Articles

ADVANCEMENTS IN PHARMACOLOGY AND ITS EFFECT ON 'HEALTH-CARE' INDUSTRY

{ DOWNLOAD AS PDF }

ABOUT AUHTOR
Neha Bala, Naresh Mali
*
Institute of Health Management Research, Jaipur
Rajasthan,  India
malinaresh888@gmail.com

The tremendous pharmacological advances witnessed during the last few decades have revolutionize virtually all aspects of modern life,including our understanding of disease.New drugs have contributed significantly to the economic impact of new developments in health care.With recognition that the pace of pharmacological development and acquiring of new knowledge will certainly accelerate in the coming years,let us consider what these advances might hold for Pharmacological advancement,Pharmacology is the branch of biology concerned with the study of drug action, where a drug can be broadly defined as any natural, or endogenous (from within body) molecule which exerts a biochemical and/or physiological effect on the cell, tissue, organ, or organism


FORMULATION AND IN-VITRO EVALUATION OF MOUTH DISSOLVING TABLETS OF KETOPROFEN: EFFECT OF DISINTEGRANTS ON DRUG RELEASE

{ DOWNLOAD AS PDF }

ABOUT AUHTOR
Kambham Venkateswarlu*,
Department of Pharmaceutics,
JNTUA-Oil Technological and Pharmaceutical Research Institute
Andhra Pradesh,  India
k.v.reddy9441701016@gmail.com

ABSTRACT 
The objective of the present investigation was to formulate and evaluate the mouth dissolving tablets (MDTs) of ketoprofen (KPN) using disintegrants like Crospovidone (CP), Croscarmellose sodium (CCS) and Sodium starch glycolate (SSG) and the effect of disintegrants on drug release was also studied. The powder blend was evaluated for flow properties and found acceptable flow properties. The prepared MDTs were evaluated for post compression parameters such as hardness, friability, weight variation, dispersion time, drug content and in-vitro drug release. Tablets possessing sufficient strength supported by hardness and friability results. The formulation KP6 showed lease dispersion time of 14 sec and it was selected for drug release studies. KP6 showed 99.9% of drug release in 5 min and time taken for 70% of the drug is 2.8 min. Based on the results obtained from the dispersion time and in-vitro dissolution studies, it could be concluded that the concentration of disintegrant is indirectly proportional to the dispersion time and directly proportional to the amount of drug release respectively.


INSILCO MOLECULAR DOCKING STUDY OF DIHYDROISOQUINOLINIUM DERIVATIVES AS DPP IV INHIBITORS IN TYPE II DIABETES MELLITUS

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Amiya Kumar Ghosh*1, Shiladitya Palit2, SaptarshiSamajdar3
1Dept. of Pharmacy, Utkal University, Orissa
2Dept. of Pharmacy, IITBHU
3Centre for Pharmaceutical Sc. And Natural Products, Central University of Punjab

amiyaghosh94@gmail.com

ABSTRACT:
With the spread of western lifestyles, the occurrence of diabetes in the world’s population is rising. Diabetes is a complex metabolic endocrine disorder that occurs when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. It is classified into two basic forms Type I and Type II diabetes. A major goal for the treatment of type II diabetes is the enhancement of insulin secretion by pancreatic islet b-cells. The current therapeutic agents, although effective in increasing insulin secretion, are associated with undesirable side effects. Dipeptidyl peptidase IV (DPP IV) is responsible for conversion of glucose tolerance (GLP-1), into inactive form. The inhibition of DPP-IV would be beneficial in the treatment of diabetes mellitus. Improved glucose tolerance in diabetic patients was achieved with several small molecules as DPP IV inhibitors, including sitagliptin. The current study was designed to identify a suitable inhibitor agent for DPP IV. Computer-assisted molecular modeling approach has contributed to the successful discovery of several novel antidiabetic DPP IV agents.Someisoquinoline was designed computationally and screened through insilico docking studies against crystal structure of Dipeptidylpeptidase-IV (DPP-IV) ( PDB entry 2P8S )as a projected target for Type 2 Diabetes Mellitus.Insilico docking methodology using Auto Dock vina comprising a search method Genetic Lamarckian algorithm was used. Genetic Lamarckian algorithm performs an Automated Docking and has an advantage of empirical binding free energy force field that allows the prediction of binding free energies for docked ligands. In-silico evaluation shows satisfactory docking results, when compared with standard using docking. It is concluded that investigational ligands has the potential of inhibiting DPP-IV and there by further screening (invitro and invivo) studies can be carried out in order to find out optimized bioflavonoids for treating type2diabetes mellitus.


PREVENTION OF MEDICATION ERRORS- A STEPAHEAD IN PROVIDING BETTER PATIENT SAFETY

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Steffi Jerry Mammen,
Inamdar Multispecialty Hospital,
Pune,
Maharashtra, India
steffi.thomas@ymail.com

Abstract:
The reality that medical treatment can harm patients is one that the healthcare community has had to come to, in terms with over recent years. Adverse events associated with medication errors are chief causes among them. A medication error is an error which can be defined as any discrepancy between the prescriber's interpretable medication order and what was administered to a patient. Prescribing & drug administration appears to be associated with greatest number of errors.

To ensure patient safety& provide better health services, medication errors should be curbed. India is still lacking the regulatory system for the control of medication errors.

Therefore, a stringent regulatory set up should be established to reduce medication errors.  Awareness among the health-care professionals regarding medication errors may be the major factor in the establishment of a successful regulatory system. Some of them might be aware but reporting is rare due to many factors such as miscommunication, fear of punishment, potential termination from job, failure to comply with the policies etc.

Reporting will disclose medication errors, could trigger warnings, but should not  create an unhealthy atmosphere post reporting, and acknowledging the facts and working on it could help prevent medication errors as all of health care domain are working for patient safety at the end.


DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MECLIZINE AND FOLIC ACID IN BULK AND PHARMACEUTICAL DOSAGE FORMS

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Naveen Kumar G.S* 1, U. Srinivas 2, Hanumanthchar Joshi 3,
1 Department of Pharmaceutical Analysis,
Sarada Vilas College of pharmacy,
Mysuru, Karnataka, India
2 Department of Pharmacognosy,
Srinivas College of pharmacy, Mangalore, Karnataka India,
3 Department Pharmacognosy,
Sarada Vilas College of pharmacy, Mysuru, Karnataka India
*naveengs.2010@gmail.com

ABSTRACT  
An UV spectrophotometric method using simultaneous equation was developed for the simultaneous determination of meclizine and folic acid in a binary mixture. In the proposed method, the signals were measured at 390.0 nm and 237.0 nm corresponding to absorbance maxima of and folic acid in methanol respectively. Linearity range was observed in the concentration range of 2-12 µg/ml for both the drugs. Concentration of each drug was obtained by using the absorptivity values calculated for both drugs at two wavelengths, 390.0 nm and 237.0 nm and solving the simultaneous equation. The method was validated and proposed method was fast, accurate and precise so it can be used for regular quality control of the drug.


NANOCAPSULES: NANO NOVEL DRUG DELIVERY SYSTEM

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Gauri Nilewar*, P.B. Mute, P.P. Talhan, Shruti Thakre,
Dr. R.G. Bhoyar college of Pharmacy,
Wardha Maharashtra, India
*samvedna.nahatkar90@gmail.com

ABSTRACT
Nano capsules are vesicular systems in which the drug is confined to a cavity consisting of an inner liquid core surrounded by a polymeric membrane. Nano capsules having various advantages and disadvantages. Preparation of Nano capsules can be used as a two types of polymers 1) Natural polymers 2) Synthetic polymers. Nano capsules are prepared by different method those are a) Solvent evaporation b) Nano precipitation c) emulsification / Solvent diffusion d) Salting out e) Dialysis f) Super critical fluid technology. Different characterization and evaluation tests are performed to Nano capsules. Dispersed polymer nanocapsules can be used as nano-sized drug carriers to get controlled release as well as efficient drug targeting. Drug-loaded polymeric nanocapsules have showed possible applications in the field of drug delivery systems. Enormous research efforts have been performed in order to develop modern nano-particulate drug delivery systems. However, newly developed drug molecules with moderate biopharmaceutical profile are still missing. The entrapment of this drug molecule can protect them from the biological environment and facilitate their transport through biological barriers. Therefore nano-carriers especially nanocapsules (NC) can give the promise for therapeutic benefits in the field of drug delivery system. Nanocapsules, existing in miniscule size, range from 10 nm to 1000 nm. They consist of a liquid/solid core in which the drug is placed into a cavity, which is surrounded by a distinctive polymer membrane made up of natural or synthetic polymers. They have attracted great interest, because of the protective coating, which are usually pyrophoric and easily oxidized and delay the release of active ingredients.


NEUROPROTECTIVE AGENTS, NATURAL PLANT HERBS & DRUGS IN ISCHEMIC STROKE: A REVIEW

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Nesar Ahmad*,Zafar Khan, Noorul Hasan, Abdul Basit, Seikh Zohrameena
Department of Pharmacology,
Faculty of Pharmacy,
Integral University, Lucknow, UP, India
*nesar50@gmail.com

ABSTRACT 
Stroke is a destructive experience which can result in permanent disability in brain. There is no permanent drug which can improve the blood flow at infracted area and also improve the neurological deficit. Due to the lack of treatments available for stroke, many researchers will investigate the suitable plants or drugs for the treatment of this disease. Numerous medicinal plants and herbal drugs are available to treat stroke, some of the plants are Ginkgo biloba, Fructus Chebulae, Pomegranate, Rosa laevigata, Garlic, Leonurus heterophyllus, Olive, Grape, Allium cepa, drugs such as Pravastatin, Senkyunolide I, Phloretin, Mgso4, HAMI 3379, Oleoylethanolamie, scopolamine and mecamylamine, Nitric Oxide, N-nitro-L-arginine methyl ester (L-NAME), 3,5,6,7,8,3’,4’-Heptamethoxy flavones, Rosiglitazone, Puerarin, the activity was estimated by parameters like superoxide dismutase (SOD) activity, Hemispheric swelling index (cerebral edema), H2O2 induced cell injury, OGD-R induced cell injury, superoxide dismutase and glutathione peroxidises, mitochondrial membrane potential, Western blotting assay, ROS scavenging assays, Superoxide anion  scavenging assay, Hydroxyl radical  scavenging assay, H2O2 scavenging assay, Singlet oxygen scavenging assay, Peroxyl radical scavenging assay, Peroxynitrite anion scavenging assay, myeloperoxidase (MPO) activity, blood–brain barrier integrity, cerebral infarct size, in Situ Apoptosis Detection, Western blotting, SOD, GSH, glutathione peroxidase, and MDA levels, Reverse transcription polymerase chain reaction (RT-PCR), Lactate dehydrogenase activity assay, Determination of caspase activity, acetylcholinesterase (AChE) activity, Determination of choline acetyltransferase activity (ChAT), Cell viability, Oxygen glucose deprivation/reperfusion assay, Flow cytometry, Immunohistochemistry.  The present review focused on different medicinal plants and drugs that have been tested in Stroke in animal models.


A REVIEW ON CREATION AND HANDLING OF DATA IN ACCORDANCE WITH CGMP REQUIREMENTS IN PHARMACEUTICALS

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Suleman S. khoja * 1, Sohil S khoja 1,Parthkumar H chauhan 2,Farhad S Khoja 3 ,Shamim S Khoja3.
1) Resource person in Pharmaceutical Quality Assurance, Audit and Compliance, Vapi -396191.
2) Resource person in Quality Assurance, Navsari
3) Registered Pharmacist ,Gujarat State Pharmacy council, Vapi -396191
*premukhoja@gmail.com

ABSTRACT:
Data integrity is fundamental in a pharmaceutical quality system which ensures the completeness, consistency, and accuracy of data. Complete, consistent, and accurate data should be attributable, legible, contemporaneously recorded, original or a true copy, and accurate (ALCOA), Arrangements shall be in place within an organisation with respect to people, systems and facilities that shall be  designed, operated and where appropriate adapted to support a working environment and  organisational culture that ensures data is complete consistent and accurate in all its forms, i.e. paper  and electronic record .When taken collectively these arrangements fulfil the concept of data governance. Regulatory bodies expect that data shall be reliable and accurate. CGMP regulations and guidance allow for flexible and risk-based strategies to detect and prevent data integrity issues. Industry should implement meaningful and effective strategies to manage their data integrity risks based upon their process understanding and knowledge management of technologies and best business models. In recent year Regulatory observation has increasingly observed GMP violations involving data integrity risks during CGMP inspections. This is troublesome because ensuring data integrity is an important component of industry’s responsibility to ensure the safety, efficacy, and quality of drugs, Regulatory is concern with ability to protect the public health.


A STUDY ON ROLE OF CLINICAL PHARMACIST IN IDENTIFICATION AND REPORTING OF DRUG INTERACTIONS IN PHYSCIATRIC WARD IN A TERITARY CARE TEACHING HOSPITAL

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
M. Manasa Rekha*, T. Mubeena
Department of Pharmacy Practice,
Annamacharya college of Pharmacy,
Rajampet, Andhra Pradesh, India.
* manasarekharoyal@gmail.com

ABSTRACT: 
Clinical pharmacy is defined as that area of pharmacy concerned with the science and practice of rational medication use. The pharmacist, along with the prescriber has a duty to ensure that patients are aware of the risk of side effects and a suitable course of action should they occur. With their detailed knowledge of medicine, pharmacists have the ability to relate unexpected symptoms experienced by patients to possible drug interactions of their drug therapy. The practice in clinical pharmacy also ensures that drug interactions are minimized by avoiding drugs with potential side effects in susceptible patients. Thus, pharmacist has a major role to play in relation to prevention, detection, and reporting drug interactions.


COMBINATORIAL CHEMISTRY - MODERN SYNTHESIS APPROACH

{ DOWNLOAD AS PDF }

ABOUT AUHTORS
Sunil Shastri*, Harsh Narang.
Seth G.L. Bihani S.D. College of Technical Education,
Sriganganagar, Rajasthan.
sunil11044@gmail.com

ABSTRACT
The Combinatorial Chemistry is a scientific method in which a very large number of chemical entities are synthesized by condensing a small number of chemical compounds together in all combinations defined by a small set of chemical reactions.

Combinatorial technologies provided a possibility to produce new compounds in practically unlimited number. New strategies and technologies have also been developed that made possible to screen very large number of compounds and to identify useful components of mixtures containing millions of different substances. Instead of preparing and examining a single compound, families of new substances are synthesized and screened. In addition, combinatorial thinking and practice proved to be useful in areas outside the pharmaceutical research Such as search for more effective catalysts and materials research. Combinatorial chemistry became an accepted new branch within chemistry.
The aim of this project is to provide a basic introduction to the field of combinatorial chemistry describing the development of major techniques and some applications. 


Pages