About Authors:
Chauhan M.K., Kawadkar J., Kishore R.*, Pathak A.M.
Department of Pharmaceutics
DIPSAR, New Delhi
*rajkishor.aryan@gmail.com
ABSTRACT
This paper discussed the problems associated with nasal drug delivery and how it is possible, sometimes by means of quite simple concepts, to improve transport across the nasal membrane. It also described the advantages, barriers, physicochemical factors, and formulation related parameters that affecting the nasal drug delivery and the applications of nasal route for delivery of peptides, proteins, non-peptide drugs, and vaccines. In this way it is feasible to deliver efficiently challenging drugs such as small polar molecules, peptides and proteins and even the large proteins and polysaccharides used in vaccines or DNA plasmids exploited for DNA vaccines. The transport of drugs from the nasal cavity directly to the brain is also described. Nasal vaccines offer several benefits, such as low enzymatic degradation compared to oral vaccines, and greater acceptability to patients. Nasal vaccines, however, have to overcome several limitations, including mucociliary clearance. Therefore, nasal vaccines require potent adjuvants and delivery systems to enhance their immunogenicity and to protect their antigens.
The DIPSAR is one of the best Pharmacy Institute in India, with a strength of approximately 500 students, situated on a beautiful 10 acre campus in South Delhi. The institute is experiencing a fast academic growth and commitment to the challenges of the 21s' century.
About Authors: 
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