Karnataka

Syngene International is one of India’s premier contract research and manufacturing organizations in providing customized service. Our services encompasses all across discovery chain: early stage discovery, process development, cGMP manufacturing and formulation development both in the small molecule and novel biologics area.

About Authors:
^*DINESH BABU GOTTIPATI¹, SREE DEVI ANANDHAM¹, NANNAPANENI VENKATA BALAKRISHNA RAO².
¹ Department of pharmaceutics, M.E.S.college of pharmacy, Aradeshally gate, Bangalore -562110,India.
² Research and Development Department, Natco Pharma Limited, Kothur.
*babu.dinesh89@live.in

ABSTRACT:
The aim of this study was to evaluate the effect of increasing nifedipine on the characteristics of fast-disintegrating sublingual tablets for the potential emergency treatment of anginal pain and hypertension. Nifedipine undergoes first pass metabolism in liver and gut wall which has oral bioavailability of 43-77%. Sublingual dosage form bypasses the metabolism of the nifedipine in liver and offers a fast relieve from anginal pain and hypertension. An attempt has been made to prepare fast dissolving tablets of nifedipine were prepared by wet granulation technique using Crospovidone and croscarmellose sodium (CCS) as super disintegrants as super disintegrants, Flavor and sweetener impart the taste to the formulation. The porous granules were compressed in to tablets by 8mm punch rotary tablet machine. All the formulations were evaluated for weight variation, hardness, friability, content uniformity, wetting time, and disintegration time and dissolution rate. Among the formulations, F9 one containing to be the best acceptable in terms of palatability, fast dissolving tablet having adequate strength. The disintegration time was found to be 56 ± 0.4 seconds, hardness of 4.6 ± g /cm², wetting time of 31sec   and drug release of 99.85 % in 9 mins. All the formulations showed low weight variation. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance.

Randstad is an international HR service provider servicing world class companies across the globe. Ma Foi Management Consultants was founded in 1992 by Mr.K.Pandia Rajan and the company was acquired in 2004 by Vedior. A leader in the HR industry in India, with 20 years rich history,Ma Foi became a part of Randstad in 2008 as part of global acquisition of Vedior by Randstad.

To facilitate the increased demand for innovative application-based products, Sami Labs Limited (formerly known as Sami Chemicals & Extracts Limited) was set up in 1991 at Singasandra in Bangalore ( India ) as a research and development facility. Today the main thrust and focus of Sami is on new product development and market oriented research.

About Authors:
^*1P.SanilKumar, ¹C K. Dhanapal, ²Sandhya Ravi
¹Department of Pharmacy,
Annamali University, AnnamaliNager,
Chidambaram, Tamilnadu.
²Lotus Labs Pvt Ltd,
No.07, Jasmabhavan Road, Vasanthanager, Bangalore, Karnataka.
*sanilmpharm@gmail.com

ABSTRACT
Hospitals are created for cure the disease but not for the spreading of diseases, even though this statement is true to the theoretical concept but it is not possible practically due to various risk factors. The spread of infection in the hospitals occurs due to the microorganism. Nosocomial infections add significantly to the economic burden of managing the underlying disease that has lead to hospitalization of the patient. More than 90% of reported infections are bacterial where as viral, fungal or protozoal infections are less commonly involved in hospital-acquired infections. This project deals with bacterial nosocomial pathogens only, since they are by far major causes of nosocomial infections. Objective of the present study include  the identification, prevention and control of nosocomial infection in our hospitals. The ultimate aim is the reduction of nosocomial infections and their costs. Baseline study for morbidity pattern in the hospitals, finding sources of exogenous and endogenous sources of nosocomial infection. Suggest measures to minimize the nosocomial infections and suggest guidelines for efficacious management of nosocomial infections.

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