Pharmacology Articles

ACTIVITIES OF AQUEOUS EXTRACTS OF MANGIFERA INDICA ON PARASITAEMIA LEVEL AND BLOOD PROFILE OF PLASMODIUM BERGHEI - INFECTED ALBINO MICE

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ABOUT AUTHORS
*Olayode, Ahmed A1; Saka, Olusola S1; Ajayi, Olusoji C2; Agbaje, Mojeed A1
1Department of Anatomy and Cell Biology, Faculty of Basic Medical Science
2Department of Pharmacognosy, Faculty of Pharmacy
Obafemi Awolowo University, Ile-Ife, Nigeria
olayodeahmed01@gmail.com

ABSTRACT
This study was carried out to assess the effect of Mangifera indica on the percentage parasitaemia and some blood parameters of Plasmodium – infected Albino mice. Forty-two male albino mice, weighing between 20 and 25 g, were used for this research. The mice were randomly assigned into six groupsA, B, C, D, E and F of seven mice each. Group A was the negative control, group B was positive control. Mice in groups C, D and E were orally administered with Mangifera indica extract (50 mg/kg, 100 mg/kg and 150 mg/kg body weight) respectively for 5 days starting from the 4th day of inoculation while mice in group F were orally administered with Artesunate for 5 days (3 mg/kg b.w on the first day and 1.5 mg/kg b.w for the next 4 days) starting from the 4th day of inoculation. Blood smears were taken every 2 days to check the parasitaemia level for 14-day post-treatment withdrawal period. The extract has a dose dependent reducing effect on the level of parasitaemia. It also showed that the increase in the rate of reticulocytosis and consequent increase in the number of red blood cells in a dose dependent manner.


BIO-MARKERS AND BIO-SENSORS: UNRAVELLING THE MAJOR MECHANISTIC INTERVENTIONS IN CANCER PROGNOSIS

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ABOUT AUTHOR
Rajesh Tiwari
Junior Technical Assistant
Pharmaceutical Science and Natural Products
Central University of Punjab, Bathinda
rajesh.tiwari851@gmail.com

ABSTRACT
Biosensors are a tool that combines the biochemical element with a transducer that generates an indication for the identification of disease. Numbers of biosensors are used in different medical application. Biomarker and Biosensors play an important role for early stage exposure of cancer. It is a cost-effective, increased assay speed, resiliency, the ability for multi-target analysis method. Genomic and proteomic molecular tools are also used for the exposure of tumors. These methods produce a molecular mark that provides a new opening for utilizing biosensors and biomarkers. As with many disease conditions, it is not easy to find exact and responsive markers that are associated with only one marker. Different numbers of molecular signatures are used for the diagnosis of cancer, such as proteins, peptides, overexpression gene and gene mutation. This review provides a general idea of the biosensors and biomarkers technology that is currently developed and researched for cancer markers and diagnosis.


BESTOWING PHARM.D TO THE ERA OF HEALTHCARE TECHNOLOGY AND PATIENT SAFETY

ABOUT AUTHORS:
Tarun Singh
India’s Leading Drugs Consultant
SSJ Hospital
doctarunsethi@gmail.com

Advancement in health and medicine has enhanced the life expectancy of human beings. For last hundred years' medicinal processes and medical equipment are proved to be the boon to human health for diagnosing properly and for applying proper medicines to the patient.

Medicine is considered as one of the most important necessity to all of us. It is derived from the Latin words arsmedicina meaning "the art of healing". Medicine and Drugs are the synonyms.  Drugs is concerned with maintaining or restoring human health through the study, diagnosis, treatment and possible prevention of disease, injury and other damage to a body or mind. It ignites the human mind to initiate more research to find other sophisticated technology for adding value to medical science. Due to consistent effort of doctors and scientists now we have latest medical equipmentfor diagnosis, High quality medicine packaging machines, Computerised blood testing machines, digital & robotic testing machines.


EFFECT OF PULSATILLA ON POLYCYSTIC OVARIAN SYNDROME AND ITS ASSOCIATED CANCER

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ABOUT AUTHORS:
Debpratim Chakraborty
Persuing M.Pharm (Pharmacognosy),
Jadavpur University, West bengal.
debpratim008@gmail.com

ABSTRACT
Polycystic Ovarian Syndrome is one of the most common female endocrine. Many papers reported the correlation between infertility that most eminently predisposes towards cancer in PCOS women from many years. From both clinical and experimental research one can conclude that correlation between PCOS and endometrial cancer is the strongest. Most studies on correlation between PCOS and ovarian cancer as well as breast cancer failed to show a link though Pulsatilla have a strong effect on it. Various synthetic drugs which mainly used in the treatment of PCOS and endometrial cancer but here the problem is those drugs has lots of side effect/Adverse effect so we should go with the natural product Pulsatilla Sp. Which is used on PCOSand various cancer. Pulsatilla is a well establish drug for PCOS with unknown mechanism of action. Deoxypodophyllotoxin, which was isolated from the roots of P. koreana, was found to inhibit the tube-like formation of HUVECs (human umbilical venous endothelial cells) and have a potent antitumor effect. The chemical constituent saponin D present in Pulsatilla root is responsible for the anti tumor activity. The results, which are expressed as Pulsatilla saponin D has such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). 23-Hydroxybetulinic acid synthesized from Pulsatilla chinensis also shows anti tumoral activity. Though the potency of pulsatilla sp. Are less than synthetic marketed drugs but by structural modification we may get potent anti canceral agent with least toxicity by Pulsatilla.


DIAGNOSIS OF GRANULAR CELL TUMOUR OF THE UPPER LIP USING POLYMER HRP DETECTION SYSTEM

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ABOUT AUTHORS:
1Neeraj Kumar Lohani*, 2Prakash Singh Nainwal
1Institute of Biomedical Education & Research, Mangalayatan University, Aligarh- Uttar Pradesh, India,
2Govt. medical College Haldwani, Nainital Uttrakhand, India
*neerajlohani06@gmail.com

ABSTRACT:
Oral granular cell tumour is a rare soft tissue tumour ofcan develop on any skin or mucosal surface. Granular cell tumors can affect all parts of the body; however, the head and neck areas are affected 45% to 65% of the time. Of the head and neck cases 70% of lesions are located intraorally (tongue, oral mucosa, hard palate). The next most common location that lesions are found in the head and neck area is the larynx(10%).[1] In patients 30% of cases have been reported to occur in the lip, but this presentation in adults is extremely rare. The present study is concerned a case of oral granular cell tumour in a 60 year-old female, located in the upper lip. Histopathological examination revealed granular cells which stained positively for S-100 protein; a finding supportive of a neural origin. A history of trauma was elicited in this case, and the lesion was treated with surgical excision.


EVLUATION OF EFFECTS OF COMMIPHORA WIGHTII IN DEHYDROEPIANDROSTERONE (DHEA) INDUCED POLYCYSTIC OVARY SYNDROME (PCOS) IN RATS

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ABOUT AUTHORS:
Kavitha.A*, Narendra Babu.A, Sathish Kumar M, Veena Kiran.S

Department of pharmacology
Chalapathi institute of pharmaceutical sciences,
Lam, Guntur-522034, Andhra Pradesh
andugulakavitha@gmail.com

ABSTRACT
Background:

Hyperandrogenism and insulin resistance are the main manifestations of polycystic ovary syndrome (PCOS), which appears to be caused by exposure to androgenized models have developed and investigated to study the etiology of polycystic ovary syndrome.
Objective:

To evaluate the modulatory effects of Commiphora wightii (C.wightii) resins in response to hyperandrogenism in polycystic ovary syndrome.
Method:

The animals were divided 18 adult (5-6 months old) wistar rats in to 4 groups the PCOS model was induced by daily administration of dehydroepiandrosterone (DHEA) 6mg/Kg in sesame oil p.o., up to 15 days and the rescue groups were take daily with metformin and C.wightii resin ethanolic extract 100mg/ kg in addition to DHEA. Serum glucose levels measured and steroid hormone levels were measured by fully automated bidirectionally interfaced chemi luminescent immunoassay. Samples were stained with hematoxylin and eosin for histological morphology.
Results:

The obtained results related to DHEA induced PCOS a significant (P<0.05) increase in hormone profile (estradiol, testosterone, progesterone, luteinizing hormone, follicle stimulated hormone) in PCOS rats in adult rats than the rescue groups. Furthermore glucose levels significantly (<0.05) elevated in PCOS rats compared with the other groups. The test treated ovaries had lower number of follicles compared to DHEA control group and similar to that of the control group than the standard.
Conclusion:

Commiphora wightii
resin has a potential role in reducing DHEA induced PCOS by reducing the morphological abnormalities of the ovarian follicles and normal hormone levels in adult rats.


A RARE CASE REPORT ON TUBEROUS SCLEROSIS

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ABOUT AUTHORS:
N. Surendra Reddy, S. Chandrakala, B. Nagendra Prasad, G. Divya, T. S. Durga Prasad, Diviti Ranganayakulu
Department of pharmacy practice,
Sri Padmavathi School of Pharmacy,
Tiruchanoor, Tirupati, india
*suriph7@gmail.com

ABSTRACT:
Tuberous sclerosis is a neurocutaneous syndrome with an autosomal dominant inheritance. Tuberous sclerosis has an approximate incidence of one in ten thousand to fifty thousand. Tuberous sclerosis complex Syndrome (TSCs) is a dominantly inherited disorder affecting multiple organs; caused by mutations of either the TSC1 or TSC2 gene encoding hamartin and tuber in respectively. It is characterized by the development of benign tumors affecting different body systems. The most common oral manifestations of TSC are fibromas (angiofibromas), gingival hyperplasia and enamel hypoplasia and the formation of hamartomas in multiple organ systems leading to morbidity and mortality. It is important to make an early diagnosis of TSC so that lifelong monitoring, early recognition of complications and proactive treatment can lower the morbidity and mortality rates. We report a case of 35 year old female in south India with the features of Tuberous sclerosis complex like seizures, weakness of the body, papules over the cheek, calcification noted in subependymal region in the brain and angiomyolipoma in both kidneys.


PHARMACOTHERAPY CONSIDERATIONS IN PALLIATIVE CARE – A REVIEW

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ABOUT AUTHOR:
Akash kurian
Clinical Pharmacist,
PSG College of Pharmacy
akash.kurian8@gmail.com

ABSTRACT
Noncommunicable diseases (NCDs), such as heart disease, stroke, cancer, chronic respiratory diseases and diabetes, are the leading cause of mortality in the world. According to world health organization, In India The probability of dying between ages 30 and 70 years from the 4 main Non-Communicable Diseases (Cancers, Diabetes, Cardiovascular Diseases, Chronic Respiratory Diseases) is 26 %   in the year  2014 [1] .

The WHO defined palliative care as “an approach that improves the quality of life of patients and their families facing the problems associated with life-threatening illness, through the prevention and relief of suffering by means of early identification and impeccable assessment and treatment of pain and other problems, physical, psychosocial, and spiritual [2]. It has been considered both a general approach to patient care and a practice specialty. A palliative care approach can be applied at any point during the course of illness and should not be confused with hospice care, which incorporates the philosophies of palliative care, but is typically provided to patients with life expectancies of 6 months or less. The purpose of this review article is to focus on pharmacotherapy decisions of chronically ill patients during the later part of life and pharmacists responsibilities in hospice and palliative care.


A REVIEW ON: EBOLA VIRUS DISEASE (EVD)

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ABOUT AUTHORS:
Anmol Eldose*, Hetal Patel, Pooja Patel, Vinish Sharma, Zeel Rajput, Hitesh Jain, U.M. Upadhyay
Sigma Institute of Pharmacy,
Vadodara, Gujarat, India
*anmoleldose38@gmail.com

ABSTRACT
Ebola virus is a fatal illness in humans and non primates. Ebola virus causes Ebola hemorrhagic fever. Ebola Virus Disease (EVD) is transmitted to people from wild animals and spread to humans through human to human transmission. EVD is caused by the sudden onset of weakness, muscle pain, headache, sore throat, fever, vomiting, diarrhoea, liver dysfunction, rashes and also internal- external bleeding. As such no specific treatment foe EVD is available but a number of researches are going on. Oral rehydration therapy or intravenous fluids are some of the treating symptoms.


A REVIEW: ANTI-DIABETIC ACTIVITY OF HERBAL DRUGS

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ABOUT AUTHOR:
Dwiti Modak
Ayurvedic Pharmacy, Lovely School of Pharmaceutical Sciences,
Lovely Professional University, Phagwara, Punjab, India
dwiti.modak@rediffmail.com

ABSTRACT
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from increased hepatic glucose production, diminished insulin secretion and impaired insulin action. Though diabetes is a global problem so the present study aims to open new avenue to explore the antidiabetic activity of various medicinal plants on a firm scientific footing and different market formulation which add value as novel antidiabetic drug.


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