Articles

DEVELOPMENT AND IN-VITRO DRUG RELEASE PROFILE OF SUSTAINED RELEASE FLOATING GRANULES OF CINNARIZINE

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ABOUT AUTHOR
Aman Mittal
Smt. Tarawati Institute of Biomedical & Allied Science
Roorkee, Uttarakhand, India
amanmittal_27@yahoo.com

ABSTRACT
Floating drug delivery systems (FDDS) are the drug delivery systems having a bulk density lower than the gastric content and they remain buoyant in the stomach for a prolonged period of time, with the potential for continuous release of drug. Cinnarizine, a H1-receptor antagonist, used for the treatment for vestibular vertigo disorders and motion sickness was selected as the drug aspirant and Gelucire 43/01 was selected as a lipid carrier in different ratio (1:0.5, 1:1, 1:1.5) along with drug to be formulated as gastro retentive multiparticulate system. The formulation F1 to F9 were prepared and formulation F4 to F9 were evaluated for in-vitro drug release and formulation F5 was selected as optimized formulation that exhibited good floating ability and zero order drug release (93.56 %) at the end of 8 hrs. The in-vitro drug release study of the aged sample show phase conversion of Gelucire. The phase conversion also caused increase in drug release. In conclusion, hydrophobic lipid, Gelucire 43/01 can be considered as an effective carrier for design of a multiple unit floating drug delivery system of cinnarizine.


RECENT INDUSTRIAL DEVELOPMENT IN ORAL THIN FILM TECHNOLOGY: AN OVERVIEW

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Kh. Hussan Reza 1*, Pranabesh Chakraborty2
1 Department of Pharmacy, Bengal School of Technology, Sugandha, Hooghly, West Bengal
2 Director, Department of Pharmacy, Bengal School of Technology, Sugandha, Hooghly, West Bengal
*hassan23pharma@gmail.com

ABSTRACT
Oral route of administration is most convenient route but often is disadvantageous for administering to geriatric and paediatric patients. Orally disintegrating film is found to be effective in delivering rapid drug action by dissolving the drug in buccal cavity. Since a decade oral thin films has got commercial importance in generic and non generic market projecting it as a multinational business asset. Current research in this field is found to be associated with industrialization and commercialization. Current article make an overview of not only technological changes in research and manufacturing but also gives an insight about growing market worldwide.


ADR MONITORING: AN ESSENTIAL NEED FOR BETTER HEALTH CARE AND SAFETY

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Annu*, Priyanka
Department of Pharmaceutical Sciences,
Maharshi Dayanand University, Rohtak, Haryana, India.
*annu.gvm@gmail.com

ABSTRACT
Adverse drug reaction (ADR) is the noxious and unintended response that occurs at the dose of drug normally used for prophylaxis, diagnosis or therapy of disease. ADRs cause a huge burden on the modern society because of the increase incidence of the morbidity and mortality. ADRs can occur with any class of drugs and the availability of the more and more number of therapeutics increases the risk of ADRs consequently. It has been found that the maximum numbers of ADRs occur more among infants and children and also they are generally more severe as compared to adults. ADRs are of particular interest in today’s practice because clinical trials are done in the limited number of the subjects and therefore the drug which is found safer in the clinical trial may produces serious ADRs. The most common reason for this is that the clinical studies generally have limited sample size and have low statistical power. Therefore the ADRs monitoring is an essential need for the better health care and therefore the health care centre should promotes the spontaneous monitoring, reporting, documentation and prevention of ADRs.


FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS TO ENHANCE DISSOLUTION RATE OF LAMOTRIGINE BY USING SOLID DISPERSION TECHNIQUE

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ABOUT AUTHORS
Bhumi B. Patel1*, Chainesh N. Shah2, Rumit M. Shah3
1Department of Pharmaceutics, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
2 Department of Pharmacy, Sumandeep Vidyapeeth, Piparia, Gujarat, India
3 Department of Pharmacognosy, Shree Naranjibhai Lalbhai Patel College of Pharmacy, Umrakh, Gujarat, India.
* patelbhumi198@gmail.com

ABSTRACT
Lamotrigine belongs to biopharmaceu­tical classification systems; BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action. Hence, the main objective of this study is to improve the solubility by solid dispersion technique and formulate it as Orodispersible tablets to avert the problems of swallowing and to provide rapid onset of action. Lamotrigine solid dispersion was prepared by using PEG 6000 as solubility enhancers and formulated it into ODT by direct compres­sion technique using different concentrations of Sodium Starch Glycolate, Cross Carmalose Sodium, and Kyron T-314 as cross linked polymers. The tablets were evaluated for various parameters and the results were found to be sat­isfactory. The batches batch containing Kyron T-314 as super disintegrant in 7% concentration, as they showed 95.75% drug release in 15 minutes with a disintegration time of 11 seconds which shows improved dissolution rate in compare to marketed formulation of Lamotrigine.


PHARMACOGNOSTICAL STUDIES FOR STANDARDISATION OF A MEDICINAL SPICE, THE FRUIT OF ILLICIUM VERUM HOOK. F.

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M. A. Rashid*, R. H. Zuberi

Pharmacognosy Section
Regional Research Institute of Unani Medicine (RRIUM),
Aligarh, UP, India
* marashid212@gmail.com

ABSTRACT
The fruit of Illicium verum Hook. f. of family Magnoliaceae has been utilized therapeutically as medicine as well as a spice. It is used to relieve a number of human ailments, owing to its properties as carminative, stimulant and appetizer. In order to set the quality standards, the market sample of the drug has been identified and standardized on the basis of Pharmacopoeial parameters, such as salient macro and microscopic characters, ash values, solubility, successive extractive values, thin layer chromatographic evaluations and U.V. spectroscopic analysis. Besides qualitative and quantitative estimations, fluorescence analysis of powdered drug has also been carried out in order to set standards for the crude drug.


HEPATOPROTECTIVE ACTIVITY OF GLIMEPIRIDE BY INDUCING CCL4 HEPATOTOXICITY

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C.V.H.Hemavathy*, B. Raj kumar, R. Kiran kumar, G. Hema latha

Department of Pharmacy,
Kottam Institute of Pharmacy,
Erravally X Roads, Mahaboob Nagar
*hemarayudu19@gmail.com

ABSTRACT
Hepatoprotective activity of  by inducing ccl4 hepatotoxicity. To study the hepatoprotective activity of against CCL4 induced hepatotoxcity. To evaluate the mechanism of hepatoprotection in terms of Liver antioxidant mechanism, Histopathological study. The animals were divided into Four groups of  three animals each. Except the normal group all the other groups received ccl4 in at a dose of 0.1 ml/kg by intraperitoneally for 14 days. Normal groups received plain tween 80 orally.  On the 14th day all the rats from all the groups were sacrificed, blood was collected from each animal for serum analysis  and their livers were stored  under freezing conditions for the estimation of endogenous anti oxidants and one sample from each group was stored in 10% formalin for histopathological studies.  In bio-chemical studies- Serum analytical methods (AST), (ALT), (Alk.P), (Bil), (TP), (TC). The present findings observed in this study revealed that,glimepirideis natural antioxidant lignin possess significant antioxidant activity against ccl4 induced hepatotoxicity via antioxidant mechanism. However, further research is required to find out the other possible mechanism of hepatoprotection to conform that  as glimepiridehepatoprotective molecule.


EMERGENCE OF NOVEL PEPTIDE MOLECULAR CLASS AS ANTIBIOTICS

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Akansha Bhandari1, Nitisha Bhandari2*
1
Department of Lifesciences,
Shri Guru Ram Rai Institute of Technology and Science, Patel Nagar, Dehradun, India
2 Department of Biotechnology, Graphic Era University, Dehradun, India
*nitishabhandari89@gmail.com

ABSTRACT
Modern era diseases bring more challenges and hurdles to the rational drug targeting. However chemotherapy is the most affected area as most reports are related to antibiotics resistance. Although some successes are accounted as new molecules and new structures are keep on synthesizing or either isolated. One such example is Teixobactin which is isolated for Eleftheria terrae, which was found to be active against Staphylococcus and Mycobacterium bacteria. The story of Teixobactin isolation could open new horizon and opportunistic ways for future designing of useful drugs against these resistance bacteria. In the similar context we tried to compile the relevant paper that was published in nature in 2015 into a commentary based critical review.


AN ISOCRATIC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF RABEPRAZOLE AND MOSAPRIDE IN TABLET DOSAGE FORMS BY USING RP-HPLC

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S. Ashutosh Kumar*, Manidipa Debnath, Venugopal Padala,
Department of Pharmaceutical Analysis and Quality Assurance,
A.K.R.G College of Pharmacy, Nallajerla, West Godavari, A.P
*ashu.mpharm2007@gmail.com

ABSTRACT
Objective:
The present work was undertaken with the aim to develop and validate a rapid and consistent RP-HPLC method in which the peaks will be appear with short period of time as per ICH Guidelines.
Method: The HPLC separation was achieved on an Inertsil-C18 ODS column (250 X 4.6 mm; 5 µ) column in an Isocratic Mode. The mobile phase composed of Methanol [HPLC Grade] (55 %) and Buffer (45 %) [pH 4.0 adjusted with triethylamine]. The flow rate was monitored at 1.0 mL/min. The wavelength was selected for the detection was 276 nm.
Results:The retention times found for rabeprazole and mosapride was 2.946 and 4.186 min respectively. The % recovery was 99.98- 100.03 for rabeprazole and 99.97 - 100.02 for mosapride. The linearity was established in the range of 20-80 µg/mL for both rabeprazole and mosapride. The LOD for rabeprazole and mosapride were 0.01 and 0.035 µg/mL respectively. The LOQ for rabeprazole and mosapride were 0.032and 0.11 µg/mL respectively.
Conclusion:The proposed method was adequate sensitive, reproducible, and specific for the determination of rabeprazole and mosapride in bulk as well as in tablet dosage forms.


A SHORT REVIEW ON ZIKA VIRUS PAST, PRESENT STRATAGIES AND FUTURE PROSPECTIVES

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ABOUT AUTHORS
M .Manasa Rekha1*, A. Bharath Kumar1, T.Mubeena1, C. Gopinath2
1Department of Pharmacy Practice,

Annamacharya college of Pharmacy, Rajampet, Andhra Pradesh, India.
2Department of Phytopharmaceuticals and Pharmacognosy,
Annamacharya college of Pharmacy, Rajampet, Andhra Pradesh, India.
manasarekharoyal@gmail.com

Zika virus(ZIKV) is a member of the virus family Flaviviridae and the genus Flavivirus and It is transmitted Aedes mosquitoes like A. aegypti and A. albopictus,which are active at day times[1,2].


REVIEW ON: INDIAN MEDICINAL PLANTS HAVING ANTICANCER PROPERTY

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ABOUT AUTHORS
Nandu Kayande*, Rakesh Patel
Department of Pharmacy,
OPJS University, Churu, Rajasthan, India
* nandu_kayande@rediffmail.com

ABSTRACT
The traditional Indian medicine - Ayurveda, describes various herbs with anticancer as well as antioxidant properties. Various plant products have been used in treatment of cancer over the years. India is a peninsula of herbal hub, in which ayurvedics system of medicine has flourished as an enlightment in the field of Medicine. Currently medicinal plants have become the paramount source of drug discovery in research for treating diverse form of diseases including Cancer. In this review ayurvedas classical literature and evidence based research data were emphasized to explore the ayurvedic medicinal plants with potent anticancer activity.


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