Gujarat

DETERMINATION OF PKA OF ACTIVE PHARMACEUTICAL INGREDIENT BY SPECTROMETRY

About Authors:
Kalpesh Ashara
Registered Pharmacist S.K.R.I.Medicines Centre, Rajkot, Gujarat, India,
M.Pharm Semester-I Student of B.K.Mody Govt.Pharmacy College Rajkot,
Department of Pharmaceutics GTU, Gujarat, India.
kalpeshashara@yahoo.com, kalpeshshr5@gmail.com*

Abstract:
Spectrophotometry is an attractive method for PKa determination in very diluted aqueous solution about 10-5 to 10-6M provided that the compound possesses PH dependent light absorption due to the presence of a chromospheres in proximity to the ionization centers. Traditionally 6 to 8 aliquot solutions of samples in identical concentrations but with different PH values are prepared & their absorption spectra are registered at single wavelength. This series of solutions can be generated by either preparing the sample in buffer solutions of known PH or titrating the sample solution e.g. alkalimetry. Then half the absorbance of maximum plotted on graph & interpolated on x-axis that will give value of PH is Pka  & negative Antilog of that value at base 10 give value of ka i.e. Dissociation Constant (Pka=-logka). This exercise is carrying out in below assignment.

RECENT ADVANCE IN PULSATILE DRUG DELIVERY SYSTEM

About Authors:
Dhirendra C. Patel1*, Ritesh B. Patel1, Gargi B. Patel2
1Department of Pharmaceutics and Pharmaceutical Technology;
S.K. Patel College of Pharmaceutical Education and Research;
Ganpat University, Kherva, Mehsana, Gujarat, India.
2Pharma Management & Regulatory Affairs,
K.B. Institute of Pharmaceutical Education & Research, Gandhinagar, Gujarat, India.
*dhiren.pharmacy@gmail.com

Abstract:
Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the obvious advantages of oral route of drug administration. However, there are certain conditions for which such a release pattern is not suitable like cardiovascular diseases, Diabetes mellitus, Asthma, Arthritis, Peptic ulcer etc. In such cases pulsatile drug delivery system is used in which release drug on programmed pattern i.e. at appropriate time & at appropriate site of action. Pulsatile Drug Delivery systems are basically time controlled drug delivery systems in which the system controls the lag time independent of environmental factors like pH, enzymes, gastro-intestinal motility, etc. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. In chronopharmacotherapy drug administration is synchronized with biological rhythms to produce maximal therapeutic effect & minimum harm for the patient. Technically, pulsatile drug delivery systems administered via the oral route could be divided into two distinct types, the time controlled delivery systems and the site-specific delivery systems, thus providing special and temporal delivery. In recent pharmaceutical applications involving pulsatile delivery; multiparticulate dosage forms (e.g. pellets) are gaining much favor over single-unit dosage forms. Various pulsatile technologies have been developed on the basis of methodologies, these includes ACCU-BREAK™, AQUALON,  CODAS®, PRODAS®, SODAS®, MINITABS®, DIFFUCAPS®, OROS® etc. Designing of proper pulsatile drug delivery will enhance the patient compliance, optimum drug delivery to the target side & minimizing the undesired effects.

PREPARATION & EVALUATION OF MICROSPHERES OF DICLOFENAC SODIUM BY SURFACE ACTIVE AGENT SLS

About Authors:
*Kalpesh Ashara, Jignesh Solanki
B.K.Mody Govt.Pharmacy College Rajkot,
Department of Pharmaceutics,GTU, Gujarat, India.
*kalpeshshr5@gmail.com

Abstract:
Microspheres are solid spherical particles containing a dispersed drug in organic solution fall in a range of 1-1000mm. Microspheres or micro particles are monolithinic device refer to a rate controlling matrix throughout the drug is dissolved or dispersed, while microcapsules are device which consists of cell-like dosage forms with the drug contain within the rate controlling membrane. Microspheres are prepared by several methods. Here Microspheres are prepared using a surface active agent SLS. Then Evaluation of Microspheres is carried out by means of several parameters. Then concluded that the diclofenac: polymer ratio of 1:2 & organic solvent (MeOH: DCM) ratio of 1:4 was found to be optimum for spherical shape of microspheres as well as Practical Yield.

BREAST CANCER: AN OVERVIEW

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About Authors:
Amardeep Sharma
Rathi Orthopaedic & research centre,
Ahmedabad, India
amardeep.sharma54@gmail.com

ABSTRACT:-
The knowledge of breast cancer development and progression has grown in recent years and relatively development of novel therapeutic strategies, but for cancer mortalities in women breast cancer stands at 2nd position as cause.

In U.S. Approximately 39970 women & 450 men in the U.S. will be diagnosed from the disease in 2011.[1] Breast cancer is a hormone dependent disease.[3] Breast cancer occurs when breast epithelial cells grows in abnormal way. HER2/neu, ER, PR, BRCA1, BRCA2 are the well known influencing factors responsible for breast cancer initiation. The major issues that limit the currently available breast cancer treatment are high cost, poor availability and resistance to chemotherapeutic agents. To overcome this problem researchers are working on several novel approaches i.e. “Novel drug targets & Novel target therapies”.

Since from past few years, mammogram is playing a huge role for decreasing incidence rate in developed countries. Breast cancer is adversely affecting the “quality of life” of patients and its impact has been increasing on the Social capital, population structure and economic growth. Need for novel anti breast cancer agent and novel early diagnosis technique is necessary to combat one of the most serious crises facing Human development.

Applications are invited for the post of Registrar and Placement Officer in National Institute of Pharmaceutical Education and Research(NIPER)

National Institute of Pharmaceutical Education and Research (NIPER) is the first national level institute in pharmaceutical sciences with a proclaimed objective of becoming a centre of excellence for advanced studies and research in pharmaceutical sciences. The Government of India has declared NIPER as an ‘Institute of National Importance’.

FORMULATION AND EVALUATION OF AMOXICILLIN TRIHYDRATE MODIFIED RELEASE DOSAGE FORMS

About Author:
*1 Patel Dimpalben Girishkumar, 2 Mr.K.H.Shah, 3 Rohit K Patel,
3Yatish Shukla, 3 Modi B, 3 Nilesh Patel
1 Dharmaj Degree Pharmacy College,

Dist- Anand, Dharmaj -388430, Gujarat
2 Professor, IPCPRC, Dharmaj, Gujarat
3 KAPTAB Pharmaceuticals
*dimplepatel70@gmail.com

Abstract
The aim of the current investigation is to design oral once daily modified  release dosage forms of amoxicillin trihydrate for treatment of pharyngitis/tonsilitis,  which release the drug for 24 hours and match with theoretical drug release profile.  The tablets and capsules were prepared by the different method using different  polymers in different concentrations. The interference of the polymers was ruled out  by FT-IR spectroscopy studies. The powder-blends of tablets and drug were evaluated  for their physical properties like angle of repose, bulk density, compressibility  index, and Hausner ratio and found to be satisfactory. The manufactured tablets  were evaluated for in process and finished product quality control tests including  appearance, thickness, weight variation, hardness, friability, drug content, and in  vitro drug release. All formulations showed appearance, thickness, weight variation,  hardness, friability and drug content in specified limit. All formulations showed  acceptable pharmacotechnical properties and complied with in-house specifications  for tested parameters. The results of dissolution studies indicated that formulation  containing 50% ethyl cellulose and 50% methocel was the most successful  formulation which was evidenced by similarity (f2) and dissimilarity (f1) factors. The  formulated amoxicillin trihydrate tablets followed zero order release kinetics and  Higuchi diffusion was the dominant mechanism of drug release, resulting in regulated  and complete release within 24 hours. Formulations were subjected to short term  stability studies as per ICH guidelines and were found stable. Capsule formulations  16  were evaluated for weight uniformity, drug content and in vitro drug release. The  results of dissolution studies indicated that drug release from capsule not extend up to  24hrs. All formulations of capsule failed in in-vitro drug release test. In comparison of  tablet and capsule formulations, tablet found to be successful dosage form.

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