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  • Gene therapy for rare epilepsy shows promise in mice
    17 February 2025

    Gene therapy for rare epilepsy shows promise in mice

    Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death.
  • 15 February 2025
    BMS melanoma drug failed in clinical trial
    Bristol Myers Squibb announced the Phase 3 RELATIVITY-098 trial evaluating Opdualag nivolumab and relatlimab-rmbw for the adjuvant treatment of patients with completely resected stage III-IV melanoma did not meet its primary endpoint of recurrence-free survival.
  • 15 February 2025
    Pfizer’s TALZENNA® in Combination with XTANDI® Improves Survival Outcomes in Metastatic Castration Resistant Prostate Cancer
    Pfizer Inc announced positive results from the Phase 3 TALAPRO-2 study of TALZENNA talazoparib, an oral poly ADP-ribose polymerase inhibitor, in combination with XTANDI enzalutamide, an androgen receptor pathway inhibitor ARPI, demonstrating a statistically significant and clinically meaningful improvement in overall survival OS compared to placebo plus XTANDI in patients with metastatic castration-resistant prostate cancer mCRPC, with or without homologous recombination repair HRR gene mutations.
  • 15 February 2025
    Breakthrough in Click Chemistry : Innovative Method Revolutionizes Drug Development

    Middle molecules with a molecular weight of more than 1,000 are difficult to synthesize due to multiple steps and time-consuming nature, demanding the development of a new approach that can overcome these disadvantages. Click chemistry has become an essential tool in applied chemistry due to its simplicity, efficiency, and versatility. This approach to chemical synthesis allows for quick and reliable joining of small molecules into larger, more complex structures, often with minimal side reactions and byproducts.

  • 15 February 2025
    New blood test identifies hard-to-detect pancreatic cancer with 85% accuracy
    A new blood test could help doctors detect pancreatic cancer earlier, potentially improving survival rates for one of the deadliest cancers. Researchers at Oregon Health & Science University have developed a test called PAC-MANN, the abbreviation for protease activity-based assay using a magnetic nanosensor which uses a small blood sample to detect changes in protease activity a key indicator of pancreatic ductal adenocarcinoma, or PDAC, the most common and deadly form of pancreatic cancer.
  • 15 February 2025
    Diabetes Can Drive the Evolution of Antibiotic Resistance

    Antibiotics are powerful, fast-acting medications designed to eradicate bacterial infections. However, in recent years, their dependability has waned as antibiotic resistant bacteria continues to evolve and spread.

    Staphylococcus aureus is a leading cause of antibiotic resistance associated infections and deaths. It is also the most prevalent bacterial infection among those with diabetes mellitus, a chronic condition that affects blood sugar control and reduces the body’s ability to fight infections.

  • 7 February 2025
    80M Euro EU-funded Projects Launch Unprecedented Collaboration to Address the Obesity Crisis in Europe
    Over the past decades, obesity has reached epidemic proportions, now affecting more than 1 billion people worldwide. Childhood obesity, in particular, is rising at an alarming rate. According to the World Obesity Federation, the number of children with obesity is expected to double between 2020 and 2035. Obesity carries serious health consequences, strains national healthcare systems, and reduces overall quality of life.
  • 7 February 2025
    The two proteins involved in Alzheimer’s disease affect brain circuits differently
    A study using a new animal model of Alzheimers disease suggests a potential breakthrough in treatment strategies. Current therapies mainly focus on blocking just one of the toxic proteins associated with the disease, but this discovery could pave the way for more comprehensive approaches.
  • 3 February 2025
    Harnessing Generative AI to Treat Undruggable Diseases
    Biomedical engineers at Duke University have developed an AI-based platform that designs short proteins, termed peptides, capable of binding and destroying previously undruggable disease-causing proteins. Inspired by OpenAI’s image generation model, their new algorithm can rapidly prioritize peptides for experimental testing.
  • 3 February 2025
    New Case Western Reserve University study identifies key protein’s role in psoriasis

    Psoriasis, a painful and uncomfortable inflammatory skin condition that affects millions worldwide, flares up from the activity of disease- and infection-protecting immune cells.

    In a new study, researchers at Case Western Reserve University School of Medicine have determined that a protein called NF-kB c-Rel can intensify the condition’s symptoms when activated by signals from the body’s immune system. Understanding how “c-Rel” affects skin inflammation could lead to new treatments, they said.

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