ANTIEPILEPTIC ACTIVITY OF MURRAYA KOENIGII LEAF EXTRACTS
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ABOUT AUTHORS
JA Sathwara1*, AM Bhandari2
1Department of Pharmacology,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar, Anand, Gujarat.
2Department of Clinical Pharmacy,
A.R.College of Pharmacy & G.H.Patel Institute of Pharmacy, V.V. Nagar, Anand, Gujarat.
*jignasa.sathwara@gmail.com
ABSTRACT
The aim of the present study was to investigate antiepileptic effect of the aqueous extract of the leaves of Murraya koenigii L. Spreng (AEMK) on electrically and chemically induced seizures. The aqueous extract of the leaves of M. koenigii (200 and 300 mg/kg) were studied for its antiepileptic effect on maximal electroshock induced seizures and pentylenetetrazole induced seizures in mice. AEMK (200 and 300 mg/kg) significantly reduced the duration of seizures induced by maximal electroshock (MES) as well as protected animals from pentylenetetrazole induced tonic seizures. The results suggest that the aqeous extract of the leaves of M. koenigii may produce its antiepileptic effects via non-specific mechanisms since it reduced the duration of seizures produced by maximal electroshock as well as delayed the latency of seizures produced by pentylenetetrazole.

Sardar Patel University, named after one of the greatest and illustrious sons of India, Sardar Vallabhbhai Patel. This University in its fifty five years of existence has become a leading seat of higher education with several unique features. The University and the township of Vallabh Vidyanagar on which sprawls the University campus, have not been created by any executive order of the State, neither have they been created by one or few wealthy people. Indeed, this land of learning and the Seat of Higher Education - The University - has been created by a unique co-operative contribution of a large number of farmers of this rural area, who were inspired and enthused by the vision, dedication, and sacrifices of Sardar Patel, Shri Bhaikaka and Shri Bhikhabhai. Having been founded on the basis of selfless voluntary contribution of the local farmers aspiring to transform this rural area into an enlightened collectivity of people with impeccable character and national spirit, Sardar Patel University has been nurtured by the cherished values of its founders and a large number of very able, selfless and visionary academic and administrative leaders.

