Deficiencies of LH and low dose HCG can improve the outcome of IVF

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A new study suggests that women with deficiencies of luteinizing hormone (LH) and low dose human chorionic gonadotropin (hCG) can improve the outcome of in vitro fertilization (IVF).

They found some patients have low LH levels during ovarian stimulation and that these patients had lower embryo implantation and pregnancy rates in that IVF cycle. Author Anthony M. Propst and collegues also  states that fertilization and implantation rates can be significantly higher in donor IVF cycles using GnRH antagonists with recombinant LH. That fact indirectly suggested to them that low LH levels might lead to decreased implantation and pregnancy rates.

As part of a larger group of 239 patients, 42 patients with LH levels ≤0.5 mIU/mL were evaluated.

And they noticed that there were no differences in implantation and pregnancy rates between the recombinant FSH and the recombinant FSH with low-dose hCG supplementation groups.

Endogenous LH levels ≤0.5 mIU/mL after GnRH antagonist treatment are associated with statistically significantly lower implantation and pregnancy rates in recombinant FSH-only cycles.



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