Mehsana

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ABOUT AUTHOR
Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry,
Shri Sarvajanik Pharmacy College,
Mehsana, Gujarat, India
dhrubosen69@yahoo.com

ABSTRACT: Our goal is to perform in-vitro biotransformation of Prodrugs of ibuprofen+paracetamol, diclofenac sodium+paracetamol and ibuprofen+diclofenac sodium by acidic and alkaline hydrolysis of both ester (–COO–) and amide (–CONH–) linkages into free drugs and chromatographically separation of their Rt in HPLC. Since both ester (–COO–) and amide (–CONH–) linkages are susceptible for hydrolysis in both acidic pH (gastric pH) and basic pH (intestinal pH) to produce parent drug ibuprofen, diclofenac and paracetamol by biotransformation in in-vivo; so it will be implemented as a Prodrug which can show prolong action on pain and fever after getting release into free parent drug by biotransformation. The HPLC (High Performance Liquid Chromatography) study reports the retention time (Rt) and release kinetics of three Prodrugs by taking HPLC degradation datas of three samples of Prodrugs and individual HPLC datas of parent drugs separately to compare the Rt value of release of three drugs from Prodrugs in both acidic and alkaline pH. Prodrug–A (logP=4.56) releases Ibuprofen & Paracetamol, Prodrug–B (logP=4.90) releases Diclofenac & Paracetamol and Prodrug–C (logP=6.13) releases Ibuprofen & Diclofenac. This is a comparison study of drug release in in-vitro gastric as well as intestinal pH focusing on in-vivo biotransformation.  Keywords: Prodrug-A/Prodrug-B/Prodrug-C, Ibuprofen, Paracetamol, Diclofenac sodium, Molecular weight, logP, UV λmax, IR, Mobile phase, TLC-Rf value, HPLC-Rt value, LOD, LOC

Mercury Laboratories is the leading manufacturer of medicines. We are GMP and ISO 9001 certified, operating with multiple divisions. We are dynamic, innovative & growth oriented pharmaceutical group operating all over India from past 54 years in Pharma Industry.

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Dhrubo Jyoti Sen
Department of Pharmaceutical Chemistry, Shri Sarvajanik Pharmacy College, Gujarat Technological University, Arvind Baug, Mehsana-384001, Gujarat, India
dhrubosen69@yahoo.com

ABSTRACT:
Aftershave is an important part of a man’s daily lifestyle routine. After shave is a liquid product applied to skin after shaving. It contains an antiseptic agent such as denatured alcohol, stearate/citrate or witch hazel to prevent infection of cuts, as well as to act as an astringent to reduce skin irritation. Menthol is used in some varieties as well to numb damaged skin and it is an ingredient that shaving cream manufacturers have started including in their formulations, too. Aftershave with alcohol usually causes an immediate burning sensation when applying it post-shave, with effects sometimes lasting several minutes, but most commonly only for seconds. For this reason, a market consisting of highly differentiated products has been created—some using alcohols, some not. Some aftershaves use fragrance or essential oil to enhance scent. Moisturizers—natural and artificial, are often touted as able to soften the skin. Rinse your face and neck with cool water next to help close up your pores before you apply the aftershave. Do not apply aftershave immediately after you have finished shaving since doing so might make your skin sore or irritated. Pat your face and neck dry gently with a towel. As you shave, feel free to keep applying shaving cream. When you're done shaving, wash the area generously with lots of warm water. When you shave, shower in warm water first to soften skin, then lubricate with a shaving cream or lotion, never dry shave. Assure you use a clean, sharp, razor and shave in the direction of hair growth. Once shaven those hair follicles are open, clean area well and apply a gently aftershave lotion or aloe vera gel. Keywords: Cologne, Moisturizer, Humectant, Denatured alcohol, Polyquaternium-10, Allantoin, Styptic

A WELL KNOWN GROWING PHARMACEUTICAL COMPANY REQUIRED FOLLOWING CANDIDATE FOR BELOW TERRITORY

Europa Healthcare Pvt Ltd. are an upcoming organization, operating in various super speciality therapy segments like Cardiac diseases, Diabetes, Hypertension, Hypercholesterolemia, Vitamin Deficiency etc .Europa Healthcare Pvt Ltd. is well cultured & process oriented organization that provides transparent and employee friendly work environment. We understand that our employees are our real assets. We provide an obvious environment and offer equal platform to our valued employees to come out with their expertise to make a positive difference and grow along with the organizationOur top management team is highly skilled and experienced with about 50 years put together in world class MNCs and prominent Indian pharmaceutical houses.

Post : Territory Manager

GPSSB, ahmedabad invites online applications for direct recruitment of compunder or pharmacists (class-3). Candidates can apply from 17-11-2016 to 30-11-2016 (till night 11.59 hour) and exam bees should be deposited in post ofiice till 02-12-2016. Candidate should upload recent photograph and signature in scan format.

Post: Compounder

Shri. Satsangi Saket Dham “Ram Ashram” Trust came into existence in 11th April 2001.  Managed by Shri. Satsangi Saket Dham “Ram Ashram”,  Shri. Satsangi Saket Dham is conceived as the educational township to house and nurture all sorts of institutions offering value added professional, internationally competitive and recognized programs on one hand, and on another hand institutions of primary and secondary education with sound foundations of learning and enculturation of orient values essentially Indian in spirit and heritage.

Post : Faculty

Helping children discover the joy of learning and making learning an exciting process - it is with the twin aim that the Ratnamani Education Campus has been initiated. These initiatives of creating a vibrant learning environment are supported by Ratnamani Metals and Tubes Ltd , one of the leading corporate houses.

Europa Healthcare operates in many super speciality therapeutic areas suchas: Diabetes / Hypertension / Cardiovascular Diseases / Hypercholesterolemia / Neuropathy / Vitamin Deficiency. Europa Healthcare is driven by valiant vision, mission, values and strong ethics. Europa Provides a transparent and Employee friendly work culture for smart and skilled professionals.

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