Articles

3 February 2013

FORMULATION AND EVALUATION OF DRY POWDER INHALERS OF BUDESONIDE FOR PULMONARY DELIVERY

About Authors:
Neethu.R.R
Uthradam
Kannayamkodu
Chenkikunnu
Kilimanoor.P.O, Trivandrum dist, Kerala 695601
neethalekshmi87@gmail.com

Abstract:
Budesonide is a corticosteroid, used in the treatment of inflammatory conditions such as asthma and COPD. The present study was undertaken with the aim to formulate and evaluate dry powder inhalers of Budesonide for pulmonary delivery. Dry powder inhalers of Budesonide were prepared using different concentrations of fine lactose and magnesium stearate by Geometric dilution method. The drug-carrrier compatibility study was carried out by FT-IR studies. A total of eleven batches were formulated and evaluated for physical appearance, average fill weight, flow properties, particle size analysis, content uniformity, moisture content and assay. In-vitro drug deposition studies were carried out by using Modified Twin Stage Impinger (TSI) apparatus. Of all eleven batches, the formulation F4, comprising of fine lactose 30% was found to be the best having comparatively higher fine particle fraction (FPF) of 25.32%. The result indicated that the amount of drug that reaches in the lung was higher for formulation F4. Further invivo safety and deposition studies on suitable animal models and human volunteers will give better insight for clinical applications of the Budesonide DPI.
3 February 2013

GLUCOSAMINE- AN ADVANCED BIOMOLECULE OF GREAT POTENTIAL WITH INNUMERABLE APPLICATIONS

About Authors:
Priya M. Padalia*, Manthan A. Padalia
Dagon Pharmaceuticals Pvt. Ltd.
*modiyapriya@gmail.com
1 February 2013

A REVIEW ON: FORMULATION AND EVALUATION OF FAST DISSOLVING TABLET

About Authors:
Nishtha Tiwari
Department of pharmacy,
b.u Bhopal (m.p.), India
Nishthatiwari.18@gmail.com

ABSTRACT
The oral route of drug administration is the most important method for administering drugs for systemic effects. Except in certain cases the parenteral route is not routinely used for self administration, e.g. insulin. The topical route of administration has only recently been employed to deliver drugs to the body for systemic effects. The parenteral route of administration is important in treating medical emergencies in which the subject is comatose or cannot swallow. Nevertheless it is probable that at least 90% of all drugs used to provide systemic effects are administered by the oral route.
1 February 2013

Automated analysis

About Authors:
Patelia emanual michael*, Keyur B Ahir
Department of Pharmaceutical Chemistry and Analysis,
Indukaka Ipcowala College of Pharmacy,
New Vallabh Vidyanagar – 388121, Gujarat, India.
*ricky.emanual@gmail.com
31 January 2013

ESTIMATION OF DRONEDARONE HYDROCHLORIDE BY SPECTROPHOTOMETRIC METHOD IN PHARMACEUTICAL FORMULATION

About Authors:
Kashyap K. Bhatt, Emanual Michael Patelia*, Ishani Amin
Department of Pharmaceutical Chemistry and Analysis,
Indukaka Ipcowala College of Pharmacy,
New Vallabh Vidyanagar – 388121, Gujarat, India.
*ricky.emanual@gmail.com
30 January 2013

SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF SOME CALCIUM CHANNEL BLOCKER THIOSALICYLAMIDE DERIVATIVES AS ANTIHYPERTENSIVE AGENTS

About Author:
ABHISHAK SINGH PARMAR,
M.PHARMACY (MEDICINAL AND PHARMACEUTICAL CHEMISTRY),
B.R.NAHATA COLLEGE OF PHARMACY,
MANDSAUR (M.P).
^*abhishakparmar@gmail.com

1. INTRODUCTION
1.1 Medicinal and Pharmaceutical chemistry
It is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Medicinal chemistry involves the identification, synthesis and development of new chemical entities suitable for therapeutic use. It also includes the study of existing drugs, their biological properties, and their quantitative structure-activity relationships (QSAR). Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. Compounds used as medicines are overwhelmingly organic compounds including small organic molecules and biopolymers. However, inorganic compounds and metal-containing compounds have been found to be useful as drugs. For example, the cis-platin series of platinum-containing complexes have found use as anti-cancer agents.¹
30 January 2013

INSIGNIFICANT EFFECT OF SUPERPOROUS HYDROGEL PARTICLES AS A SUPERDISINTEGRANTS IN FAST DISPERSIBLE TABLETS OF ACECLOFENAC

About Authors:
Dr. HV Chavda^1*, Ms. SK Patel¹, Dr. CN Patel¹,
¹Shri Sarvajanik Pharmacy College,
Nr. Arvind Baug, Mehsana, Gujarat-384001, India.
^*hvchavda@sspcmsn.org

ABSTRACT
Background: In present investigation an attempt has been made to formulate a fast dispersible formulation of aceclofenac using three different superdisintegrants. The role of superporous hydrogel particle as a superdisintegrant was checked for its further future applications. Materials and Methods: The selection of superdisintegrants viz. poly (Acrylamide-co-Acrylic acid) superporous hydrogel particles, cross carmellose sodium and starch 1500 were done using the simplex lattice design. Tablet formulations were prepared using direct compression technique and evaluated for hardness, weight variation, friability, drug content, dispersion time, wetting time, water absorption ratio and in vitro drug release studies. Results and Discussion: The dispersion time of all formulation showed less than 21 second. Superporous hydrogel particles did not showed significant improvement in dispersion time compared cross carmellose sodium and starch 1500. The in vitro drug release from batch F7, tablets containing equal proportions of superdisintegrants showed fast dispersion and fast release compared to other batches. Batch F7 was stable for the period of six months at 40 ^oC / 75 %RH. Conclusions: Combination of three superdisintegrants was more suitable in fast dispersible tablet formulation of aceclofenac. The superporous hydrogel particles showed equivalent effect as a superdisintegrant, however process complexity of its preparation suspects its role or an option as a superdisintegrant in fast dispersible or immediate release formulations.
29 January 2013

BETA-LACTAM CLASS OF DRUGS : A REVIEW

About Authors:
Mayure.Vijay Kumar*, V. Sravanthi Yadav, C.P.Meher,
Department of pharmaceutical chemistry
Maheshwara College of Pharmacy, Chitkul (V)
Isnapur “X” Road, Patancheru, Hyderabad.
mayurevijaykumar@gmail.com

ABSTRACT:-
β- lactam antibiotics are the most commonly prescribed drugs. The β- lactam group of antibiotics are a broad class of antibiotics, consisting of all antibiotic agents that contain a β- lactam nucleus in their molecular structures. This includes penicillin derivatives (penams), cephalosporins (cephems), monobactams, and carbapenems. Most of the β- lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organisms and are the most widely used group of antibiotics. Bacteria often develop resistance to β- lactam antibiotics by synthesizing that attacks the β- lactam ring. To overcome this resistance, β- lactam antibiotics are often given with β- lactamase inhibitors such as clavulanic acid. Presnted article deals about the structure of various marketed as well as drugs under investigation containing β-lactam nucleus and their pharmacological activities. The presented article is related wth the various β- lactam derivative with their various pharmacological activities.
29 January 2013

HEALING ANXIETY WITH HERBS

About Author:
Bhatt Mehul K,
Asst.professor, PhD continue
Department of Pharmacognosy,
Shivam Pharmaceutical Studies & Research Centre,
Valasan-388 326, Anand-380 015, Gujarat, India.
mkb_0999@yahoo.co.in

Abstract:
Now-a-days many people of the world are suffering from anxiety, stress and depression. They experience feelings of anxiety before an important event such as exam, business deal or first date. Anxiety disorders however are illness that fills people^’s lives with unreal & imaginary fear that are chronic, unremitting and can grow progressively worse. By now, most of us know that anxiety is quite a common complaint and many people have tried some of the various medications used for anxiety. But many don’t know that there are a variety of herbs available used to treat anxiety in natural way. This article includes, “What is Anxiety?” Herbs used to cure Anxiety, depression, and Stress”, and “Natural Self-Healing”.
28 January 2013

Herbal Cosmetics: A safe and effective approach

About Author:
Bhuwanchandra Joshi,
Division of Pharmaceutical Science
SHRI GURU RAM RAI INSTITUTE OF TECHNOLOGY AND SCIENCES,
PATEL NAGAR, DEHRADUN, UTTARAKHAND
*bhuwan.joshi000@gmail.com

Abstract:
The concept of beauty and cosmetics is as ancient as mankind and civilization. Women are obsessed with looking beautiful. So, they use various beauty products that have herbs to look charming and young. Indian herbs and its significance are popular worldwide. An herbal cosmetic have growing demand in the world market and is an invaluable gift of nature. Herbal formulations always have attracted considerable attention because of their good activity and comparatively lesser or nil side effects with synthetic drugs. Herbs and spices have been used in maintaining and enhancing human beauty. Indian women have long used herbs such as Sandalwood and Turmeric for skin care, Henna to color the hair, palms and soles; and natural oils to perfume their bodies. Not too long ago, elaborate herbal beauty treatments were carried out in the royal palaces of India to heighten sensual appeal and maintain general hygiene. The herbal cosmetics manufactured and used commonly for daily purpose include herbal face wash, herbal conditioner, herbal soap, herbal shampoo etc. The industry is now focusing on the growing segment with a vast scope of manifold expansion in coming years. Herbal cosmetics are defined as the beauty products which posses desirable physiological activity such as healing, smoothing appearance, enhancing and conditioning properties because of herbal ingredient. Here we reported the introduction, classification, common herbs used in cosmetics.

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