Swati k. Nagar*1, Dr. Harsha V. Patel1, Dr.Vishnu A. Patel2, Vinod V. Siju3
1Indukaka Ipcowala College of pharmacy, New V.V.Nagar
2ARCP, Vallabh vidhyanagar
3Anand Pharmacy College, Anand.
The aim of the present study was to investigate the applicability of liquisolid technique in improving the dissolution properties and solubility of olmesartan medoxomil (OLM) in a solid dosage form. This study was designed to optimize and evaluate the effects of different formulation variables: ratio of carrier to coating material (X1) and drug concentration (X2) on angle of repose (Y1), hardness(Y2), saturation solubility study (Y3) and cumulative percentage release at 10 min (CPR 10min)(Y4) of formulation using five level two factor central composite design. The quadratic model generated by the design is of the form: Y = A0 + A1X1 + A2X2 + A3X1X2 + A4X12 + A5X22 + E, where Y is the measured response associated with each factor level combination. Contour and response surface plots were depicted based on the equation given by the model. The optimized formula yields observed values close to the predicted values. The liquisolid tablets were formulated with liquid vehicles, poly ethylene glycol 400 (PEG400) at five drug concentrations, 10% w/w, 15% w/w, 20% w/w, 25% w/w and 30% w/w. Avicel PH102 was used as a carrier material, Aerosil 200 as a coating material and cross carmellose sodium as a disintegrant.In-vitro drug dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation (olmezest), in simulated intestinal fluid (pH 6.8). The drug release rates of LS compacts were higher as compared to directly compressed tablets, which show significant benefit of LS in increasing wetting properties and surface area of drug available for dissolution. From this study it concludes that the LS technique is a promising alternative for improvement of dissolution property.