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Parmar Krutin D.1*, Pandya Kirtan B.2, Gajjar Alpesh M.3, Zala Shivraj D.3, Kela Amit N.1, Nathani Hitesh S.1
1*C. U. Shah College of Pharmacy and Research, Wadhwan city, Surendranagar, Gujarat, India.
2 Shree Balaji pharmacy college, Jaipur, Rajasthan, India.
3Shree V.B. Manvar college of pharmacy, Upleta, Gujarat, India.
Tablet coating is perhaps one of the oldest pharmaceutical processes still in existence. Earlier, Sugar coating was adopted for pharmaceutical as from confectionary industry. But as it was tedious process and required skilled manipulation, film coating was started to be preferred over sugar coating. Development of film coating was mainly based on solutions of different polymers in various organic solvents. All these solvents are toxic in nature. Nobody ever was concerned about the problems like material cost, toxic effects due to coating or pollution etc. In today's competitive business environment, any cost saved will improve the market viability and success of any product. Therefore, left with no other choice but to eliminate the use of organic solvents and to start using water as the solvent system for tablet coating.
The main focus of this review is, to study various aspects of aqueous based film coating.
Master’s In Clinical Biochemistry
University Of Kashmir
There has been increasing public concern that chemicals in the environment are affecting human health by disrupting normal endocrine function. The exposure to these chemicals with steroid-like activity can disrupt normal endocrine function leading to altered reproductive capacity, infertility, endometriosis and breast and uterine cancer. In order to detect and evaluate the safety of such chemicals, several rodent experimental models have been developed. The OECD Enhanced Test Guideline 407 (repeated 28-day oral dose toxicity study) is one of rodent experimental models for detection of endocrine disrupters of these chemicals .
DEVELOPMENT AND VALIDATION OF FIRST ORDER DERIVATIVE METHOD FOR ANALYSIS OF EPERISONE HYDROCHLORIDE AND LORNOXICAM IN SYNTHETIC MIXTURE
Harshil R. Patel*, Sejal K. Patel
Department of Quality Assurance,
S. K. Patel College of Pharmaceutical Education and Research,
Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical derivative spectroscopic methodfor the simultaneous determination of Eperisone Hydrochloride(EPE) and Lornoxicam (LOR) in synthetic mixture. Derivative spectroscopy offers a useful approach for the analysis of drugs in mixtures. In this study a first-derivative spectroscopic method was used for simultaneous determination of Eperisone Hydrochloride and Lornoxicam using the zero-crossing technique. The measurements were carried out at wavelengths of 264 nm and 225.2 nm for Eperisone Hydrochloride and Lornoxicam respectively. The method was found to be linear (r2>0.998) in the range of 2- 30 μg/ml for Eperisone Hydrochloride at 264 nm. The linear correlation was obtained (r2>0.996) in the range of 2-14 μg/ml for Lornoxicam at 225.2 nm. The limit of detection was 0.2565 and 0.235 μg/ml for Eperisone Hydrochloride and Lornoxicam respectively. The limit of quantification was 0.7774 and 0.7121 μg/ml respectively. The method was successfully applied for simultaneous determination of Eperisone Hydrochloride and Lornoxicam in synthetic mixture.
Sanjay Singh Bhandari *, Mahaveer Prasad Kabra, Raman Gupta, Ami Sharma
Kota College of Pharmacy, SP-1, RIICO Industrial Area, Ranpur,
Jhalawar road, Kota, Rajasthan, India – 324009
Damage to cells caused by free radicals is believed play a central role in the aging process and in disease progression. Antioxidants are our first line of defense against free radical damage, and are critical for maintaining optimum health and well being. The need for antioxidants becomes even more critical with increased exposure to free radicals. Pollution, cigarette smoke, drugs, illness, stress, and even exercise can increase free radical exposure. Because so many factors can contribute to oxidative stress, individual assessment of susceptibility becomes important. Many experts believe that the Recommended Dietary Allowance (RDA) for specific antioxidants may be inadequate and, in some instances, the need may be several times the RDA. As part of a healthy lifestyle and a well-balanced, wholesome diet, antioxidant supplementation is now being recognized as an important means of improving free radical protection.
ANALYTICAL METHOD DEVELOPMENT OF MONTELUKAST AND FEXOFINADINE COMBINATION IN PHARMACEUTICAL DOSAGE FORM BY USING HPLC METHOD
Rituraj Singh Chundawat*, Yuvraj Singh Sarangdevot, Bhupendra Vyas, Gajendra Singh Rathore, Udaibhan Singh Rathore, Pankaj Sharma
Department of Quality Assurance, Bhupal Nobles’ College of Pharmacy,
Udaipur- 313002, Rajasthan, India
Pharmaceutical analysis may be defined as a process or a sequence of processes to identify and/or quantify a substance or drug, the components of a pharmaceutical solution or mixture or the determination of the structures of chemical compounds used in the formulation of pharmaceutical product. HPLC is the most rapid and reliable analytical technique for analysis of drugs. Its simplicity, high specificity and wide range of sensitivity makes it ideal for analysis of many drugs in both dosage forms and biological fluids. Montelukast is a CysLT1 antagonist which blocks the action of leukotriene D4 (and secondary ligands LTC4 and LTE4) on the cysteinyl leukotriene receptor CysLT1 in the lungs and used in asthma. Fexofenadine competes with free histamine for binding at H1-receptors in the GI tract, large blood vessels, and bronchial smooth muscle. It blocks the action of endogenous histamine and relieves from allergy. The analytical method development of Montelukast and Fexofinadine combination in pharmaceutical dosage form is done by using HPLC method.
1Abhijeet Welankiwar*, Sushant tope.
1Government College of pharmacy
kathora naka Amravati (Maharashtra) 444604.
The validation is a Fundamental segment that supports to a commitment of company towards quality assurance. It also assures that product meets its predetermined quality specification and quality characteristics. Validation of individual step of manufacturing is called as process validation. Here this article concerns with the process validation of tablet dosage form which has a numerous advantages over other dosage forms. The objective is to present a review and to discuss aspects of validation in terms of pharmaceutical unit operations; that is, those individual technical operations that comprise the various steps involved in product design and evaluation.
Vishal V. Timaliya*, Prof.Mital v. Dalal
Gujarat Technical University
The main objectives of this study were the prevalence of depression and cognitive function impairments in patients undergoing hemodialysis.
An observational study performed on 60 patients with CKD stage IV and V undergoing hemodialysis two or three times in a week and CKD stage I to III without hemodialysis. Depressive symptomatology, defined by a Center for Epidemiological Studies Depression Scale (CES-D) score of 16 or higher and cognitive function measured by Mini Mental State Examination (MMSE) questionnaire. All data was analyzed by MS excel and Graph pad Prism 5.0.
Dhananjay R. Abhang*, Sudhir S. Waghmode, Raju K.Hire, GangurdeA.B, Kasar S.A, Bairagi V.A
K.B.H.S.S.Trust’s Institute of Pharmacy, Bhaygaon road,
Malegaon camp, Malegaon,
Dist: Nasik– 423 105, Maharashtra, India.
Drug care considered as one of the most important formulation approaches for poorly soluble drugs.Nanocrystal dispersions comprise water, active drug substance and a stabilizer. They are physically stable due to the presence of stabilizers that prevent reagragregation of the active drug substance. Different techniques can be used to prepare nanocrystal formulations of a drug powder such as high-pressure homogenization, sol gel method, micro fluidization, co precipitation, spray drying and milling. Nanocrystals are considered as first choice in case simpler formulation approaches as. The number of poorly soluble actives which cannot be formulated by traditional approaches is steadily increasing. In addition optimised nanocrystals formulations can reduce distinctly side effects; therefore they might also replace existing products. Each system can be improved which was achieved with the smart Crystals as second generation of drug nanocrystals. There are several advantages of nanocrystal formulations such as, enhanced oral bioavailability, improved dose proportionality, reduced food effects, suitability for administration by all routes and possibility of sterile filtration due to decreased particle size range.
M.Sc in Clinical Research
Osteoarthritis is one type of degenerative joint disease and also known as chronic musculoskeletal disease and it occurs mainly in elderly patients with the severe cause of disability. There are approximately 30 million persons affected with severe osteoarthritis and about 26 million persons are affected with severe osteoarthritis in United States only. The approximate annual cost to the public society in medical care is expected to reach 100 billion dollars by the end of 2020. From this much of cost, most of the cost is spent only in finding out the new diagnosis and treatment for this severe disease and also for the prevention of side effects. Today till 2010, 50% of the persons with the age over 75 suffer from the knee osteoarthritis. 80% of the aged persons with knee osteoarthritis feel difficulty in daily routine activities, while 20 % of the aged persons with mild osteoarthritis feel no difficulty in their daily routine activities.
In this disorder, the joint loses the slippery cartilage those results from ‘wear and tear’ on a joint. Thus the joint becomes large, thick and painful. Thus the bone near the cartilage tries to change and produce overgrowth of the bone. That’s why the tissue near the bone becomes inflamed and ligaments lose and joint muscle becomes weak. So the people with osteoarthritis feel pain when they are doing their normal routine activities.
Dipal Patel*1, Dr. Kamal Singh Rathore1, Dr. O.P.Mahatma1, Twinkal Patel2
1B.N. Institute of Pharmaceutical Sciences, Udaipur (Rajasthan), 313001
2Shree Sarvajanik College of Pharmacy, Mahesana (Gujarat).
Asthma is a respiratory disease that affects both adults and children and asthma is today one of the most common chronic childhood ailments. There is no scientifically proven cure for asthma but it can be controlled and regulated. Natural treatments for asthma are meant to complement, or as an addition, to your existing medication but never as a replacement. Before using an herbal asthma remedy keep in mind that medicinal herbs can be as powerful as pharmaceutical drugs and should be treated as such so it is important to seek the support of your health care provider as some natural herbs for asthma treatment may conflict with pharmaceuticals commonly prescribed for asthma.