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CERVICAL CANCER AND ITS VARIOUS EMERGING IMPACT

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ABOUT AUTHOR:
Shambhavi Singh
Department of Pharmacology, Singhania University,
Jhunjhunu, Rajasthan
shambhavisingh6777@gmail.com

ABSTRACT
Cervical cancer, malignant neoplasm, appears in tissues of the cervix, a likely preventable disease that originates as the second most widespread malignancy in women. In spite of being considering as a treatable disease, 95% preventive and conditions that can be easily examined through Pap smear. This disease accounts for a miserable condition, probable 24 percent of India’s cancer cases among women and in addition to that 80,000 Indian women die annually from the disease, which results from the unusual growth of cells in the cervix. No proper vaccination program from Indian government and miserable earning can be said responsible for this condition. Though the disease is both preventable and curable but still mortality rate in India is aggravating subsequently.


ATHEROSCLEROSIS: RESEARCH REVIEW

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ABOUT AUTHOR:
Shambhavi Singh
Department of Pharmacology, Singhania University,
Jhunjhunu, Rajasthan
shambhavisingh6777@gmail.com

ABSTRACT
Atherosclerosis a disease of the larger arteries is the major cause of heart disease and stroke.  Nowadays, serve as leading reason of death not only in senility peoples but in youth also worldwide. Researches in the atherosclerosis disease have led to many persuasive hypotheses about the pathophysiology of atherosclerotic lesion development and of tricky situation such as myocardial infarction and stroke. It is now unambiguous that atherosclerosis is not simply an unavoidable degenerative consequence of ageing, but somewhat a chronic inflammatory situation that can be transformed into an acute clinical occasion by plaque rupture and thrombosis. Evidently, crystallization of information concerning atherosclerosis will approach only by the appropriate free interplay and satisfactory fusion of the three foremost looms to the trouble, epidemiologic, clinical and investigational.


EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF TRITICUM AESTIVUM

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ABOUT AUTHORS:
K.Charan
A.U.College of Pharmaceutical Sciences,
Waltair, Visakhapatnam, Andhra Pradesh, India.
charan.karumuri@gmail.com

ABSTRACT
The present study was designed to screen anti-depressant activity of Hydro alcoholic extract of Triticum Aestivum using Chronic models (14 day study) of Tail suspension test (TST) and Forced Swim Test (FST) in Swiss Albino rats. Wheat grass were collected and authenticated. Extraction of dried wheat grass was carried out using a Soxhlet apparatus to obtain its Hydro alcoholic extract. The extract of Triticum Aestivum showed the significant anti-depressant activity comparable to the standard drug. The oral administration of Triticum Aestivum extract at doses 200 mg/kg & 400 mg/kg respectively as compared to the control treated group showed an anti-depressant activity comparable to that of standard drug.
The anti-depressant effects of Triticum Aestivum extract seem to be mainly associated with the activation of dopaminergic system and possess potential anti-depressant activity.


MINI-STROKE (TIA): A REVIEW

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ABOUT AUTHORS:
V. Sravanthi*1, Mayure vijay kumar1, Donthineni Kalyan2, G.J.Finny1, C.P.Meher1
1Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
2Department of Pharmaceutical Analysis, Saraswathi College of Pharmaceutical Sciences.
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com

ABSTRACT:
TIA stands for transcient ischemic attack, is a temporary blockage of blood flow in the brain that causes stroke symptoms. A transient ischemic attack is often called a mini-stroke. It is considered a warning sign that a more serious stoke will happen in the future. They may include weakness on one side of the body, dizziness, blurred vision, confusion, and speech problems. A TIA is a medical emergency. Following the below words cover about transient ischemic attacks (TIA), medication, prevention, diagnosing etc.


A REVIEW OF NATEGLINIDE IN THE MANAGEMENT OF TYPE 2 DIABETES

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ABOUT AUTHORS:
Mistry Ripal*, Haresh T. Mulani
Department of Pharmaceutics
Indubhai Patel College of Pharmacy and Research Centre,
Dharmaj, Gujarat
*rx.ripalmistry@gmail.com

ABSTRACT:
Diabetes mellitus, or simply diabetes, is a chronic disease that occurs when the pancreas is no longer able to make insulin, or when the body cannot make good use of the insulin it produces. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The success of oral hypoglycemic drug therapy is usually based on are storation of normal blood glucose levels. Traditionally, the term oral hypoglycemic was used interchangeably with sulfonylureas, but more recently the development of several new drugs has broadened this designation to include all oral medications for diabetes. Nateglinide, a D-phenylalanine derivative, is a novel insulinotropic drug which has recently been launched as a therapeutic agent for Type II diabetes. Clinical studies have shown that nateglinide induces a rapid onset of insulin release synergistic with meal administration which effectively restores the early phase of insulin secretion. Since the loss of early insulin secretion is thought to play an important role in the development of glucose in tolerance the ability of nateglinide to promote early insulin release is potentially of considerable therapeutic benefit.


HUNTINGTON’S DISEASE: AN UPDATE

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About Author:
Amandeep Kaur
Department of Pharmacology, G.H.G Khalsa College of Pharmacy
Gurusar Sadhar, Ludhiana, Punjab, INDIA
amananny2011@gmail.com

Abstract
Huntington's disease is a complex degenerative disorder that affects the central nervous system. Huntington's disease is an autosomal-dominant, progressive neurodegenerative disorder typically presents during mid-life with a distinct phenotype, including chorea and dystonia, incoordination, cognitive decline, and behavioral abnormalities. HD is caused by an expanded CAG repeat in the gene that encodes the protein huntingtin on chromosome 4; this results in progressive atrophy of the striatum as well as cortical and other extra striatal structures. Since 1993, genetic testing has been available to confirm diagnosis in affected adults and for pre-symptomatic testing in at-risk individuals. The review aims majorly on these areas namely: History, etiology, symptoms, pathophysiology, treatment and other aspects of Huntington’s disease.


CEREBRAL AGING AND NEUROLOGICAL DISORDERS

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ABOUT AUTHORS:
Alok Khunteta1,2, Vikas Pareek2*
1Registrar, Rajasthan Pharmacy Council,
2 Department of Pharmaceutics,
Lal Bahadur Shastri College of Pharmacy,
Rajasthan University of Health Sciences, Jaipur, Rajasthan
* Vikaspareek@yahoo.com

ABSTRACT:
Age-related cognitive decline is a well-known phenomenon, called by various means such as age-associated memory impairment and age associated cognitive impairment. Since cerebral aging is idiopathic, so due to lack of pure reasons it’s diagnosis is typical and also it’s not being recognized at early ages by person too.  As per the reports by 2050, it is anticipated that Americans aged 65 or older will number nearly 89 million people, or more than double the number of older adults in the United States in 2010, these stats are complementary to global scenario. The review is to collectively cast Cerebral aging with reasons and solutions. The detail of theories regarding cerebral aging and its related deficits is provided. Pharmacological action of both Allopathic and Ayurvedic medicines are illustrated. The role of yoga and pranayam being a quencher of Reactive oxygen species (ROS) thus reducing cerebral aging is also provided further in review.


A POTENT TARGET FOR CANCER TREATMENT – TUMOR HYPOXIA NECROSIS: AN OVERVIEW

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ABOUT AUTHORS:
Pankaj Dinkar Patil*, Raju Tayade
Department of Pharmaceutical sciences and technology,
ICT Mumbai, Maharashtra
pankaj.patil46@gmail.com

ABSTRACT:
Tumor hypoxia is feature of locally advancing solid tumor and also considered as potential therapeutic challenge. It causes solid tumor resistible to the cancer treatment like radiation and chemotherapeutic drugs. The transcription factor HIF-1 is the major player in the regulation of tumor progression into malignant phenotype. We can target this hypoxic conditions using pathophysiological approach for targeted drug delivery for treatment of cancer. This review will focus on various biological aspects of tumor hypoxia necrosis and approaches for targeting hypoxic tumors. This tumor selective treatment will include bioreductive drugs, gene therapy, and recombinant bacteria.


BRAIN AS A SANCTURIAN SITE IN DRUG DELIVERY APPROACHES TO IMPROVE BIOAVAILABILITY IN BRAIN

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ABOUT AUTHOR
Sagar Vishwanath Sonawane*
Dept. of Pharmaceutical Sciences and Technology,
Institute of Chemical Technology,
Matunga, Mumbai, Maharashtra, India.
*sssagarvs@gmail.com

ABSTRACT
Brain is the highly protected organ of the body by the sanctuary known as blood brain barrier (BBB). BBB comprises of tight junctions formed by the closed fenestration network of astrocytes, pericytes microglial cells and endothelial cells. Thus it is very difficult for drug molecules to cross BBB. Thus various approaches are discussed to overcome this barrier. Disruption of BBB was conventional invasive approach. The permeability of BBB increases in various diseases. This increased permeability of BBB is made use for drug trafficking. With advances in nanotechnology, various nanocarrier systems including Polymeric nanoparticles, Micelle, Dendrimer, Liposomes, Solid lipid nanoparticles, Nanostuctured lipid carriers, nanogels, etc. emerged as potential delivery systems.
Administration of inhibitors of p-glycoprotein with drug is another approach. Making lipophilic prodrugs of active drug substances can also be done.
Recently PEGylation of nanoparticles can be done to improve its half life in the body, known as the stealth technology. Further various receptor mediated processes are made use of for transport of nanocarrier across BBB. In this method the nanocarrier is attached to the targeting ligand thus making it receptor specific. The newer concept of molecular Trojan horses is also discussed. Finally the advantages of intranasal drug delivery are emphasized.


A COMPARATIVE STUDY FOR SAFETY AND EFFICACY OF OXACEPROL AND DIACEREIN IN OSTEOARTHRITIS OF KNEE JOINTS

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ABOUT AUTHOR:
Jay Shah1, Nazima Mirza2, Vivek Patel3
1Department of Clinical Pharmacy, A.R.College of Pharmacy and G.H.Patel Institute of Pharmacy,
Vallabh Vidyanagar, Gujarat, India.
2Department of Pharmacology, Pramukh Swami Medical College, Karamsad, Gujarat
3Department of Orthopedic, Shree Krishna Hospital, Karamsad, Gujarat
shahjayg@yahoo.com

ABSTRACT
Objectives: Osteoarthritis (OA) is the most common form of arthritis which has a growing number of patients and having major impact on the quality of life. According to modes of action the drugs for OA are divided into two groups. First group, NSAIDs which provide symptomatic relief but have no influence on progress of the disease and shows higher adverse events. The second group of drugs acts as disease modifying agents. Recent data from clinical trials have demonstrated that agents like Diacerein & Oxaceprol specifically block key disease mechanisms & effectively retard the progression of structural changes in knee OA patients. The study was undertaken to compare the efficacy & safety of Oxaceprol and Diacerein in the patients of Osteoarthritis of Knee joints.
Experimental/ Computational work done: Total 60 patients(4 withdrawn) suffering from mild to moderate OA of knee joint were included from outpatient orthopedic department of Shree Krishna hospital, Karamsad. Twenty eight patients received diecerein(50 mg b.i.d.) and 28 patients were given Oxaceprol(200 mg t.i.d.)  for 10 days and patient responses were measured using VAS and Lequesne scale, before and after drug treatment. Suspected adverse event was evaluated by filling ADR form. Ethical committee approval and patient consents were obtained prior to the beginning of the study.
Results and discussion: The VAS Scale was reduced from 7.321 ± 0.9449 to 4.75 ± 1.146 (Mean±SD) for Diacerein and 6.821 ±1.1564 to 4.321±1.1564 for Oxaceprol. The Lequesne scale was reduced from 6.0±1.054 to 4.21±1.0923 for Diacereine and 6.0±0.8819 to 3.839±1.0475 for Oxaceprol. Both the results were found to be statistically significant. Difference in VAS and Lequesne scale between the Diacerein and Oxaceprol were 0.757 and 0.099 respectively (p >0.05). There was not any Adverse Event reported.
Conclusions: Both the drugs, Diacerein and Oxaceprol, individually and equally effective in Osteoarthritis condition. Both Diacerein and Oxaceprol are found to be safer.


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