Sahyadri College of Pharmacy

ESTIMATION OF ONDANSETRON HYDROCHLORIDE IN BULK AND FORMULATION BY SECOND ORDER DERIVATIVE AREA UNDER CURVE UV-SPECTROPHOTOMETRIC METHODS

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ABOUT AUTHORS:
Jadhav Santosh1*, Kharat Rekha1, Ansari Afaque2, Tamboli Ashpak3
1Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
2Department of Pharmaceutic’s, D. S. T. S Mandal’s College Of Pharmacy Solapur, Maharashtra India.
3Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade,
Sangola-413307, Solapur, Maharashtra, India.
*jadhavsan88@gmail.com

ABSTRACT:
Simple, fast and reliable spectrophotometric methods were developed for determination of Ondansetron Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Distilled Water. The quantitative determination of the drug was carried out using the second order Derivative Area under Curve method values measured at 248-254nm. Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Ondansetron Hydrochloride using 2-10μg/ml (r²=0.9986) for second order Derivative Area under Curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. The developed methods were successfully applied to estimate the amount of Ondansetron Hydrochloride in pharmaceutical formulations.

DIFFERENCE SPECTROSCOPIC METHOD FOR THE ESTIMATION OF CIPROFLOXACIN HYDROCHLORIDE IN BULK AND IN ITS FORMULATION

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ABOUT AUTHORS:
Kharat Rekha1*, Jadhav Santosh1, Pawar Seemarani2, Tamboli Ashpak2
1Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola, Solapur, Maharashtra, India
2Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade,
Sangola, Solapur, Maharashtra, India
*kharatrs26@gmail.com

ABSTRACT:
A simple, precise and accurate difference spectroscopic method has been developed for the estimation of Ciprofloxacin Hydrochloride in bulk drug form by difference spectrophotometric method. Ciprofloxacin Hydrochloride has exhibited maximum absorbance at about 272nm and 278nm in acidic and basic solution respectively. Beer’s law was obeyed in the concentration range of 2-10 µg/ml in both the cases. The regression of coefficient was found to be r2=0.9982. The LOD and LOQ value were found to be 0.5140ppm and 0.5577ppm respectively. The proposed method was successfully applied for the determination of Ciprofloxacin Hydrochloride in bulk drug. As per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.

ZERO ORDER AND AREA UNDER CURVE SPECTROPHOTOMETRIC METHODS FOR DETERMINATION OF FLUOXETINE HYDROCHLORIDE IN PHARMACEUTICAL FORMULATION

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ABOUT AUTHROS:
Mali Audumbar*, Jadhav Santosh, Hake Gorakhnath, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola-413307, Solapur, Maharashtra, India.
maliaudu442@gmail.com

ABSTRACT:
Simple, fast and reliable spectrophotometric methods were developed for determination of Fluoxetine Hydrochloride in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in Distilled Water. The quantitative determination of the drug was carried out using the zero order derivative values measured at 226 nm and the area under the curve method values measured at 220-231  nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Fluoxetine Hydrochloride using 5-25μg/ml (r²=0.999 and r²=0.997) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Fluoxetine Hydrochloride in tablets.

RESOURCES, GUIDANCE, CONTROL AND PREVENTION FOR EBOLA VIRUS DISEASE-AN OVERVIEW

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ABOUT AUTHORS:
Jadhav Santosh1*, Mali Audumbar1, Tamboli Ashpak2
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India1.
Department of Pharmaceutical chemistry, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India2.
jadhavsan88@gmail.com*

ABSTRACT
Since the current Ebola Virus Disease (also referred to as Ebola Haemorrhagic Fever) outbreak began in Guinea in December of 2013, the outbreak now involves trans-mission in Guinea, Liberia, Nigeria, and Sierra Leone. Ebola haemorrhagic fever (EHF) is a zoonosis affecting both human and non-human primates (NHP). Ebola virus (formerly officially designated Zaire Ebolavirus, or EBOV) was first seen infecting humans in African continent; especially  Sudan, Democratic Republican of Congo, Zaire and nearby countries. Fruit bats of the Pteropodidae family are considered to be the natural host of the Ebola virus. The virus is transmitted to people from wild animals and spreads in the human population through human-to-human transmission. The World Health Organization (WHO) reports that this is the largest Ebola Virus Disease (EVD) outbreak ever recorded. EVD outbreaks have a case fatality rate ofup to 90%. The research is on-going on development of making vaccine to curb this virus yet licensed success or specific treatment is not achieved.

DEVELOPMENT AND VALIDATION OF UV SPECTROPHOTOMETRIC ESTIMATION OF DICLOFENAC SODIUM BULK AND TABLET DOSAGE FORM USING AREA UNDER CURVE METHOD

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ABOUT AUTHORS:
Mali Audumbar Digambar*, Jadhav Santosh, Mane Pandurang, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola- 413307, Solapur, Maharashtra, India
maliaudu442@gmail.com

ABSTRACT
A simple, precise, accurate and economical UV visible spectrophotometric method has  been developed for estimation of Diclofenac sodium drug by AUC method. The standard and  sample solutions were prepared by using double distilled water as a solvent. Quantitative determination of the drug was performed at wavelength range 270-282 nm. The linearity was established over the concentration range of 05,10,15,20&25µg/ml for Diclofenac sodium with correlation coefficient value of 0.9981. Precision studies showed that % relative standard  deviation was within range of acceptable limits. The mean percentage recovery was found to be 99.38%.The proposed method has been validated as per ICH guidelines.

SYSTEMATIC APPROACH FOR COMPLAINT HANDLING IN PHARMACEUTICAL INDUSTRIES- AN UPDATED REVIEW

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ABOUT AUTHORS:
Jadhav Santosh*, Mali Audumbar, Bathe Ritesh, Tamboli Ashpak, Sawale Jyotiram
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola, Solapur, Maharashtra, India.
*jadhavsan88@gmail.com

ABSTRACT:
This article covers fundamental basics of quality complaint.Complaints show customer dissatisfaction about the quality of a pharmaceutical Product. Complaints may be about: Services, delivery, quality of product, communication, response time, documentation, billing, follow up etc. a good complaint handling system gives the company an opportunity to improve the quality of their products, being a good tool for the maintenance of Good Manufacturing Practices. A systematic procedure must be developed and implemented in order to register and investigate each complaint received and not only the Quality Assurance area must be involved. Systematic handling of complaints maintains a good relationship between customer and company. Thus the aim of this article is to discuss the main steps of a good complaint handling procedure that can be readily implemented in pharmaceutical companies.

DIFFERENCE SPECTROSCOPIC METHOD FOR THE ESTIMATION OF ACEBUTOLOL HYDROCHLORIDE IN BULK AND IN ITS FORMULATION

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ABOUT AUTHORS:
Jadhav Santosh*, Mali Audumbar, Pawar Seemarani, Kharat Rekha, Tamboli Ashpak
Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade,
Sangola-413307, Solapur, Maharashtra, India.
*jadhavsan88@gmail.com

ABSTRACT:
A simple, precise and accurate difference spectroscopic method has been developed for the estimation of Acebutolol Hydrochloride in bulk drug form by difference spectrophotometric method. Acebutolol Hydrochloride has exhibited maximum absorbance at about 233nm and 234nm in acidic and basic solution respectively. Beer’s law was obeyed in the concentration range of 2-10 µg/ml in both the cases. The regression of coefficient was found to be r2=0.9992. The LOD and LOQ value were found to be 0.2670ppm and 0.8091ppm respectively. The proposed method was successfully applied for the determination of Acebutolol Hydrochloride in bulk drug. As per ICH guidelines the result of the analysis were validated statistically and were found to be satisfactory.