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DIABETIC FOOT ULCER: A SERIOUS PROBLEM FOR DIABETIC PATIENT

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ABOUT AUTHOR:
Amitava Sinha Ray
RANBAXY LABORATORIES LTD.
West Bengal, India
a.amitava.s@gmail.com

ABSTRACT:
Diabetes is a major problem across the world also it is a serious problem in India. Diabetes Mellitus is a silent killer of human body. Several types of complication are occurred in diabetic patient. One of the serious complications is Diabetic foot ulcer. Generally occurred due to breakdown in the skinand subcutaneous tissue also muscle. It will be more dangerous if it will become infected. Sometimes it is also needed to cut down the leg by surgery to prevent the spread of infection. A diabetic patient should take care for his foot to avoid this type of complication, also should be more care full to the management of blood sugar in normal level.


LOCAL ANAESTHESIA (LA): AN OVERVIEW

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ABOUT AUTHORS:
Mayure Vijay Kumar*, V. Sravanthi
Maheshwara College of Pharmacy (B-Pharm Scholar)
Department of pharmacology,
Maheshwara College of Pharmacy, Chitkul (V), Isnapur “X” Road, Patancheru, Hyderabad, A.P.
mayurevijaykumar@gmail.com

ABSTRACT:
The anaesthetic agents are the drugs which causes anaesthesia-reversible loss sensation. It deals with the property of relieving the pain without eliminating sensation. These drugs are generally administered to facilitate surgery. It can be described by two main classes. General anaesthetic, which causes a reversible loss of consciousness, and local anaesthetics, which causes a reversible loss of sensation for a limited region of the body while maintaining consciousness. Here I explain about the Local anaesthetics agents that prevent transmission of nerve impulses without causing unconsciousness. They act by binding to fast sodium channels from within in an open state.
BACKGROUND: The purpose of this Review article is to summarize the Local anaesthetics agents, general mechanism, structures, therapeutic uses, adverse effects and also explains their properties.


FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES: ISONIAZID

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ABOUT AUTHORS:
Umatiya Imran*, Chintan Aundhia, A.K.Seth, Sachin Chauhan, Nirmal Shah
Department of pharmacy, Sumandeep Vidhyapeeth University,
Piparia, Waghodia, Vadodara, Gujarat, India
imran_umatiya@yahoo.com

ABSTRACT
Tuberculosis is an infectious disease caused by Mycobacterium Tuberculosis which attacks lungs and other parts of the body. Isoniazid is a hydrophilic drug that is having a first line antituberculosis drug. Entrapment Efficiency has been improved by preparing Solid Lipid Nanoparticles (SLNs). Two different variable Stearic acid and Tween 80 were used by using w/o/w double emulsion-solvent evaporation method by using 32 factorial designs. Particle size, Surface Morphology, Entrapment efficiency and In-vitro diffusion studies were evaluated for prepared SLNs. Different combination of Surfactant and Lipid were found to have significant effect on entrapment efficiency but not on drug release. The prepared SLNs were found in spherical shape and 678 nm particle size was found. % Entrapment efficiency were found from 31.90±0.41 to 74.89±0.67. Present Work is focused on increase incorporation of drug into SLN. Work indicates that formulation of SLNs loaded INH can give reliable therapeutic effect for the treatment of tuberculosis by prolonged action.


RESEALED ERYTHROCYTES AS A POTENTIAL DRUG CARRIER: A REVIEW

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ABOUT AUTHORS:
Tapan Behl*, Ishneet Kaur, Rashi Wanchoo Misri, Heena Goel
Senior Research Fellow, Department of Pharmacology,
Vallbhbhai Patel Chest Institute, University of Delhi, Delhi.
tapanbehl31@gmail.com

ABSTRACT
Drug delivery and drug targeting systems developed by various researchers are beleaguered to deliver the drug safely to the target sites without much interaction with other tissues of the body, so as to increase its bioavailability and reduce the adverse effects of that drug. In this approach, many drug carriers have been developed which are being widely used these days for increasing the efficacy and safety of the pharmaceutical products. Among the cellular carriers, the erythrocytes are the most potentiated drug carriers with very capitalizing properties like precise site specificity and sustained drug release. The circulation of erythrocytes into every corner of the human body is one such another advantage, thus making them useful for drugs which cannot be taken to their target site by any other carrier. Resealed erythrocytes are prepared by isolating erythrocytes from the plasma of the blood sample of an organism of interest, breakdown of cells using different methods and then entrapping the drug (which is to be administered into the body) into the erythrocytes by various techniques such as hypotonic haemolysis, hypotonic dilution, hypotonic pre-swelling method, dialysis method, isotonic osmocytosis, chemical perturbation of the membrane, electro-insertion method, entrapment by endocytosis, lipid fusion method etc., and then finally they are sealed back again, thus, accounting for their name – “Resealed Erythrocytes”.


FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET OF SILYMARIN

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ABOUT AUTHORS:
Brij Mohan*, Seema Saini, Sachin Dev Sharma, Mohit Kumar
Department of Pharmaceutics,
Rayat Institute of Pharmacy, SBS Nagar, Punjab
rana.brijmohan@gmail.com

ABSTRACT:
In this investigation mouth dissolving tablets of Silymarin were prepared using different superdisintegrants by dry granulation method. Fast dissolving tablets were evaluated for physicochemical properties and in vitro dissolution. The preformulation studies and tablet evaluation test were performed and result were within the limit. The powder blend was evaluated for angle of repose, bulk density, tapped density, compressibility index and Hausner ratio. The powder blend show satisfactory flow properties. The silymarin tablet evaluated for tablet general appearance, hardness test, weight variation and drug content estimation. Oral route is the most preferred route for administration of various drugs because it is regarded as safest most convenient and economical route. Recently researcher develop the new dosage form fast dissolving tablet (FDT) with improve patient compliance and convenience. Fast dissolving tablets which dissolve rapidly in saliva without additional water and chewing. Fast dissolving tablets overcome the disadvantages of conventional dosage form especially dysphagia in pediatric and geriatric patients.
All the formulations shows uniform weight, hardness and friability data indicates good mechanical resistance of the tablet. All the tablets were disintegrated between min. The optimized (F6) formulation showed good disintegration time and release profile with maximum drug being released.


MEDICATION ERROR - MAJOR PROBLEM IN HEALTHCARE PRACTICE

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ABOUT AUTHOR:
Dinesh Kumar Meena
Department of Pharmacy,
Annamalai University, Annamalai nagar, Tamil Nadu.
*dinesh8989pharmd@gmail.com

ABSTRACT
A medication error is the failure of treatment process that may be harmful for the patient. A medication error can occur in deciding which medicine and dosage regimen to use, prescription writing, manufacturing the formulation, administrating the medicine, monitoring therapy. Avoiding medication error is important for the safety of patient as well as better therapeutic outcomes. Medication error may not be clinically significant on many occasions but they have serious economic consequences like extended hospital stays, additional treatment and malpractice litigation. Medication error are well known problem in hospitals. Medication error and adverse drug reactions are one of the main causes for adverse events in hospital leading to disability and death. Pharmacist is responsible for the safe and appropriate use of medication in all pharmacy practice settings. As the part of the multidisciplinary health care team, the pharmacist role is to cooperate to establish patient-specific drug therapy regimens designed to achieve predefined therapeutic outcomes without subjecting the patient to undue them. As pharmacist becomes more involved in patient – specific care, technician is asked to perform tasks that have previously been restricted to pharmacists. As their responsibilities expand, technician need to be aware of the significance and cause of medication errors and to recognize their role in preventing those errors.


A REVIEW ON GOOD MANUFACTURING PRACTICE (GMP) FOR MEDICINAL PRODUCTS

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ABOUT AUTHORS:
Vikash Kumar Chaudhari1*, Vijay Yadav2, Praveen Kumar Verma1, Amit Kumar Singh2
1Department of Pharmaceutical Chemistry,
2Department of Pharmacognosy,
Kunwar Haribansh Singh College of Pharmacy, Jaunpur, U.P.
*vikashk464@gmail.com

ABSTRACT
Good manufacturing practices (GMP) is a part of quality assurance which ensures that products are consistently produced and controlled to the quality standards appropriate to their intended use and as required by the marketing authorization. GMP guidelines provide minimum requirements for pharmaceutical or a food product manufacturer must meet to assure that the products are of high quality and do not pose any risk to the consumer or public.


A REVIEW PAPER ON PSYCHIATRY DISORDERS & ITS TREATMENT BY AYURVEDIC APPROACH

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ABOUT AUTHORS:
Kuntal Pal1, Sampat Kumar Kundu2, Shatabisha Bhattacharjee2, Shounak Roy3
1Institute of Medical Sciences, Rajiv Gandhi South Campus, Banaras Hindu University, Barkaccha, Mirzapur.
2Gurunanak Institute of Pharmaceutical Sciences & Technology, Sodepur, West Bengal.
3Birla Institute of Technology, Mesra, Ranchi, Jharkhand
sampatkundu001@gmail.com

ABSTRACT
Psychiatric disorders are astonishingly common. In any given year, over 25 percent of adults have one or more diagnosable mental disorders, according to the National Institute of Mental Health. For the most part, psychiatric disorders are highly responsive to treatment. There have many ayurvedic plants/medicine which are effectively use for the psychiatric disorders. Ayurveda, being a stream of treatment, can no way ignore the importance of psychic condition of a patient to effectively diagnosis and treat disorders. Medical science admits that the root cause of multiple disorders lies in psychic tensions. Ayurveda too has a well developed branch of psychiatry, which has clinically proven practices of treating mental ailments and also physical problems associated with psychological imbalances. On a psychological level we naturally try to harmonies these problems but if we are not able to it can lead to a mental disorders. The causes are many but often stem from our own way of looking at things and the inability or unwillingness of our mind to process what is happening. Sometimes we just don’t want to let go of a belief or viewpoint. At other times we might be attached to a result and when something comes to challenge this, as life tends to do, we find our mind under stress in trying to work through the issue. On an unconscious level the mind may know what to do but at a conscious level the mind wants to do something else creating a conflict between the inner and outer, or the personality and the soul. The result often manifests as a Mental Disorder or sickness.


TOXICOLOGICAL SCREENING OF ‘GOWRI CHINTHAMANI CHENDOORAM'- A SIDDHA METALLIC PREPARATION

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ABOUT AUTHORS:
Shanmugapriya.P1, Thamodharan.S1, M.Ramamurthy2, V.C. Jiji Mol3, M. Nijavizhi3
1 Department of Nanjunool, National instistute of siddha, Chennai, Tamil Nadu, India
2Assistant medical officer, Salavakkam
3PG scholars, National institute of siddha, Chennai, Tamil Nadu, India
drjijivijay@gmail.com

ABSTRACT
'Gowri chinthamani chendooram', a siddha drug was evaluated for its acute and chronic toxicity studies in wistar albino rats with reference to haematological, bio-chemical and histopathological studies. Acute study revealed a maximum tolerated does of 640 mg/100 gm b.w chronic toxicity study revealed a minimum toxic effect at adoes level of 40 mg/100 gm b.w. Where in, the changes observed were non-specific. The toxicity findings were dose specific, which had tissue damage in higher dosages.


PREVALENCE OF MALNUTRITION AMONG SCHOOL CHILDREN IN RURAL NORTH KARNATAKA

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ABOUT AUTHORS:
Srividya V.L, Ashok Kumar Malpani, A.Manjunath
Department of Pharmacy Practice, NET Pharmacy College,
Navodaya Medical Hospital & Research Centre, Raichur, Karnataka
drsrividyapharmacy@gmail.com

ABSTRACT
The objective of the present study is to evaluate the level of malnutrition and the impact of households on the nutritional status of school children in a rural area of north karnataka region. Factors included:  the number of children of 5 to 14 years of age in the family, occupation of the parents, family income, maternal education, type of residence (kacha  or pucca) and children gender. The study was a cross-sectional descriptive survey using a structured questionnaire which includes Anthropometric measurements height (H/A) and weight (W/A). Two hundred and seventy school children representing a rural area of Raichur district, North karnataka were participated in the study. Reference standards used were those of WHO growth charts. The results showed the level of stunting and underweight in school children as per percentile standards from the WHO. Most of the boys and girls of the study fall under < 3rd percentile. Hence, malnutrition was significantly higher among the school children. The higher the level of the mother’s education, the lower the level of child’s underweight was observed. In the present study, growing children by and large are deprived of good nutrition on account of their poor socio-economic status, ignorance and lack of health promotional facilities. The study findings imply that efforts for redressing child under nutrition issues in rural areas should focus on factors associated with development outcomes such as family income, maternal education and the creation of employment.