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Neha singh*1, Chandana Majee2
1.M.Pharm ( Department of Pharmaceutics)
2.Assistant Professor, Departmrnt of pharmaceutical chemistry.
Noida Institute of Engineering and Technology, Noida
In order to achieve a successful colon targeted drug delivery system, a drug needs to be protected from degradation, release and/or absorption in the upper portion of the gastrointestinal tract (GIT) and then ensure abrupt or controlled release in the proximal colon. Such a system can be formulated by utilizing microbial triggering degradation of polymer coating/ gastro intestinal (GI) transit time (time dependent)/ pH dependent approach etc. But unfortunately it has been found that colonic microflora, GI transit time and pH varies considerably inside a human system by several factors, in addition to this the native biodegradable polysaccharides which are used widely for the microbial triggering colonic drug delivery system (CDDS), are having high aqueous solubility on account of which a single unit colon targeted drug delivery systems may suffer from dose dumping due to overall catastrophic failure of the film around a monolith, which would then release the whole drug, that may lead to drastically compromised systemic drug bioavailability or loss of local therapeutic action in the colon. This review emphasizes some of the causes which make a single unit dosage form unsuitable for targeting to colon by using microbial triggering/GI transit time/pH dependent approach, and at the same time discusses researches which have been carried out to alleviate these problems by utilizing multiparticulate combined approaches.
Keshava Murthy S R*, Shiva kumar
Provimi Animal Nutrition India Pvt. Ltd.
Bangalore - 560 064 Karnataka INDIA
Reactive oxygen species(ROS) are free radicals which are generated from exogenous factors, where excessive ROS will result in Oxidative stress. These harmful free radicals generated continuously can be counteracted by the antioxidant defense system by the body. Multiple antioxidant methods were used to study the complete profile of an antioxidant compound so to establish a single antioxidant method which can determine the complete nature of antioxidant molecules is of great importance. CUPRAC method which involves the reduction of cupric ion to cuprous by antioxidant compound is found to be advantageous over other commonly followed antioxidant methods. The present review article includes detailed in vitro procedure, principle behind, application of this cuprac method.
*Ramchandra Gupta2, Prabhakar Sharma2, Prakash Pandey2, Pratik Jain1, Ajay Shukla3
1Department of Pharmacognosy,
2Department of Pharmaceutics,
3Department of Pharmaceutical Chemistry
1,2,3Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy) Jabalpur, 483001, M.P.
In the pharmaceutical world, an impurity is considered as any other organic material, besides the drug substance, or ingredients, arise out of synthesis or unwanted chemicals that remains with API’s. Pharmaceuticals impurities are the unwanted chemicals that remain or are generated during the formulation of medicines. The presence and quantity of impurities in pharmaceutical drugs can have a significant impact on their quality and safety, with the continuous pressure for increased industry productivity, there is urgent need for a systematic and comprehensive drug impurity profiling strategy. The impurities present in the drug are adversely affecting the quality of the drug product. There are various types of impurities like starting materials, intermediates, penultimate impurity, by product and degradation product. Impurity profiling helps in detection, identification and quantification of various types of impurities as well as residual solvents in bulk drugs and in pharmaceutical formulations. It is a best way to characterize quality and stability of bulk drugs and pharmaceutical formulations. This review paper deals with the impurity profile of pharmaceuticals.
Mr. Shaikh Parvej H*, Chilwant K.M., Birajdar Shivprasad M., Prof. Garad S.V.
Maharashtra College of Pharmacy,
Nilanga, dist. Latur (MS) 413521, India
E-Prescribing is a prescriber's ability to electronically send an accurate, error-free and understandable prescription directly to a pharmacy from the point-of-care - is an important element in improving the quality of patient care. Electronic prescribing (sometimes called “eRx”),
Through e-prescribing tools, the physician has access to drug reference checking, drug-allergy interactions, and drug-drug interactions. This additional information up front ensures a safer prescription and reduces pharmacy call backs to the practice to clarify information. Also, the electronic communication is bidirectional; patients can call the pharmacy for a prescription renewal rather than the physician, and the pharmacy can then transmit an electronic message asking the physician to authorize or deny the prescription renewal.
e- Prescription has offering & cure of disease by obtaining data from the foreign expert’s clinical trials, Electronic Prescribing can save time and money. by using software skills of various software likes electronic health recordPharmacy Benefit Manager (PBM)
SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF MEROPENEM AND SULBACTAM SODIUM IN COMBINED DOSAGE FORM BY FIRST ORDER DERIVATIVE METHOD
Patel Sannil R*, Patel Satish A
Department of Quality Assurance,
Shree S. K. Patel College of Pharmaceutical Education & Research,
Ganpat University, Ganpat Vidyanagar – 384012, Mehsana, Gujarat, India.
The present manuscript describes simple, sensitive, rapid, accurate, precise and economical First order derivative spectrophotometry method for the simultaneous determination of Meropenem and Sulbactam Sodium in bulk and combined dosage form. The absorbance values at 333nm and 252 nm of first derivative spectrum was used for the estimation of Meropenem and Sulbactam Sodium, respectively without mutual interference. This method obeyed beer’s law in the concentration range of 5-70 μg/ml for Meropenem and 2-21 μg/ml for Meropenem. The method was successfully applied to pharmaceutical combined dosage form because no interference from the excipients was found. The suitability of this method for the quantitative determination of Meropenem and Sulbactam Sodiumwas proved by validation. The proposed method was found to be simple and sensitive for the routine quality control analysis of Meropenem and Sulbactam Sodium in bulk and combined dosage form. The results of analysis have been validated statistically and by recovery studies.
Karri Deviprasanna, Metla Vennela, Bandla Rajyalakshmi
Avanthi institute of pharmaceutical sciences,
Vizianagaram-535003, Andhra Pradesh, india
The recommendation for first line therapy for diabetics remains a metformin. Two or more agents from different pharmacological classes are often needed to achieve adequate blood glucose control. Combination therapy is an important option that combines efficacy of blood glucose reduction and a low side effect profile with convenient once daily dosing to enhance compliance. Combination of anti- diabetics include biguandies+sulfonylureas, biguanides+glitazones, biguandies+α glucosidase inhibitors and miscellaneous combinations.
DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUM AND LEVOCETRIZINE DIHYDROCHLORIDE IN BULK AND TABLET DOSAGE FORMULATION.
Gohel Bhavika A*, Patel Bhavna A, Parmar Sharddha J, Mital Sondagar M, Jadav Alpa V
P G Department of Pharmaceutical Sciences, Sardar Patel University,
V. V. Nagar, Gujarat
A new, simple, rapid and novel Spectrophotometric method has been developed for simultaneous estimation of Montelukast sodium and Levocetrizine dihydrochloride from tablet formulation. The method employs formation and solving of simultaneous equation using 230nm and 283nm as two analytical wavelengths which are absorbance maxima of Levocetrizine dihydrochloride and Montelukast sodium, respectively. The linearity was obtained in the concentration range of 5-25 g/mL for both the drugs. Recovery studies range from 98.45-100.30% for Levocetrizine dihydrochloride and 98.80-101.84% for Montelukast sodium. The results of analysis have been validated statistically and by recovery studies according to ICH guidelines. The proposed methods can be successfully applied in routine work for the determination of Levocetrizine dihydrochloride and Montelukast sodium in combined dosage form.
final year graduate student
Sri lakshmi narasimha college of pharmacy,
palluru, chittoor-517132, andhra pradesh.
Mango (Mangifera indica L.) is the most popular fruit crop in the orient particularly in India, where it is considered as the best choice among all indigenous fruits. It occupies relatively the same position as that enjoyed by apple in temperate America or Europe. It ranks first among all the fruits of India in area and production.
Global production of mango is concentrated mainly in Asia and more precisely in India. Mango is grown in 85 countries, among which 63 countries produce more than 1000 metric tonnes in a year. In these countries, mango serves as an integral part in human life since it is not only a rich source of nutrients but also a common good shared in culture, life style and religion.
Ghodke D.V*, Bhusnure O.G, Kulkarni A.A
Department Of Quality Assurance in Maharashtra College of M .Pharmacy Nilanga.* Dist –Latur
Department Of Medicinal chemistry in Maharashtra College of Pharmacy Nilanga, Dist –Latur
Pharma Industry is facing growing demands for increased productivity and reduced manufacturing costs and also has to meet the evolving need for higher quality standards and higher drug expectations. In traditional approach quality of the raw material attributes both physically and chemically testing was done by off-line process. The application of Process Analytical Technology in pharmaceutical production checks the quality at-line, in-line or on-line thereby decreasing the chances of contamination and cross contamination. Implementation of Process Analytical Technology to pharma industry increased process understanding and continuous improvement also improve regulatory compliance. PAT involves the use of different technologies and tools to build quality into the products. Effective PAT implementation is based on detailed, science-based understanding of the physical, chemical and mechanical properties of all elements of the proposed drug product. In this article, Process Analytical Technology has been introduced its application different tools have been discussed to ensures quality of the pharmaceutical products.
School of Pharmacy and Emerging Sciences,
Baddi University of Emerging Sciences and Technology,
The success of transdermal drug delivery has been severely limited by the inability of most drugs to enter the skin at therapeutically useful rates. Using the tools of the microelectronics industry, microneedles have been fabricated with a range of sizes, shapes and materials. Microneedles have been used for the dermal and transdermal delivery of a broad range of drugs, such as small molecular weight drugs, oligonucleotides, DNA, peptides, proteins and inactivated viruses. Most drug delivery studies have emphasized solid microneedles, which have been shown to increase skin permeability to a broad range of molecules and nanoparticles in vitro. Microneedles inserted into the skin of human subjects were reported as painless. In addition to applications in the skin, microneedles have also been adapted for delivery of bioactives into the eye and into cells. Successful application of microneedles depends on device function that facilitates microneedle insertion and possible infusion into skin, skin recovery after microneedle removal, and drug stability during manufacturing, storage and delivery, and on patient outcomes, including lack of pain, skin irritation and skin infection, in addition to drug efficacy and safety. These results suggest that microneedles represent a promising technology to deliver therapeutic compounds into the skin for a range of possible applications.