Telangana

A COMPARATIVE STUDYOF CENTRAL ANALGESIC ACTIVITY OF POTENTIAL ANTIDEPRESSANTS

{ DOWNLOAD AS PDF }

ABOUT AUTHORS
S. VISWANTH REDDY*, G.AVINASH1, R. SAGAR2
PNR College of Pharmacy,
Shadnagar, Mahaboob Nagar (Dist), Telangana
vishwanth555@gmail.com

ABSTRACT
Pain is an ill defined, disabling accompaniment of many medical conditions. It is often evoked by an external and internal noxious stimulus. It affects millions of people suffering with depression and other psychiatric disorders. Most of the antidepressants are having analgesic capacity to treat the pain by inhibiting nociceptive stimuli by increasing the seratonergic and noradrenergic transmission in CNS.

Objectives
The Present study carried out to investigate the central analgesic activity of potential antidepressants like Fluoxetine, Imipramine, Amitriptyline and to compare the analgesic activity with standard central analgesic Pentazocine.

Methods
Analgesic activity was evaluated by using hot plate and tail immersion models in mice. Fluoxetine (10 mg/kg), Imipramine (20 mg/kg), Amitriptyline(20 mg/kg) were used as test drugs and Pentazocine (10 mg/kg) was used as standard drug. 

Results
In tail immersion model of analgesic activity Fluoxetine possess significant analgesic activity (*p<0.05 at 60 min interval, ***p<0.001 at 90 and 120 min interval) Amitriptyline also showed significant analgesic activity (**p<0.01) at 90 min interval and ***p<0.001 at 120 min interval. Imipramine is the least effective analgesic in this study showed mild analgesic activity (*p<0.05 at 90 min interval and **p <0.01 at 120 min interval).

In hot plate analgesic model Fluoxetine and Amitriptyline possess significant analgesic activity (***p<0.001 at 120 min interval), Imipramine same like above said model less effective, doesn’t shown significant analgesic activity.

Conclusion
All the test drugs significantly reduce the painful stimuli when compared to the control group in both the models. These results suggest that the antidepressants which increase the monoamine transmission in the brain posse’s significant antidepressant activity and might be useful as potent analgesics.

Career for Pharmacists (7 posts) in SCCL - A Government Company

The Singareni Collieries Company Limited, the turn around marvel of Indian Coal Mining Industry, is redefining excellence. This is the Golden Chance to prove your mettle as we move along meeting new challenges and seeking opportunities. Our tradition of strengths in having the finest Mining Technology at our 16 Opencast Mines and 30 Under Ground Mines is being geared up by increased usage of IT and serviced by Workshops, Stores & Coal Handling Plants, adopting the best operational & maintenance systems. Our quest for excellence with emphasis on Safety, Quality & Highest Productivity continues.

Post : Pharmacist - 07 posts

Wanted Faculty Post at Sri Kakatiya Institute of Pharmaceutical Sciences

Kakatiya University was established on 19th August, 1976 to fulfil the aspirations of the Telangana people for higher education. The founding of the University was in fact a historic event in the sense that heralded a new era in the realms of higher education of this region. The erstwhile Post-Graduate Centre of Osmania University was upgraded and named Kakatiya University. The development of the University over the years has been gradual but impressive. The University was initially accredited with B+ grade by the NAAC in 2002 and reaccredited with A grade in 2008. The University situated in a sprawling area of about 650 acres, has now 24 departments in four colleges on the campus with a network of eleven constituent colleges and 471 affiliated colleges. It has its Post-graduate Colleges at Subedari (Hanamkonda), Nirmal, Karimnagar, Godavarikhani, Khammam and Kothagudem in addtion to University Engineering College at Kothgudem.

Post : Faculty

Wanted Project Fellows, JRF, SRF in National Institute of Animal Biotechnology

National Institute of Animal Biotechnology (NIAB), an autonomous institute under the aegis of Department of Biotechnology, Government of India, is aimed to harness novel and emerging biotechnologies and create knowledge in the cutting edge areas for improving animal health and productivity.

Opening for Associate Team Manager PV Ops in PAREXEL

PAREXEL has supported the Bio-Tech and Pharmaceutical industries in helping the development of new drugs and treatments on a global basis. As a leading global biopharmaceutical service provider, they supply knowledge-based contract research, medical communications and consulting services across a broad range of therapeutic areas to the worldwide pharmaceutical, biotechnology and medical device industries. They have helped over 800 clients to develop and launch some of the most important drugs and devices of our time-helping people live better and healthier lives everywhere in the world. Headquartered near Boston, Massachusetts, PAREXEL operates in more than 50 countries around the world.

Post: Associate Team Manager

Recruitment for Chemists in TSGENCO - 42 posts

Telangana State Power Generation Corporation Limited (TSGENCO) is one of the pivotal organizations of Telangana State, engaged in the generation of power with an installed capacity of 5045.6 MW. It has also taken-up vast expansion of existing Power Generating Stations and also undertaken new Power Projects to supply quality and quantity power at an affordable cost, invites applications from the eligible and qualified candidates for the post of Chemist

Post- Chemist-(42 Post)

Career in Reference Standards Evaluation at U.S. Pharmacopeia - Masters in Pharmacy or chemistry

The U.S. Pharmacopeial Convention (USP) is a scientific nonprofit organization that sets standards for the identity, strength, quality, and purity of medicines, food ingredients, and dietary supplements manufactured, distributed and consumed worldwide. USP’s drug standards are enforceable in the United States by the Food and Drug Administration, and these standards are used in more than 140 countries.

Post: Senior Manager: Reference Standards Evaluation

Job for B.Pharm/M.Pharm at National Institute of Pharmaceutical Education and Research

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an 'Institute of National Importance. It is an autonomous body set up under the aegis of Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, Government of India. The Institute is conceived to provide leadership in pharmaceutical sciences and related areas not only within the country, but also to the countries in South East Asia, South Asia and Africa. NIPER is a member of Association of Indian Universities and Association of Commonwealth Universities.

Post: Junior Research Fellow (2 posts)

Pages