Articles

A REVIEW ON ANALYTICAL METHODS FOR RANOLAZINE DETERMINATION IN SYNTHETIC MIXTURE

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ABOUT AUTHORS:
Patel Vishakha. D.*, Raj Hasumati, Gheewala Nirav
Department of Quality Assurance,
Shree Dhanvantary Pharmacy College, Kim, Surat
vishuk7293@gmail.com

ABSTRACT
Ranolazine is a piperazine derivative is a new anti-ischemic drug for the treatment of angina.

Ranolazine is to inhibit late INa thus preventing sodium overload of the cell. As a consequence, ranolazine prevents reverse mode sodium–calcium exchange and thus diastolic accumulation of calcium possibly resulting in improved diastolic tone and improved coronary blood flow.

This review article represent the various analytical methods which has been reported for estimation of Ranolazine in synthetic mixture. The spectrophotometric techniques like fluorescent assay and area under curve spectroscopy; Chromatogrraphic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.


EFFECTS OF GARLIC EXTRACTS ON THE MYOCARDIUM OF LEFT VENTRICLE OF THE HEART OF HIGH SALT FED ADULT WISTAR RATS

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ABOUT AUTHORS:
*Saka, O. S; Olayode, A. A; Adelodun, S. T
Department of Anatomy and Cell Biology,
Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria.
olusolasaka1@gmail.com

ABSTRACT
This study was designed to evaluate the effects of garlic extracts on the morphology of myocardium of left ventricle of the heart and also determine the body weight and relative weight of the organs on high salt fed adult Wistar rats. Twenty-five healthy female Wistar rats weighing 130-180 g were randomly assigned into 5 groups of 5 rats each (Groups A, B, C, D and E). Rats in group A was fed with standard laboratory pellets, while groups B, C, D and E were fed on the high-salt diet for five weeks. Thereafter, daily administration of 50 mg kg-1, 100 mg kg-1 and 150 mg kg-1 of the garlic extract were giving orally to groups C, D and E respectively for 3 weeks. The rats were sacrificed under ketamine anesthesia (5mg/kg i.m). The left ventricle of the heart was excised, processed routinely in paraffin wax and stained with routine special stained. Result showed significant decreased (p<0.05) in weight of all high salt fed groups when (F=46.90, p<0.05) compared with control. Whereas, treatment with garlic extract help in weight management in high salt fed+garlic extract treated groups and also no significant difference (p<0.05) in the relative heart weight when (F=1.773, p<0.05) compared the control with other groups. Histological results revealed morphological alterations in the left ventricle in high salt fed group. In conclusion, Garlic extract has ameliorative property at the level of 100 mg kg-1 or 150 mg kg-1 of the extract on high salt fed induced cardiac injury.


COMMONLY USED MEDICINAL PLANTS IN TEHSIL PACHHAD, DISTRICT SIRMOUR, HIMACHAL PRADESH

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ABOUT AUTHORS:
Shubham Sharma*1, Monika Rana2
1Abhilashi College of Pharmacy, Mandi (H.P)
2Abhilashi University, Mandi (H.P)
Shubhamcoolsharma045@gmail.com

ABSTRACT
Himachal Pradesh is located in Western Himalaya, is a store house of medicinal plants. Most of the population lives in villages and use various plants for their basic needs such as food, fodder, wood and to treat various diseases.  The present study is carried out in district Sirmour of Himachal Pradesh, regarding the ethno medicinal plants used by the locals in their own traditional health system. This study reveals the status of ethno-medicinal plants and their importance preserved by locals of Distt Sirmour. The paper encompasses the 43 medicinal plants. These plants were collected from different villages of Sirmour Distt and information was collected from locals peoples.


INDIAN PHARMACEUTICAL INDUSTRY-A PLETHORA OF SUSTAINABLE GROWTH OPPORTUNITIES FOR PHARMA BUSINESS ASPIRANTS

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ABOUT AUTHORS:
Rhit Srivastava*, Saurabh Kumar Banerjee
School of pharmaceutical management,
The IIHMR University, Jaipur,
Rajasthan, India
rhitsrivastava@gmail.com

INTRODCUTION
Worldwide the Pharmaceutical industry dynamics is undergoing a significant transformation in terms of cutting edge advancement in the areas of pharmaceutical R&D specially the biotechnology based products, innovative drug delivery technologies, and large scale efficient pharmaceutical manufacturing capacities and so on. According to the list published by FDA for GMP facilities producing generic drug products and APIs for the US market 70% of the APIs and FDFs (Finished dosage Form Facilities) are produced outside US and India counts for 23.7 % of the API and FDF facilities and is by far the largest country exporting to the US. Even China counts for less than a half of the FDF and API facilities exporting to the US, as compared to India[1]


DETERMINATION OF ANTIBACTERIAL, ANTIFUNGAL AND CYTOTOXIC ACTIVITIES OF N-HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS OF MOMORDICA CHARANTIA LEAVES

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ABOUT AUTHOR:
Israt Jahan Bulbul
Department of Pharmacy,
Southeast University Banani, Dhaka, Bangladesh
israt_jahanb872@yahoo.com

ABSTRACT
A study was conducted to determine the antibacterial and antifungal activitieswith minimum inhibitory concentration and cytotoxic activity of Momordica charantia (Family: Cucurbitaceae) leaves. In our present study, the antimicroial activity of n-hexane, chloroform and ethyl acetate fractions of the plant were investigated against a number of pathogenic Gram-positive (Bacillus megaterium, Bacillus subtilis, Staphylococcus aureus and Sarcina lutea), Gram- negative (Salmonella paratyphi, Salmonella typhi, Vibrio parahaemolyticus, Vibrio mimicus, Escherichia coli, Shigella dysenteriae, Shigella boydii and Pseudomonas aeruginosa) bacteria and three funguses (Candida albicans, Aspergillus niger and Saccharomyces cerevesiae). Here the zones of inhibitions for the test samples (500 µg /disc) werecompared with that of reference standard (30 µg /disc) in determining antimicrobial activity. All the extracts showed significant antibacterial and antifungal activities against all the pathogenic bacteria except A. niger. The highest sensitivity for n-hexane, chloroform and ethyl acetate fractionswas against gram positive bacteria B.cereus. Almost all the gram positive, gram negative bacteria and fungus were inhibited by ethyl acetate extract and showed better activity compared to n-hexane and chloroform extracts. All the three fractions were tested as antifungal against C. albicans and S. cerevesiae. They showed moderate activity against C. albicans whereas a very good activity against S. cerevesiae. But A. niger was not sensitive to the experimental extracts.Minimum inhibitory concentration (MIC) that is the lowest concentration at which the test sample shows its highest activity against microorganisms was tested by serial dilution method. The MIC for n-Hexane and chloroform extracts was against B. cereus (64 µg /ml).  The ethyl acetate extract exhibited antibacterial activity with MIC of 64 µg /ml against S. aureus, S. luteae, S. boydii, S. dysentereae and V. mimicus. The Brine shrimp lethality bioassay method was used to determine the cytotoxic activity and vincristine sulphate was used as positive control. The LC50 values of standard vincristine sulphate, n-hexane, chloroform and ethyl acetate extract were 10.18 µg /ml, 24.71 µg /ml, 19.02 µg /ml and 30.38 µg/ml respectively which indicate the presence of bioactive compounds present in the plant extracts are promisingly cytotoxic.


DIFFERENCE SPECTROPHOTOMETRIC ESTIMATION OF CAPECITABINE FROM TABLET DOSAGE FORM

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ABOUT AUTHORS:
Rohit A. Patil, Rajendra C. Doijad, Pravin D.Lade, Pournima S. Sankpal
Department of Pharmaceutical Chemistry,
Shree Santkrupa College of Pharmacy,
Ghogaon, Karad (M.S.) India
rohitpharma3250@gmail.com

ABSTRACT:
Simple, sensitive and specific spectrophotometric method were developed and validated for quantification of CAPECITABINE (CAP) by difference spectroscopy. CAP exhibits a substantial difference in absorbance in the two solvents that is in 0.01 N HCL and 0.01 N NAOH at 295 nm. Beer’s law was obeyed in the concentration range of 1 to 20 µg ml-1for CAP. Results of tablet analysis showed standard deviation in the range of 98.42 to 101.95 % for CAP which indicate repeatability of the method. The results indicated excellent recoveries ranging from 98.45 to 101.70 % for CAP with a mean of 99.12 %. Recoveries obtained do not differ significantly from 100% showed that there was no interference from the common excipients used in the tablet formulation indicating accuracy and reliability of the method.


AN OVERVIEW ON NIOSOMES A NOVEL VESICULAR APPROACH FOR OPHTHALMIC DRUG DELIVERY

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ABOUT AUTHORS:
Anupriya Kapoor
University Institute Of Pharmacy,
Chhatrapati Shahu Ji Maharaj University, Kanpur
anupriya321@gmail.com

ABSTRACT
Non-ionic surfactant vesicles (Niosomes or NSVS) are widely studied as an alternative to hydrated surfactant monomers. Non-ionic surfactants of wide structural types have been found to be useful alternatives to phospholipids in fabrication of vesicular system. They are the microlamellar structures formed by the mixing of Non-ionic surfactant of alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. This review article deals with the detailed use of Niosome as novel drug delivery system for ophthalmic use, since this route is most frequently used for the treatment of eye infection.


TOMATO CUISINES: A DELECTABLE REJOINDER TO THREAT OF CHRONIC AILMENTS?

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ABOUT AUTHORS:
Vikram S. Chauhan1*, Bina Rani2, Priyanka Bishnoi3, Raaz K. Maheshwari3

1
Department of Botany, SBRM Govt PG College, Nagaur, Rajasthan, India
2Department of Engineering chemistry & Environmental Engineering, Poornima College of Engineering, Jaipur, India
3Department of Chemistry, SBRM Government PG College, Nagaur, Rajasthan, India
*vikkysingh2000@yahoo.com; rkmgreenchem.jaipur@gmail.com

ABSTRACT
With the advent of modern times, stress and pollution have led to major effect on rise of death toll due to chronic diseases. Such diseases are major cause of concern for the medical society. Lycopene, a carotenoid pigment found in tomatoes and its products has antioxidant properties due to the presence of numerous double bonds. Increased consumption of lycopene containing diet has been proposed to offer a protection against many types of cancers and cardio-vascular diseases. Its potential role as nutraceutical has been suggested in many studies. The present review deals with fundamental biochemistry, bio-availability and benefits of lycopene rich diet and its relation with some chronic diseases like various forms of cancers and cardiovascular diseases.


STUDY ON AGARWOOD (AQUILARIA MALACCENSIS) TO EVALUATE ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF N – HEXANE, CHLOROFORM AND ETHYL ACETATE EXTRACTS

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ABOUT AUTHOR:
Yesmin Begum
Department of Pharmacy,
Southeast University, Banani, Dhaka
yesumyta@gmail.com

ABSTRACT
The present research aims to investigate the antibacterial and antioxidant activities of different leaf extracts of Aquillaria malaccensis. Antibacterial tests were done by Disc diffusion method using Kanamycin as standard. The chloroform extract showed good antibacterial activity against Shigella boydii and Escherichia coli with 19 mm and 17 mm zone of inhibition respectively. All other extracts showed mild to moderate antibacterial activity against other bacteria with 7 – 16mm zone of inhibition. The antioxidant activity of the extracts was determined by using DPPH spectrophotometrically and ascorbic acid was used as standard. All three extracts showed significant antioxidant activities having IC50 value of 38.96 µg/ml, 39.63 µg/ml and 64.75 µg/ml for ethyl acetate, n –hexane and chloroform extracts respectively.


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