Research News

Heart attacks, heart failure, stroke: COVID-19's dangerous cardiovascular complications

  • Posted on: 16 May 2020
  • By: PharmaTutor News

COVID-19 can cause serious cardiovascular complications including heart failure, heart attacks and blood clots that can lead to strokes, emergency medicine doctors report in a new scientific paper. They also caution that COVID-19 treatments can interact with medicines used to manage patients' existing cardiovascular conditions.

New project to develop human monoclonal antibodies for neutralizing SARS-CoV-2

  • Posted on: 13 May 2020
  • By: PharmaTutor News

The Council of Scientific and Industrial Research (CSIR), through its New Millennium Indian Technology Leadership Initiative (NMITLI) program, has approved a project towards development of human monoclonal antibodies (hmAbs) that can neutralize SARS-CoV-2 in patients. This project on generation of neutralizing human monoclonal antibodies as a therapeutic strategy will be implemented by a multi-institutional and multi-disciplinary team.

New triple antiviral drug combination shows early promise for treating COVID-19 in clinical trial

  • Posted on: 9 May 2020
  • By: PharmaTutor News

A two-week course of antiviral therapy with interferon beta-1b plus lopinavir-ritonavir and ribavirin, started within 7 days of showing COVID-19 symptoms, is safe and more effective at reducing the duration of viral shedding than lopinavir-ritonavir alone in patients with mild to moderate illness, according to the first randomised trial of this triple combination therapy involving 127 adults (aged 18 and older) from six public hospitals in Hong Kong.

Possible vaccine for virus linked to type 1 diabetes : Researchers

  • Posted on: 9 May 2020
  • By: PharmaTutor News

According to many observations, certain virus infections may play a part in the autoimmune attack that leads to type 1 diabetes. Researchers at Karolinska Institutet in Sweden and their Finnish colleagues have now produced a vaccine for these viruses in the hope that it could provide protection against the disease. The study is published today in the scientific journal Science Advances.

Scientists to culture novel coronavirus in human lung epithelial cell

  • Posted on: 7 May 2020
  • By: PharmaTutor News

Centre for Cellular and Molecular Biology (CCMB), Hyderabad has tied up with a Bengaluru-based company, Eyestem Research Private Limited, to take up research activities on COVID-19. Through this research collaboration, an attempt will be made to grow novel coronavirus in human cell lines, which will enable in vitro testing of potential drugs and vaccines against the COVID-19.

Inhibiting thrombin protects against dangerous infant digestive disease

  • Posted on: 6 May 2020
  • By: PharmaTutor News

Necrotizing enterocolitis (NEC), a rare inflammatory bowel disease, primarily affects premature infants and is a leading cause of death in the smallest and sickest of these patients. The exact cause remains unclear, and there is no effective treatment. No test can definitively diagnose the devastating condition early, so infants with suspected NEC are carefully monitored and administered supportive care, such as IV fluids and nutrition, and antibiotics to fight infection caused by bacteria invading the gut wall. Surgery must be done to excise damaged intestinal tissue if the condition worsens.

Two drugs show promise against COVID-19 : Researcher

  • Posted on: 5 May 2020
  • By: PharmaTutor News

Korean researchers have screened 48 FDA-approved drugs against SARS-CoV-2, and found that two, that are already FDA-approved for other illnesses, seem promising. The FDA approval for other uses would greatly reduce the time needed to gain FDA approval of use in COVID-19. The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.

Activating an estrogen receptor can stop pancreatic cancer cells from growing : Study

  • Posted on: 5 May 2020
  • By: PharmaTutor News

Caption : Activating a receptor found on the surface of many normal and cancer tissues can not only stop pancreatic cancer from growing but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy Credit : Penn Medicine

Activating the G protein-coupled estrogen receptor (GPER) - a receptor found on the surface of many normal and cancer tissues - has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy. Researchers at the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center observed the effects of GPER activation in human and mouse pancreatic cancer models and published their findings in Cellular and Molecular Gastroenterology and Hepatology today.

JNCASR scientists develop a natural product based Alzheimer inhibitor

  • Posted on: 4 May 2020
  • By: Shalini.Sharma

Scientists from Jawaharlal Nehru Centre For Advanced Scientific Research (JNCASR) an autonomous institute under the Department of Science & Technology (DST), Govt. of India have modified the structure of Berberine, a natural and cheap product similar to curcumin, available commercially, into Ber-D to use as a Alzheimer’s inhibitor. Their research work has been published in the scientific journal iSceince. Alzheimer’s disease is the most prevalent neurodegenerative disorder and accounts for more than 70% of all dementia. The multifactorial nature of the disease attributed to multifaceted toxicity has made it difficult for researchers to develop effective medication.

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