Punjab Technical University

PHARMACOLOGICAL BASIS OF ANGIOGENESIS AND ANTIANGIOGENIC THEREPY

ABOUT AUTHOR:
Hargobind Rajput
Punjab Technical University,
Jalandhar
hargobind.rajput@gmail.com

ABSTRCT:
The use of antiangiogenic drug is an advantage as a novel treatment for a number of conditions, ranging from cancer to psoriasis. Antiangiogenic therapy becomes a new course of treatment for cancer. This has led to the reassessment of antiangiogenic therapy for cancer, and new strategies have been proposed to increase the efficacy of these agents in this setting. Angiogenesis has also been implicated in other conditions that are notoriously difficult to treat, such as arteriosclerosis, arthritis, psoriasis and diabetic retinopathy.Increased understanding of the angiogenic process, the diversity of its inducers and mediators, appropriate drug schedules and the use of these agents with other modalities may lead to radically new treatment regimens for many of these conditions. The role of angiogenesis in different pathological settings and emerging antiangiogenic agents currently in preclinical and clinical studies are discussed in this review. However, while potential benefits are profound, limitations of antiangiogenic therapy have also been identified, suggesting that there is also a need for caution in applying these compounds to the clinical setting.