Amity University

About Author:
Mridula Jayaraman,
Amity Institute of Pharmacy,
Amity University, India
mridulajayaraman1990@gmail.com

Abstract
The word ‘cancer’ itself sends chills down our spines as its prognosis and treatment, even if detected at an early stage is cumbersome and tortuous. With the advent of modern medicines, even though it is claimed that cancer is curable, there exists virtually no chemotherapeutic agent for cancer without side effect(s), not to mention the cost of these medicines which are skyrocketing.
Hence, we are left with little choice but to go for new fronts in research on the therapeutic agents present in plants (Phytotherapy), which are not only cost effective but also relatively side effects free.  These plants are available in plenty in the Himalayan and Aravali Region of India.  
University of Wisconsin lists 150 plants which they have established as having potential value in the treatment of cancer.  However, the real issue here is that not many drugs derived from plants have been standardized and standardization of these plants for therapeutic purpose is still in the nascent stage.

About Authors:
Sachin Saxena*¹,Pankaj Sharma¹ ,Nimisha²
1-M Pharm (Pharmaceutics) , Amity Univerity,Lucknow
2-Lecturer,
Amity University,
Lucknow

Abstract:
Rapid developments in the field of molecular biology and gene technology resulted in generation of many macromolecular drugs including peptides, proteins, polysaccharides and nucleic acids in great number possessing superior  pharmacological efficacy with site specificity and devoid of unwanted and toxic effects. However, the main impediment for the oral delivery of these drugs as potential therapeutic agents is their extensive presystemic metabolism, instability  in acidic environment resulting into inadequate and erratic oral absorption. Parentral route of administration is the only  established route that overcomes all these drawbacks associated  with  these  orally  less/inefficient  drugs  but,  these   formulations  are  costly,  have  least  patient compliance, require repeated administration, in addition to the other hazardous effects associated with this route. Buccal drug delivery leads direct access to the systemic circulation through the internal jugular vein bypasses drugs from the hepatic first pass metabolism leading to high bioavailability. Buccal route is an attractive route of administration for systemic drug delivery. Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases.