Articles

H/H BLOOD GROUP SYSTEM: A RARE BLOOD GROUP

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ABOUT AUHTORS
L Reddenna1*, Dr. P. Venkatesh1, K Siva Kumar2, A Sai keshava Reddy2
1* Department of Pharmacy Practice,
Jagan’s College of Pharmacy,
Nellore, Andhra Pradesh, India
2 Department of Pharmacy Practice,
Nirmala College of Pharmacy, Kadapa, Andhra Pradesh, India
*reddennapharmd@gmail.com

ABSTRACT
The subsistence of a human H/h genetic polymorphism was first recognized by the innovation of an individual devoid of the H antigen on red cells in Bombay who had antibodies in plasma reacting with all the red cells exhibiting the normal red cell ABO phenotypes. These persons were genetically termed as homozygous hh or Bombay phenotype. H-deficient Bombay phenotype is exceptional, since it occurs in about 1 in 10,000 individuals in India and 1 per 1,000,000 individuals in Europe. After the first report of Oh phenotype from Mumbai in 1952 by Bhende, numerous other workers detected this weird phenotype in India. The complexity with the Bombay phenotype is that the individuals having blood group of Bombay phenotype (Oh) can either receive autologous donation or blood from an individual of Bombay phenotype only; no other blood will match in case of an emergency blood transfusion. The aim of present study was to communicate the information about rare blood entity and to review the previous case reports.


CLINICAL PHARMACIST SPECIALIZED CARE IN MANAGEMENT OF CONGESTIVE HEART FAILURE - A BRIEF REVIEW

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ABOUT AUHTORS
M.S.Umashankar*1, K.S.Lakshmi, A.Bharath Kumar, A.Porselvi
SRM College of Pharmacy,
SRM University, Kattankulathur,
Tamil Nadu, India

*abharatpharma@gmail.com

ABSTRACT : 
It is a critical clinical condition in which more abnormalities in cardiac structure and its functions may impact the ineffectiveness of the heart to supply required oxygen to meet the cellular metabolic demands of the body. Heart is covered with protective layers and express the various functions in the body. Clinically cardiac disease prevalence rises with individual age. Cardiac dysfunction happens because of changes in blood volume, and neurohumoral transmission status. These desirable mechanisms to maintain adequate cardiac output and arterial blood pressure. The neurohumoral responses act as compensatory mechanisms and provokes heart failure by increasing ventricular after load and increasing preload,which further elevates the cardiac failure. Health care system with a clinical pharmacist is well allocated to impact the disease management through identification of risk factors, stage of severity, educating the patients and health care practioners and implementing the awareness programmes, modification of life style interventions with in health care system beneficial to the community may reduce the progression of disease severity.


INDIAN DOCTOR, INDIAN PATIENTS & GENERICS: A TRIO OR OPPONENTS

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ABOUT AUHTORS
S.P.Sethy*, Tahseen Sameena, Prathima Patil
Department Of Pharmaceutical Chemistry,
Sushrut Institute of Pharmacy,
Medak, Andhra Pradesh, India

*sarada9439504350@gmail.com

ABSTRACT
This is a review aimed towards the current scenario of health care system in India with respect to the approach of Indian doctors towards the use of generics for a convenient and cost effective healthcare which is a major concern for all Indian citizens and this scenario should get clear for the betterment of Indian patient and the overall healthcare scenario in India. We can say the health care system is four tare system consisting doctors, patients, pharmacist and medicines, so there is a need to establish a significant relation between these four systems for a better health care facility in the country. In this review we have analyzed the Indian doctor’s perception status towards generic medicines, a patient’s feedback status towards generic medicines and from the side of pharmacist in dispensing generics medicines in India. We found that a major part of this system is running out of track and if it remains unsolved an Indian patient can’t expect a cost effective and efficient health services in future


A REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF ASPIRIN, CLOPIDOGREL BISULPHATEAND ROSUVASTATIN CALCIUMIN PHARMACEUTICAL DOSAGE FORM

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ABOUT AUHTORS
1Jyoti Yadav , 2Amit Sharma*
1Maharishi Dayanad University Rohatak
2 NIMS University, Jaipur

*amitsharma84945@gmail.com

ABSTRACT
This review article is intended to highlight the analytical methods of aspirin, clopidogrel and rosuvastatin in individual as well as combined pharmaceutical dosage form. Aspirin, clopidogrel and rosuvastatin play an important role in the various cardiovascular diseases. Aspirin and clopidogrel are the antiplatelet whereas Rosuvastatin is antilipemic agent which are used in the treatment of various cardiovascular diseases, cerebrovascular and peripheral vascular diseases. Now these days these drugs are easily available in the market in their individual form as well as in their combined dosage form. Aspirin, clopidogrel and rosuvastatin are official in the pharmacopoeias .Various analytical methods have been reported for the estimation of these drugs in their individual form as well as in their combined dosage form.


A REVIEW ON ALCOHOL DRINKING RELATED PROBLEM

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ABOUT AUHTORS
Babita A. Dodke*
, Sukeshini B. Lote, Monali B. Wawre, Priyanka R. Waghmare
Dr. R.G.Bhoyar Institute of Pharmaceuitical Education and Research Wardha

*babitadodke@gmail.com

ABSTRACT 
There are many forms of excessive drinking that cause substantial risk or harm to the individual. They include high level drinking each day, repeated episodes of drinking to intoxication, drinking that is actually causing physical or mental harm, and drinking that has resulted in the person becoming dependent or addicted to alcohol. Excessive drinking causes illness and distress to the drinker and his or her family and friends. It is a major cause of breakdown in relationships, trauma, hospitalization, prolonged disability and early death. Alcohol-related problems represent an immense economic loss to many communities around the world. Because alcohol is a small molecule it interacts with many neurotransmitter systems in the brain; this makes the action of alcohol in the brain very different from and much more complex than large molecules such as opiates, Alcohol does not lead to an increase of dopamine throughout the brain; it only causes an increase in dopamine in the area of the reward pathway. This reward pathway is comprised primarily of the nucleus accumbens, the VTA (ventral tegmental area), and a part of the prefrontal cortex   or amphetamine which simulate a specific neurotransmitter and interact with a specific neurotransmitter system. Alcoholism is a debilitating disorder for the individual and very costly for society this review article provides an evaluation of the literature on the alcohol drinking its effect on life and treatment of various harmful effects of alcohol.


NITAZOXANIDE: A REVIEW OF ANALYTICAL METHODS

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ABOUT AUHTORS
1Mr. Bhushan M. Firake*, 1Ms. Ranjini Chettiar, 2Mrs. Tejal B. Firake

1 Depertment of Pharmaceutical Analysis, JSPM’s Jayawantrao Sawant College of Pharmacy & Research, Hadapar, Pune.
2 Dignus Consulting Pvt. Ltd., Camp, Pune .

*bmf.jscopr@gmail.com

ABSTRACT: Nitazoxanide is an antiprotozoal and anthelmintic agent, which is mostly used in the treatment and prevention of wide variety of protozoa, helminthes and gram negative organisms.  This article studies published analytical techniques that are reported so far for the determination of nitazoxanide in bulk, pharmaceutical formulation and biological samples. They include various techniques like spectrophotometry, electrochemical methods, capillary electrophoresis, high performance liquid chromatography, high performance thin layer chromatography, and liquid chromatography-mass spectrophotometry.


MULTI ORGAN DYSFUNCTION FOLLOWING CONSUMPTION OF TUBERS OF GLORIOSA SUPERBA : A RARE CASE REPORT

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ABOUT AUHTORS
*K. Vinod1, B, Dr. N. Surendra Reddy1,Dr. K. Chandra Sekhar2, Dr. D. Ranganayakulu1

1Department of Pharmacy Practice,
Sri Padmavathi School of Pharmacy,
Tiruchanoor, Tirupati, India.
2 Department of General Medicine,
Sri Venkateswara Medical College,
Tirupati, Andhra Pradesh, India .

*drvinodkatiboina@gmail.com

ABSTRACT:
A 25 years married man was admitted on to emergency acute medical care unit. He had fallen ill after an afternoon meal from 4 days ago which consisted of rice and 3 tubers identified as gloriosa superb. About 3hrs after the ingestion, he developed abdominal pain, vomiting (15-20 episodes), and watery diarrhoea 15-20 episodes. He developed bleeding gums, yellowish discoloration, hematemesis 30-50 ml, 24episodes, haematuria, decreased urine output along with continued diarrhoea and vomiting. He was treated with iv fluids crystalloids and colloids titrated, 1 fresh frozen plasma (FFP), 1fresh platelet transfusion, inj. vit K, supportive treatment with close monitoring of vitals. Therapy as planned for ventilator support, however had ever had bleeding per rectum and hematemesis with aspiration, even with best available resuscitative efforts he succumbed to his illness and declared clinically dead after 36hrs of admission, his cause of death was given as multiorgan dysfunction see to gloriosa superb. Though poisoning with gloriosasuperba is rare it is mostly fatal and requires aggressive and prompt treatment is mandatory from saving the patient from death.


SIGNIFICANCE OF PHARMACEUTICAL REGULATORY BODIES - A REVIEW

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ABOUT AUHTORS
G. TARUN KUMAR REDDY *1, G. NAVEEN KUMAR REDDY 2
1 Department of Pharmaceutics and Drug regulatory affairs,
Annamacharya college of Pharmacy,
Rajampet, Kadapa, Andhra Pradesh, India.
2 Department of Pharmaceutical analysis,
Sri Padmavathi school of Pharmacy,
Chittoor, Andhra Pradesh, India.

*gtarunkreddy@gmail.com

ABSTRACT: 
The regulatory bodies are being established in various pharmaceutical industries across the globe which plays a vital role to meet the requirements of legal procedures related to drug development process in a country. The pharmaceutical industry is considered as the most highly regulated industries worldwide. The regulatory body ensures compliances in various legal and regulatory aspects of a drug. Countries possess their own regulatory authority, which is responsible for enforcing the rules and regulations and issue the guidelines to regulate drug development process, licensing, registration, manufacturing, marketing, labeling and the product life cycle of pharmaceutical products. In an ever-changing regulatory environment, the role of regulatory affairs personnel is essential to ensure compliance with legislation in all regions in which a company wishes to distribute its drug. This article describes about the development of the drugs as it is a cumbersome process which includes several months of time, volunteers, and a huge finical investment majorly through the funding process, so it is strictly regulated as per the norms and regulations as given by those individual countries to carry out the drug development which were generally governed by the Drug Regulatory Affairs Personals.


MICROMERITIC STUDY OF AZADIRACHTA INDICA HERBAL TABLET WITH ITS EVALUATION

ABOUT AUHTORS
*Ladi Alik kumar , Dash Priyadarshini , Nayak Chandan , Barri Prasanta kumar   Gayatri Institute of Science and Technology,
Gunupur, Rayagada,765022, Odisha
*alikkumar3@gmail.com

ABSTRACT
Neem is a large, dense evergreen tree in India growing 10-105m tall leaves divided into numerous leaflets. It has great healing power, acts as purifier, helps in treatment of eczema, leprosy and epiphoram.

The aim of the present work is to improvise the flow ability of herbal powders and minimized processing problems of herbal drug tablet. Macroscopic character of neem tree bark is thick, rough, brown in colour. leaf is alternate estipulate and are closely clustered towards the ends of the branches.
Micromeritic study is done using bulk density and tapped density, porosity, compressibility index, Carr’s index and Hausner’s ratio.
Preparation of extract of neem tablet is done by weight granulation method. It can be evaluated by weight variation, hardness test, friability test and disintegration test.
After all the evaluation is done, the prepared neem leaf passes all the Q.C test.


PREPARATION AND CHARACTERIZATION OF ETHYL CELLULOSE BASED SALBUTAMOL SULPHATE AND THEOPHYLLINE COMBINATION MICROSPHERE

ABOUT AUHTORS
*Nayak Chandan1, PadhiPriyanka1
Gayatri Institute of Science and Technology,
Gunupur Odisha, India
*nayakchandan279@gmail.com

ABSTRACT: 
The study is concerned with the development of Ethyl Cellulose microspheres by the o/w emulsification and solvent evaporation method in the presence of tween 80 as an emulsifying agent. The influence of process parameters such as solvent mixture, composition, concentration of the emulsifying agent and speed of stirring has been examined. The microspheres have been analysed for their size, drug loading capacity and drug release study. Spherical and smooth surfaced microspheres with desired encapsulation efficiencies were obtained. Slow drug release from microspheres observed up to6- 8 h. An optimization procedure was employed to investigate and identify the key parameters affecting the properties of the microspheres.


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