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PRESCRIBING TREND OF ANTIHYPERTENSIVE DRUGS IN SRI GANGANAGAR DISTRICT: A RETROSPECTIVE STUDY

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ABOUT AUTHORS:
Amarjeet Singh*, Sudeep Bhardwaj, Ashutosh Aggarwal
Department of Pharmacology,
Seth G. L. Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research,
Sri Ganganagar, Rajasthan 335001, India
*amarjeetsingh024@gmail.com

ABSTRACT
Objective
: The choice of drug for the treatment of hypertension changes at short intervals. Drug utilization studiesconducted at regular intervals help to guide the physician in prescribing drugs rationally. The present study was done toanalyze the prescribing patterns of antihypertensive drugs in a NorthIndian  hospital.

Material & method: A retrospective, crosssectional analysis of prescriptions of antihypertensive cases admitted in Medicine in-patient wards of civil hospital of Sri Ganganagar was conducted. All the prescription files with diagnosis ofessential hypertension were analyzed. Prescriptions for hypertension with other co-morbid conditions were also included. Frequency and proportions of utilization of antihypertensive medications were charted and figured.

Result: During the studyperiod, there were 435 prescriptions for essential hypertension. The most frequently prescribed antihypertensive medications were:  monotherapy (42.06%), (57.94%) of patients were on multiple drugtherapy, the most favored fixed drug combination being diuretics with angiotensin receptor blockers (31.74%).

Conclusion: The present study revealed that Angiotensin receptor blockers arethe drugs of choice as monotherapy and as combination therapy for hypertensives. This pattern of prescription is also supported by the current JNC VIII guidelines for the treatment of hypertension.


MOLECULAR MODELING STUDIED FOR INHIBITION OF CALCIUM CHANNEL RECEPTOR: A STRATEGY FOR THE DEVELOPMENT OF NEW ANTIEPILEPTIC DRUG

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ABOUT AUTHORS:
Vinit Raj*, Amit Rai, Deepak Kumar and Vinod Kumar
Department of Pharmaceutical Sciences,
Babasaheb Bhimrao Ambedkar University (A Central University),
VidyaVihar, Raebreli Road, Lucknow, Uttar Pradesh, 226025, India
*raj.vinit24@gmail.com

ABSTRACT
Epilepsy is a common brain disease that is characterized by recurrent and spontaneous seizures that result from abnormal and excessive synchronization of neuronal activity. Whereas, accumulation of Ca++ in presynaptic terminals, leading to improved neurotransmitter release. In additional, depolarization-induced inauguration of the NMDA subtype of the excitatory amino acid receptor, which causes more Ca++ influx and neuronal activation. The main aim of this study to focus on the deactivation of Ca++ influx and prevent the augmentation of neuron activation. However, we performed molecular modeling of  novel 1,3,4-thiadiazole derivatives keeping in view structural requirement of pharmacophore and Quantitative structure activity relationship (QSAR) and evaluated in silico anticonvulsant activity. Docking procedures allow virtually screening a database of compounds and predict the strongest binder based on various scoring functions. In the docking study, targeted ligand  produced significantly affinity with the calcium channel receptor which is slightly higher than the phenytoin drug. A computational study was also carried out including prediction of pharmacokinetic properties, toxicity and bioactivity studies. All above parameter was calculated which exhibited slightly excellent compared than standard Phenytoin drug. The above observation suggested that these compounds would serve as better lead for anticonvulsant screening for future drug design perspective.


EVALUATION OF ADAPTOGENIC ACTIVITY OF VARIOUS EXTRACTS OF BREYNIA VITIS-IDAEA (BURM.F) C. FISHER LEAVES BY USING SWIM ENDURENCE TEST

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ABOUT AUTHORS:
Manju Gowda M R*, Gnanasekaran D, Ashik navas T, Antony george
Department of Pharmacology, Bharathi College of Pharmacy,
Bharathinagara, Mandya, Karnataka-571422
manjugowdamr@gmail.com

ABSTRACT
The present study was under taken to study the Adaptogenic activity of ethanol, aqueous and ethyl acetate extracts of Breynia vitis-idaea (burm.f) c. fisher. (Euphorbiaceae) leaves. Adaptogenic activity of these extracts were studied using in-vivo Swim Endurance test and compared with the standard Fluoxetin. All the extracts showed significant increase in the swimming time. Adaptogenic nature of the extracts may be attributed to the presence of constituents such as alkaloids, glycosides, flavonoids and saponins in plant extracts. This study proven that the potential adaptogenic nature of the extract of Breynia vitis-idaea leaves.


RESOURCES, GUIDANCE, CONTROL AND PREVENTION FOR EBOLA VIRUS DISEASE-AN OVERVIEW

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ABOUT AUTHORS:
Jadhav Santosh1*, Mali Audumbar1, Tamboli Ashpak2
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India1.
Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India2.
jadhavsan88@gmail.com*

ABSTRACT
Since the current Ebola Virus Disease (also referred to as Ebola Haemorrhagic Fever) outbreak began in Guinea in December of 2013, the outbreak now involves trans-mission in Guinea, Liberia, Nigeria, and Sierra Leone. Ebola haemorrhagic fever (EHF) is a zoonosis affecting both human and non-human primates (NHP). Ebola virus (formerly officially designated Zaire Ebolavirus, or EBOV) was first seen infecting humans in African continent; especially  Sudan, Democratic Republican of Congo, Zaire and nearby countries. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. The World Health Organization (WHO) reports that this is the largest Ebola Virus Disease (EVD) outbreak ever recorded. EVD outbreaks have a case fatality rate ofup to 90%. The research is on-going on development of making vaccine to curb this virus yet licensed success or specific treatment is not achieved.


PLANT SPECIES USED BY LOCALS AS ETHANO - MEDICINE IN GOHAR TEHSIL, DISTT. MANDI REGION OF NORTH WESTERN HIMALAYA

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ABOUT AUTHORS:
Monika Rana*1, Atul Kabra1, Ruchika Kabra1, Meenakshi Rana2, Vinay Dhatwalia3
1 Department of Pharmacy, Abhilashi university, Chailchowk, Mandi (H.P)
2 HIPER college of Pharmacy, Nadaun, (H.P)
3 Abhilashi College of Pharmacy, Mandi (H.P)
*sairana.rana43@gmail.com

ABSTRACT
Objective:
An exhaustive ethno medicinal investigation of plants was carried out in Gohar Tehsil of Distt. Mandi.
Methods:
The paper encompasses 38 medicinal plants, collected from forest of Chailchowk and its adjoining areas, and authenticated. The information was collected from local people. This study reveals the status of ethno-medicinal plants and their importance preserved by locals of Gohar Tehsil of Distt. Mandi.
Results:
Total 38 medicinal plants were studied in the forest of Chailchowk Village and its adjoining areas of Gohar Tehsil are very valuable medicinal plants which are already known for their numerous medicinal values.
Conclusion:
This study will assist the forest, pharmaceutical firm, medicos and wild life manager in their efforts for improving the public health service and medicinal plant wealth of the area.


DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF DICLOFENAC SODIUM BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD

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ABOUT AUTHORS:
Mali Audumbar Digambar*, Jadhav Santosh, Mane Pandurang, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola- 413307, Solapur, Maharashtra, India
maliaudu442@gmail.com

ABSTRACT
A simple, precise, accurate and economical UV visible spectrophotometric method has  been developed for estimation of Diclofenac sodium drug by AUC method. The standard and  sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 270-282 nm. The linearity was established over the concentration range of 05,10,15,20&25µg/ml for Diclofenac sodium with correlation coefficient value of 0.9981. Precision studies showed that % relative standard  deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.38%.The proposed method has been validated as per ICH guidelines.


RISK ASSESSMENT OF DEVELOPING TYPE 2 DIABETES MELLITUS IN PATIENT ON ANTIHYPERTENSIVE MEDICATION

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ABOUT AUTHORS
Amarjeet Singh*, Sudeep bhardwaj, Ashutosh aggarwal
Department of Pharmacology,
Seth G. L. Bihani S. D. College of Technical Education,
Institute of Pharmaceutical Sciences & Drug Research
amarjeetsingh024@gmail.com

ABSTRACT
Objective:
The purpose of this study was to examine the risk assessment of developing type 2 diabetes mellitus in patient on antihypertensive medication.

Material & Method: In the present study total 30 patient with essential hypertension of both sex with mean age (48.6±0.8313) were recruited as per the inclusion criteria. Patients were segregated on the behalf of therapy they were using. 22 patients were on Losartan+HCTZ therapy and 8 patients were on Atenolol therapy.

Result: After six month of antihypertensive therapy Atenolol group showing a significant difference in their blood glucose (0.0014) whereas in Losartan+HCTZ group significant difference was not observed (0.1542). Patients of Atenolol group when compared with patient of Losartan+HCTZ group a significant difference was observed in the serum cholesterol level (0.0290).

Conclusion: We found that the use of β-blocker was independently associated with increased risk of type 2 diabetes. So increase in blood glucose in the Atenolol group patient revealed a significant association between use of Atenolol therapy and metabolic dysfunction whereas in Losartan+HCTZ group significant increase in blood glucose was not observed and from these we can conclude therapy with Losartan+HCTZ therapy not associated with metabolic dysfunction.


WONDERS OF IMMUNE SYSTEM: SPONTANEOUS REGRESSION OF CANCERS

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About Author
Vishwas B. Chavan
Consultant, Sunflower laboratory and diagnostic Center and Clinical Diagnostic Center
Mumbai, Maharashtra.
vishwaschavan2003@yahoo.co.in

Cancer incidence is increasing worldwide [1]. It can affect any part of the body, showing symptoms often in late stages. Diagnosis of cancer has a huge impact on patient and his/her family. Cancer treatments are costly and toxic, many times giving rise to secondary cancers. Even after successful treatment, risk of recurrence of cancer is significant sometimes.


A REVIEW ON DYSLEXIA

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ABOUT AUTHORS:
S.Ramyasilpa
Department of pharmacology,
Nargund college of pharmacy, Bengaluru
shilpasankarapu@gmail.com

ABSTRACT
Dyslexia is a specific reading disorder. It is common childhood disorder affecting around 5% of school aged children. The main deficits of dyslexia include inability to process sensory input (i.e., acoustic information) that comes into the nervous system rapidly, and an impaired reading ability. Secondary consequences may include problems in reading comprehension and reduced reading experience that can impede growth of vocabulary and background knowledge. The dyslexia is associated with alteration of several biological levels like genetic, biochemical, physiological, cognitive levels.


CLINICAL PHARMACY IN INDIA: RECENT ADVANCES AND PERSPECTIVE

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ABOUT AUTHORS:
Mazhar M1, Ansari. A2, Rajput SK1*
1Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201313.
2Department of Social Work, University Road, University of Delhi, Delhi-110007.
*skrajput95@amity.edu

ABSTRACT
In lieu of the fact that without adequate supervision, the assurance of quality of any system is not possible; clinical pharmacy has emerged as one of the latest and unmapped discipline of pharmacy in the 21st century. The existence of clinical pharmacists in medical rounds could support physicians in optimizing pharmacotherapy. This novel profession in India extends its diversions to good manufacturing practices, procurement/preparation/distribution of medication, reporting ADRs/ ADEs and on the whole to a very promising aspect of patient healthcare service. The state of clinical pharmacy in India is in the transformational state showing serious positive promising changes in the past couple of years. Even hospitals have started distinguishing the importance of clinical pharmacy and have taken initiatives for making it possible although at a budding stage. The clinical pharmacy branch of pharmacy is surely attaining new heights in regard to patient care services which have certainly increased the services and satisfaction to the patients.