Articles

8 January 2013

A REVIEW OF MITRAGYNA PARVIFOLIA (ROXB) KORTH

About Authors:
Sharda roy*, vikas chandra roy, dr. R. C. Roy
Address Faculty of Pharmaceutical Sciences. Global College of Pharmacy.
Kahnpur Khui. Punjab.
*roysharda08@gmail.com

Abstract:
Mitragyna parvifolia is a medium to large size tree belonging to the family Rubiaceae. It is popularly known as Kaim and is found growing gregariously throughout the drier parts of India, Pakistan and Srilanka. The aerial parts, stem-bark and roots of the tree contain various indolic (tetrahydroalstonine, akkuamigine, hirsuteine etc) and oxindolic (mitraphylline, isomitraphylline, pteropodine, isopteropodine etc) alkaloids. Important variations in the nature and quantity of alkaloids present in different parts of the plant are visible with change in geographical locations. In addition, various parts of the tree such as fruit juice, leaves and stem bark have been used in the traditional system of medicine by the natives and tribal since times immemorial. Mitragyna parvifolia has also got diverse medicinal and therapeutic properties such as analgesic, antipyretic, anti-inflammatory, antiarthritic, anthelmentic, antioxidant etc which have been validated scientifically. In this study we have critically reviewed the pharmacognostic and chemical profile, the traditional and the scientifically validated bioactivities of the plant.
7 January 2013

NASAL DRUG DELIVERY SYSTEM: A COMPLETE REVIEW

About Authors:
Dharmendra Kumar^*1, Sumedha Bansal¹
¹Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology,
Meerut, Uttar Pardesh, India, 250005
*rvnimiet@gmail.com

Abstract:
In present era, nasal drug delivery system has been considered as potential and favourable route of drug delivery because it provides patient compliance, easy to administration, bypass first pass metabolism, excellent penetration, low dose required, rapid absorption and gives desirable effects. So many times nasal drug delivery has been considered as alternative of parenteral route. The purpose of this review, to provide a complete information about nasal drug delivery system such as advantage, limitations, anatomy of nose, mechanism of drug absorption, factors affecting of nasal drug delivery, absorption improvement aspects, novel drug formulations, types of nasal drug delivery system with uses of nasal drug delivery in various disease. So we have expectation, that researches and others cited person get benefitted from this review.
7 January 2013

A REVIEW ARTICLE ON ANTIFUNGAL AND ANTIMICROBIAL ACTIVITY OF TAGETES ERECTA

About Author:
Bandana patel
Shri Ram Institute Of Technology
Jabalpur(M.P.) 482002
Vandanapatel.mbbs@gmail.com

Abstract:
Tagetes erectus leaf were evaluated against various gram +ve and gram–ve bacteria and fungi, ethanol extracts exhibited very satisfactory inhibitory activity. Further studies involving the isolation, characterization and purification of the chemical compounds of the plant and screening for antibacterial and antifungal may result in the development of a potent entity which will be of lower toxicity and a high therapeutic value to the mankind.
6 January 2013

TOTAL PHENOLIC AND FLAVONOID CONTENT OF DIFFERENT EXTRACTS OF INDIGOFERA TINCTORIA LINN

About Authors:
Nagasaraswathi.M*, Rafi khan.P, Aleemuddin.MA, Gopi Chand.K, Nagaprashanthi.Ch
Faculty of Pharmacy, PRIST University,
Thanjavur-614901, Tamilnadu (INDIA)
abdulaleemuddin@gmail.com

ABSTRACT
The importance for medicinal herbs is increasing day by day due to its high availability and lower side effects. The present study investigated the total phenolic and flavonoid content of various extractions of Indigofera tinctoria linn. The total phenolic content was determined by folin-ciocatechu reagent using Gallic acid as standard and total flavnoid content by aluminium chloride assay using Quercetin as a standard. The present study showed the ratio of phenolic and flavonoid content in different extracts of Indigofera tinctoria linn. Aqueous extract showed the more flavonoid and phenolic content in comparision with other extracts.
6 January 2013

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL 3-(2-(1H-INDOL-2-YL) PHENYL)-2-ARYLIMIDAZO[4,5-b]INDOLES

About Authors:
Aditya Dixit¹, Gyanendra Kumar Sharma², Devender Pathak^*3
¹M. Pharmacy (Pharmaceutical Chemistry)
²Associate Professor (Pharmaceutical chemistry)
³Director, Professor and Head of the Dept. (Pharmaceutical Chemistry)
Rajiv Academy for Pharmacy, Mathura,
Delhi-Mathura Highway, Chhattikara, 281006, India
dev_15@rediffmail.com*, adixit70@gmail.com

ABSTRACT
A traditional but effective method of developing new targets is lead molecule modification, where an existing popular drug from the market is taken as a lead and similar derivatives are synthesized. With the advent of modern techniques conventional methods have lost their gleam but, reactions are still best understood when performed by the conventional techniques. One such endeavor has been made here where indole has been used as a parent moiety and by adding some functional groups some novel indole derivatives were synthesized and screened for their in vitro antitubercular, and anticancer activity. This synthesis of some fresh indole derivatives was done by using various benzaldehyde derivatives and 2-(o-Aminophenyl)indole in acidic condition then with ammonium acetate and isatin in presence of glacial acetic acid.. The structures of newly synthesized compounds were characterized by IR, ¹H NMR, MASS and elemental analysis.Compounds 3h & 3i showed good antitubercular activity and 3d, 3e & 3g showed good anticancer compared to the standard drug.

(adsbygoogle = window.adsbygoogle || []).push({});
4 January 2013

MODIFIED LIPID VESICLES, ETHOSOMES AND INVASOMES: POTENTIAL CARRIERS FOR TRANSDERMAL DRUG DELIVERY

About Authors:
Ravindra K. Kamble, Priyadarshani R. Kamble*
Department of Pharmaceutics and Quality Assurance,
Bhupal Nobles’ College of Pharmacy, Udaipur, Rajasthan, INDIA.
*priya.s.bansode@gmail.com

ABSTRACT
Recent studies reported approval of lipid vesicles as drug carriers for chemotherapeutic agents and bio-actives which have been revealed in a number of lipid vesicles based formulations, which are commercially available or are currently undergoing clinical trials. This review is mainly focused on effectiveness and permeation enhancing controversy of lipid vesicles as dermal and transdermal drug delivery with special emphasis on recent advances in this field, including the development of deformable vesicles, ethosomes and invasomes. Only specially designed lipid vesicles have been shown to be capable of achieving enhanced delivery. The incorporation of additives, such as anionic surfactants and ethanol, fluidize the phospholipid bilayers, thus can penetrate the intercellular pathways of the skin.
4 January 2013

DISCUSSION ON RADIOISOTOPE & RADIOPHARMACEUTICAL: IT’S USES

About Authors:
C.P.Meher*, S.P.Sethy, B.Pochaiah
Asst. Professor
Maheshwara Institute of Pharmacy,
Department Of Pharmaceutical Chemistry
Chitkul, Patancheru, Medak, A.P
*chaitanyameher84@gmail.com

ABSTRACT
Radioactive isotope, also called radioisotope, any of several species of the same chemical element with different masses whose nuclei are unstable and dissipate excess energy by spontaneously emitting radiation in the form of alpha, beta, and gamma rays. Radioisotopes are elements that are atomically unstable and radioactive. Radioisotopes stabilize by releasing energy and matter. Natural radioisotopes, which have relatively low radioactive energy, have been largely replaced by artificially produced radioisotopes. Artificially produced radioisotopes are widely utilized as sources of radiation for radiography, gauging, and as tracers for a multitude of measurements that are not easily made by other methods. Radiopharmaceuticals are drugs containing a radionuclide and are used routinely in nuclear medicine for the diagnosis and therapy of various diseases. Presented article is concerned with brief discussion about the radioisotope & Radiopharmaceuticals.
3 January 2013

EFFECT OF LYOPHILIZATION AND CRYOPRESERVATION ON PLANT LEAVES OF TERMINALIA ARJUNA TERMINALIA CATAPPA, TERMINALIA CHEBULA, JATROPHA GOSSYPIFOLIA, JATROPHA CURCAS

About Authors:
¹Hardik R. Patel*, ²Upanita C. Patel
¹Industrial biotechnologist, ²Microbiologist
Anand, Gujarat, India.
*hardikigbt@gmail.com

INTRODUCTION:
Cryopreservation and lyophilization of plant germplasm has obvious advantages over in vitro storage in term of space saving and improved phytosanitation. We compared cryopreserved and lyophilized leaf as sources for genomic DNA isolation by CTAB protocol and PVP protocol.Our results showed that cryopreservation of leaf tissue yielded high molecular weight genomic DNA. The DNA was suitable for restriction-enzyme digestion and as a template for polymerase chain reaction (PCR) amplification. While these results rule out cryopreserved tissue as a source for DNA isolation, the ability to freeze-dry, powder, and efficiently store voluminous tissue samples for later use in DNA and protein isolation could be of great benefit to laboratories involved in molecular genetics and molecular biology.
2 January 2013

A NOVEL ANTIDIABETIC DRUG: MIGLITOL: A REVIEW

About Authors:
Rahul kumar Singh
M.Pharm (Quality Assurance)
Sr. Officer Quality Assurance at Shreya Life Sciences Pvt. Ltd.,
Roorkee, Uttarakhand
rahulsingh.qa@gmail.com

Abstract
Miglitol, an oral alpha-glucosidase inhibitor, is a desoxynojirimycin derivative that delays the digestion of ingested carbohydrates, thereby resulting in a smaller rise in blood glucose concentration following meals. As a consequence of plasma glucose reduction, miglitol reduce levels of glycosylated hemoglobin in patients with Type II (non-insulin-dependent) diabetes mellitus. Systemic nonenzymatic protein glycosylation, as reflected by levels of glycosylated hemoglobin, is a function of average blood glucose concentration over time. Because its mechanism of action is different, the effect of miglitol to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, miglitol diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance.
2 January 2013

BIODEGRADABLE POLYMERS AND THEIR ROLE IN DRUG DELIVERY

About Authors:
Kotta Kranthi kumar¹, V Bhargava Reddy²
Sku college of pharmaceutical sciences S.K.University Anantapur
*kranthikumarkotta@gmail.com

ABSTRACT
In the nature so many polymers are available. With this natural polymers will not shows any interactions with the api. In the drug delivery systems the polymers are plays an important role for the delivery of the drugs. By using the polymers we will deliver the drugs in the targeting points. Now a day this polymers science is the emerging field for the development and invention of new polymers. In the coming years polymers will plays a vital role in dug delivery.

(adsbygoogle = window.adsbygoogle || []).push({});