optimized resin with 84.47 % drug loading. Dry syrup was made using suspending agent like gellan gum, guar gum and CMC and evaluated for various parameters like colour, odour, taste, viscosity, sedimentation volume, redispersibility, % drug content, drug release. By evaluating all the parameter the batch formulation contained guar gum 3 % was the best one amongst all the other formulations.


STUDY OF ANTIMICROBIAL AND CYTOTOXIC ACTIVITIES OF VIGNAMUNGO LINN.HEPPER ( FAMILY-LEGUMINOSAE)

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ABOUT AUTHORS:
Fatema Nasrin1*, Saikat Ranjan Paul2, Sonia Zaman2, Sabiha Ferdowsy Koly2
1Senior Lecturer,  Department of Pharmacy, Southeast University, Banani, Dhaka-1213
2Lecturer, Department of Pharmacy, Southeast University, Banani, Dhaka-1213
nasrin_0209@yahoo.com

ABSTRACT
In the present study the antimicrobial & cytotoxic activity of crude methanolic extracts of leaves and stems of VignaMungoLinn. Hepper (Family-Leguminosae)were studied. Antimicrobial activity was tested against eleven important pathogenic bacteria including both gram positive and gram negative bacteria and two common fungi. The bacteria are B. megaterium, B. subtilis, Staphylococcus aureus, Sarcina lutea, Escherichia coli, Salmonella paratyphi, S. typhi, Shigella boydii, S. dysenteriae Vibrio mimicus and V. parahemolyticus. Disc diffusion technique was used for invitro antibacterial and antifungal screening. Here kanamycin disc (30mg /disc) was used as standard for antibacterial study. The extracts showed antimicrobial activity against most of the bacterial strains with an average zone of inhibition of 10-20mm. The tested fungi are Candida albicans and Aspergillus niger. The extracts showed very good antifungal activity with an average 15 -19 mm zone of inhibition. The methanolic extracts of leaves of V. mungo  showed maximum activity (19 mm, zone of inhibition)  against Bacillus  megaterium (19mm) with Minimum inhibitory concentration (MIC) values of 64mg/ml. The maximum zone of inhibition for the methanolic extracts of  stems was found 20mm  against Shigellaboydii with MIC values of 64mg/ml. Cytotoxicity test was also studied by Brine Shrimp Lethality Bioassay and compare with LC50 values of standard vincristin sulphate as a positive control. The results illustrated significant cytotoxicity against A. salina, with LC50 0.67μg/ml, 4.52 μg/ml and 3.25 μg/ml for vincristine sulphate as standard, leaves and stems extracts, respectively. Further pharmacological investigations are required to understand the underlying mechanism of these pharmacological activities.


PHARMACY: BOON OR BANE

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ABOUT AUTHOR:
Pranita Pradip Dharmadhikari
Department of Phrmacology,
N.D.M.V.P. College of Pharmacy, Nashik
2009pranitadh@gmail.com

“Pharmacy is the health profession that links the health science with the chemical science and it is charged with ensuring safe and effective use of pharmaceutical drugs.” That’s how the Wikipedia defines it. For a student it is a career, an ambition and of a course a learning process.

Pharmacy education in India was initiated by Medical College; Madras in 1860, the purpose was to develop pharmaceutical skills of students of medical degree or diploma course or of that pursuing hospital assistance. From 1860 to 2014 the pharmacy profession shows a tremendous growth in India, it shows that pharmacist is one of the major fraternities of health care system around the world. As a pharmacist, I must say that pharmacy is profession which benefits to the world. But certain area in pharmacy are consistently points the pharmacist as towards negative aspects. Hence it’s a pharmacist’s duty to focus on wrong practices to make a profession as boon for world.[1]


PRESCRIBING TREND OF ANTIHYPERTENSIVE DRUGS IN SRI GANGANAGAR DISTRICT: A RETROSPECTIVE STUDY

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ABOUT AUTHORS:
Amarjeet Singh*, Sudeep Bhardwaj, Ashutosh Aggarwal
Department of Pharmacology,
Seth G. L. Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research,
Sri Ganganagar, Rajasthan 335001, India
*amarjeetsingh024@gmail.com

ABSTRACT
Objective
: The choice of drug for the treatment of hypertension changes at short intervals. Drug utilization studiesconducted at regular intervals help to guide the physician in prescribing drugs rationally. The present study was done toanalyze the prescribing patterns of antihypertensive drugs in a NorthIndian  hospital.

Material & method: A retrospective, crosssectional analysis of prescriptions of antihypertensive cases admitted in Medicine in-patient wards of civil hospital of Sri Ganganagar was conducted. All the prescription files with diagnosis ofessential hypertension were analyzed. Prescriptions for hypertension with other co-morbid conditions were also included. Frequency and proportions of utilization of antihypertensive medications were charted and figured.

Result: During the studyperiod, there were 435 prescriptions for essential hypertension. The most frequently prescribed antihypertensive medications were:  monotherapy (42.06%), (57.94%) of patients were on multiple drugtherapy, the most favored fixed drug combination being diuretics with angiotensin receptor blockers (31.74%).

Conclusion: The present study revealed that Angiotensin receptor blockers arethe drugs of choice as monotherapy and as combination therapy for hypertensives. This pattern of prescription is also supported by the current JNC VIII guidelines for the treatment of hypertension.