TOXICOLOGICAL ASPECTS OF ARIPIPRAZOLE- A NEW ANTIPSYCHOTIC DRUG: REVIEW ARTICLE
About Author:
Renuka G. Hade
Quality Assurance Department, Wockhardt Limited,
Aurangabad (431210), M.S.
renukahade@gmail.com
Abstract:
Aripiprazole is a new antipsychotic agent. There is presently no evidence to suggest that it is more effective than existing antipsychotics in the treatment of schizophrenia but it offers prescribers another treatment option for this illness. Its efficacy in treatment-resistant schizophrenia is not established; for these patients clozapine is generally considered the drug of choice.
Aripiprazole is a widely used antipsychotic drug supplied in various dosage forms of Aripiprazole Tablets, Aripiprazole Orodispersible tablets and Aripiprazole Oral solution. These formulations are approved by United States Food and Drug Administartion (USFDA) and European Medicinal Agency (EMA) under the brand name Abilify®, manufactured by Otsuka Pharmaceuticals Limited.1
Based upon the current market demands of the Aripiprazole worldwide, a complete review of the non-clinical (Animal) safety (toxicological studies), is of considerable importance.