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IN-VITRO SCREENING OF DHATURA INOXIA FOR ITS ANTI-MALARIAL ACTIVITY AGAINST P. FALCIPARUM

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ABOUT AUTHORS:
S.O. Pratap1,2, Ruchi Gaur3, R.Stephan4, J.L bhatt3, C.R. Pillai1, Usha Devi1
1Department of  Parasitology, Malaria Research Center, New Delhi
2Department of  Biotechnology, SR Group of Institutions, Jhansi, UP
3School of Life Science, ITM University Gwalior, MP
4Department of Botany, Government P.G. College Ariyalur, Tamilnadu, India
dixitshivom@gmail.com

ABSTRACT
The natural products are important source of biologically active compounds having potential for developing a novel malaria drug. Malaria is one of the most important infectious vector born parasitic disease caused by Coccidian protozoan parasite of genus Plasmodium carried out by mosquito, invade red blood cells. Malaria is thousand times more complex than any disease. In the current study, a natural ingredient of herb; Dhatura Inoxia is analyzed, for its anti-malarial activity by preparing crude extract of water and ethanol, analyzed on schizont stage of plasmodial life cycle against two Chloroquine strains: sensitive and resistant of Plasmodium falciparum isolates. The results revealed that IC50 values of crude water extract was recorded as; 71± 1.41µg/ml and 105±7.07 while as the ethanol crude extract produced IC50 concentrates: 52±3.53 µg/ml and 59.5± 70 µg/ml against sensitive and resistant P. f. isolates, respectively. The results showed that this herb plant possess significant antiplasmodial activity in terms of IC50 as recorded in this study.


A REVIEW ON PHARM.D EDUCATION IN INDIA

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About Authors:
Gayathri Krishnamoorthy, Kanaka Durga Vadlapatla, Rini Susan Varghese, Britto Duraisingh*
Department of Pharmacy Practice,
PSG College of Pharmacy,
Coimbatore, Tamil Nadu
*brittopharmaco@gmail.com

Abstract:
The intention behind this piece of review work is to enable every single individual thoroughly understand this emerging field in Indian pharmacy that is Pharm.D, newly introduced in 2008 by the Pharmacy Council of India. It gives a direct doctorate degree after five years of college and one year internship in a hospital. This paper highlighted all the information regarding the prospectus of this field in India, colleges offering this course, scope, roles and responsibilities and feedback from student, intern and clinical pharmacist. Pharm.D is already well recognised in United States of America and majority of the gulf countries. Let’s look forward for an eye-opening future in India!!!!


SOLID DISPERSION: A TOOL TO ENHANCE SOLUBILITY OF POORLY WATER SOLUBLE DRUGS

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ABOUT AUTHORS:
Ravindra M Hanwate*1, Dehghan M H G2, Saifee M2
1Department of Pharmaceutics, Dr.Vedprakash Patil College Of Pharmacy, Auranganad, Maharashtra, India
2Department of Pharmaceutics, Y.B.Chavan College of Pharmacy, Aurangabad, Maharashtra, India
* ravi_hanwate@yahoo.co.in

ABSTRACT
Solid dispersions have been used to increase the dissolution rates of poorly water soluble drugs. Many methods are used to prepare solid dispersions. This paper reports various solubility enhancement strategies in solid dispersion. The methods described are fusion (melting), solvent evaporation, lyophilization (freeze drying), melt agglomeration process, spray drying technology, use of surfactant. The paper also shows study of characterization, selection of carriers, potential applications and limitations of these methods in solid dispersion.


MICROSCOPICAL AND PRELIMINARY PHYTOCHEMICAL SCREENING OF ‘Piper betel’

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About Authors:
Kambham Venkateswarlu1, N.Devanna2, N.B.L.Prasad3
1M.Pharm Scholar, Department Of Pharmaceutics,
2Director of JNTUA-Oil Technological Research Institute,
3Head of Examination branch-JNTUA-OTRI
k.v.reddy9441701016@gmail.com

Abstract:
The aim of the present study was to develop the microscopical authentication for the selected leaf of piper betel from the literature were the microscopical evidence is not available earlier and also to develop the pharmacognostic evaluation for the leaf of the crude drug and to evaluate the pharmacognostic parameters of the piper betel leaf. This work has clearly shown that the microscopical evidence for the leaf and what are the phytoconstituents present in the leaf.


ASPERGILLOMA SYNDROME

ABOUT AUTHOR:
Akshay Rajgaria, Prajna Tripathy
Kanak Manjari Institute of pharmaceutical Sciences.
Rourkela, Orissa
akshaykrish2007@gmail.com

ABSTRACT:
An aspergilloma, also known as a mycetoma or fungus ball, is a clump of fungus which exists in a body cavity such as the lung. It is associated with the Aspergillus species, but Zygomycota and Fusarium may also form similar structures


RATIONAL USE OF MEDICINES: CAN WE PROMOTE

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About Authors:
Languluri Reddenna
Department of Pharmacy Practice,
Rajiv Gandhi Institute of Medical Sciences,
Kadapa, Andhra Pradesh, India-516003
reddennapharmd@gmail.com

Abstract
Rational use of drugs can be defined as prescribing the right drug, in sufficient dose for the adequate duration and suitable to the clinical requirements of the patients at least cost. Causes of irrational use comprise not have of knowledge, skills or self-determining information, unhampered accessibility of medicines, overburden of health personnel, unsuitable promotion of medicines and earnings motives from selling medicines. In appropriate drug usecan have dire consequences; it has been associated with hospitalization and evencaused deaths of inpatients in health carefacilities. A variety of situations and circumstancespromote irrational use of medicines.Rational use of medication saves lives, confines undesired toxicity, adverse events and maximize on the benefits that can be imitative from best use of medications. According to surveys conducted in 2004 by HAI Africa and WHO in 11 Sub-Saharan Africa countries in 2004, the average accessibility of the essential medicines in public health facilities was below 70%. Communication between professionals and consumers is essential to the enhancement of rational use of medicines. It is essential to recommence collaboration of physicians and pharmacists concerning accurate and competent drugs prescribing. Governments, private health care institutions, entity health care providers and patients all have an accountability to endorse rational use of medicines. Professionals should provide information to the customers about the name of the medicine, the intention for which the medicine is being taken, dose, frequency of use, and duration of use.


INTERLEUKINS IN THERAPEUTICS

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ABOUT AUTHOR:
Anjan Khadka
Department of Pharmacology,
AFMC, Pune, India
anjankhadka14@yahoo.com

ABSTRACT:
Interleukins are a subset of a larger group of cellular messenger molecules called cytokines, which are modulators of cellular behaviour. On the basis of their respective cytokine profiles, responses to chemokines, and interactions with other cells, these T-cell subsets can promote different types of inflammatory responses. During the development of allergic disease, effector TH2 cells produce IL-4, IL-5, IL-9, and IL-32.  IL-25, IL- 31, and IL-33 contributes to TH2 responses and inflammation. These cytokines have roles in production of allergen-specific IgE, eosinophilia, and mucus. ILs have role in therapeutics as well as diagnosis and prognosis as biomarker in various conditions. Therapeutic targeting of the IL considered to be rational treatment strategy and promising biologic therapy.


A REVIEW ON INTERSTITIAL CYSTITIS SYNDROME (ICS)

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About Authors:
M Sushma*, TVV Vidyadhar, R Mohanraj, M Babu
Department of Pharmacy Practice, Raghavendra Institute of Pharmaceutical Education & Research (RIPER),
K R Palli Cross, Near S.K University, Anantapuramu District, Andhra Pradesh, INDIA.
*sushma.banthi@gmail.com

Abstract:
Interstitial cystitis (IC) is an irritative bladder syndrome of multifactorial aetiology and is said to be one of the several conditions that causes bladder pain, which is most commonly seen in women than in men. It is of unknown aetiology. But some factors like autoimmune disorder, Genetic predisposition, Gynaecologic surgery in the past, History of recurrent UTIs. The body's immune system attacks the bladder, similar to other autoimmune conditions. The urologist may use a special scope called a cytoscope to look inside your bladder for inflammation, pinpoint bleeding. Management of IC is done by oral therapy of pentosanpolysulphate, Tricyclic anti-depressants, Anti-histamines, Non-steroidal anti-inflammatory drugs, Bladder analgesics. Whereas intravesical therapy Dimethyl sulphoxide, heparin, Bacillus calmette-Guerin


KNOCKDOWN (MICRO-RNA INHIBITING TECHNIQUE) TECHNIQUE FOR EVALUATION OF ALPHA-1A ADRENERGIC RECEPTOR AND P2X1 RECEPTOR FUNCTIONS

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About Authors:
Emanual Michael Patelia*, Emma Spiking
University of Bedfordshire, England,
United Kingdom, LU1 3JU
ricky.emanual@gmail.com

Abstract
The new approach regarding the knocking down the protein expression by the use of shmRNA complimentary to the mRNA sequence of the respected protein expression have a major impact on the research area. The knockdown of P2X1 and ADRA1A genes have no effect on chromosomal DNA but have a lack of effect on expression of P2X1 and α1A receptors. The produced genetically engineered male mice can be of 100% infertile. The simple PCR (polymerase chain reaction) based approach can be used for the generation of knockdown cell lines. The Animals should have the treatments according to the guidelines mentioned under international society for applied ethnology. The SIRION biotech have shown the managed shRNA knockdown of about 90% significance interval.


A REVIEW: ATHEROSCLEROSIS & ITS TREATMENT

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About Author:
Mr. Yogesh K. Patil
Lecturer, Department of Pharmacology,
Shree Mahavir Institute of Pharmacy,
Nashik.
yogesh_kpatil85@yahoo.co.in

Abstract:
Atherosclerosis is deposition of fatty substances into the inner wall of blood vessels. Due to deposition of lipid material into blood vessels there is restricted flow to blood to various organs like kidney, heart, lungs etc. To overcome this effect various drugs available in market like statins, fibrates etc. There is also way to clean lipid from inner lining of blood vessels through surgery which is last step of treatment. There are mainly two surgeries available that is bypass surgery of heart and angioplasty.