Pharmaceutics Articles

13 June 2013

LYOPHILIZATION PROCESS - AN OVERVIEW

ABOUT AUTHORS:
*Naveen Kamboj¹, Sadanand Maurya², Sonia Kamboj³, Gaurav kumar Singh²
¹Chandigarh College of Pharmacy, Landran, Mohali, Panjab
²Transalam Institute of Pharmaceutical Education and Reaserch, Meerut, Uttar Pradesh
³ISF college of pharmacy moga, Punjab
*kamboj.naveen21@gmail.com

ABSTRACT
The most important method for developing the very stable and suitable formulation for thermolabile as well as thermostable drug is lyophilization which works on the principle of sublimation of ice crystal from frozen material. Principle of the process through the basis of formulation, freezing, primary drying and secondary drying . In order to design optimum lyophilization process, process development scientific need to the critical properties of the formulation and how to apply to this information to process design. Lyophilized formulation not only has the advantage of better stability, but also provide easy handling i.e. shipping and storage. This article present an overview of lyophilization process, its advantage and pharmaceutical application.
4 June 2013

DEVELOPMENT AND VALIDATION OF ANALYTICAL METHOD FOR METRONIDAZOLE AND NORFLOXACIN IN TABLETS DOSAGE FORM

ABOUT AUTHORS:
Yogesh Kumar Jain*, Dr. R.P.S. Rathore, Udaibhan Singh Rathore, Dharmendra Singh sisodiya, Vijendra Singh Chauhan
Bhupal Nobles’ College of Pharmacy,
Udaipur – 313002, Rajasthan, India.
*jain.yogesh1987@gmail.com
3 June 2013

SUPERDISINTEGRANTS: A REVIEW

About Authors:
Hemant Rathod*, M.P.Khinchi, Dilip Agrawal, Natasha Sharma
*Department of Pharmaceutics
Kota College of Pharmacy,
Kota, Rajasthan, India
*hemant2787@gmail.com

Abstract
Fast dissolving, fast melting, chewable and orally dissolving or disintegrating tablets are solid dosage forms that disintegrate rapidly and dissolve in the mouth without water. These products have staying power in the marketplace because they appeal to consumers and support increased compliance among users as well as provide effective life-cycle management. The principle challenge with orally disintegrating tablets (ODTs) is to develop tablet formulations that deliver rapid disintegration, pleasant mouth feel and high breaking force for tablet robustness. Superdisintegrants affect a range of formulation parameters; including the rate of disintegration, tablet breaking force, and mouth feel i.e. Polyplasdone XL-10 superdisintegrant provides optimal performance in ODT formulations.
2 June 2013

AN OVERVIEW: MELT-IN-MOUTH TABLETS

About Authors:
Hemant Rathod*, Shakti Shekhawat, Jimit Shah, Parth Gandhi
Department of Pharmaceutics,
Kota College of Pharmacy, Kota, Rajasthan.
*hemant2787@gmail.com
31 May 2013

NANOROBOTICS - AN EMERGING TREND FOR CANCER TREATMENT

About Authors:
Prabhakar Sharma*¹, Prakash Pandey¹, Ramchandra Gupta¹, Ashish Garg², Prateek Jain³
¹Department of Pharmacognosy
²Department of Pharmaceutics
³Department of Pharmacy
Guru Ramdas Khalsa Institute of Science and Technology (Pharmacy) Jabalpur, M.P.
*mr.pks19@gmail.com

Abstract
Size reduction is one of most fundamental unit operation which is of prime importance in pharmacy. It helps in improving stability and bioavailability, reducing toxicity, enhancing release and providing better formulation opportunities for drug. Nanotechnology involves the engineering of molecularly precise structures and,ultimately, molecular machines. This paper presents the study of nanorobotscontrol activation for stenosed coronary occlusion, with thepractical use of chemical and thermal gradients for biomedicalproblems. This review paper describes all the information about pharmaceutical nano-robots, their types, components mechanismetc.
30 May 2013

NANOPARTICLE TECHNOLOGY IN DRUG DELIVERY SYSTEM

ABOUT AUTHORS:
Vishwa Deepak Kumar*, Abhishek Sharma, Rajneesh Mishra, Kanchan Sharma
B.Pharmacy, 2nd year
Department of Pharmacy, IEC group of institutions,
Greater Noida (U.P) INDIA, Pin- 201301
*vdkumar.iec@gmail.com

ABSTRACT
For the past few decades, there has been a considerable research interest in the area of drug delivery using particulate delivery systems as carriers for small and large molecules. Particulate systems like nanoparticles have been used as a physical approach to alter and improve the pharmacokinetic and pharmacodynamic properties of various types of drug molecules. They have been used in vivo to protect the drug entity in the systemic circulation; various polymers have been used in the formulation of nanoparticles for drug delivery research to increase therapeutic benefit, while minimizing side effects. Here, we review various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and therapeutic genes. Nanoparticles are the preparations having size in nanometers.
30 May 2013

FORMULATION AND CHARACTERIZATION OF MELOXICAM LOADED MICROEMULSION FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

ABOUT AUTHOR:
Verma Siddharth
Sri Ram Institute of Technology,
ITI Jabalpur M.P. 482003
luckyverma84@gmail.com

ABSTRACT
Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. The process produces an inflammatory response of the synovium (synovitis) secondary to hyperplasia of synovial cells, excess synovial fluid and the development of pannus in the synovium. Various treatments are available. Non-pharmacological treatment includes physical therapy, orthoses, occupational therapy and nutritional therapy. Analgesia (painkillers) and anti-inflammatory drugs including steroids are used to suppress the symptoms, while disease-modifying antirheumatic drugs (DMARDs) are often required to inhibit or halt the underlying immune process and prevent long-term damage. In recent times, the newer group of biologics has increased treatment options.
29 May 2013

OFFERING FLEXIBILITY OF EXPRESSION TO MEDICINE DESIGNERS

About Authors:
Madhulika Kabra¹, Pramod Khatri²*, Neerja Gupta³
¹ Professor of Pediatrics,
^2,3Department of Pediatrics,
AIIMS Hospital, India
*pramodsinghkhatri@gmail.com
28 May 2013

PRESENT REVIEW- TRANSDERMAL DRUG DELIVERY SYSTEM

About Author:
Akshay Rajgaria
Kanak Manjari Institute of Pharmaceutical Sciences
akshaykrish2007@gmail.com

ABSTRACT
Transdermal drug delivery system (TDDS) provides a means to sustain drug release as well as reduce the intensity of action and thus reduce the side effects associated with its oral therapy. Transdermal drugs are self contained, discrete dosage form. Transdermal Drug Delivery System is the system in which the delivery of the active ingredients of the drug occurs by the means of skin. Skin is an effective medium from which absorption of the drug takes place and enters the circulatory system. Various types of transdermal patches are used to incorporate the active ingredients into the circulatory system via skin. The patches have been proved effective because of its large advantages over other controlled drug delivery systems.
22 May 2013

STRUCTURE AND APPLICATION OF DENDRIMER IN NOVEL DRUG DELIVERY SYSTEM: A REVIEW ARTICLE

About Authros:
Khushbu Singh*¹, Chandana Majee²
¹ M.Pharm ( department of pharmaceutics)
² Assistant Professor, department of pharmaceutical chemistry.
Noida institute of engineering and technology, noida
*khushbu1991singh@gmail.com