Amity University

Applications are invited from highly motivated and bright candidates for the position of  Junior Research Fellow in the  DST-SERB sponsored Project titled as "Probing Microtubule Remodeling in Tumor Associated Macrophages and its implication for Microtubule-targeted Chemotherapy”

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across London, Singapore, New Jersey, Dubai, Mauritius, Romania, Abu Dhabi, South Africa and China.

Amity University is part of the not-for-profit Amity Education Group with over 2 decades of excellence that includes 8 world-class universities, 25 schools & pre-schools, 150 top-ranked institutions and 12 international campuses across London, Singapore, New Jersey, Dubai, Mauritius, Romania, Abu Dhabi, South Africa and China.

Post : Junior Research Fellow

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ABOUT AUTHORS
Abdul Waheed*, Swati Pathak, Roohi Mirza
Department of Pharmacology,
Amity Institute of Pharmacy,
Amity University, Noida, U.P., India
*abdul.waheed2050@gmail.com

ABSTRACT
Epilepsy is a chronic brain disorder characterized by tendency to recurrent seizures or fits. The seizures can leads to loss of consciousness, disturbance of movement, muscle spasms, autonomic and mental functions. Epilepsy is developed because of imbalance in nerve signalling chemical called neurotransmitters. During epilepsy, the level of excitatory neurotransmitter glutamate increases and the level of inhibitory neurotransmitter GABA decrease. These lead to abnormal signalling in brain causes epilepsy. Primary diagnosis of epilepsy includes eye–witness and family history. Electroencephalograph (EEG) is the cornerstone for diagnosis of epilepsy and measures the brain wave activity. Neuroimaging like computed tomography (CT) scan, magnetic resonance imaging (MRI) and positron emission tomography (PET) techniques are used to diagnose abnormalities in structure and function of brain. Video recording is also useful for the monitoring of epileptic events. The most common approach of treatment is to prescribe antiepileptic drugs (AEDs). Three generations of AEDs including phenytoin, valproate, carbamazapine, lamotrigine, Oxcarbazepine, Primidone,Phenobarbitone,Gabapentin, Topiramate, Levetiracetam, Felbamate, Rufinamide, Zonisamide, Tiagabinand Vigabatrin etc. are prescribed. These AEDs have some teratogenic effects on  pragnent woman and lactating mother; need precautions. Instead of  pharmacological approaches, Non-pharmacological approaches also used for the treatment of epileptic seizures like ketogenic diet, atkins diet, yoga etc. Thr purpose of this review is to update the current knowledge on epilepsy classification, diagnostics, approaches of treatment, pathophysiology, mechanism of epileptogenesis and teratogenic effects.

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ABOUT AUTHORS:
Nidha Amir*, Mohd Mazhar, Abhinav Sawhney, S.K Rajput
Department of Pharmacology
Amity Institute of Pharmacy, Amity University, NOIDA, Uttar Pradesh-201313, India
nidha.amir05@gmail.com

ABSTRACT
Fluorine, the 13th most abundant element of the earth’s crust, represents about 0.3g / kg of earth’s crust. It occurs mainly in the form of chemical compounds such as sodium fluoride or hydrogen fluoride, which are present in minerals fluorospar, fluorapatite, topaz and cryolitect. Fluoride is frequently encountered in minerals and in geochemical deposits and is generally released into subsoil water sources by slow natural degradation of fluorine contained in rocks. Fluoride being a natural element has several effects on health. Fluoride is beneficial to health if the concentration (CF) of the fluoride ion (F-) in drinking water is less than 1.5 mg/L (WHO 1994). A higher concentration causes serious health hazards. The disease caused manifests itself in three forms, namely, dental, skeletal, and non-skeletal fluorosis. On a large scale, it is used in dental product due to its anti- sensitizing property and abrasive action. Application of fluoride must be controlled and restricted to reduce the side effect induced by it.

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ABOUT AUTHORS:
Mazhar M¹, Ansari. A², Rajput SK^1*
1Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh-201313.
²Department of Social Work, University Road, University of Delhi, Delhi-110007.
*skrajput95@amity.edu

ABSTRACT
In lieu of the fact that without adequate supervision, the assurance of quality of any system is not possible; clinical pharmacy has emerged as one of the latest and unmapped discipline of pharmacy in the 21^st century. The existence of clinical pharmacists in medical rounds could support physicians in optimizing pharmacotherapy. This novel profession in India extends its diversions to good manufacturing practices, procurement/preparation/distribution of medication, reporting ADRs/ ADEs and on the whole to a very promising aspect of patient healthcare service. The state of clinical pharmacy in India is in the transformational state showing serious positive promising changes in the past couple of years. Even hospitals have started distinguishing the importance of clinical pharmacy and have taken initiatives for making it possible although at a budding stage. The clinical pharmacy branch of pharmacy is surely attaining new heights in regard to patient care services which have certainly increased the services and satisfaction to the patients.

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ABOUT AUTHORS:
Abhinav Sawhney*, Nidha Amir, Mohd Mazhar, Sumeet Gullaiya, Satyendra K Rajput
Department of Pharmacology,
Amity institute of Pharmacy, Amity University,
Noida, Uttar Pradesh
abhinavsawhney@live.com

ABSTRACT:
Obesity has emerged as a major health issues for pediatric population as well as in adults in the present global scenario. In children, numerous studies have reveiled a relationship between the breast feeding and obesity in children. Apart from these, Family economic and education level, child meal pattern, duration of sleep and birth weight are also responsible for obesity. Some genetic problems including environmental and socio-economic factors are also responsible for the child obesity. Several studies have shown an evidence of protective effect of breast feeding against obesity while some shows a time dependent effect of breast feeding on childhood obesity. As per WHO recommendations, a child should be exclusively breast fed upto 6 months and breast fed along with the complementary food of good quality.  Introduction of the complementary food has a relationship bound with adipose rebound, which goes upto the age of 14. The intake of complementary food reduces the intake of breast milk and also induces the allergic reactions in the child. Apart from these leptin level and energy regulation in the body also plays and important role in pediatric obesity.

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ABOUT AUTHORS:
Abdul Waheed¹*, Ankit Gupta², Parth Patel^3
1Department of Pharmacology
²Department of Pharmaceutics
³Department of Drug Regulatory Affair
Amity Institute of Pharmacy, Amity University, Noida-125, U.P. (INDIA)
abdul.waheed2050@gmail.com

ABSTRACT
In the present scenario, lung cancer is one of the most prevalent and malignant cancer especially among the smoking group of people. The targeted delivery of chemotherapeutic agents to the lungs represents a novel therapeutic approach in lung cancer. Lung is an ideal route for administration of anticancer drug as it provides larger alveolar surface area, low thickness of epithelial barrier & extensive vascularization. Nanoparticles with nanocarriers have possibility of cell-targeted drug delivery with minimal systemic side effect and toxicity. Pulmonary epithelial cell, enzymes, receptors and genes are the target of the targeted drug delivery in lung cancer. This paper reviews the till date targeted drug delivery research performed for the treatment of lung cancer.