Genotoxicity

  • Posted on: 31 August 2017
  • By: admin

 

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September 2017 ARTICLE LIST >>

PharmaTutor (September - 2017)

 

ISSN: 2347 - 7881
(Volume 5, Issue 9)

 

Received On: 13/04/2017; Accepted On: 22/05/2017; Published On: 01/09/2017

 

AUTHORS:
L Reddenna1*, Dr. P. Venkatesh1, K Siva Kumar2, A Sai keshava Reddy2
1* Department of Pharmacy Practice,
Jagan’s College of Pharmacy, Nellore, Andhra Pradesh, India
2 Department of Pharmacy Practice,
Nirmala College of Pharmacy, Kadapa, Andhra Pradesh, India
* reddennapharmd@gmail.com

 

 

ABSTRACT:
Genotoxicity describes the possessions of chemical agents that damage the genetic information within a cell causing mutations, which may lead to cancer. Heritable changes can influence either somatic cells of the organism or germ cells to be passed on to future generations. As a result, many urbane techniques including Ames Assay, in vitro and in vivo Toxicology Tests, and Comet Assay have been developed to evaluate the chemicals probable to cause DNA damage that may lead to cancer. The genotoxic substances provoke damage to the genetic material in the cells through exchanges with the DNA sequence and structure. Genotoxicity testing is to resolve if a substrate will sway genetic material or may cause cancer.

 

 

How to cite this article: Reddenna L, Venkatesh P, Kumar KS, Reddy ASK;Genotoxicity; PharmaTutor; 2017; 5(9);23-34

 

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