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DIABETIC FOOT ULCER: A SERIOUS PROBLEM FOR DIABETIC PATIENT

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ABOUT AUTHOR:
Amitava Sinha Ray
RANBAXY LABORATORIES LTD.
West Bengal, India
a.amitava.s@gmail.com

ABSTRACT:
Diabetes is a major problem across the world also it is a serious problem in India. Diabetes Mellitus is a silent killer of human body. Several types of complication are occurred in diabetic patient. One of the serious complications is Diabetic foot ulcer. Generally occurred due to breakdown in the skinand subcutaneous tissue also muscle. It will be more dangerous if it will become infected. Sometimes it is also needed to cut down the leg by surgery to prevent the spread of infection. A diabetic patient should take care for his foot to avoid this type of complication, also should be more care full to the management of blood sugar in normal level.


LOCAL ANAESTHESIA (LA): AN OVERVIEW

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ABOUT AUTHORS:
Mayure Vijay Kumar*, V. Sravanthi
Maheshwara College of Pharmacy (B-Pharm Scholar)
Department of pharmacology,
Maheshwara College of Pharmacy, Chitkul (V), Isnapur “X” Road, Patancheru, Hyderabad, A.P.
mayurevijaykumar@gmail.com

ABSTRACT:
The anaesthetic agents are the drugs which causes anaesthesia-reversible loss sensation. It deals with the property of relieving the pain without eliminating sensation. These drugs are generally administered to facilitate surgery. It can be described by two main classes. General anaesthetic, which causes a reversible loss of consciousness, and local anaesthetics, which causes a reversible loss of sensation for a limited region of the body while maintaining consciousness. Here I explain about the Local anaesthetics agents that prevent transmission of nerve impulses without causing unconsciousness. They act by binding to fast sodium channels from within in an open state.
BACKGROUND: The purpose of this Review article is to summarize the Local anaesthetics agents, general mechanism, structures, therapeutic uses, adverse effects and also explains their properties.


MEDICATION ERROR - MAJOR PROBLEM IN HEALTHCARE PRACTICE

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ABOUT AUTHOR:
Dinesh Kumar Meena
Department of Pharmacy,
Annamalai University, Annamalai nagar, Tamil Nadu.
*dinesh8989pharmd@gmail.com

ABSTRACT
A medication error is the failure of treatment process that may be harmful for the patient. A medication error can occur in deciding which medicine and dosage regimen to use, prescription writing, manufacturing the formulation, administrating the medicine, monitoring therapy. Avoiding medication error is important for the safety of patient as well as better therapeutic outcomes. Medication error may not be clinically significant on many occasions but they have serious economic consequences like extended hospital stays, additional treatment and malpractice litigation. Medication error are well known problem in hospitals. Medication error and adverse drug reactions are one of the main causes for adverse events in hospital leading to disability and death. Pharmacist is responsible for the safe and appropriate use of medication in all pharmacy practice settings. As the part of the multidisciplinary health care team, the pharmacist role is to cooperate to establish patient-specific drug therapy regimens designed to achieve predefined therapeutic outcomes without subjecting the patient to undue them. As pharmacist becomes more involved in patient – specific care, technician is asked to perform tasks that have previously been restricted to pharmacists. As their responsibilities expand, technician need to be aware of the significance and cause of medication errors and to recognize their role in preventing those errors.


PHARMACOLOGICAL PROPERTIES OF AEGLE MARMELOS: A MINI REVIEW

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ABOUT AUTHORS:
Sampat Kumar Kundu1, Shatabisha Bhattacharjee1, *Kuntal Pal2
1 Gurunanak Institute of Pharmaceutical Science & Technology, Sodepur, West Bengal, India
2 Faculty of Ayurveda, Institute of Medical Sciences, Rajiv Gandhi South Campus, Banaras Hindu University, Barkachha, Mirzapur
kuntalpal20@gmail.com

ABSTRACT
Ayurvedic plants have shown their effects on various kind of diseases. Those properties of the plants are sublimed in some molecules in the plants, which can be extracted out by performing various kind of processes (eg. Soxhlation, Percolation). Many plants which are used by the human being in daily life, also have some effects in curing some disease conditions. Likewise in our current review Aegle marmelos (Beal) have Antidiarrhoeal, Antidiabetic activities etc. Many Pharmacological Activities have been revealed & organized in this review article, but there have a wide scope of research to perform on this plant.


EFFECT OF HYDROALCOHOLIC EXTRACT OF MIMOSA PUDICA LINN. WITH IMIPRAMINE AND FLUOXETINE ON RESERPINE-INDUCED BEHAVIOURAL DESPAIR IN RATS

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ABOUT AUTHORS:
Mayuri Lawar1, Varsha Shende1*, Suvarna Ingle2, Monali Sanghvi1, Naeem Hamdulay1
1Department of Pharmacology, Sinhgad College of Pharmacy, Post-Graduate Research Department, Off Sinhgad road, Vadgaon (Bk), Pune, Maharashtra, India.  
2Department of Pharmacology, Indira College of Pharmacy, New Pune Mumbai Highway, Tathwade, Pune, Maharashtra, India.
*shende.varsha@gmail.com

ABSTRACT
Depression and related mood disorders are among the world’s greatest public health problems. Mimosa pudica L. (MP), a creeping perennial herb exhibits analgesic, anxiolytic, diuretic, antiasthmatic, hepatoprotective activities. Although, previous study reveal antidepressant like effects of aqueous extract of MP at behavioral levels, but antidepressant like effects of hydroalcoholic extract of Mimosa pudica L. (HEMP) and its combinational effect with standard antidepressant drugs at behavioral and biochemical level is not scientifically evaluated. Hence, the present investigation evaluates the antidepressant activity of HEMP and its interaction with fluoxetine and imipramine in reserpine-induced behavioural despair in rats and the potential mechanism involved in HEMP action. HEMP at doses 50, 100 and 200 mg/kg p.o., fluoxetine at 5 & 20mg/kg p.o., imipramine at 5 & 15mg/kg p.o. and reserpine 6mg/kg i.p. were administered to different groups of rat (n=6). After reserpine treatment, rats were subjected to forced swimming test followed by assessment of locomotor activity. Rats were sacrificed after behavioural study for estimation of serotonin, monoamine oxidase (MAO) levels in rat brain. Results demonstrate that combination of subeffective doses of HEMP, fluoxetine and imipramine reduced the duration of immobility in forced swimming test, increased serotonin and decreased MAO-A and MAO-B enzyme levels in reserpine treated rats. These findings suggest that combination of HEMP with standard drugs in subeffective doses can exert potential antidepressant like effect through modulation of brain serotonergic system and MAO inhibition.


CERVICAL CANCER AND ITS VARIOUS EMERGING IMPACT

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ABOUT AUTHOR:
Shambhavi Singh
Department of Pharmacology, Singhania University,
Jhunjhunu, Rajasthan
shambhavisingh6777@gmail.com

ABSTRACT
Cervical cancer, malignant neoplasm, appears in tissues of the cervix, a likely preventable disease that originates as the second most widespread malignancy in women. In spite of being considering as a treatable disease, 95% preventive and conditions that can be easily examined through Pap smear. This disease accounts for a miserable condition, probable 24 percent of India’s cancer cases among women and in addition to that 80,000 Indian women die annually from the disease, which results from the unusual growth of cells in the cervix. No proper vaccination program from Indian government and miserable earning can be said responsible for this condition. Though the disease is both preventable and curable but still mortality rate in India is aggravating subsequently.


ATHEROSCLEROSIS: RESEARCH REVIEW

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ABOUT AUTHOR:
Shambhavi Singh
Department of Pharmacology, Singhania University,
Jhunjhunu, Rajasthan
shambhavisingh6777@gmail.com

ABSTRACT
Atherosclerosis a disease of the larger arteries is the major cause of heart disease and stroke.  Nowadays, serve as leading reason of death not only in senility peoples but in youth also worldwide. Researches in the atherosclerosis disease have led to many persuasive hypotheses about the pathophysiology of atherosclerotic lesion development and of tricky situation such as myocardial infarction and stroke. It is now unambiguous that atherosclerosis is not simply an unavoidable degenerative consequence of ageing, but somewhat a chronic inflammatory situation that can be transformed into an acute clinical occasion by plaque rupture and thrombosis. Evidently, crystallization of information concerning atherosclerosis will approach only by the appropriate free interplay and satisfactory fusion of the three foremost looms to the trouble, epidemiologic, clinical and investigational.


EVALUATION OF ANTI-DEPRESSANT ACTIVITY OF HYDRO ALCOHOLIC EXTRACT OF TRITICUM AESTIVUM

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ABOUT AUTHORS:
K.Charan
A.U.College of Pharmaceutical Sciences,
Waltair, Visakhapatnam, Andhra Pradesh, India.
charan.karumuri@gmail.com

ABSTRACT
The present study was designed to screen anti-depressant activity of Hydro alcoholic extract of Triticum Aestivum using Chronic models (14 day study) of Tail suspension test (TST) and Forced Swim Test (FST) in Swiss Albino rats. Wheat grass were collected and authenticated. Extraction of dried wheat grass was carried out using a Soxhlet apparatus to obtain its Hydro alcoholic extract. The extract of Triticum Aestivum showed the significant anti-depressant activity comparable to the standard drug. The oral administration of Triticum Aestivum extract at doses 200 mg/kg & 400 mg/kg respectively as compared to the control treated group showed an anti-depressant activity comparable to that of standard drug.
The anti-depressant effects of Triticum Aestivum extract seem to be mainly associated with the activation of dopaminergic system and possess potential anti-depressant activity.


MINI-STROKE (TIA): A REVIEW

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ABOUT AUTHORS:
V. Sravanthi*1, Mayure vijay kumar1, Donthineni Kalyan2, G.J.Finny1, C.P.Meher1
1Department of pharmaceutical chemistry, Maheshwara College of Pharmacy
2Department of Pharmaceutical Analysis, Saraswathi College of Pharmaceutical Sciences.
Isnapur chitkul ‘X’ road, Patancheru, Hyderabad-502307
*v.sravanthi27@gmail.com

ABSTRACT:
TIA stands for transcient ischemic attack, is a temporary blockage of blood flow in the brain that causes stroke symptoms. A transient ischemic attack is often called a mini-stroke. It is considered a warning sign that a more serious stoke will happen in the future. They may include weakness on one side of the body, dizziness, blurred vision, confusion, and speech problems. A TIA is a medical emergency. Following the below words cover about transient ischemic attacks (TIA), medication, prevention, diagnosing etc.


A REVIEW OF NATEGLINIDE IN THE MANAGEMENT OF TYPE 2 DIABETES

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ABOUT AUTHORS:
Mistry Ripal*, Haresh T. Mulani
Department of Pharmaceutics
Indubhai Patel College of Pharmacy and Research Centre,
Dharmaj, Gujarat
*rx.ripalmistry@gmail.com

ABSTRACT:
Diabetes mellitus, or simply diabetes, is a chronic disease that occurs when the pancreas is no longer able to make insulin, or when the body cannot make good use of the insulin it produces. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. The success of oral hypoglycemic drug therapy is usually based on are storation of normal blood glucose levels. Traditionally, the term oral hypoglycemic was used interchangeably with sulfonylureas, but more recently the development of several new drugs has broadened this designation to include all oral medications for diabetes. Nateglinide, a D-phenylalanine derivative, is a novel insulinotropic drug which has recently been launched as a therapeutic agent for Type II diabetes. Clinical studies have shown that nateglinide induces a rapid onset of insulin release synergistic with meal administration which effectively restores the early phase of insulin secretion. Since the loss of early insulin secretion is thought to play an important role in the development of glucose in tolerance the ability of nateglinide to promote early insulin release is potentially of considerable therapeutic benefit.


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