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A REVIEW ON: EBOLA VIRUS DISEASE (EVD)

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ABOUT AUTHORS:
Anmol Eldose*, Hetal Patel, Pooja Patel, Vinish Sharma, Zeel Rajput, Hitesh Jain, U.M. Upadhyay
Sigma Institute of Pharmacy,
Vadodara, Gujarat, India
*anmoleldose38@gmail.com

ABSTRACT
Ebola virus is a fatal illness in humans and non primates. Ebola virus causes Ebola hemorrhagic fever. Ebola Virus Disease (EVD) is transmitted to people from wild animals and spread to humans through human to human transmission. EVD is caused by the sudden onset of weakness, muscle pain, headache, sore throat, fever, vomiting, diarrhoea, liver dysfunction, rashes and also internal- external bleeding. As such no specific treatment foe EVD is available but a number of researches are going on. Oral rehydration therapy or intravenous fluids are some of the treating symptoms.


A REVIEW: ANTI-DIABETIC ACTIVITY OF HERBAL DRUGS

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ABOUT AUTHOR:
Dwiti Modak
Ayurvedic Pharmacy, Lovely School of Pharmaceutical Sciences,
Lovely Professional University, Phagwara, Punjab, India
dwiti.modak@rediffmail.com

ABSTRACT
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia resulting from increased hepatic glucose production, diminished insulin secretion and impaired insulin action. Though diabetes is a global problem so the present study aims to open new avenue to explore the antidiabetic activity of various medicinal plants on a firm scientific footing and different market formulation which add value as novel antidiabetic drug.


MIDDLE EAST RESPIRATORY SYNDROME CORONAVIRUS: AN EMERGING INFECTION

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ABOUT AUTHORS:
Suresh Rewar1*, Dashrath Mirdha2, Prahlad Rewar3
1Department of pharmaceutics, Rajasthan University of Health Sciences, Jaipur, Rajasthan,
2Dr. Sarvepali Radhakrishnan Rajasthan Ayurved University, Jodhpur, Rajasthan, India
3Jawaharlal Nehru Medical College, Ajmer, Rajasthan, India
sureshrewar1990@gmail.com

ABSTRACT
A severe viral illness caused by a newly discovered coronavirus was first reported in the Middle East in 2012. The virus has since been named the Middle East respiratory syndrome coronavirus (MERS-CoV). MERS-CoV cases have been reported in several countries around the world in travelers from the Middle East., A substantial number of Indians live and work in Gulf countries. People from India also travel to Saudi Arabia as Pilgrims to Hajj. The illness has a high mortality rate. Limited human-to-human transmission has occurred including transmission to health care workers. The source of the virus remains unclear, but camels are a possible source. Since April 2012 and as of 20 February 2015, 1042 cases (including 419 deaths) of Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported by local health authorities worldwide. Laboratory confirmation of MERS-CoV infections to date has largely been by real-time reverse transcription polymerase chain reaction (rRT-PCR) of lower respiratory tract specimens. Neither a vaccine nor effective therapy against the virus is available. Treatment consists of limited to supportive care, including mechanical ventilation for respiratory failure and/or hemodialysis in the setting of renal failure. Therapeutic modalities based on monoclonal antibodies (mAbs) have shown clinical success in the treatment of many diseases.


NANOPARTICLE (NP) AS A TARGETING DRUG DELIVERY SYSTEM TO BLOOD-BRAIN BARRIER (BBB): A REVIEW

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ABOUT AUTHROS:
Bikash Debnath*, Md. JashimUddin, Debasish Maiti
State Biotech Hub, Department of Human Physiology,
Tripura University, Suryamaninagar.
*bikashrips2014@gmail.com

ABSTRACT:
Central nervous system (CNS) drug development will be biology driven. Due to absence of functional platform for CNS drug targeting since, the large molecules pharmaceuticals cannot be delivered to brain. About 1.5 billion people worldwide are suffering from various type of central nervous system (CNS) disorders. Overcome to this problem modern pharmaceutical technology manufacturing the nonaparticles. Properly use of nonamedicines (nanoparticles) is one of the ways to control the CNS disorder in all over world. Nanoparticles are particles between 1 to 100 nm in size. Using nanotechnology it is possible to deliver the drug to the specific site of the tissue across the Blood -Brain Barrier (BBB).Various types of nanoparticle are available for treatment of CNS disorders. These are lipid based nanoparticles, solid lipid nanoparticles, polymer-based nanoparticles etc.


EVALUATION OF ADAPTOGENIC ACTIVITY OF VARIOUS EXTRACTS OF BREYNIA VITIS-IDAEA (BURM.F) C. FISHER LEAVES BY USING SWIM ENDURENCE TEST

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ABOUT AUTHORS:
Manju Gowda M R*, Gnanasekaran D, Ashik navas T, Antony george
Department of Pharmacology, Bharathi College of Pharmacy,
Bharathinagara, Mandya, Karnataka-571422
manjugowdamr@gmail.com

ABSTRACT
The present study was under taken to study the Adaptogenic activity of ethanol, aqueous and ethyl acetate extracts of Breynia vitis-idaea (burm.f) c. fisher. (Euphorbiaceae) leaves. Adaptogenic activity of these extracts were studied using in-vivo Swim Endurance test and compared with the standard Fluoxetin. All the extracts showed significant increase in the swimming time. Adaptogenic nature of the extracts may be attributed to the presence of constituents such as alkaloids, glycosides, flavonoids and saponins in plant extracts. This study proven that the potential adaptogenic nature of the extract of Breynia vitis-idaea leaves.


RESOURCES, GUIDANCE, CONTROL AND PREVENTION FOR EBOLA VIRUS DISEASE-AN OVERVIEW

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ABOUT AUTHORS:
Jadhav Santosh1*, Mali Audumbar1, Tamboli Ashpak2
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India1.
Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India2.
jadhavsan88@gmail.com*

ABSTRACT
Since the current Ebola Virus Disease (also referred to as Ebola Haemorrhagic Fever) outbreak began in Guinea in December of 2013, the outbreak now involves trans-mission in Guinea, Liberia, Nigeria, and Sierra Leone. Ebola haemorrhagic fever (EHF) is a zoonosis affecting both human and non-human primates (NHP). Ebola virus (formerly officially designated Zaire Ebolavirus, or EBOV) was first seen infecting humans in African continent; especially  Sudan, Democratic Republican of Congo, Zaire and nearby countries. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. The World Health Organization (WHO) reports that this is the largest Ebola Virus Disease (EVD) outbreak ever recorded. EVD outbreaks have a case fatality rate ofup to 90%. The research is on-going on development of making vaccine to curb this virus yet licensed success or specific treatment is not achieved.


CHRONOPHARMACOTHERAPY OF HYPERTENSION: TIME-DEPENDENT EFFECTS OF TREATMENT ON BLOOD PRESSURE

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ABOUT AUHTORS:
Suresh Rewar1*, Bansal BK1, Singh CJ2, Sharma AK2
1Department of pharmaceutics, Arya College of Pharmacy, Jaipur, Rajasthan India
2Department Of Pharmacology, Arya College of Pharmacy, Jaipur, Rajasthan India
sureshrewar1990@gmail.com

ABSTRACT
Chronopharmaceutical drug delivery systems are gaining a lot of interest as they deliver the drug at the right site of action, right time and right amount, as per the pathophysiological needs of the diseases. These systems are basically time-controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, GIT motility, etc. These systems are designed for chronopharmacotherapy which is based on the circadian rhythm of the body. The effectiveness and toxicity of many drugs vary depending on dosing time associated with 24 hr. rhythms of biochemical, physiological and behavioral processes under the control of circadian clock. The chronobiology of the various common 24-hour BP profiles seen in hypertensive patients in relation to cardiovascular risk and end-organ injury and ultimately the control and normalization of abnormal BP throughout daytime activity and night time sleep. Chronopharmacotherapy provides a means of individualizing the treatment of hypertension according to the circadian BP profile of each patient, and constitutes a new option to optimize BP control and to reduce the risk of cardiovascular disease. Various latest and upcoming marketed technologies of Chronopharmaceutical drug delivery used in treatment of hypertension diseases like OROS®, CODAS®, CEFORM®, DIFFUCAPS®, PULSINCAP® etc.


ROLE OF BCG IN TREATMENT OF BLADDER CANCER

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ABOUT AUTHOR
Abhishek Singhal
Department of Pharmacology,
Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.),
Pune, Maharastra, India
*abhishekspharma@gmail.com

ABSTRACT
Aim: This review is written to describe the role of immunotherapy in cancer treatment.
Annually, 13,000 deaths result from bladder cancer. Since the first report of intravesical use of BCG in 1976, investigators try to understand the working mechanism of BCG as an antitumour modality. Arbitrarily, BCG therapy consists of a single course of six weekly intravesical instillations. Bacillus Calmette-Gue´rin, an attenuated strain of Mycobacterium bovis, was developed by Calmette and Gue´rin with the intention to generate a vaccine against tuberculosis. Extension of BCG treatment (maintenance immunotherapy) is used to increase efficacy.
Results of various experiments describe that after instillation in the bladder, BCG accumulates near the bladder wall and is internalised and processed by professional antigen-presenting cells (APCs) and (high-grade) tumour cells. Then BCG antigens are presented to CD4+ T cells. Then local synthesis of a particular set of cytokines or cell-mediated immune response. NK cells may be involve in tumour cell killing.


DEADLY BUT CURABLE: A REVIEW ON POTENTIAL TREATMENTS FOR EBOLA HAEMORRHAGIC FEVER

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ABOUT AUTHOR:
Bushra Shamim
Department of Pharmaceutics,
Faculty of Pharmacy,
Hamdard University, New Delhi, India
bushrashamim21@gmail.com

ABSTRACT
This is a review article on potential treatments for Ebola virus disease, also known as Ebola haemorrhagic fever. Ebola fever has emerged as one of the deadliest known forms of hemorrhagic fever since discovered in 1976.  Transmission among humans occurs through the exchange of blood and body secretions. The Ebola virus causes an acute, serious illness which is often fatal if untreated. In this article experimental treatments like blood, immunological and drug therapies are discussed that are under development


EFFECT OF MAGNETIC FIELD ON CANCER CELLS

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ABOUT AUTHORS:
Rajesh Tiwari1*, Roshan kumar2
1Chemistry Department, Dr. Ghanshyam Singh Post Graduate College, Varanasi
2SBCBE VIT University, Vellore
*Rajesh.tiwari851@gmail.com

ABSTRACT
In 16th century physician were of the opinion that magnet can be used for the treatment or eliminate the diseases from the body. Here the reports about the chemical synthesis, protection, functionalization and application of magnetic nanoparticles of nano structured system. Research of magnetic nanoparticles for targeted drug delivery system and function of magnetic nanoparticles on particular area are reviewed. Use of magnetic nanoparticles for cancer diagnosis has been advancing day by day. This review is related to the multifunctional use of magnetic nanoparticles probes and their use in bio imaging and nano medicine.


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