Articles

A REVIEW ON GASTRORETENTIVE DRUG DELIVERY SYSTEMS

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ABOUT AUTHORS
Hemendrasinh J. Rathod*, Dhruti P. Mehta, Jitendra singh Yadav
Department of Pharmaceutics,
Vidyabharti Trust College of Pharmacy,
Umrakh, Gujarat, India.
* hariomh.j.rathod@gmail.com

ABSTRACT
The purpose of writing the review on gastroretentive drug delivery systems (GRDDS) was to accumulate the current literature with a special emphasis on several gastroretentive approaches that have recently become important methodologies in the field of site-specific orally administered sustained/controlled release drug delivery. Technological efforts have been made in research and development of rate-controlled oral drug delivery systems to solve physiological difficulties, like short gastric residence times (GRT) and unpredictable gastric emptying times (GET). GRDDS are an approach to prolong the GRT, thereby targeting site-specific drug release in the upper gastrointestinal tract (GIT) for local or systemic effect. Conventional oral dosage forms pose low bioavailability problems because of their quick gastric transition from the stomach, particularly in case of drugs that are less soluble at an alkaline pH of the intestine. Also, drugs that produce their local action in the stomach get quickly emptied and don’t get sufficient residence time in the stomach. Several efforts have been made to extend the retention time of drug delivery system to reduce the frequency of dose administration. GRDFs not only prolong dosing intervals, but also increase patient compliance beyond the level of existing controlled release dosage forms. This article gives an overview on advantages, disadvantages and characterization of gastroretentive drug delivery systems. This review also includes commercially available gastroretentive products and patents.


FORMULATION AND EVALUATION OF METFORMIN HYDROCHLORIDE BUCCAL PATCH

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ABOUT AUTHOR
S. Z. Chemate, Vaishali N. Garje*, Shubhada A. Gayake
Department of Pharmaceutics,
Padmashri Dr. Vithhalrao Vikhe Patil Foundation’s College of Pharmacy,
Ahmednagar, Maharashtra, India
*garjev@gmail.com

ABSTRACT
The aim of present investigation was to design and evaluate, mucoadhesive buccal patch of Metformin hydrochloride, a BCS class II drug, to provide unidirectional sustained drug delivery to the buccal mucosa that has potential to enhance the bioavailability. The patches were prepared using HPMC K4M as a polymer, polyethylene glycol 400 as a plasticizer, by solvent casting technique. The patches, which were prepared by the solvent casting method, were smooth and elegant in appearance; were uniform in thickness, weight and drug content; showed no visible cracks; and showed good folding endurance. The amount of polymer, which significantly influenced characteristics like swelling index, mucoadhesive strength, diffusion study


CHROMATOGRAPHY BASED CHEMOMETRIC FINGERPRINTING, ISOLATION & QUALITY CONTROL OF PHYTOCHEMICALS

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ABOUT AUTHOR
Deepak chowrasia
Institute of Pharmacy, CSJM University,
Kanpur, Uttar Pradesh
chowrasia.deepak@gmail.com

ABSTRACT
The present paper explores key consideration of different chromatographic procedures in phytochemical screening of natural products to investigate novel plant based therapeutically active compounds. Sophistication in instrumentation has sharpened the edges of chromatography making the technique an indispensable specialized laboratory as well as industrial tool for isolation, identification, and quality control of herbal products round the globe.


REGULATORY CANVAS OF INDIAN PHARMACEUTICAL INDUSTRY: CHALLENGES AND FUTURE

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Ayushi Srivastava*, Veena Gupta
QC Department,
Akums Drugs & Pharmaceuticals Ltd, Haridwar, India
*ayushisr@gmail.com

ABSTRACT
This article undertakes a review and assessment of regulatory framework in the Indian pharmaceutical industry. Understanding the regulatory circumstances in this segment is extremely critical. The Pharmaceutical industry is one of the major industries in India and it contributes a large share in the overall macro level growth of the India. It is one of the most dynamic sectors in the country but its compliance structure is more complex. The pharmaceutical industry has always been a buoyant sector in the eyes of Investors. With increasing returns, lower risks and high growth, investors are more interested in this industry than ever before.


IN VITRO EVALUATION OF ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES OF CHLOROFORM EXTRACT OF GARUGA PINNATA LEAVES

ABOUT AUTHOR
Sonia Zaman
Department of Pharmacy,
Southeast University, Banani, Dhaka, Bangladesh
sonia_6995@yahoo.com

ABSTRACT
Garuga pinnata
(family: Burseraceae) has many traditional medicinal uses including as astringent, bronchodilator, stomachic, expectorant, pulmonary infection, antidiabetic etc. The present study is based on this plant to evaluate the antimicrobial, antioxidant and cytotoxic properties of G. pinnata leaves. Antimicrobial activity of chloroform extract was evaluated against four Gram positive bacteria Bacillus megaterium, Bacillus subtilis, Sarcina lutea, Staphylococcus aureus and five Gram negative bacteria Escherichia coli, Pseudomonas aeruginosa, Salmonella paratyphi, Shigella dysentriae, Vibrio mimicus, and two common fungus Aspergillus niger, Candida albicans by applying disc diffusion method where Kanamycin disc (30 µg/disc) was used as reference standard. The chloroform extract of G. pinnata leaves showed very good antimicrobial activity against both gram positive and gram negative bacteria and fungus A. niger. The most susceptible microorganism was S. paratyphi (19 mm zone of inhibition) followed by B. subtilis (15 mm zone of inhibition). The antioxidant activity of chloroform extract of G. pinnata leaves was evaluated spectrophotometrically using 1,1-diphenyl-2-picrylhydrazyl (DPPH) for radical scavenging and  ascorbic acid was used as standard. The extract exhibited strong DPPH radical scavenging activity with IC50 value of 57.06 µg/ml as compared to the IC50 value of the reference standard, ascorbic acid (37.21 µg/ml). The cytotoxic activity of G. pinnata  was determined by brine shrimp lethality bioassay using vincristine sulfate as standard. The chloroform extract revealed significant cytotoxic activity with LC50 of 6.607 µg/ml whereas LC50 of Vincristine sulphate was 6.026 µg/ml.


EXTRACTION AND PURIFICATION OF NUCLEIC ACID USING CBNP & PCIA TECHNIQUE

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About Author
Nirav Soni
Department of Quality Assurance,
A-One Pharmacy College,
Anasan, Ahmedabad, Gujarat, India
nirav_sonic@yahoo.com

ABSTRACT
Isolation of Nucleic acid easily by Solid Phase Extraction (SPE) and this approach, using commercially available Extraction of nucleic acid column-based kits, requires no toxic chemicals and is a rapid and consistent method for concomitant protein extraction. It is a modern technique useful for separation of Nucleic acid which is  most reliable, less time consuming and separation of  impurities and continuity of reactive products using listed techniques like column-based nucleic acid purification, Nucleic acid methods& ethanol precipitation, DNA separation by silica adsorption. Buffer choice is significant to completely solubilized all proteins in the sample. This technique provides a simple and effective way to analyze protein and nucleic acids simultaneously from the same sample not affecting yield and quality.


REVIEW: COMBINED CANDESARTAN CILEXETIL AND PIOGLITAZONE HYDROCHLORIDE THERAPY IN METABOLIC SYNDROME

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Chauhan Sudhanshu*1,2, Savani Pankaj2, Solanki Divya2, Raj Hasumati2, Patel Sagar2
1Research Scholar 2015, Gujarat Technological University, Ahmedabad, Gujarat, India
2Department of Quality Assurance,
Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India
* sudhanshuchauhan32@yahoo.com

ABSTRACT
This review article presents the pharmacology of combined Candesartan Cilexetil and Pioglitazone Hydrochloride therapy specially in Metabolic syndrome. Candesartan Cilexetil is a antihypertensive agent. Pioglitazone Hydrochloride is a selectively stimulates nuclear receptor peroxisome proliferator activated receptor gamma (PPAR-gamma). The use of Candesartan Cilexetil in combination with Pioglitazone Hydrochloride has been proved to provide beneficial effect (Synergistic effect) in metabolic syndrome. The mechanism of Candesartan Cilexetil and Pioglitazone Hydrochloride is quite different. The combination of both also have anti inflammatory and enhanced organ protective effects. The main objective of this review article is to provide pharmacological information of combined therapy of Candesartan Cilexetil and Pioglitazone Hydrochloride to researcher in development of combined dosage form of this combination.


PHARMACOLOGY OF COMBINED MESALZINE AND RIFAXIMIN THERAPY TO INFLAMMATORY BOWEL DISEASE

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Prajapati Krishna V*, Raj Hasumati A, Jain Vinit C, Prajapati Neelam S.
Department of Quality Assurance,
Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat, India
*krish1112k@gmail.com

ABSTRACT
This review article presents the pharmacology of combined Mesalazine and Rifaximin therapy especially in inflammatory bowel disease. Mesalazine is used as in anti-inflammatory agent, Non-Steroidal. Rifaximin is used in Gastrointestinal Agents, Anti-infective agent. The use of Rifaximin in combination with Mesalazine has been proved to provide beneficial effect in inflammatory bowel disease. The mechanism of Mesalazine and Rifaximin is quite different. Mesalamine and Rifaximin are two different types of drugs offering some symptomatic relief to the IBD patients. Mesalamine treats inflammation, whereas, Rifaximin reduces bio burden.
Patent for combination of both drugs were approved by WIPO. The main objective of this review article is to provide pharmacological information of combined therapy of Mesalazine and Rifaximin to researcher in development of combined dosage form of this.


BIOTECHNOLOGICAL/BIOLOGICAL PRODUCTS: ABOUT ITS STABILITY TESTING

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ABOUT AUTHORS
Vivek P. Chavda1*, Dharmesh Shaliya2, Bhargav Patel3, Ashish Gabani4
1Department of Pharmaceutics, B.K. Mody Government Pharmacy College, Rajkot, Gujarat, India
2Quality Assurance, Intas Pharmaceuticals Ltd., Ahmedabad, Gujarat, India
3Quality Assurance, Zydus cadila pharmaceuticals Ltd., Ahmedabad, Gujarat, India
4 Intas Biopharmaceuticals Ltd., Ahmedabad, Gujarat, India

* vivek7chavda@gmail.com

ABSTRACT
The drug delivery systems have made some of the technological advances especially in the case of biopharmaceuticals. When one talks about biotechnological product stability of drug product becomes main culprit due to dynamic nature of drug molecule. This review is grafted using ICH and other regulatory guidelines to provide an overview to stability testing of such molecules.


A REVIEW ON: PRESERVATIVES USED IN PHARMACEUTICALS AND IMPACTS ON HEALTH

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ABOUT AUTHORS
Sabir M. Shaikh*1, Rajendra C. Doijad1, Amol S. Shete1, Poournima S. Sankpal2
1 Department of Pharmaceutics, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.
2 Department of Pharmaceutical chemistry, Shree Santkrupa College of Pharmacy, Ghogaon, Karad, Maharashtra, India.
*sabirmshaikh17@gmail.com

ABSTRACT
For several decades pharmacist have been aware of the need to protect their products against microbial contamination but it is only during the last one or perhaps two decades the serious thought of has been applied to the science of preservation. Preservatives are commonly used as additives in pharmaceutical products, food and cosmetics. Some of the liquid preparation are susceptible to microbial contamination because of the nature of ingredients present in it. Such preparation are protected by preservatives which avoids degradation and alteration of the product.A preservative is a natural or synthetic chemical added to various products which helps to prevent microbial decomposition. Present article deals with the study of ideal properties, classification, mechanism of action, Pharmaceutical applications and its impact on health of various preservatives used in pharmaceuticals.


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