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SNAKE BITE ITS FIRST AID & ANTI SNAKE VENOM (ASV): DETAILS GUIDELINES

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ABOUT AUTHOR:
Amitava Sinha Ray
B.Pharmacy, DPM
RANBAXY LABORATORIES LTD.
West Bengal, India
a.amitava.s@gmail.com

ABSTRACT:
Snakebite is an injury caused by a bite from a snake. It can be dangerous and life threatening if the snake will venomous. India is the top country having the highest no. of death due to snake bite. Some specific venomous snake is responsible for this death. Till now people are not serious about that. Most of the people don’t know just the first aid of snake bite. After a snake bite most village people are going to unqualified person and quacks for treatment not to hospital, this is one of the most serious causes of death. People should be aware about the sign and symptoms of snake bite and at least the first aid treatment of snakebite. In this type of emergency victim should be admit to nearest hospital and Anti Snake Venom (ASV) is very much necessary to save the patient life.


EDARAVONE: A REVIEW ON ANALYTICAL METHOD AND ITS DETERMINATION IN BIOLOGICAL MATRIX AND SYNTHETIC MIXTURE

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ABOUT AUTHORS:
Patel Divya .A.1*, Raj.Hasumati1, Patel Roshni2
1Department of Quality Assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat
2Piooner College of pharmacy, Baroda, Gujarat
*divyapatel388@gmail.com

ABSTRACT
Edaravone is a potent free radical scavenger (antioxidant) mainly use in the form of injection. It is used in the treatment of various cardiovascular diseases like acute ischemic stroke as well as in gastrointestinal injuries. This review article represent the various analytical methods which has been reported for estimation of edaravone in biological matrix as well as in synthetic mixture.The spectrophotometric techniques like fluorescent assay and ratio derivative spectroscopy; Chromatogrraphic methods like HPLC, HPTLC and RP HPLC were reported.


DEVELOPMENT AND VALIDATION OF HPTLC METHOD FOR ESTIMATION OF TAPENTADOL HYDROCHLORIDE

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ABOUT AUTHORS:
Shoumik Roy*, Samil D. Desai, Bhavna A. Patel, Shraddha J. Parmar
Post Graduation Department of Pharmaceutical Sciences,
Sardar Patel University, Vallabh Vidyanagar, Gujarat, India.
roy.shoumik@gmail.com

ABSTRACT
The main thrust of the paper was to develop and validate a simple, precise high performance thin-layer chromatographic (HPTLC) method for estimation of tapentadol hydrochloride in tablet dosage form. Chromatography was performed on silica gel 60 F254 plates with Chloroform: Acetone: Ammonia (2.5: 2.4: 0.1 v/v/v) as mobile phase. This mobile phase system gave a good resolution for tapentadol hydrochloride (Rf value of 0.49 ± 0.02). Detection and quantification were carried out at 272 nm. The linear regression data for the calibration plot showed a good relationship with r=0.999. The limits of detection and quantification were 62.68 and 189.94ng/spot for tapentadol hydrochloride. The amounts of the drugs in the marketed formulation were 99.98%.


UPDATED REVIEW: VALIDATION AND METHOD VALIDATION PARAMETERS

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ABOUT AUTHORS:
Paras Virani1, 2*, Parul Jain3, Hasumati Raj2, Vineet Jain2
1Research Scholar 2014, Gujrat Technological University, Gujarat
2Department of Quality assurance, Shree Dhanvantary Pharmacy College, Kim, Surat, Gujarat
3Department of Quality assurance, Maliba Pharmacy College, Bardoli, Surat, Gujarat
parasvirani@gmail.com

ABSTRACT
Validation is an act of proving that any procedure, process, equipment, material, activity  or system performs as expected under given set of conditions and also give the required accuracy, precision, sensitivity, ruggedness. Validation parameter is used for establishing documented evidence which proves that performance characteristics of the method meet the requirements for the intended analytical applications. The goal of validation is to demonstrate that analytical results produced by the application of a particular method are fit for an intended purpose. In this review article we discussed about the validation and its important parameter.


PRODUCT QUALITY COMPLAINT MANAGEMENT IN PHARMACEUTICAL INDUSTRY – AN OVERVIEW

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ABOUT AUTHOR:
Himani Devliyal
Department of Pharmacology,
Delhi Institute of Pharmaceutical Sciences and Research
Delhi University, New Delhi
himanidevliyal@gmail.com

ABSTRACT
This article covers fundamental basics of product quality complaint. We would learn what product quality is all about, how the product quality complaints are made, processed, investigated and changes implemented. Also we would go through the basics of case processing, how the complaints are classified, categorized based on the priority and then investigated. We would also go through the formal process of responding to the customer and increasing their faith in the company.
A PQP (product quality problem) can be defined as an issue arising due to change in color, odor, appearance, quality, safety and effectiveness of a product. A PQP is a grave concern and is directly related to the efficacy and safety of a drug.


CASE REPORT ON OGILVIE’S SYNDROME: A RARE CLINICAL ENTITY

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ABOUT AUTHORS:
Jyothi.P, A.Sireesha, D.Venugopal*, J.Jyothi
Department of Pharmacy Practice, P. RamiReddy Memorial College of Pharmacy,
Kadapa, Andhra Pradesh, India.
venugopal.pharmd@gmail.com

ABSTRACT
This is a syndrome of acute intestinal pseudo-obstruction associated with massive dilation, usually of the colon, but also of the small intestine. It describes the phenomenon of an acute colonic pseudo-obstruction without a mechanical cause. Mechanical obstruction is absent and there is parasympathetic nerve dysfunction. It was first described by Sir William Ogilvie in 1948, an English surgeon who was also an examiner for Oxbridge and wrote papers on fractures and hernias. It is a relatively rare condition. Males are more commonly affected than females. It is more common in the elderly. An imbalance in the autonomic innervations (sympathetic over activity and parasympathetic suppression) has been thought to be the pathophysiological factor in the causation of this condition. Reported here is a case of acute colonic pseudo-obstruction which developed in a female patient of age 45 with hypertension and histerectomy was made 25 years back and was treated conservatively. The patient stool culture should be done periodically and if any infectious agents were found should be monitored and appropriate treatment has to be done. It usually responds to non-operative therapy, but occasionally requires surgical intervention.


A SHORT REVIEW ON ANTI-DIABETIC AGENT

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ABOUT AUTHORS:
Deepika Gautam1*, Deepti Gautam2
1Department of Chemistry, Lucknow University,
Lucknow, Uttar Pradesh, India
2Department of Nursing, Era’s Lucknow Medical college and Hospital,
Lucknow, Uttar Pradesh, India
*yashdeepika1@gmail.com

ABSTRACT
Different type of natural and synthetic agents for the treatment of Type 2 diabetes mellitus improve the metabolic profile but do not reestablished normality. They also reduce chronic diabetic complications, but they do not remove completely them. Thus, for the treatment of type2 diabetes mellitus new agents with novel actions are required to complement and extend the capabilities of existing treatments. Insulin resistance and beta-cell failure, which are main cause in the pathogenesis of Type 2 diabetes, in this review we discussed about some natural and synthetic molecule and their targets and some old oral ant diabetic drug and their mode of action.


DIABETIC FOOT ULCER: A SERIOUS PROBLEM FOR DIABETIC PATIENT

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ABOUT AUTHOR:
Amitava Sinha Ray
RANBAXY LABORATORIES LTD.
West Bengal, India
a.amitava.s@gmail.com

ABSTRACT:
Diabetes is a major problem across the world also it is a serious problem in India. Diabetes Mellitus is a silent killer of human body. Several types of complication are occurred in diabetic patient. One of the serious complications is Diabetic foot ulcer. Generally occurred due to breakdown in the skinand subcutaneous tissue also muscle. It will be more dangerous if it will become infected. Sometimes it is also needed to cut down the leg by surgery to prevent the spread of infection. A diabetic patient should take care for his foot to avoid this type of complication, also should be more care full to the management of blood sugar in normal level.


LOCAL ANAESTHESIA (LA): AN OVERVIEW

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ABOUT AUTHORS:
Mayure Vijay Kumar*, V. Sravanthi
Maheshwara College of Pharmacy (B-Pharm Scholar)
Department of pharmacology,
Maheshwara College of Pharmacy, Chitkul (V), Isnapur “X” Road, Patancheru, Hyderabad, A.P.
mayurevijaykumar@gmail.com

ABSTRACT:
The anaesthetic agents are the drugs which causes anaesthesia-reversible loss sensation. It deals with the property of relieving the pain without eliminating sensation. These drugs are generally administered to facilitate surgery. It can be described by two main classes. General anaesthetic, which causes a reversible loss of consciousness, and local anaesthetics, which causes a reversible loss of sensation for a limited region of the body while maintaining consciousness. Here I explain about the Local anaesthetics agents that prevent transmission of nerve impulses without causing unconsciousness. They act by binding to fast sodium channels from within in an open state.
BACKGROUND: The purpose of this Review article is to summarize the Local anaesthetics agents, general mechanism, structures, therapeutic uses, adverse effects and also explains their properties.


FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLES: ISONIAZID

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ABOUT AUTHORS:
Umatiya Imran*, Chintan Aundhia, A.K.Seth, Sachin Chauhan, Nirmal Shah
Department of pharmacy, Sumandeep Vidhyapeeth University,
Piparia, Waghodia, Vadodara, Gujarat, India
imran_umatiya@yahoo.com

ABSTRACT
Tuberculosis is an infectious disease caused by Mycobacterium Tuberculosis which attacks lungs and other parts of the body. Isoniazid is a hydrophilic drug that is having a first line antituberculosis drug. Entrapment Efficiency has been improved by preparing Solid Lipid Nanoparticles (SLNs). Two different variable Stearic acid and Tween 80 were used by using w/o/w double emulsion-solvent evaporation method by using 32 factorial designs. Particle size, Surface Morphology, Entrapment efficiency and In-vitro diffusion studies were evaluated for prepared SLNs. Different combination of Surfactant and Lipid were found to have significant effect on entrapment efficiency but not on drug release. The prepared SLNs were found in spherical shape and 678 nm particle size was found. % Entrapment efficiency were found from 31.90±0.41 to 74.89±0.67. Present Work is focused on increase incorporation of drug into SLN. Work indicates that formulation of SLNs loaded INH can give reliable therapeutic effect for the treatment of tuberculosis by prolonged action.